ZA987781B - Use of inhibitors of the sodium-hydrogen exchanger for the production of a pharmaceutical for the treatment of disorders which are caused by protozoa - Google Patents

Use of inhibitors of the sodium-hydrogen exchanger for the production of a pharmaceutical for the treatment of disorders which are caused by protozoa

Info

Publication number
ZA987781B
ZA987781B ZA987781A ZA987781A ZA987781B ZA 987781 B ZA987781 B ZA 987781B ZA 987781 A ZA987781 A ZA 987781A ZA 987781 A ZA987781 A ZA 987781A ZA 987781 B ZA987781 B ZA 987781B
Authority
ZA
South Africa
Prior art keywords
protozoa
disorders
inhibitors
pharmaceutical
sodium
Prior art date
Application number
ZA987781A
Other languages
English (en)
Inventor
Hans Jochen Lang
Michael Lanzer
Jochen Wiesner
Cecilia Sanchez
Stefan Wuensch
Original Assignee
Hoechst Marion Roussel De Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel De Gmbh filed Critical Hoechst Marion Roussel De Gmbh
Publication of ZA987781B publication Critical patent/ZA987781B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
ZA987781A 1997-08-28 1998-08-27 Use of inhibitors of the sodium-hydrogen exchanger for the production of a pharmaceutical for the treatment of disorders which are caused by protozoa ZA987781B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19737463A DE19737463A1 (de) 1997-08-28 1997-08-28 Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden

Publications (1)

Publication Number Publication Date
ZA987781B true ZA987781B (en) 1999-05-27

Family

ID=7840411

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA987781A ZA987781B (en) 1997-08-28 1998-08-27 Use of inhibitors of the sodium-hydrogen exchanger for the production of a pharmaceutical for the treatment of disorders which are caused by protozoa

Country Status (26)

Country Link
US (1) US6114393A (pl)
EP (1) EP0901788A3 (pl)
JP (1) JPH11171792A (pl)
KR (1) KR100567144B1 (pl)
CN (1) CN1244322C (pl)
AR (1) AR013949A1 (pl)
AU (1) AU738599B2 (pl)
BR (1) BR9803243A (pl)
CA (1) CA2246407A1 (pl)
CZ (1) CZ296815B6 (pl)
DE (1) DE19737463A1 (pl)
HK (1) HK1018589A1 (pl)
HR (1) HRP980468A2 (pl)
HU (1) HU225583B1 (pl)
ID (1) ID20794A (pl)
IL (1) IL125946A0 (pl)
MY (1) MY137406A (pl)
NO (1) NO320368B1 (pl)
NZ (1) NZ331566A (pl)
PL (1) PL191267B1 (pl)
RU (1) RU2225726C2 (pl)
SG (1) SG74074A1 (pl)
SK (1) SK285457B6 (pl)
TR (1) TR199801669A2 (pl)
TW (1) TW592690B (pl)
ZA (1) ZA987781B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9224739D0 (en) * 1992-11-26 1993-01-13 Wellcome Found Medicaments
CN1402632A (zh) * 1999-12-23 2003-03-12 辉瑞产品公司 水凝胶驱动的药物剂型
US7375138B2 (en) * 2002-05-18 2008-05-20 Sanofi-Aventis Deutschland Gmbh Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them
FR2840302B1 (fr) * 2002-06-03 2004-07-16 Aventis Pharma Sa Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
US6878748B2 (en) 2002-06-13 2005-04-12 Aventis Pharma Deutschland Gmbh Fluorinated cycloalkyl-derivatized benzoylguanidines, process for their preparation, their uses as medicament, and medicament containing them
CA3069046A1 (en) * 2017-07-04 2019-01-10 Sanofi Ethynyl compounds, their preparation and their therapeutic use for the treatment of malaria

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1336871A (en) * 1970-01-02 1973-11-14 Wellcome Found Method for preparing biologically active substituted amidines
US4032655A (en) * 1974-05-15 1977-06-28 Bayer Aktiengesellschaft Phenylguanidines useful as anthelmintic agents
US4088780A (en) * 1974-05-15 1978-05-09 Bayer Aktiengesellschaft Substituted phenylguanidines and processes for their preparation and use
US4544670A (en) * 1982-08-24 1985-10-01 William H. Rorer, Inc. Method of treating coccidiosis with acyl guanidines
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
IN172842B (pl) * 1990-05-17 1993-12-11 Boots Pharmaceuticals Limited
EP0617705B1 (en) * 1991-11-22 1997-09-24 Yeda Research And Development Company, Ltd. Non-peptidic surrogates of the arg-gly-asp sequence and pharmaceutical compositions comprising them
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
GB9224739D0 (en) * 1992-11-26 1993-01-13 Wellcome Found Medicaments
DE4318658A1 (de) * 1993-06-04 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4318756A1 (de) * 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19502644A1 (de) * 1995-01-28 1996-08-01 Merck Patent Gmbh 4-Amino-benzoylguanidin-Derivate
FR2734263B1 (fr) * 1995-05-17 1997-06-20 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur procede de preparation et leur utilisation en therapeutique
DE69631527T2 (de) * 1995-06-07 2004-09-23 Genaera Corp. Aminosterinverbindungen als inhibitoren der natrium/proton-pump, pharmazeutische methoden und präparaten davon
DE19542306A1 (de) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
HU9801925D0 (en) 1998-10-28
CN1209994A (zh) 1999-03-10
IL125946A0 (en) 1999-04-11
NZ331566A (en) 2001-03-30
KR100567144B1 (ko) 2006-11-30
PL328265A1 (en) 1999-03-01
PL191267B1 (pl) 2006-04-28
NO983943L (no) 1999-03-01
ID20794A (id) 1999-03-04
HK1018589A1 (en) 1999-12-30
CZ296815B6 (cs) 2006-06-14
MY137406A (en) 2009-01-30
AR013949A1 (es) 2001-01-31
EP0901788A3 (de) 2004-01-02
SK285457B6 (sk) 2007-02-01
TR199801669A3 (tr) 1999-03-22
CA2246407A1 (en) 1999-02-28
DE19737463A1 (de) 1999-03-04
AU8189498A (en) 1999-03-11
BR9803243A (pt) 2000-03-21
NO983943D0 (no) 1998-08-27
CZ272998A3 (cs) 1999-03-17
NO320368B1 (no) 2005-11-28
CN1244322C (zh) 2006-03-08
AU738599B2 (en) 2001-09-20
KR19990023905A (ko) 1999-03-25
HU225583B1 (en) 2007-03-28
TR199801669A2 (xx) 1999-03-22
SK117498A3 (en) 1999-03-12
TW592690B (en) 2004-06-21
US6114393A (en) 2000-09-05
HRP980468A2 (en) 1999-06-30
EP0901788A2 (de) 1999-03-17
HUP9801925A3 (en) 2004-11-29
SG74074A1 (en) 2000-07-18
HUP9801925A1 (hu) 2000-02-28
RU2225726C2 (ru) 2004-03-20
JPH11171792A (ja) 1999-06-29

Similar Documents

Publication Publication Date Title
HU0003863D0 (en) Alpha-sulfonylamino hidroxamic acid inhibitors of matrix metalloproteinases for the treatment of peripheral or central nervous system disorders
PL350050A1 (en) Acyl derivatives which treat vla-4 related disorders
ID28529A (id) Vinileter heterosiklik untuk gangguan neurologi
NO20004688D0 (no) Terapi ved østrogenassosierte lidelser
GB0010669D0 (en) Compositions for treatment of disorders of the oesophagus
PL373626A1 (pl) Leczenie zaburzeń centralnego układu nerwowego
IL153425A0 (en) Sulfonyl-pyrrolidine derivatives useful for the treatment of neurological disorders
AU2002356525A1 (en) Substituted amines for the treatment of neurological disorders
ZA9810218B (en) Isoquinoline derivatives for use against cns disorders
HUP0004613A3 (en) Process for the production of aromatic amines
SG74074A1 (en) Use of inhibitors of the sodium-hydrogen exchanger for the production of a pharmaceutical for the treatment of disorders which are caused by protozoa
PT1294710E (pt) Derivados de indole uteis para o tratamento de disturbios do snc
IS4569A (is) Bensamíð til að meðhöndla taugahrörnunarsjúkdóma
FR2777560B1 (fr) Procede de purification de polyamines aromatiques
CZ20011872A3 (cs) Isonipekotamidy pro léčbu onemocnění zprostředkovaných integriny
IL126068A0 (en) The use of inhibitors of the sodium-hydrogen exchanger for the production of a medicament for decreasing undesired effects of substances on the heart
PL346842A1 (en) New pharmaceutical uses for nos inhibitors
IL126276A0 (en) The use of an inhibitor of the na+/H+ exchanger for the production of a medicament for the treatment or prophylaxis of disorders of the central nervous system
HK1040933A1 (zh) N-取代的氮雜二環烷衍生物在治療中樞神經系統疾病中的應用
ZA988729B (en) The use of an inhibitor of the Na/H+ exchanger for the production of a medicament for the treatment or prophylaxis of disorders of the central nervous system
FR2770214B1 (fr) Procede de preparation d'un benzamide halogene
EP1178814A4 (en) METHOD OF IDENTIFYING THERAPEUTIC COMPOUNDS FOR THE TREATMENT OF HEPATIC DISORDERS
FR2765576B1 (fr) Procede de preparation des dinitroanilines 4-substituees
FR2761685B1 (fr) Procede de preparation des dinitroanilines 4-substituees
PT102299B (pt) Processo metalurgico para a utilizacao de minerais piriticos polimetalicos