ZA9811338B - Process for the production of fludarabine-phosphate lithium sodium potassium calcium and magnesium salts - Google Patents

Process for the production of fludarabine-phosphate lithium sodium potassium calcium and magnesium salts

Info

Publication number
ZA9811338B
ZA9811338B ZA9811338A ZA9811338A ZA9811338B ZA 9811338 B ZA9811338 B ZA 9811338B ZA 9811338 A ZA9811338 A ZA 9811338A ZA 9811338 A ZA9811338 A ZA 9811338A ZA 9811338 B ZA9811338 B ZA 9811338B
Authority
ZA
South Africa
Prior art keywords
fludarabine
production
magnesium salts
sodium potassium
phosphate lithium
Prior art date
Application number
ZA9811338A
Other languages
English (en)
Inventor
Ulf Tilstam
Thomas Schmitz
Klaus Nickisch
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7852365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA9811338(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA9811338B publication Critical patent/ZA9811338B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/19—Purine radicals with arabinosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA9811338A 1997-12-11 1998-12-10 Process for the production of fludarabine-phosphate lithium sodium potassium calcium and magnesium salts ZA9811338B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19756289 1997-12-11

Publications (1)

Publication Number Publication Date
ZA9811338B true ZA9811338B (en) 1999-06-10

Family

ID=7852365

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9811338A ZA9811338B (en) 1997-12-11 1998-12-10 Process for the production of fludarabine-phosphate lithium sodium potassium calcium and magnesium salts

Country Status (21)

Country Link
US (2) US6046322A (sl)
EP (1) EP1047704B2 (sl)
JP (2) JP4261051B2 (sl)
KR (2) KR20050085937A (sl)
AT (2) ATE231880T1 (sl)
AU (1) AU739574B2 (sl)
CA (1) CA2313486A1 (sl)
CZ (1) CZ296366B6 (sl)
DE (2) DE29825173U1 (sl)
DK (1) DK1047704T4 (sl)
ES (1) ES2190136T5 (sl)
HK (1) HK1033831A1 (sl)
HU (1) HU226997B1 (sl)
IL (1) IL136283A (sl)
NO (1) NO315324B1 (sl)
PL (1) PL195712B1 (sl)
SI (1) SI1047704T2 (sl)
SK (1) SK283475B6 (sl)
TW (1) TW424093B (sl)
WO (1) WO1999029710A2 (sl)
ZA (1) ZA9811338B (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1047704T2 (sl) 1997-12-11 2008-02-29 Bayer Schering Pharma Ag Postopek za pripravo fludarabin-fosfat litijevih,natrijevih, kalijevih, kalcijevih in magnezijevihsoli, cistilni postopek za pripravo fludarabin-fosfata in fludarabin-fosfat z vsaj 99,5 % cistoto
KR100381930B1 (ko) * 2000-03-16 2003-04-26 (주)바이오니아 유전자 변형 농산물 검출방법 및 검출용 프라이머
WO2003049763A1 (en) 2001-12-12 2003-06-19 Fh Faulding & Co Limited Composition for the preservation of viruses
DE10164510A1 (de) * 2001-12-20 2003-07-10 Schering Ag Orale Fludara reinst Formulierung mit schneller Freisetzung des Wirkstoffes
EP1542531A4 (en) * 2002-05-24 2011-01-05 Sicor Inc Aqueous fludarabine phosphorus composition
EP1464708A1 (en) * 2003-04-03 2004-10-06 Pro. Bio. Sint. S.p.A. A process for the preparation of fludarabine phosphate from 2-fluoroadenine
US7698201B2 (en) * 2006-09-14 2010-04-13 The Prudential Insurance Company Of America Financial instrument utilizing an optional benefit election
CN103040855B (zh) * 2012-12-28 2014-05-14 海南锦瑞制药股份有限公司 一种磷酸氟达拉滨的药物组合物及其制备方法
US10669302B2 (en) * 2015-08-28 2020-06-02 Zhejianf Hisun Pharmaceutical Co., Ltd. Crystal form of fludarabine phosphate, preparation method therefor, and application thereof
CN109265505A (zh) * 2018-09-12 2019-01-25 连云港杰瑞药业有限公司 一种磷酸氟达拉滨异构体杂质的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756704A (fr) 1969-09-26 1971-03-01 Parke Davis & Co Procede de production du 5'-phosphate de 9-(beta-d- arabinofuranosyl) adenine et de ses sels
US4188378A (en) * 1978-01-04 1980-02-12 The United States Of America As Represented By The Department Of Health, Education And Welfare Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4210745A (en) * 1978-01-04 1980-07-01 The United States Of America As Represented By The Department Of Health, Education And Welfare Procedure for the preparation of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4357324A (en) * 1981-02-24 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
DE3323621A1 (de) 1982-07-08 1984-03-01 Yamasa Shoyu K.K., Choshi, Chiba Pharmazeutisches praeparat mit die antitumor-wirkung verstaerkender wirkung, ein solches praeparat enthaltende chemotherapeutische zusammensetzung und verwendung des praeparates zur unterstuetzung der antitumor-behandlung beim menschen und tier
US5110919A (en) 1989-12-04 1992-05-05 Ash Stevens, Inc. Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
CA2064723C (en) * 1990-06-27 1997-09-09 Peter Blumbergs Process for the preparation of 9-beta-d-arabinofuranosyl-2-fluoroadenine 5'-phosphate
US5602246A (en) 1992-11-25 1997-02-11 Schering Aktiengesellschaft Process for the preparation of fludarabine or fludarabine phosphate from guanosine
FR2701027B1 (fr) * 1993-02-01 1997-07-18 Warner Lambert Co Procede de synthese ameliore du 9-(beta-d-arabinofuranosyl)adenine 5'-phosphate.
DE19543052A1 (de) * 1995-11-06 1997-05-07 Schering Ag Verfahren zur Herstellung und Reinigung von Fludarabin-Phosphat und die Verwendung von sauren Ionenaustauschern im Verfahren
IT1276126B1 (it) 1995-11-14 1997-10-27 Archimica Spa Procedimento per la preparazine di 9-((2-idrossietossi)metil) guanina
SI1047704T2 (sl) 1997-12-11 2008-02-29 Bayer Schering Pharma Ag Postopek za pripravo fludarabin-fosfat litijevih,natrijevih, kalijevih, kalcijevih in magnezijevihsoli, cistilni postopek za pripravo fludarabin-fosfata in fludarabin-fosfat z vsaj 99,5 % cistoto
US6174873B1 (en) 1998-11-04 2001-01-16 Supergen, Inc. Oral administration of adenosine analogs

Also Published As

Publication number Publication date
IL136283A0 (en) 2001-05-20
CZ20002159A3 (cs) 2000-09-13
ES2190136T5 (es) 2008-03-01
CZ296366B6 (cs) 2006-02-15
JP4261051B2 (ja) 2009-04-30
CA2313486A1 (en) 1999-06-17
KR20050085937A (ko) 2005-08-29
HUP0100169A1 (hu) 2001-11-28
ATE231880T1 (de) 2003-02-15
HU226997B1 (en) 2010-04-28
EP1047704A2 (de) 2000-11-02
KR20010032919A (ko) 2001-04-25
NO20002962L (no) 2000-06-09
HUP0100169A3 (en) 2002-04-29
EP1047704B1 (de) 2003-01-29
US7547776B1 (en) 2009-06-16
PL195712B1 (pl) 2007-10-31
AT8617U1 (de) 2006-10-15
DE59807096D1 (de) 2003-03-06
DK1047704T3 (da) 2003-06-23
SI1047704T1 (sl) 2004-02-29
IL136283A (en) 2006-10-31
NO20002962D0 (no) 2000-06-09
HK1033831A1 (en) 2001-09-28
PL341659A1 (en) 2001-04-23
US6046322A (en) 2000-04-04
JP2001525418A (ja) 2001-12-11
TW424093B (en) 2001-03-01
KR100532898B1 (ko) 2005-12-05
WO1999029710A3 (de) 1999-09-10
ES2190136T3 (es) 2003-07-16
AU739574B2 (en) 2001-10-18
EP1047704B2 (de) 2007-11-07
AU2155099A (en) 1999-06-28
SI1047704T2 (sl) 2008-02-29
JP2009040797A (ja) 2009-02-26
DE29825173U1 (de) 2005-12-22
SK283475B6 (sk) 2003-08-05
DK1047704T4 (da) 2008-03-25
WO1999029710A2 (de) 1999-06-17
NO315324B1 (no) 2003-08-18
SK8872000A3 (en) 2001-03-12

Similar Documents

Publication Publication Date Title
GB9727048D0 (en) Process for the preparation of magnesium and carbonate substituted hydroxyapatite
HK1041907A1 (zh) 製備氯化鎂溶液的方法
CZ151599A3 (cs) Způsob krystalizace draselné soli losartanu
ZA9811338B (en) Process for the production of fludarabine-phosphate lithium sodium potassium calcium and magnesium salts
SG65049A1 (en) Process for the production of polyther polyols
IL133363A (en) Process for the production of herapin
GR3030549T3 (en) Continuous process for the production of precipitated calcium carbonate
GB9802999D0 (en) Production of products containing precipitated calcium carbonate
IL113732A0 (en) A process for the production of anhydrous magnesium chloride
IL128279A0 (en) Process for producing anhydrous mgci2
AU5584699A (en) Process for producing potassium sulfate from potash and sodium sulfate
SG44950A1 (en) Continuous process for the manufacture of sodium C4C8alkoxide
GB2291414B (en) Process for the manufacture of anhydrous sodium carbonate
IL113104A0 (en) Process for the production of granulated potassium chloride
FI973836A0 (fi) Enfasig gipsbaeddsprocess foer produktion av kaliumsalter
HUP0004950A3 (en) Process for the production of formylimidazoles
ZA984269B (en) Process for the manufacture of sodium percarbonate
GB2323971B (en) Process for the production of polarisation selective reflectors
IL121638A0 (en) Method of production of magnesium
SI0716640T1 (en) Process for producing granulated sodium percarbonate
PL299458A1 (en) Method of obtaining sodium salt of n-chloro-p-toluene sulfonamide
AU2555895A (en) Process for the manufacture of sodium carbonate, sodium bicarbonate and/or sesquicarbonate
IL89182A0 (en) Process for the production of sodium carbonate
GB9707993D0 (en) Methods of using calcium carbonate
CS14290A2 (en) (4-0-methyl-alpha-d-glucurono)-beta-d-xylan-0-phosphate, its potassium and sodium salt and method of production