ZA983234B - Preparation of recombinant factor viii in a protein free medium - Google Patents

Preparation of recombinant factor viii in a protein free medium

Info

Publication number
ZA983234B
ZA983234B ZA983234A ZA983234A ZA983234B ZA 983234 B ZA983234 B ZA 983234B ZA 983234 A ZA983234 A ZA 983234A ZA 983234 A ZA983234 A ZA 983234A ZA 983234 B ZA983234 B ZA 983234B
Authority
ZA
South Africa
Prior art keywords
preparation
factor viii
free medium
recombinant factor
protein free
Prior art date
Application number
ZA983234A
Other languages
English (en)
Inventor
Shan-Yuen Chan
Kathleen Harris
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25293446&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA983234(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA983234B publication Critical patent/ZA983234B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/35—Polyols, e.g. glycerin, inositol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C12N2500/95—Protein-free medium and culture conditions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
ZA983234A 1997-04-18 1998-04-17 Preparation of recombinant factor viii in a protein free medium ZA983234B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/844,714 US5804420A (en) 1997-04-18 1997-04-18 Preparation of recombinant Factor VIII in a protein free medium

Publications (1)

Publication Number Publication Date
ZA983234B true ZA983234B (en) 1998-10-22

Family

ID=25293446

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA983234A ZA983234B (en) 1997-04-18 1998-04-17 Preparation of recombinant factor viii in a protein free medium

Country Status (29)

Country Link
US (2) US5804420A (de)
EP (1) EP0872487B1 (de)
JP (1) JP4257685B2 (de)
KR (1) KR100496111B1 (de)
CN (1) CN1127518C (de)
AR (1) AR012451A1 (de)
AT (1) ATE342921T1 (de)
AU (1) AU748731B2 (de)
BR (1) BRPI9801092B8 (de)
CA (1) CA2234215C (de)
CO (1) CO4790112A1 (de)
CZ (1) CZ295049B6 (de)
DE (1) DE69836164T2 (de)
DK (1) DK0872487T3 (de)
ES (1) ES2273380T3 (de)
HK (1) HK1018797A1 (de)
HU (1) HU224306B1 (de)
ID (1) ID20193A (de)
IL (1) IL124123A (de)
MY (1) MY115583A (de)
NZ (1) NZ330183A (de)
PL (1) PL192072B1 (de)
PT (1) PT872487E (de)
RU (1) RU2222547C2 (de)
SK (1) SK285684B6 (de)
TR (1) TR199800493A1 (de)
TW (1) TW490469B (de)
UA (1) UA66340C2 (de)
ZA (1) ZA983234B (de)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501040D0 (en) * 1995-01-19 1995-03-08 Quadrant Holdings Cambridge Dried composition
US8183344B2 (en) * 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
US6528286B1 (en) * 1998-05-29 2003-03-04 Genentech, Inc. Mammalian cell culture process for producing glycoproteins
AUPP521298A0 (en) * 1998-08-12 1998-09-03 Life Therapeutics Limited Purification of fibrinogen
US6358703B1 (en) * 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
AUPP790898A0 (en) 1998-12-23 1999-01-28 Life Therapeutics Limited Renal dialysis
AUPP790698A0 (en) 1998-12-23 1999-01-28 Life Therapeutics Limited Separation of microorganisms
US20050224355A1 (en) * 1999-12-23 2005-10-13 Brendon Conlan Removal of biological contaminants
AUPP971399A0 (en) 1999-04-12 1999-05-06 Life Therapeutics Limited Separation of plasma components
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
NZ516400A (en) 1999-07-13 2004-02-27 Biovitrum Ab Stable factor VIII compositions
US6767741B1 (en) * 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
AU6734300A (en) 1999-08-31 2001-03-26 Sony Computer Entertainment Inc. Entertainment system, entertainment apparatus, recording medium, and program
US7077942B1 (en) 1999-12-23 2006-07-18 Gradipore Limited Removal of biological contaminants
AUPQ691400A0 (en) * 2000-04-14 2000-05-11 Life Therapeutics Limited Separation of micromolecules
ATE449200T1 (de) 2000-04-18 2009-12-15 Gradipore Ltd Trennung und behandlung von proben durch elektrophorese
AUPQ697300A0 (en) * 2000-04-18 2000-05-11 Life Therapeutics Limited Separation apparatus
US6923896B2 (en) * 2000-09-22 2005-08-02 The Texas A&M University System Electrophoresis apparatus and method
DE60142520D1 (de) * 2000-10-06 2010-08-19 Arturus Capital Ltd Multi-port-elektrophorese-trennvorrichtung und entsprechendes verfahren
AUPR222300A0 (en) * 2000-12-21 2001-01-25 Life Therapeutics Limited Electrophoresis device and method
US7220718B2 (en) 2001-08-03 2007-05-22 United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Oral treatment of hemophilia
EP2305314B1 (de) 2001-10-10 2015-12-23 ratiopharm GmbH Neumodulierung und Glykokonjugation von Antikörpern
KR20040065278A (ko) * 2001-12-21 2004-07-21 노보 노르디스크 에이/에스 변경된 인자 ⅶ 폴리펩티드의 액체 조성물
EP1458408B1 (de) * 2001-12-21 2009-04-15 Novo Nordisk Health Care AG Flüssige zusammensetzung aus faktor vii polypeptiden
US20040009918A1 (en) * 2002-05-03 2004-01-15 Hanne Nedergaard Stabilised solid compositions of modified factor VII
EP1517698B2 (de) 2002-06-21 2017-12-06 Novo Nordisk Health Care AG STABILISIERTE FESTE ZUSAMMENSETZUNGEN VON FAKTOR VIIa POLYPEPTIDEN
JP2005532057A (ja) 2002-07-09 2005-10-27 バクスター・インターナショナル・インコーポレイテッド 細胞を培養するための動物性タンパク質非含有培地
EP1596887B1 (de) * 2003-02-26 2022-03-23 Nektar Therapeutics Polymer-factor viii-konjugate
JP2006524195A (ja) * 2003-03-18 2006-10-26 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｖｉｉ因子ポリペプチドの液状水性医薬組成物
US7897734B2 (en) * 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
WO2004103398A1 (en) * 2003-05-23 2004-12-02 Novo Nordisk Health Care Ag Protein stabilization in solution
JP4658041B2 (ja) * 2003-06-25 2011-03-23 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｖｉｉ因子ポリペプチドの液体組成物
ATE446768T1 (de) * 2003-07-01 2009-11-15 Novo Nordisk Healthcare Ag Flüssige wässrige pharmazeutische zusammnesetzung von factor vii polypeptiden
EP1656158B1 (de) * 2003-08-14 2016-03-09 Novo Nordisk Health Care AG Flüssige, wässrige pharmazeutische zusammensetzung von faktor-vii-polypeptiden
EP2298287B1 (de) * 2003-12-19 2018-04-11 Novo Nordisk Health Care AG Stabilisierte Zusammensetzungen von Faktor-VII-Polypeptiden
GB0414825D0 (en) * 2004-07-02 2004-08-04 Biostatus Ltd Gel formulations and uses thereof
US7422875B2 (en) * 2004-07-20 2008-09-09 Board Of Regents Of The University Of Nebraska Compositions and methods for increasing protein production
JP2008518597A (ja) * 2004-10-29 2008-06-05 セントカー・インコーポレーテツド 化学的規定培地組成物
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
RU2442822C2 (ru) * 2005-01-25 2012-02-20 Вайет Рисерч Айрлэнд Лимитед Вещества, защищающие клетки от рассечения при сборе микрофильтрацией
EP1707634A1 (de) * 2005-03-29 2006-10-04 Octapharma AG Verfahren zur Isolierung von rekombinant hergestellten Proteinen
EP2522717B1 (de) * 2006-01-04 2014-04-02 Baxter International Inc Oligopeptid-freie Zellkulturmedien
AU2007269233B2 (en) * 2006-06-30 2011-06-09 Cnj Holdings, Inc. Method of producing Factor VIII proteins by recombinant methods
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
KR101389376B1 (ko) 2007-02-23 2014-04-29 에스케이케미칼주식회사 제 ８ 인자 및 그의 유도체의 제조 및 정제 방법
CN101678066B (zh) 2007-04-26 2014-09-24 拜尔健康护理有限责任公司 稳定用于冷冻储藏的重组蛋白液体溶液的方法
RU2531493C2 (ru) * 2007-11-01 2014-10-20 Юниверсити Оф Рочестер Рекомбинантный фактор viii, обладающий повышенной стабильностью
DK2235197T3 (en) 2007-12-27 2017-10-09 Baxalta GmbH Methods of cell culture
DE102008051574A1 (de) 2008-10-14 2010-04-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung von Interferon-beta und deren Varianten
HUE026210T2 (en) * 2008-11-12 2016-05-30 Baxalta Inc Procedure for serum-free, insulin-free VII. factor
BR122021005965B1 (pt) 2009-07-31 2022-01-25 Baxalta Incorporated Método para produzir uma composição de desintegrina e metaloproteinase com motivo trombospondina (adamts)
CN102573792B (zh) 2009-09-21 2014-10-15 巴克斯特国际公司 稳定化的液体和冻干的adamts13制剂
PL2499165T3 (pl) 2009-11-13 2017-04-28 Grifols Therapeutics Inc. Preparaty zawierające czynnik von willenbranda (vwf) oraz sposoby, zestawy i zastosowania z nim powiązane
ES2533074T3 (es) 2010-04-26 2015-04-07 Novartis Ag Medio de cultivo celular mejorado
TR201815211T4 (tr) 2010-07-08 2018-11-21 Baxalta GmbH Hücre kültüründe rekombinant adamts13 üretmeye yönelik yöntem.
GB201014121D0 (en) * 2010-08-24 2010-10-06 Univ Gent Particulate biologic drug delivery system
EP2702077A2 (de) 2011-04-27 2014-03-05 AbbVie Inc. Verfahren zur steuerung des galactosylierungsprofil von rekombinant exprimierten proteinen
WO2012147048A2 (en) 2011-04-29 2012-11-01 Biocon Research Limited Methods for reducing accumulation of lactate during culturing and method for producing polypeptide
DK3626737T3 (da) 2011-05-13 2024-02-05 Octapharma Ag Fremgangsmåde til at forøge produktiviteten af eukaryote celler i produktionen af rekombinant fviii
WO2013098676A1 (en) 2011-12-30 2013-07-04 Grifols, S.A. Method for purifying factor viii
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
AU2013381687A1 (en) 2013-03-12 2015-09-24 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US8956830B2 (en) 2013-03-14 2015-02-17 Momenta Pharmaceuticals, Inc. Methods of cell culture
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
US20140271622A1 (en) * 2013-03-14 2014-09-18 Momenta Pharmaceuticals, Inc. Methods of cell culture
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9677105B2 (en) 2013-03-14 2017-06-13 Momenta Pharmaceuticals, Inc. Methods of cell culture
EP3052640A2 (de) 2013-10-04 2016-08-10 AbbVie Inc. Verwendung von metallionen zur modulation von proteinglykosylierungsprofilen rekombinanter proteine
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
EP3122770A4 (de) * 2014-03-23 2017-08-23 Advantech Bioscience Farmacêutica Ltda. Verstärkung der expression von rekombinanten proteinen mit kupfer
ES2778680T3 (es) 2014-03-25 2020-08-11 Hoffmann La Roche Procedimientos de preparación de un poloxámero para su uso en medio de cultivo celular
MX2016012869A (es) 2014-04-01 2017-05-12 Advantech Bioscience Farmacêutica Ltda Estabilizacion del factor viii sin calcio como un excipiente.
MX2016012870A (es) 2014-04-01 2017-05-12 Advantech Bioscience Farmacêutica Ltda Formulaciones de factor viii estables con bajo tenor de azucar - glicina.
EP3456816A4 (de) * 2016-05-09 2019-12-11 Kyowa Hakko Bio Co., Ltd. Medium, additiv für albuminfreies medium und verfahren zur züchtung von pluripotenten stammzellen
WO2018210771A1 (en) * 2017-05-17 2018-11-22 Octapharma Ag Method for the production of a recombinant target protein
JP7344902B2 (ja) 2018-04-20 2023-09-14 ヤンセン バイオテツク，インコーポレーテツド 抗ｔｎｆ抗体組成物を産生するための製造方法におけるクロマトグラフィカラムの品質評価
CN113015805A (zh) 2018-11-13 2021-06-22 詹森生物科技公司 抗cd38抗体产生期间的痕量金属的控制
MA55282A (fr) 2019-03-14 2022-01-19 Janssen Biotech Inc Procédés de fabrication pour la production de compositions d'anticorps anti-tnf
KR20210141990A (ko) 2019-03-14 2021-11-23 얀센 바이오테크 인코포레이티드 항-il12/il23 항체 조성물을 생성하기 위한 제조 방법
TW202128744A (zh) 2019-12-06 2021-08-01 美商再生元醫藥公司 抗ｖｅｇｆ蛋白組合物及其製備方法
AU2021248679A1 (en) 2020-04-02 2022-10-27 Takeda Pharmaceutical Company Limited ADAMTS13 variant, compositions, and uses thereof
EP4367137A1 (de) 2021-07-09 2024-05-15 Janssen Biotech, Inc. Herstellungsverfahren zur herstellung von anti-tnf-antikörperzusammensetzungen
IL309987A (en) 2021-07-09 2024-03-01 Janssen Biotech Inc Production methods for the production of anti-IL12/IL23 antibody compositions
US20230287043A1 (en) 2022-03-02 2023-09-14 Regeneron Pharmaceuticals, Inc. Cell culture methods for antibody production

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4767704A (en) * 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
NO162160C (no) * 1987-01-09 1989-11-15 Medi Cult As Serumfritt vekstmedium, samt anvendelse derav.
US5024947A (en) * 1987-07-24 1991-06-18 Cetus Corporation Serum free media for the growth on insect cells and expression of products thereby
JPH0387173A (ja) * 1987-09-10 1991-04-11 Teijin Ltd ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
US5378612A (en) * 1990-05-11 1995-01-03 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Culture medium for production of recombinant protein
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex
US6103529A (en) * 1996-10-10 2000-08-15 Life Technologies, Inc. Animal cell culture media comprising peptides derived from rice

Also Published As

Publication number Publication date
PT872487E (pt) 2007-01-31
HK1018797A1 (en) 2000-01-07
HU9800901D0 (en) 1998-07-28
DK0872487T3 (da) 2007-02-05
BRPI9801092A (pt) 2000-01-11
IL124123A (en) 2006-07-05
SK285684B6 (sk) 2007-06-07
JP4257685B2 (ja) 2009-04-22
KR19980081531A (ko) 1998-11-25
CO4790112A1 (es) 1999-05-31
HUP9800901A2 (hu) 1999-05-28
CZ295049B6 (cs) 2005-05-18
TW490469B (en) 2002-06-11
TR199800493A1 (xx) 1998-11-23
BRPI9801092B8 (pt) 2021-07-06
CN1210866A (zh) 1999-03-17
AU6198298A (en) 1998-10-22
EP0872487A3 (de) 1999-10-27
CZ115698A3 (cs) 1998-11-11
US5804420A (en) 1998-09-08
SK49798A3 (en) 1998-12-02
CN1127518C (zh) 2003-11-12
AU748731B2 (en) 2002-06-13
HUP9800901A3 (en) 2001-08-28
RU2222547C2 (ru) 2004-01-27
UA66340C2 (uk) 2004-05-17
EP0872487B1 (de) 2006-10-18
CA2234215A1 (en) 1998-10-18
HU224306B1 (hu) 2005-07-28
AR012451A1 (es) 2000-10-18
ATE342921T1 (de) 2006-11-15
CA2234215C (en) 2008-06-17
ES2273380T3 (es) 2007-05-01
KR100496111B1 (ko) 2005-09-09
PL192072B1 (pl) 2006-08-31
BRPI9801092B1 (pt) 2013-04-02
ID20193A (id) 1998-10-22
MY115583A (en) 2003-07-31
US6171825B1 (en) 2001-01-09
EP0872487A2 (de) 1998-10-21
DE69836164T2 (de) 2007-08-16
JPH10295397A (ja) 1998-11-10
PL325862A1 (en) 1998-10-26
NZ330183A (en) 1999-08-30
DE69836164D1 (de) 2006-11-30

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