AP2332A - Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors. - Google Patents
Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors.Info
- Publication number
- AP2332A AP2332A AP2007003906A AP2007003906A AP2332A AP 2332 A AP2332 A AP 2332A AP 2007003906 A AP2007003906 A AP 2007003906A AP 2007003906 A AP2007003906 A AP 2007003906A AP 2332 A AP2332 A AP 2332A
- Authority
- AP
- ARIPO
- Prior art keywords
- pyrazole
- protein kinase
- kinase inhibitors
- aminoheteroaryl compounds
- substituted aminoheteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60524404P | 2004-08-26 | 2004-08-26 | |
US69080305P | 2005-06-14 | 2005-06-14 | |
PCT/IB2005/002695 WO2006021881A2 (en) | 2004-08-26 | 2005-08-15 | Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
AP2007003906A0 AP2007003906A0 (en) | 2007-02-28 |
AP2332A true AP2332A (en) | 2011-12-05 |
Family
ID=35677463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2007003906A AP2332A (en) | 2004-08-26 | 2005-08-15 | Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors. |
Country Status (44)
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
OA13151A (en) * | 2003-02-26 | 2006-12-13 | Sugen Inc | Aminoheteroaryl compounds as protein kinase inhibitors. |
ME01788B (me) * | 2004-08-26 | 2011-02-28 | Pfizer | Enantiomerno čista aminoheteroaril jedinjenja kao inhibitori protein kinaza |
US20070072908A1 (en) * | 2005-06-08 | 2007-03-29 | Japan Tobacco Inc. | Heterocyclic compounds |
EP1959955B1 (en) * | 2005-12-05 | 2010-11-17 | Pfizer Products Inc. | Method of treating abnormal cell growth |
CA2632283C (en) * | 2005-12-05 | 2011-06-21 | Pfizer Products Inc. | Polymorphs of a c-met/hgfr inhibitor |
EA200970403A1 (ru) | 2006-10-23 | 2009-10-30 | ЭсДжиЭкс ФАРМАСЬЮТИКАЛЗ, ИНК. | Бициклические триазолы в качестве модуляторов протеинкиназы |
GB0621607D0 (en) * | 2006-10-31 | 2006-12-06 | Chroma Therapeutics Ltd | Inhibitors of c-Met |
WO2008071451A1 (en) | 2006-12-14 | 2008-06-19 | Bayer Schering Pharma Aktiengesellschaft | Dihydropyridine derivatives useful as protein kinase inhibitors |
US8551995B2 (en) * | 2007-01-19 | 2013-10-08 | Xcovery Holding Company, Llc | Kinase inhibitor compounds |
US8715665B2 (en) * | 2007-04-13 | 2014-05-06 | The General Hospital Corporation | Methods for treating cancer resistant to ErbB therapeutics |
US8263585B2 (en) | 2007-05-04 | 2012-09-11 | Novartis Ag | Organic compounds |
DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
US8748143B2 (en) | 2007-09-13 | 2014-06-10 | Codexis, Inc. | Ketoreductase polypeptides for the reduction of acetophenones |
KR20100089090A (ko) | 2007-10-25 | 2010-08-11 | 아스트라제네카 아베 | 세포 증식 장애의 치료에 유용한 피리딘 및 피라진 유도체 |
WO2009099982A1 (en) * | 2008-02-04 | 2009-08-13 | Osi Pharmaceuticals, Inc. | 2-aminopyridine kinase inhibitors |
AR070317A1 (es) | 2008-02-06 | 2010-03-31 | Osi Pharm Inc | Furo (3,2-c) piridina y tieno (3,2-c) piridinas |
US8268834B2 (en) * | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
WO2009131173A1 (ja) | 2008-04-23 | 2009-10-29 | 協和発酵キリン株式会社 | 2-アミノキナゾリン誘導体 |
KR101034351B1 (ko) * | 2008-05-14 | 2011-05-16 | 한국화학연구원 | 신규 벤즈옥사졸로 치환된 피리딘 유도체 또는 이의약학적으로 허용가능한 염, 이의 제조방법 및 이를유효성분으로 함유하는 이상세포 성장 질환의 예방 및치료용 약학적 조성물 |
US8697866B2 (en) | 2008-06-19 | 2014-04-15 | Xcovery Holding Company Llc | Substituted pyridazine carboxamide compounds as kinase inhibitor compounds |
JP2012509342A (ja) | 2008-11-20 | 2012-04-19 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換ピロロ[2,3−b]−ピリジンおよび−ピラジン |
DE102009003975A1 (de) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Benzothiazolonderivate |
MX2011012522A (es) * | 2009-05-28 | 2012-02-08 | Vertex Pharma | Inhibidores de pirazol sustituido de proteina cinasa c-met. |
AR080945A1 (es) | 2009-07-07 | 2012-05-23 | Pathway Therapeutics Inc | Pirimidinil y 1,3,5-triazinil benzimidazoles y su uso en la terapia contra el cancer |
DE102009056886A1 (de) | 2009-12-03 | 2011-06-09 | Bayer Schering Pharma Aktiengesellschaft | cMet-Inhibitoren zur Behandlung der Endometriose |
US8378104B2 (en) * | 2010-02-11 | 2013-02-19 | OSI Pharmaceuticals, LLC | 7-aminofuropyridine derivatives |
CN102858175A (zh) * | 2010-02-22 | 2013-01-02 | 葛兰素史密斯克莱有限责任公司 | 作为脂肪酸合成酶抑制剂的三唑酮 |
WO2011109593A1 (en) | 2010-03-03 | 2011-09-09 | OSI Pharmaceuticals, LLC | Substituted-5-aminopyrrolo/pyrazolopyridines |
CA2796967C (en) * | 2010-05-04 | 2015-12-01 | Pfizer Inc. | Heterocyclic derivatives as alk inhibitors |
US8513238B2 (en) * | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
WO2011143646A1 (en) | 2010-05-14 | 2011-11-17 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
NZ604306A (en) | 2010-05-17 | 2015-02-27 | Incozen Therapeutics Pvt Ltd | Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of protein kinases |
CN101857594B (zh) * | 2010-06-18 | 2013-04-03 | 南方医科大学 | 一种四氢吡啶并吲哚类化合物及其制备方法和应用 |
US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
US8962830B2 (en) * | 2010-07-09 | 2015-02-24 | The Walter And Eliza Hall Institute Of Medical Research | Protein kinase inhibitors and methods of treatment |
CN101967140A (zh) * | 2010-09-14 | 2011-02-09 | 郑州泰基鸿诺药物科技有限公司 | 氘代克里唑蒂尼及其衍生物、制备方法和应用 |
CA2813607C (en) | 2010-10-08 | 2021-08-31 | Xcovery Holding Company, Llc | Substituted pyridazine carboxamide compounds |
US9145390B2 (en) | 2011-03-03 | 2015-09-29 | Concert Pharmaceuticals, Inc. | Derivatives of pyrazole-substituted amino-heteroaryl compounds |
KR101940831B1 (ko) | 2011-03-28 | 2019-01-21 | 메이 파마, 아이엔씨. | (알파-치환된 아르알킬아미노 및 헤테로아릴알킬아미노)피리미딘일 및 1,3,5-트라이아진일 벤즈이미다졸, 이들을 함유하는 약학 조성물, 및 증식성 질병의 치료에 사용하기 위한 이들 화합물 |
US20140088114A1 (en) | 2011-05-16 | 2014-03-27 | OSI Pharmaceuticals ,LLC | Fused bicyclic kinase inhibitors |
CN102850328B (zh) * | 2011-07-01 | 2014-12-24 | 苏州东南药业股份有限公司 | 吡啶类化合物、其制备方法、包含该化合物的药物组合物及其用途 |
CN103732588B (zh) * | 2011-07-27 | 2016-10-12 | 南京奥昭生物科技有限公司 | 螺环分子作为蛋白激酶抑制剂 |
MX2014001354A (es) * | 2011-08-02 | 2014-10-14 | Pfizer | Crizotinib para uso en el tratamiento de cancer. |
JP2014526524A (ja) * | 2011-09-21 | 2014-10-06 | テリジーン リミテッド | キナーゼ阻害剤としてのピリジン化合物 |
CN103087050A (zh) * | 2011-10-28 | 2013-05-08 | 山东轩竹医药科技有限公司 | 芳基激酶抑制剂 |
MD4590C1 (ru) | 2012-03-06 | 2019-03-31 | Pfizer Inc. | Макроциклические производные для лечения пролиферативных заболеваний |
CN103304552B (zh) * | 2012-03-09 | 2016-12-28 | 广东东阳光药业有限公司 | 取代的吡啶化合物及其使用方法和用途 |
WO2013138210A1 (en) * | 2012-03-14 | 2013-09-19 | Ning Xi | Substituted cyclic compounds and methods of use |
CN104302640A (zh) | 2012-03-16 | 2015-01-21 | 埃克希金医药品有限公司 | 3,5-二氨基吡唑激酶抑制剂 |
CN103319468B (zh) * | 2012-03-21 | 2016-07-13 | 广东东阳光药业有限公司 | 取代的螺双环化合物及其使用方法和用途 |
WO2013144191A1 (de) | 2012-03-29 | 2013-10-03 | Bayer Intellectual Property Gmbh | Substituierte 2 -amino - 3 - cyanopyridine als inhibitoren des natrium calcium austausches und ihre verwendung bei kardiovaskulären erkrankungen |
EP2831073B1 (en) | 2012-03-30 | 2020-12-09 | Rhizen Pharmaceuticals S.A. | Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b]pyridine compounds as modulators of c-met protein kinases |
WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
CN106349222B (zh) * | 2012-04-22 | 2019-03-05 | 东南大学 | 克里唑替尼前药及其制备方法与用途 |
KR101582852B1 (ko) | 2012-05-24 | 2016-01-07 | 서울대학교 산학협력단 | 타우 단백질 매개 신경 퇴행성 질환 치료제 |
WO2013181251A1 (en) | 2012-05-29 | 2013-12-05 | Ratiopharm Gmbh | Crizotinib hydrochloride salt in crystalline |
GB201211310D0 (en) * | 2012-06-26 | 2012-08-08 | Chroma Therapeutics Ltd | CSF-1R kinase inhibitors |
WO2014020467A2 (en) | 2012-07-30 | 2014-02-06 | Fresenius Kabi Oncology Ltd | Process for the preparation of pyrazole substituted aminoheteroaryl compounds |
JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
WO2014033136A1 (en) | 2012-08-27 | 2014-03-06 | Cemm - Research Center For Molecular Medicine Of The Austrian Academy Of Sciences | Aminoheteroaryl compounds as mth1 inhibitors |
CN103720691A (zh) * | 2012-10-11 | 2014-04-16 | 韩冰 | 一类治疗脑性瘫痪的化合物及其用途 |
WO2014060381A1 (de) | 2012-10-18 | 2014-04-24 | Bayer Cropscience Ag | Heterocyclische verbindungen als schädlingsbekämpfungsmittel |
WO2014081816A1 (en) * | 2012-11-21 | 2014-05-30 | Concert Pharmaceuticals, Inc. | Fluoro-derivatives of pyrazole-substituted amino-heteroaryl compounds |
TWI498325B (zh) * | 2013-01-18 | 2015-09-01 | Hoffmann La Roche | 3-取代吡唑及其用途 |
RU2671212C2 (ru) * | 2013-02-02 | 2018-10-30 | Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд | Замещенный 2-аминопиридин в качестве ингибитора протеинкиназы |
CN103992307B (zh) * | 2013-02-16 | 2017-07-14 | 浙江九洲药物科技有限公司 | 一种克里唑替尼的制备方法 |
WO2014139391A1 (en) * | 2013-03-11 | 2014-09-18 | Teligene Ltd | Substituted pyridine compounds as kinases inhibitors |
EP2970181B1 (en) | 2013-03-14 | 2017-06-07 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
US9765035B2 (en) | 2013-03-14 | 2017-09-19 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
EP3363434A1 (en) | 2013-03-14 | 2018-08-22 | Epizyme Inc | Arginine methyltransferase inhibitors and uses thereof |
WO2014153172A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
EP2970132B1 (en) | 2013-03-14 | 2020-09-23 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
EP2970135B1 (en) | 2013-03-14 | 2018-07-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
EP2970136A1 (en) | 2013-03-14 | 2016-01-20 | Epizyme, Inc. | Arginine methyl transferase inhibtors and uses thereof |
EP2970137A1 (en) | 2013-03-14 | 2016-01-20 | Epizyme, Inc. | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof |
CN104059054B (zh) * | 2013-03-19 | 2018-11-20 | 浙江导明医药科技有限公司 | 用于治疗癌症的三级环状胺alk激酶抑制剂 |
WO2014203177A1 (en) * | 2013-06-18 | 2014-12-24 | Shilpa Medicare Limited | Amorphous (r) -3- [1- (2, 6-dichloro-3-fluorophenyl) methoxy] -5- [1- (piperidin-4- yl) -1h-pyrazol-4-yl] pyridin-2-amine |
CN104230890A (zh) * | 2013-06-19 | 2014-12-24 | 信诺凯(北京)化工有限公司 | 吡啶-2-胺衍生物及其制法和药物组合物与用途 |
CN104650049B (zh) * | 2013-08-28 | 2018-06-08 | 广东东阳光药业有限公司 | 取代的吡啶化合物及其使用方法和用途 |
KR101598664B1 (ko) | 2013-09-04 | 2016-03-02 | 씨제이헬스케어 주식회사 | 피롤로피리다진 유도체를 포함하는 단백질 키나제 억제제 |
WO2015034729A1 (en) * | 2013-09-05 | 2015-03-12 | Calitor Sciences, Llc | Substituted pyridine compounds and methods of use |
NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
CN104703988B (zh) | 2013-09-30 | 2017-04-12 | 韩国化学研究院 | 新的三唑并吡嗪衍生物及其用途 |
CN107002119A (zh) | 2014-03-24 | 2017-08-01 | 豪夫迈·罗氏有限公司 | 使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联 |
WO2015172747A1 (en) * | 2014-05-16 | 2015-11-19 | Zhaoyin Wang | Spirocyclic molecules as mth1 inhibitors |
US10695426B2 (en) | 2014-08-25 | 2020-06-30 | Pfizer Inc. | Combination of a PD-1 antagonist and an ALK inhibitor for treating cancer |
WO2016044576A1 (en) * | 2014-09-17 | 2016-03-24 | Epizyme, Inc. | Salts, co-crystals, amorphous forms, and crystalline forms of an arginine methyltransferase inhibitor |
CN104402868B (zh) * | 2014-11-04 | 2016-08-24 | 郑州泰基鸿诺医药股份有限公司 | 氘代克里唑蒂尼晶型及其制备方法 |
JP6864953B2 (ja) | 2014-12-09 | 2021-04-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Axlに対するヒトモノクローナル抗体 |
AR103264A1 (es) | 2014-12-23 | 2017-04-26 | Axikin Pharmaceuticals Inc | Derivados de 3,5-aminopirazol como inhibidores de quinasa rc |
WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
WO2016145383A1 (en) * | 2015-03-11 | 2016-09-15 | Board Of Regents, University Of Texas System | Mth1 inhibitors for treating disease |
EP3287463A4 (en) | 2015-04-24 | 2018-07-11 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. | Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof |
CN106279112A (zh) * | 2015-06-12 | 2017-01-04 | 浙江九洲药业股份有限公司 | 一种克里唑替尼中间体及其制备方法和应用 |
JP2018529719A (ja) | 2015-09-30 | 2018-10-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Alk陰性がんを処置するためのpd−1系結合アンタゴニストおよびalk阻害剤の組合せ |
IL292302B2 (en) | 2016-05-20 | 2023-10-01 | Biohaven Pharm Holding Co Ltd | Use of glutamate modulating factors in cancer immunotherapy |
TWI646094B (zh) | 2016-06-01 | 2019-01-01 | 大陸商貝達藥業股份有限公司 | Crystal form of inhibitory protein kinase active compound and application thereof |
CN106632260B (zh) * | 2016-09-29 | 2019-04-26 | 上海天慈生物谷生物工程有限公司 | 一种小分子激酶抑制剂的制备方法 |
CN117860758A (zh) | 2017-05-23 | 2024-04-12 | 梅制药公司 | 联合疗法 |
WO2019036489A1 (en) | 2017-08-14 | 2019-02-21 | Mei Pharma, Inc. | COMBINATION THERAPY |
CN110372664A (zh) * | 2018-04-13 | 2019-10-25 | 华东理工大学 | 选择性jak2抑制剂及其应用 |
KR102207608B1 (ko) | 2019-04-24 | 2021-01-26 | 윤종오 | 카르복실산으로 유기화된 규소 이온 복합체 및 복합체의 제조방법과 이를 이용한 제품 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003066608A1 (en) * | 2002-02-06 | 2003-08-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Catechol bioisosteres |
WO2004013091A2 (en) * | 2002-08-01 | 2004-02-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | 4-anilido substituted quinazolines and use thereof as inhibitors of epidermal growth factor receptor kinases |
WO2004076412A2 (en) * | 2003-02-26 | 2004-09-10 | Sugen, Inc. | Aminoheteroaryl compounds as protein kinase inhibitors |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5587458A (en) * | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
DE69333807T2 (de) * | 1992-02-06 | 2006-02-02 | Chiron Corp., Emeryville | Marker für krebs und biosynthetisches bindeprotein dafür |
US5863949A (en) * | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
ES2153031T4 (es) * | 1995-04-20 | 2001-05-16 | Pfizer | Derivados del acido arilsulfonil hidroxamico como inhibidores de mmp y tnf. |
US5747498A (en) * | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
GB9518953D0 (en) * | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
CA2259222A1 (en) * | 1996-06-27 | 1997-12-31 | Pfizer Inc. | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors |
JPH11236333A (ja) * | 1997-12-30 | 1999-08-31 | Pfizer Prod Inc | 抗ガン剤として有用なイミダゾリン−4−オン誘導体 |
ID27562A (id) * | 1998-08-27 | 2001-04-12 | Pfizer Prod Inc | Turunan-turunan kinolin-2-ona tersubstitusi alkunil yang berguna sebagai zat anti kanker |
EP1107962B1 (en) * | 1998-08-27 | 2005-02-23 | Pfizer Products Inc. | Quinolin-2-one derivatives useful as anticancer agents |
EP1006113A1 (en) * | 1998-12-02 | 2000-06-07 | Pfizer Products Inc. | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth |
US6682736B1 (en) * | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
UA71945C2 (en) * | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
JP3270834B2 (ja) * | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
DE60020812T2 (de) * | 1999-02-11 | 2006-05-04 | Pfizer Products Inc., Groton | Heteroaryl-substituierte chinolin-2-on derivate verwendbar als antikrebsmittel |
US6586447B1 (en) * | 1999-04-01 | 2003-07-01 | Pfizer Inc | 3,3-disubstituted-oxindole derivatives useful as anticancer agents |
EP1081137A1 (en) * | 1999-08-12 | 2001-03-07 | Pfizer Products Inc. | Selective inhibitors of aggrecanase in osteoarthritis treatment |
ES2212971T3 (es) * | 1999-11-30 | 2004-08-16 | Pfizer Products Inc. | Derivados de quinolina utiles para la inhibicion de la farnesil protein transferasa. |
HN2000000266A (es) * | 2000-01-21 | 2001-05-21 | Pfizer Prod Inc | Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto. |
US6844357B2 (en) * | 2000-05-01 | 2005-01-18 | Pfizer Inc. | Substituted quinolin-2-one derivatives useful as antiproliferative agents |
SE0102438D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
SE0102439D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
AU2003246927A1 (en) * | 2002-07-03 | 2004-01-23 | Astex Technology Limited | 3-`(hetero) arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors |
SE0203754D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
DE10307845A1 (de) * | 2003-02-25 | 2004-09-02 | Bayer Cropscience Gmbh | Heterocyclische Amide, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel |
ME01788B (me) * | 2004-08-26 | 2011-02-28 | Pfizer | Enantiomerno čista aminoheteroaril jedinjenja kao inhibitori protein kinaza |
-
2005
- 2005-08-15 EA EA200700321A patent/EA011725B1/ru active Protection Beyond IP Right Term
- 2005-08-15 GE GEAP20059888A patent/GEP20094845B/en unknown
- 2005-08-15 DK DK05782821.2T patent/DK1784396T3/da active
- 2005-08-15 AU AU2005276132A patent/AU2005276132B2/en active Active
- 2005-08-15 CN CN200580030636XA patent/CN101018780B/zh active Active
- 2005-08-15 WO PCT/IB2005/002695 patent/WO2006021881A2/en active Application Filing
- 2005-08-15 SI SI200531231T patent/SI1784396T1/sl unknown
- 2005-08-15 BR BRPI0514537A patent/BRPI0514537B8/pt active IP Right Grant
- 2005-08-15 RS RS20110085A patent/RS51601B/en unknown
- 2005-08-15 CA CA2577937A patent/CA2577937C/en active Active
- 2005-08-15 MX MX2007002310A patent/MX2007002310A/es active IP Right Grant
- 2005-08-15 JP JP2007529029A patent/JP4167295B2/ja active Active
- 2005-08-15 PT PT05782821T patent/PT1784396E/pt unknown
- 2005-08-15 NZ NZ552946A patent/NZ552946A/en unknown
- 2005-08-15 AP AP2007003906A patent/AP2332A/xx active
- 2005-08-15 ES ES05782821T patent/ES2355923T3/es active Active
- 2005-08-15 ME MEP-2011-40A patent/ME01309B/me unknown
- 2005-08-15 DE DE602005025499T patent/DE602005025499D1/de active Active
- 2005-08-15 AT AT05782821T patent/ATE492544T1/de active
- 2005-08-15 EP EP05782821A patent/EP1784396B8/en active Active
- 2005-08-15 KR KR1020077004564A patent/KR100869393B1/ko active Protection Beyond IP Right Term
- 2005-08-15 PL PL05782821T patent/PL1784396T3/pl unknown
- 2005-08-19 MY MYPI20053921A patent/MY139942A/en unknown
- 2005-08-23 AR ARP050103534A patent/AR050529A1/es active IP Right Grant
- 2005-08-23 UY UY29080A patent/UY29080A1/es active IP Right Grant
- 2005-08-24 PE PE2005000974A patent/PE20060651A1/es active IP Right Grant
- 2005-08-24 HN HN2005000477A patent/HN2005000477A/es unknown
- 2005-08-24 GT GT200500226A patent/GT200500226A/es unknown
- 2005-08-25 TW TW094129028A patent/TWI300411B/zh active
- 2005-08-25 NL NL1029809A patent/NL1029809C2/nl active Search and Examination
- 2005-08-26 SV SV2005002208A patent/SV2006002208A/es unknown
- 2005-08-26 US US11/213,039 patent/US20060128724A1/en not_active Abandoned
- 2005-08-26 PA PA20058643201A patent/PA8643201A1/es unknown
-
2007
- 2007-01-29 IL IL181045A patent/IL181045A0/en unknown
- 2007-02-13 ZA ZA200701281A patent/ZA200701281B/xx unknown
- 2007-02-21 CR CR8938A patent/CR8938A/es unknown
- 2007-02-23 NI NI200700058A patent/NI200700058A/es unknown
- 2007-02-23 TN TNP2007000071A patent/TNSN07071A1/fr unknown
- 2007-02-26 EC EC2007007278A patent/ECSP077278A/es unknown
- 2007-02-26 MA MA29719A patent/MA28827B1/fr unknown
- 2007-03-09 NO NO20071320A patent/NO338656B1/no unknown
- 2007-10-04 HK HK07110744.1A patent/HK1105415A1/xx unknown
-
2011
- 2011-01-27 CY CY20111100092T patent/CY1111138T1/el unknown
- 2011-02-16 HR HR20110116T patent/HRP20110116T1/hr unknown
-
2012
- 2012-08-10 CR CR20120421A patent/CR20120421A/es unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003066608A1 (en) * | 2002-02-06 | 2003-08-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Catechol bioisosteres |
WO2004013091A2 (en) * | 2002-08-01 | 2004-02-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | 4-anilido substituted quinazolines and use thereof as inhibitors of epidermal growth factor receptor kinases |
WO2004076412A2 (en) * | 2003-02-26 | 2004-09-10 | Sugen, Inc. | Aminoheteroaryl compounds as protein kinase inhibitors |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AP2332A (en) | Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors. | |
AP2005003383A0 (en) | Aminoheteroaryl compounds as protein kinase inhibitors. | |
ZA200700127B (en) | Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors | |
ZA200606683B (en) | Pyrazolotriazines as kinase inhibitors | |
AP2005003353A0 (en) | Diazepinoindole derivatives as kinase inhibitors. | |
EP1794137A4 (en) | SPECIFIC KINASE INHIBITORS | |
ZA200709269B (en) | Protein kinase inhibitors | |
HK1114380A1 (en) | Pyrrolopyrazoles as kinase inhibitors | |
ZA200606573B (en) | Pyrazolopyrimidine-derivatives as cyclin dependent kinase inhibitors | |
IL183276A0 (en) | Kinase inhibitors | |
HK1100141A1 (en) | Kinase inhibitors | |
ZA200805028B (en) | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor Xla inhibitors | |
SI1603570T1 (sl) | Spojine aminoheteroarila kot zaviralci proteinkinaze | |
AU2004907155A0 (en) | Imidazopyrazine-based Kinase Inhibitors | |
ITPD20040243A1 (it) | Inserto per sottotacchi. | |
IL160448A0 (en) | Kinase compounds |