ZA9810219B - Benzothiazole protein tyrosine kinase inhibitors. - Google Patents
Benzothiazole protein tyrosine kinase inhibitors.Info
- Publication number
- ZA9810219B ZA9810219B ZA9810219A ZA9810219A ZA9810219B ZA 9810219 B ZA9810219 B ZA 9810219B ZA 9810219 A ZA9810219 A ZA 9810219A ZA 9810219 A ZA9810219 A ZA 9810219A ZA 9810219 B ZA9810219 B ZA 9810219B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzothiazole
- tyrosine kinase
- kinase inhibitors
- protein tyrosine
- protein
- Prior art date
Links
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6504297P | 1997-11-10 | 1997-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA9810219B true ZA9810219B (en) | 2000-06-22 |
Family
ID=22059964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9810219A ZA9810219B (en) | 1997-11-10 | 1998-11-09 | Benzothiazole protein tyrosine kinase inhibitors. |
Country Status (25)
Country | Link |
---|---|
US (1) | US6825355B2 (tr) |
EP (1) | EP1037632B1 (tr) |
JP (1) | JP2001522800A (tr) |
KR (1) | KR20010031912A (tr) |
CN (1) | CN1290165A (tr) |
AR (1) | AR017588A1 (tr) |
AT (1) | ATE315394T1 (tr) |
AU (1) | AU744281B2 (tr) |
BR (1) | BR9814956A (tr) |
CA (1) | CA2309319A1 (tr) |
DE (1) | DE69833224T2 (tr) |
ES (1) | ES2256969T3 (tr) |
HU (1) | HUP0102101A3 (tr) |
ID (1) | ID24289A (tr) |
IL (1) | IL135176A0 (tr) |
NO (1) | NO20002121L (tr) |
NZ (1) | NZ503491A (tr) |
PE (1) | PE129799A1 (tr) |
PL (1) | PL340727A1 (tr) |
RU (1) | RU2212407C2 (tr) |
TR (1) | TR200001312T2 (tr) |
TW (1) | TW510898B (tr) |
UY (1) | UY25242A1 (tr) |
WO (1) | WO1999024035A1 (tr) |
ZA (1) | ZA9810219B (tr) |
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US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
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DE60014130T2 (de) * | 1999-10-06 | 2006-03-09 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Heterocyclische verbindungen verwendbar als tyrosinkinase inhibitoren |
US6506769B2 (en) | 1999-10-06 | 2003-01-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
DE19951360A1 (de) * | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
US7101869B2 (en) | 1999-11-30 | 2006-09-05 | Pfizer Inc. | 2,4-diaminopyrimidine compounds useful as immunosuppressants |
SK12712002A3 (sk) * | 2000-02-07 | 2003-02-04 | Abbott Gmbh & Co. Kg | Deriváty 2-benzotiazolylmočoviny a ich použitie ako inhibítorov proteínkináz |
GB0003254D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
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JP5000068B2 (ja) * | 2000-08-11 | 2012-08-15 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | チロシンキナーゼのインヒビターとして有用な複素環化合物 |
EP1341771A2 (en) | 2000-11-29 | 2003-09-10 | Glaxo Group Limited | Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors |
ES2200617B1 (es) | 2001-01-19 | 2005-05-01 | Almirall Prodesfarma, S.A. | Derivados de urea como antagonistas de integrinas alfa 4. |
HN2002000156A (es) | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización. |
BR0214019A (pt) | 2001-11-09 | 2004-10-13 | Boehringer Ingelheim Phamaceut | Benzimidazóis úteis como inibidores de proteìna quinase |
US6734179B2 (en) | 2001-12-12 | 2004-05-11 | Hoffmann-La Roche Inc. | Benzothiazoles |
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CN107021937B (zh) * | 2017-03-27 | 2019-06-21 | 沈阳药科大学 | 苯并噻唑甲酰胺类化合物及其应用 |
JP7123429B2 (ja) * | 2017-05-04 | 2022-08-23 | シャンハイ ロングウッド バイオファルマシューティカルズ カンパニー リミテッド | 二環式縮合環系ヌクレオカプシド阻害剤および薬物としてb型肝炎を治療するためのその使用 |
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CN111315727B (zh) * | 2017-10-02 | 2023-09-29 | 第一生物治疗股份有限公司 | 苯并噻唑化合物及使用其治疗神经退行性疾病的方法 |
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JPS62194251A (ja) * | 1986-02-20 | 1987-08-26 | Konishiroku Photo Ind Co Ltd | 保存安定性が改良されたハロゲン化銀写真感光材料 |
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JP2869561B2 (ja) | 1989-05-22 | 1999-03-10 | 大塚製薬株式会社 | 血小板粘着抑制剤 |
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US5496816A (en) | 1994-03-14 | 1996-03-05 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
HRP960159A2 (en) | 1995-04-21 | 1997-08-31 | Bayer Ag | Benzocyclopentane oxazolidinones containing heteroatoms |
TW513418B (en) | 1996-07-31 | 2002-12-11 | Otsuka Pharma Co Ltd | Thiazole derivatives, their production and use |
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-
1998
- 1998-11-02 AT AT98957468T patent/ATE315394T1/de not_active IP Right Cessation
- 1998-11-02 HU HU0102101A patent/HUP0102101A3/hu unknown
- 1998-11-02 BR BR9814956-3A patent/BR9814956A/pt not_active IP Right Cessation
- 1998-11-02 TR TR2000/01312T patent/TR200001312T2/tr unknown
- 1998-11-02 EP EP98957468A patent/EP1037632B1/en not_active Expired - Lifetime
- 1998-11-02 ES ES98957468T patent/ES2256969T3/es not_active Expired - Lifetime
- 1998-11-02 JP JP2000520127A patent/JP2001522800A/ja active Pending
- 1998-11-02 AU AU13719/99A patent/AU744281B2/en not_active Ceased
- 1998-11-02 CN CN98811003A patent/CN1290165A/zh active Pending
- 1998-11-02 KR KR1020007005014A patent/KR20010031912A/ko not_active Application Discontinuation
- 1998-11-02 IL IL13517698A patent/IL135176A0/xx unknown
- 1998-11-02 RU RU2000114635/04A patent/RU2212407C2/ru not_active IP Right Cessation
- 1998-11-02 ID IDW20000858A patent/ID24289A/id unknown
- 1998-11-02 WO PCT/US1998/023204 patent/WO1999024035A1/en not_active Application Discontinuation
- 1998-11-02 DE DE69833224T patent/DE69833224T2/de not_active Expired - Lifetime
- 1998-11-02 NZ NZ503491A patent/NZ503491A/xx unknown
- 1998-11-02 CA CA002309319A patent/CA2309319A1/en not_active Abandoned
- 1998-11-02 PL PL98340727A patent/PL340727A1/xx not_active Application Discontinuation
- 1998-11-05 TW TW087118450A patent/TW510898B/zh not_active IP Right Cessation
- 1998-11-09 ZA ZA9810219A patent/ZA9810219B/xx unknown
- 1998-11-10 UY UY25242A patent/UY25242A1/es not_active Application Discontinuation
- 1998-11-10 AR ARP980105676A patent/AR017588A1/es not_active Application Discontinuation
- 1998-11-10 PE PE1998001078A patent/PE129799A1/es not_active Application Discontinuation
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2000
- 2000-04-26 NO NO20002121A patent/NO20002121L/no not_active Application Discontinuation
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2001
- 2001-10-26 US US10/032,609 patent/US6825355B2/en not_active Expired - Lifetime
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EP1037632A4 (en) | 2002-08-21 |
WO1999024035A1 (en) | 1999-05-20 |
EP1037632A1 (en) | 2000-09-27 |
KR20010031912A (ko) | 2001-04-16 |
PL340727A1 (en) | 2001-02-26 |
RU2212407C2 (ru) | 2003-09-20 |
TR200001312T2 (tr) | 2000-09-21 |
HUP0102101A2 (hu) | 2001-11-28 |
NO20002121D0 (no) | 2000-04-26 |
DE69833224T2 (de) | 2006-09-28 |
AU744281B2 (en) | 2002-02-21 |
EP1037632B1 (en) | 2006-01-11 |
AU1371999A (en) | 1999-05-31 |
TW510898B (en) | 2002-11-21 |
UY25242A1 (es) | 2001-08-27 |
US6825355B2 (en) | 2004-11-30 |
JP2001522800A (ja) | 2001-11-20 |
ID24289A (id) | 2000-07-13 |
CN1290165A (zh) | 2001-04-04 |
BR9814956A (pt) | 2000-10-03 |
HUP0102101A3 (en) | 2002-11-28 |
CA2309319A1 (en) | 1999-05-20 |
PE129799A1 (es) | 2000-03-08 |
ES2256969T3 (es) | 2006-07-16 |
US20020123484A1 (en) | 2002-09-05 |
IL135176A0 (en) | 2001-05-20 |
AR017588A1 (es) | 2001-09-12 |
NZ503491A (en) | 2002-08-28 |
ATE315394T1 (de) | 2006-02-15 |
DE69833224D1 (en) | 2006-04-06 |
NO20002121L (no) | 2000-05-09 |
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