ZA985705B - Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases. - Google Patents

Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases.

Info

Publication number
ZA985705B
ZA985705B ZA9805705A ZA985705A ZA985705B ZA 985705 B ZA985705 B ZA 985705B ZA 9805705 A ZA9805705 A ZA 9805705A ZA 985705 A ZA985705 A ZA 985705A ZA 985705 B ZA985705 B ZA 985705B
Authority
ZA
South Africa
Prior art keywords
microparticles
diameter
polymers
imaging
applications
Prior art date
Application number
ZA9805705A
Other languages
English (en)
Inventor
Charles C Church
Howard Bernstein
Julie Ann Straub
Henry T Brush
Original Assignee
Acusphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acusphere Inc filed Critical Acusphere Inc
Publication of ZA985705B publication Critical patent/ZA985705B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Acoustics & Sound (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Drying Of Gases (AREA)
ZA9805705A 1997-06-30 1998-06-30 Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases. ZA985705B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/885,933 US6045777A (en) 1997-06-30 1997-06-30 Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases

Publications (1)

Publication Number Publication Date
ZA985705B true ZA985705B (en) 1999-08-04

Family

ID=25388026

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9805705A ZA985705B (en) 1997-06-30 1998-06-30 Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases.

Country Status (22)

Country Link
US (1) US6045777A (fr)
EP (1) EP0996470B1 (fr)
JP (1) JP2002507214A (fr)
KR (1) KR100637022B1 (fr)
CN (1) CN1268397C (fr)
AT (1) ATE352322T1 (fr)
AU (1) AU740728B2 (fr)
BR (1) BR9810371A (fr)
CA (1) CA2294199C (fr)
CY (1) CY1107593T1 (fr)
DE (1) DE69836961T2 (fr)
DK (1) DK0996470T3 (fr)
ES (1) ES2280094T3 (fr)
HK (1) HK1029273A1 (fr)
IL (1) IL133595A (fr)
MY (1) MY122120A (fr)
NO (1) NO316614B1 (fr)
NZ (1) NZ501830A (fr)
PT (1) PT996470E (fr)
TW (1) TW360521B (fr)
WO (1) WO1999000149A1 (fr)
ZA (1) ZA985705B (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT239807Y1 (it) * 1996-09-11 2001-03-13 Lgl Electronics Spa Dispositivo perfezionato di separazione delle spire di filato perapparecchi alimentatori di trama
DE19882362T1 (de) * 1997-04-30 2000-05-18 Point Biomedical Corp Mikropartikel, geeignet als Ultraschallkontrastmittel und zum Transport von Arzneimitteln in den Blutstrom
AU1705300A (en) * 1998-10-12 2000-05-01 Mallinckrodt, Inc. Novel ultrasound contrast agents
EP1202670A4 (fr) 1999-08-13 2004-11-10 Point Biomedical Corp Microspheres creuses a fragilite controlee a usage medical
US6626854B2 (en) 2000-12-27 2003-09-30 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
US6645162B2 (en) 2000-12-27 2003-11-11 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
IL159624A0 (en) 2001-06-29 2004-06-01 Medgraft Microtech Inc Biodegradable injectable implants and related methods of manufacture and use
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US20030215394A1 (en) * 2002-05-17 2003-11-20 Short Robert E. Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream
US20040185108A1 (en) * 2003-03-18 2004-09-23 Short Robert E. Method of preparing gas-filled polymer matrix microparticles useful for delivering drug
WO2005041897A2 (fr) 2003-10-31 2005-05-12 Point Biomedical Corporation Compositions de microspheres reconstitutables utilisees en tant qu'agents de contraste ultrasonores
WO2005118016A1 (fr) * 2004-05-27 2005-12-15 Medtronic, Inc. Dispositif medical comprenant un agent biologiquement actif
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
CA2569134C (fr) * 2004-06-04 2010-11-23 Acusphere, Inc. Formulation de dosage d'agent de contraste ultrasonore
DE602004026164D1 (de) * 2004-06-04 2010-05-06 Acusphere Inc Ultraschallkontrastmittel
EP1714642A1 (fr) * 2005-04-18 2006-10-25 Bracco Research S.A. Formulation pharmaceutique comprenant des microcapsules remplies de gaz pour la délibération échographique
US20070037215A1 (en) * 2005-08-11 2007-02-15 Patton Wayne F Assay particles and methods of use
US7955281B2 (en) * 2006-09-07 2011-06-07 Nivasonix, Llc External ultrasound lipoplasty
US8262591B2 (en) * 2006-09-07 2012-09-11 Nivasonix, Llc External ultrasound lipoplasty
US8697098B2 (en) 2011-02-25 2014-04-15 South Dakota State University Polymer conjugated protein micelles
KR101061224B1 (ko) * 2008-10-08 2011-08-31 포항공과대학교 산학협력단 Ｘ 선을 이용한 유동정보 측정용 캡슐
US9177543B2 (en) 2009-08-26 2015-11-03 Insightec Ltd. Asymmetric ultrasound phased-array transducer for dynamic beam steering to ablate tissues in MRI
EP2489034B1 (fr) 2009-10-14 2016-11-30 Insightec Ltd. Cartographie de transducteurs à ultrasons
US8331194B1 (en) * 2010-04-26 2012-12-11 The United States Of America As Represented By The Secretary Of The Navy Underwater acoustic waveguide
US9852727B2 (en) 2010-04-28 2017-12-26 Insightec, Ltd. Multi-segment ultrasound transducers
CN103945830B (zh) 2011-02-25 2017-06-06 南达科他州立大学 缀合蛋白的聚合物胶束
WO2012136813A2 (fr) 2011-04-07 2012-10-11 Universitetet I Oslo Agents pour un diagnostic par radar médical
JP2011140527A (ja) * 2011-04-20 2011-07-21 Acusphere Inc 超音波造影剤の投薬処方物
US10357450B2 (en) 2012-04-06 2019-07-23 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
US20160067276A1 (en) * 2013-03-15 2016-03-10 Children's Medical Center Corporation Hollow particles encapsulating a biological gas and methods of use
US10577554B2 (en) 2013-03-15 2020-03-03 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
WO2015156359A1 (fr) * 2014-04-10 2015-10-15 シャープ株式会社 Solution visqueuse contenant des bulles, son procédé de production, son appareil de production, et son procédé de stockage
CN107952085A (zh) * 2016-10-17 2018-04-24 北京凯莱天成医药科技有限公司 一种超声造影剂及其制备方法和用途
WO2018160752A1 (fr) 2017-02-28 2018-09-07 Children's Medical Center Corporation Particules sensibles aux stimuli encapsulant un gaz et méthodes d'utilisation

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5334381A (en) * 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
EP0586524B2 (fr) * 1991-06-03 2000-11-02 Nycomed Imaging As Ameliorations apportees a ou concernant des agents contrastants
DE4219723A1 (de) * 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
EP0693924B2 (fr) * 1993-02-22 2008-04-09 Abraxis BioScience, Inc. Procedes d'administration (in vivo) de substances biologiques et compositions utilisees dans ces procedes
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
NO940711D0 (no) * 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US5955143A (en) * 1995-12-21 1999-09-21 Drexel University Hollow polymer microcapsules and method of producing the same
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents

Also Published As

Publication number Publication date
TW360521B (en) 1999-06-11
DK0996470T3 (da) 2007-05-21
JP2002507214A (ja) 2002-03-05
CN1261809A (zh) 2000-08-02
CA2294199A1 (fr) 1999-01-07
NO316614B1 (no) 2004-03-08
BR9810371A (pt) 2000-09-05
CA2294199C (fr) 2009-01-20
MY122120A (en) 2006-03-31
NO996512L (no) 2000-02-29
NO996512D0 (no) 1999-12-28
CY1107593T1 (el) 2013-03-13
ES2280094T3 (es) 2007-09-01
HK1029273A1 (en) 2001-03-30
IL133595A0 (en) 2001-04-30
DE69836961D1 (de) 2007-03-15
CN1268397C (zh) 2006-08-09
AU8273198A (en) 1999-01-19
WO1999000149A1 (fr) 1999-01-07
KR20010014300A (ko) 2001-02-26
ATE352322T1 (de) 2007-02-15
EP0996470B1 (fr) 2007-01-24
PT996470E (pt) 2007-03-30
DE69836961T2 (de) 2007-10-18
AU740728B2 (en) 2001-11-15
IL133595A (en) 2004-06-01
US6045777A (en) 2000-04-04
EP0996470A1 (fr) 2000-05-03
KR100637022B1 (ko) 2006-10-20
NZ501830A (en) 2003-01-31

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