AP2214A - Pyrrolo [3,4-c] pyrazole derivatives active as kinase inhibitors. - Google Patents
Pyrrolo [3,4-c] pyrazole derivatives active as kinase inhibitors.Info
- Publication number
- AP2214A AP2214A AP2006003480A AP2006003480A AP2214A AP 2214 A AP2214 A AP 2214A AP 2006003480 A AP2006003480 A AP 2006003480A AP 2006003480 A AP2006003480 A AP 2006003480A AP 2214 A AP2214 A AP 2214A
- Authority
- AP
- ARIPO
- Prior art keywords
- pyrrolo
- kinase inhibitors
- pyrazole derivatives
- derivatives active
- active
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- QBMRFAZXVYJCCO-UHFFFAOYSA-N pyrrolo[3,4-c]pyrazole Chemical class N1=NC=C2C=NC=C21 QBMRFAZXVYJCCO-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48581403P | 2003-07-09 | 2003-07-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP2006003480A0 AP2006003480A0 (en) | 2006-02-28 |
| AP2214A true AP2214A (en) | 2011-03-04 |
Family
ID=34062099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2006003480A AP2214A (en) | 2003-07-09 | 2004-07-08 | Pyrrolo [3,4-c] pyrazole derivatives active as kinase inhibitors. |
Country Status (41)
| Country | Link |
|---|---|
| US (2) | US7141568B2 (fr) |
| EP (1) | EP1644376B1 (fr) |
| JP (1) | JP4728232B2 (fr) |
| KR (1) | KR101075711B1 (fr) |
| CN (1) | CN100564380C (fr) |
| AP (1) | AP2214A (fr) |
| AR (1) | AR050045A1 (fr) |
| AT (1) | ATE480540T1 (fr) |
| AU (1) | AU2004255347B2 (fr) |
| BR (1) | BRPI0411868B8 (fr) |
| CA (1) | CA2531759C (fr) |
| CR (1) | CR8171A (fr) |
| CY (1) | CY1110832T1 (fr) |
| DE (1) | DE602004029045D1 (fr) |
| DK (1) | DK1644376T3 (fr) |
| DO (1) | DOP2004000949A (fr) |
| EA (1) | EA009462B1 (fr) |
| EC (1) | ECSP056246A (fr) |
| ES (1) | ES2349780T3 (fr) |
| GE (1) | GEP20084395B (fr) |
| GT (2) | GT200400133AA (fr) |
| HN (1) | HN2004000232A (fr) |
| IL (1) | IL172923A (fr) |
| IS (1) | IS2843B (fr) |
| MA (1) | MA28064A1 (fr) |
| ME (1) | MEP51908A (fr) |
| MX (1) | MXPA06000362A (fr) |
| MY (1) | MY139072A (fr) |
| NO (1) | NO332361B1 (fr) |
| NZ (1) | NZ544514A (fr) |
| PA (1) | PA8606201A1 (fr) |
| PE (1) | PE20050325A1 (fr) |
| PL (1) | PL1644376T3 (fr) |
| PT (1) | PT1644376E (fr) |
| RS (2) | RS20060004A (fr) |
| SI (1) | SI1644376T1 (fr) |
| TN (1) | TNSN06009A1 (fr) |
| TW (1) | TWI343382B (fr) |
| UA (1) | UA81682C2 (fr) |
| WO (1) | WO2005005427A1 (fr) |
| ZA (1) | ZA200600095B (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2416527C (fr) * | 2000-08-10 | 2009-12-22 | Pharmacia Italia S.P.A. | Bicyclo-pyrazoles actifs en tant qu'inhibiteurs de kinase, leur procede de preparation et compositions pharmaceutiques les contenant |
| WO2005030776A1 (fr) * | 2003-09-23 | 2005-04-07 | Vertex Pharmaceuticals Incorporated | Derives de pyrazolopyrrole utilises en tant qu'inhibiteurs de proteines kinases |
| US7572914B2 (en) * | 2003-12-19 | 2009-08-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| WO2005105788A1 (fr) * | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Derives d'indole et leur utilisation en tant qu'inhibiteurs de kinases |
| WO2006023931A2 (fr) * | 2004-08-18 | 2006-03-02 | Takeda San Diego, Inc. | Inhibiteurs de kinase |
| EP1812439B2 (fr) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Inhibiteurs de kinase |
| CA2593428C (fr) * | 2005-01-10 | 2012-04-17 | Pfizer Inc. | Pyrrolopyrazoles, puissants inhibiteurs de kinases |
| US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| TW200808311A (en) | 2006-03-30 | 2008-02-16 | Nerviano Medical Sciences Srl | Use of a kinase inhibitor for the treatment of particular resistant tumors |
| WO2008017465A1 (fr) * | 2006-08-10 | 2008-02-14 | F. Hoffmann-La Roche Ag | Dérivés de lactame bicycliques, leur fabrication et utilisation en tant qu'agents pharmaceutiques |
| EP2223925A1 (fr) * | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Inhibiteurs de kinase |
| JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
| EP2117539B1 (fr) * | 2006-11-03 | 2010-09-01 | Nerviano Medical Sciences S.r.l. | Procédé d'administration d'un composé anti-tumeur |
| AR071780A1 (es) * | 2008-05-15 | 2010-07-14 | Nerviano Medical Sciences Srl | Derivados de carbamoilo de carbonilamino-pirazoles biciclicos como profarmacos |
| US20110117212A1 (en) * | 2008-07-24 | 2011-05-19 | Nerviano Medical Sciences S.R.L. | Therapeutic combination comprising an aurora kinase inhibitor and an antineoplastic agent |
| US20100022553A1 (en) * | 2008-07-24 | 2010-01-28 | Nerviano Medical Sciences S.R.L. | Therapeutic Combination Comprising an Aurora Kinase Inhibitor and Imatinib |
| EP2313097B1 (fr) | 2008-07-24 | 2013-03-27 | Nerviano Medical Sciences S.r.l. | Combinaison thérapeutique renfermant un inhibiteur de la kinase aurora et des agents antiprolifératifs |
| CN102264368B (zh) | 2008-12-22 | 2014-09-10 | 米伦纽姆医药公司 | 极光激酶抑制剂与抗cd20抗体的组合 |
| KR20140105508A (ko) | 2011-12-12 | 2014-09-01 | 닥터 레디스 레보러터리즈 리미티드 | 트로포미오신 수용체 키나제(Trk) 억제제인 치환된 피라졸로[1,5-a]피리딘 |
| CN104072498B (zh) * | 2013-03-26 | 2016-12-28 | 沈阳药科大学 | （R）‑N‑[5‑(2‑甲氧基‑2‑苯基乙酰基)‑1,4,5,6‑四氢吡咯并[3,4‑c]吡唑‑3‑基]‑4‑(4‑甲基哌嗪‑1‑基)苯甲酰胺的合成方法 |
| US10335494B2 (en) | 2013-12-06 | 2019-07-02 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-CD30 antibodies |
| WO2015200341A1 (fr) | 2014-06-23 | 2015-12-30 | Dr. Reddy's Laboratories Ltd. | Composés d'imidazo [1,2-a] pyridine substitués utiles pour le traitement de la douleur |
| AU2016281225B2 (en) | 2015-06-15 | 2020-10-15 | Ube Corporation | Substituted dihydropyrrolopyrazole derivative |
| EP3324976A4 (fr) | 2015-07-21 | 2019-03-27 | Millennium Pharmaceuticals, Inc. | Administration d'inhibiteur de kinase aurora et d'agents chimiothérapeutiques |
| CN107337674B (zh) * | 2016-04-29 | 2019-09-20 | 江苏吉贝尔药业股份有限公司 | 用于dpp-iv抑制剂的四氢吡喃胺衍生物、其药物组合物和制剂以及用途 |
| WO2019195658A1 (fr) | 2018-04-05 | 2019-10-10 | Dana-Farber Cancer Institute, Inc. | Niveaux sting comme biomarqueur pour l'immunothérapie du cancer |
| WO2021041532A1 (fr) | 2019-08-26 | 2021-03-04 | Dana-Farber Cancer Institute, Inc. | Utilisation d'héparine pour favoriser la signalisation de l'interféron de type 1 |
| CN113563346A (zh) * | 2021-08-19 | 2021-10-29 | 守恒(厦门)医疗科技有限公司 | 吡咯[3,4-c]并吡唑二酰胺类衍生物及其在抗肿瘤药物中的应用 |
| US20250228848A1 (en) | 2022-04-07 | 2025-07-17 | Eli Lilly And Company | Process for making a kras g12c inhibitor |
| CA3247183A1 (fr) | 2022-04-08 | 2023-10-12 | Eli Lilly And Company | Méthode de traitement comprenant des inhibiteurs de kras g12c et des inhibiteurs d’aurora a |
| KR20250027777A (ko) | 2022-06-30 | 2025-02-27 | 일라이 릴리 앤드 캄파니 | 암을 치료하기 위한 kras g12c 억제제 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002012242A2 (fr) * | 2000-08-10 | 2002-02-14 | Pharmacia Italia S.P.A. | Bicyclo-pyrazoles actifs en tant qu'inhibiteurs de kinase, leur procede de preparation et compositions pharmaceutiques les contenant |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2717380B1 (fr) * | 1994-03-15 | 1996-04-26 | Oreal | Compositions cosmétiques contenant un mélange synergétique de polymères conditionneurs. |
| GB9911053D0 (en) | 1999-05-12 | 1999-07-14 | Pharmacia & Upjohn Spa | 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents |
| DE19932144A1 (de) * | 1999-07-09 | 2001-01-11 | Basf Ag | Mikrokapselzubereitungen und Mikrokapseln enthaltende Wasch- und Reinigungsmittel |
| US6387900B1 (en) | 1999-08-12 | 2002-05-14 | Pharmacia & Upjohn S.P.A. | 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents |
| MXPA02001498A (es) | 1999-08-12 | 2003-07-21 | Pharmacia & Italia S P A | Derivados de 3(5)-amino-pirazol, procedimiento para la preparacion de los mismos y usos como agentes antitumorales. |
| FR2815032B1 (fr) | 2000-10-10 | 2003-08-08 | Pf Medicament | Nouveaux derives d'aminophenyle piperazine ou d'amino phenyle piperide inhibiteurs de proteines prenyl transferase ainsi que leurs preparations |
| AU2002215053A1 (en) | 2000-11-27 | 2002-06-24 | Pharmacia Italia S.P.A. | Phenylacetamido- pyrazole derivatives and their use as antitumor agents |
| US20040116497A1 (en) | 2001-01-26 | 2004-06-17 | Gabriella Traquandi | Chromane derivatives, process for their preparation and their use as antitumor agents |
| KR20040047869A (ko) | 2001-09-26 | 2004-06-05 | 파마시아 이탈리아 에스.피.에이. | 키나제 억제제로서 활성인 아미노인다졸 유도체, 이의제조방법 및 이를 함유하는 약제학적 조성물 |
| US20060100233A1 (en) | 2002-07-25 | 2006-05-11 | Manuela Villa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
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2004
- 2004-07-01 US US10/882,493 patent/US7141568B2/en not_active Expired - Lifetime
- 2004-07-08 MX MXPA06000362A patent/MXPA06000362A/es active IP Right Grant
- 2004-07-08 JP JP2006518148A patent/JP4728232B2/ja not_active Expired - Fee Related
- 2004-07-08 ME MEP-519/08A patent/MEP51908A/xx unknown
- 2004-07-08 RS YUP-2006/0004A patent/RS20060004A/sr unknown
- 2004-07-08 AP AP2006003480A patent/AP2214A/xx active
- 2004-07-08 PL PL04763132T patent/PL1644376T3/pl unknown
- 2004-07-08 TW TW093120474A patent/TWI343382B/zh not_active IP Right Cessation
- 2004-07-08 GE GEAP20049209A patent/GEP20084395B/en unknown
- 2004-07-08 AU AU2004255347A patent/AU2004255347B2/en not_active Ceased
- 2004-07-08 PE PE2004000657A patent/PE20050325A1/es not_active Application Discontinuation
- 2004-07-08 DK DK04763132.0T patent/DK1644376T3/da active
- 2004-07-08 BR BRPI0411868A patent/BRPI0411868B8/pt not_active IP Right Cessation
- 2004-07-08 KR KR1020067000310A patent/KR101075711B1/ko not_active Expired - Fee Related
- 2004-07-08 AT AT04763132T patent/ATE480540T1/de active
- 2004-07-08 DE DE602004029045T patent/DE602004029045D1/de not_active Expired - Lifetime
- 2004-07-08 CA CA2531759A patent/CA2531759C/fr not_active Expired - Fee Related
- 2004-07-08 CN CNB2004800195930A patent/CN100564380C/zh not_active Expired - Fee Related
- 2004-07-08 RS RS20060004A patent/RS52155B/sr unknown
- 2004-07-08 ES ES04763132T patent/ES2349780T3/es not_active Expired - Lifetime
- 2004-07-08 EP EP04763132A patent/EP1644376B1/fr not_active Expired - Lifetime
- 2004-07-08 NZ NZ544514A patent/NZ544514A/xx not_active IP Right Cessation
- 2004-07-08 PT PT04763132T patent/PT1644376E/pt unknown
- 2004-07-08 EA EA200600209A patent/EA009462B1/ru not_active IP Right Cessation
- 2004-07-08 WO PCT/EP2004/007515 patent/WO2005005427A1/fr not_active Ceased
- 2004-07-08 SI SI200431502T patent/SI1644376T1/sl unknown
- 2004-07-09 PA PA20048606201A patent/PA8606201A1/es unknown
- 2004-07-09 GT GT200400133AK patent/GT200400133AA/es unknown
- 2004-07-09 MY MYPI20042753A patent/MY139072A/en unknown
- 2004-07-09 DO DO2004000949A patent/DOP2004000949A/es unknown
- 2004-07-09 GT GT200400133A patent/GT200400133A/es unknown
- 2004-07-09 HN HN2004000232A patent/HN2004000232A/es unknown
- 2004-07-12 AR ARP040102447A patent/AR050045A1/es active IP Right Grant
- 2004-08-07 UA UAA200601248A patent/UA81682C2/ru unknown
-
2005
- 2005-12-22 EC EC2005006246A patent/ECSP056246A/es unknown
- 2005-12-22 IS IS8192A patent/IS2843B/is unknown
- 2005-12-29 IL IL172923A patent/IL172923A/en active IP Right Grant
-
2006
- 2006-01-03 ZA ZA200600095A patent/ZA200600095B/en unknown
- 2006-01-05 CR CR8171A patent/CR8171A/es unknown
- 2006-01-06 NO NO20060113A patent/NO332361B1/no not_active IP Right Cessation
- 2006-01-09 TN TNP2006000009A patent/TNSN06009A1/fr unknown
- 2006-01-09 MA MA28721A patent/MA28064A1/fr unknown
- 2006-08-11 US US11/503,256 patent/US7582628B2/en not_active Expired - Lifetime
-
2010
- 2010-10-18 CY CY20101100924T patent/CY1110832T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002012242A2 (fr) * | 2000-08-10 | 2002-02-14 | Pharmacia Italia S.P.A. | Bicyclo-pyrazoles actifs en tant qu'inhibiteurs de kinase, leur procede de preparation et compositions pharmaceutiques les contenant |
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