ZA983301B - Alkyl alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition. - Google Patents
Alkyl alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition.Info
- Publication number
- ZA983301B ZA983301B ZA9803301A ZA983301A ZA983301B ZA 983301 B ZA983301 B ZA 983301B ZA 9803301 A ZA9803301 A ZA 9803301A ZA 983301 A ZA983301 A ZA 983301A ZA 983301 B ZA983301 B ZA 983301B
- Authority
- ZA
- South Africa
- Prior art keywords
- alzheimer
- disease
- prevention
- derivatives
- vivo imaging
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/66—Polycyclic acids with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/14—Styryl dyes
- C09B23/141—Bis styryl dyes containing two radicals C6H5-CH=CH-
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/837,494 US6168776B1 (en) | 1994-07-19 | 1997-04-18 | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA983301B true ZA983301B (en) | 1999-10-20 |
Family
ID=25274617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9803301A ZA983301B (en) | 1997-04-18 | 1998-04-20 | Alkyl alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition. |
Country Status (19)
Families Citing this family (80)
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KR20210071943A (ko) | 2018-07-02 | 2021-06-16 | 더 제너럴 하스피탈 코포레이션 | 크로몰린 소듐 및 α-락토스의 분말화된 제형 |
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US329638A (en) | 1885-11-03 | Fabriken | ||
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US1979534A (en) | 1931-10-15 | 1934-11-06 | Farastan Company | Disazo compound for therapeutic use |
CH554848A (de) | 1967-10-03 | 1974-10-15 | Ciba Geigy Ag | Verfahren zur herstellung neuer stilben-derivate. |
CH513785A (de) | 1967-10-03 | 1971-10-15 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Bis-stilbenverbindungen |
CH540958A (de) | 1970-07-23 | 1973-08-31 | Ciba Geigy Ag | Verwendung von Styrylverbindungen als optische Aufhellmittel für organische Materialien ausserhalb der Textilindustrie |
DE2039993A1 (de) | 1970-08-12 | 1972-02-17 | Basf Ag | Optische Aufheller der Bisstyrylbenzolreihe |
US4016156A (en) | 1972-06-30 | 1977-04-05 | Ciba-Geigy Corporation | Distyryl compounds |
CH574950A5 (US06168776-20010102-C00068.png) | 1972-06-30 | 1976-04-30 | Ciba Geigy Ag | |
DE2364396A1 (de) | 1973-12-22 | 1975-07-10 | Basf Ag | Neue bisstyrylarylverbindungen |
LU75628A1 (US06168776-20010102-C00068.png) | 1976-08-19 | 1978-04-13 | ||
US5039511A (en) | 1987-04-08 | 1991-08-13 | Salutar, Inc. | Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor |
JPS63290858A (ja) | 1987-04-08 | 1988-11-28 | サルター・インコーポレーテツド | アミロイド症及びアルツハイマー病の診断分析法及びそのための試薬 |
US5008099A (en) | 1987-04-08 | 1991-04-16 | Salutar, Inc. | Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor |
US4933156A (en) | 1987-04-08 | 1990-06-12 | Salutar, Inc. | Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor |
US5231000A (en) | 1987-10-08 | 1993-07-27 | The Mclean Hospital | Antibodies to A4 amyloid peptide |
JP2641529B2 (ja) * | 1988-10-26 | 1997-08-13 | 三菱化学株式会社 | 新規有機高分子 |
AU654013B2 (en) | 1991-03-13 | 1994-10-20 | Regents Of The University Of Minnesota | 2-hydroxy-3(4-iodophenyl)-1-(4-phenylpiperidinyl) propane |
US5297562A (en) | 1991-04-01 | 1994-03-29 | President And Fellows Of Harvard College | Method for detecting and treating Alzheimer's disease |
US5434050A (en) | 1991-08-13 | 1995-07-18 | Regents Of The University Of Minnesota | Labelled β-amyloid peptide and methods of screening for Alzheimer's disease |
US5276059A (en) | 1992-07-10 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of diseases associated with amyloid formation |
JPH11505526A (ja) | 1995-05-01 | 1999-05-21 | ユニヴァーシティ・オヴ・ピッツバーグ | アルツハイマー病の死前診断ならびにアミロイド沈着のイン・ビボのイメージ化及び予防のためのアゾ化合物 |
-
1997
- 1997-04-18 US US08/837,494 patent/US6168776B1/en not_active Expired - Lifetime
-
1998
- 1998-04-20 EP EP98918448A patent/EP0977815A1/en not_active Withdrawn
- 1998-04-20 PL PL98336321A patent/PL336321A1/xx unknown
- 1998-04-20 IL IL13242698A patent/IL132426A0/xx unknown
- 1998-04-20 SK SK1440-99A patent/SK144099A3/sk unknown
- 1998-04-20 ZA ZA9803301A patent/ZA983301B/xx unknown
- 1998-04-20 HU HU0003804A patent/HUP0003804A3/hu unknown
- 1998-04-20 BR BR9809580-3A patent/BR9809580A/pt unknown
- 1998-04-20 TR TR1999/03115T patent/TR199903115T2/xx unknown
- 1998-04-20 WO PCT/US1998/007889 patent/WO1998047969A1/en not_active Application Discontinuation
- 1998-04-20 KR KR1019997009642A patent/KR20010006552A/ko not_active Application Discontinuation
- 1998-04-20 JP JP54622398A patent/JP2002500634A/ja active Pending
- 1998-04-20 NZ NZ500714A patent/NZ500714A/en unknown
- 1998-04-20 CA CA002286607A patent/CA2286607A1/en not_active Abandoned
- 1998-04-20 EE EEP199900503A patent/EE9900503A/xx unknown
- 1998-04-20 CN CN98806318A patent/CN1261906A/zh active Pending
- 1998-04-20 AU AU71369/98A patent/AU7136998A/en not_active Abandoned
- 1998-04-20 AR ARP980101817A patent/AR012845A1/es not_active Application Discontinuation
- 1998-11-09 US US09/188,244 patent/US6114175A/en not_active Expired - Fee Related
- 1998-11-09 US US09/188,200 patent/US6133259A/en not_active Expired - Fee Related
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1999
- 1999-10-18 NO NO995088A patent/NO995088L/no not_active Application Discontinuation
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BR9809580A (pt) | 2001-06-19 |
TR199903115T2 (xx) | 2000-05-22 |
WO1998047969A1 (en) | 1998-10-29 |
HUP0003804A2 (hu) | 2001-06-28 |
MX9909557A (es) | 2002-12-13 |
EE9900503A (et) | 2000-06-15 |
HUP0003804A3 (en) | 2002-09-30 |
EP0977815A1 (en) | 2000-02-09 |
AU7136998A (en) | 1998-11-13 |
NO995088L (no) | 1999-12-17 |
CN1261906A (zh) | 2000-08-02 |
NZ500714A (en) | 2001-09-28 |
CA2286607A1 (en) | 1998-10-29 |
JP2002500634A (ja) | 2002-01-08 |
NO995088D0 (no) | 1999-10-18 |
AR012845A1 (es) | 2000-11-22 |
SK144099A3 (en) | 2000-07-11 |
IL132426A0 (en) | 2001-03-19 |
US6168776B1 (en) | 2001-01-02 |
KR20010006552A (ko) | 2001-01-26 |
US6114175A (en) | 2000-09-05 |
US6133259A (en) | 2000-10-17 |
PL336321A1 (en) | 2000-06-19 |
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