ZA975727B - Inhibitors of prenyl transferases. - Google Patents

Inhibitors of prenyl transferases.

Info

Publication number
ZA975727B
ZA975727B ZA9705727A ZA975727A ZA975727B ZA 975727 B ZA975727 B ZA 975727B ZA 9705727 A ZA9705727 A ZA 9705727A ZA 975727 A ZA975727 A ZA 975727A ZA 975727 B ZA975727 B ZA 975727B
Authority
ZA
South Africa
Prior art keywords
inhibitors
prenyl transferases
image
prenyl
transferases
Prior art date
Application number
ZA9705727A
Other languages
English (en)
Inventor
Zheng Xin Dong
Sun H Kim
Original Assignee
Biomeasure Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomeasure Inc filed Critical Biomeasure Inc
Publication of ZA975727B publication Critical patent/ZA975727B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ZA9705727A 1996-06-28 1997-06-27 Inhibitors of prenyl transferases. ZA975727B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/672,474 US5773455A (en) 1996-06-28 1996-06-28 Inhibitors of prenyl transferases

Publications (1)

Publication Number Publication Date
ZA975727B true ZA975727B (en) 1998-01-26

Family

ID=24698698

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9705727A ZA975727B (en) 1996-06-28 1997-06-27 Inhibitors of prenyl transferases.

Country Status (17)

Country Link
US (1) US5773455A (cs)
EP (1) EP0932606B1 (cs)
JP (1) JP2000514056A (cs)
CN (1) CN1081187C (cs)
AT (1) ATE380797T1 (cs)
AU (1) AU726784B2 (cs)
CA (1) CA2254759C (cs)
CZ (1) CZ295437B6 (cs)
DE (1) DE69738373T2 (cs)
ES (1) ES2296309T3 (cs)
IL (1) IL127574A (cs)
NZ (1) NZ332559A (cs)
PL (1) PL189835B1 (cs)
RU (1) RU2186776C2 (cs)
TW (1) TW415945B (cs)
WO (1) WO1998000409A1 (cs)
ZA (1) ZA975727B (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2780892B1 (fr) * 1998-07-08 2001-08-17 Sod Conseils Rech Applic Utilisation d'inhibiteurs de prenyltransferases pour preparer un medicament destine a traiter les pathologies qui resultent de la fixation membranaire de la proteine g heterotrimerique
ATE349462T1 (de) * 1998-07-28 2007-01-15 Santen Pharmaceutical Co Ltd Thiazolidin-derivate
CA2546727C (en) 2003-11-20 2012-10-02 Children's Hospital Medical Center Gtpase inhibitors and methods of use
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
DE602005021970D1 (de) * 2004-08-27 2010-08-05 Ucb Pharma Gmbh Verwendung von peptidverbindungen zur behandlung von schmerzen durch knochenkrebs, chemotherapie- und nucleosid-bedingten schmerzen
US7759383B2 (en) 2005-02-22 2010-07-20 The Regents Of The University Of Michigan Small molecule inhibitors of MDM2 and the uses thereof
BRPI0609172A2 (pt) * 2005-02-22 2010-02-23 Univ Michigan inibidores de pequenas moléculas de mdm2 e usos destes
WO2007016539A2 (en) 2005-07-29 2007-02-08 Children's Hospital Medical Center Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase
US7737174B2 (en) 2006-08-30 2010-06-15 The Regents Of The University Of Michigan Indole inhibitors of MDM2 and the uses thereof
US8222288B2 (en) 2006-08-30 2012-07-17 The Regents Of The University Of Michigan Small molecule inhibitors of MDM2 and the uses thereof
EP2499145B1 (en) 2009-11-12 2016-01-27 The Regents Of The University Of Michigan Spiro-oxindole mdm2 antagonists
ES2705719T3 (es) 2010-07-28 2019-03-26 Janssen Diagnostics Llc Métodos de determinación de la respuesta de la leucemia mieloide aguda al tratamiento con inhibidores de la farnesiltransferasa
MX2013005238A (es) 2010-11-12 2013-09-02 Univ Michigan Antagonistas de mdm2 de espiro-oxindol.
JP2014513699A (ja) 2011-05-11 2014-06-05 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン スピロ−オキシインドールｍｄｍ２アンタゴニスト
US9980942B2 (en) 2012-05-02 2018-05-29 Children's Hospital Medical Center Rejuvenation of precursor cells
US10028503B2 (en) 2014-06-18 2018-07-24 Children's Hospital Medical Center Platelet storage methods and compositions for same
JP6630742B2 (ja) 2015-08-17 2020-01-15 クラ オンコロジー， インコーポレイテッド ファルネシルトランスフェラーゼ阻害剤を用いて癌患者を治療する方法
ES2863730T3 (es) 2016-11-03 2021-10-11 Kura Oncology Inc Inhibidores de la farnesiltransferasa para uso en el tratamiento del cáncer
WO2019113269A1 (en) 2017-12-08 2019-06-13 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
WO2020190604A1 (en) 2019-03-15 2020-09-24 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
WO2021034616A1 (en) 2019-08-16 2021-02-25 Children' S Hospital Medical Center Methods of treating a subject with a cdc42-specific inhibitor
WO2024261302A1 (en) 2023-06-22 2024-12-26 Institut National de la Santé et de la Recherche Médicale Nlrp3 inhibitors, pak1/2 inhibitors and/or caspase 1 inhibitors for use in the treatment of rac2 monogenic disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2310348A1 (fr) * 1975-05-07 1976-12-03 Ugine Kuhlmann Nouveaux derives heterocycliques antidotes contre herbicides
US4192878A (en) * 1976-12-03 1980-03-11 E. R. Squibb & Sons, Inc. Derivatives of thiazolidinecarboxylic acids and related acids
IT1201489B (it) * 1985-11-13 1989-02-02 Chiesi Farma Spa Derivati di tiazolidina,loro procedimento di preparazione e formulazioni farmaceutiche
IT1216119B (it) * 1988-03-17 1990-02-22 Boehringer Biochemia Srl Beta_carbonil_carbossiamidi di 1,3_tiazolidine.
US5212191A (en) * 1988-04-08 1993-05-18 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
IL96654A (en) * 1989-12-21 1995-06-29 Lilly Co Eli Hydroxybenzyl substituted sulfur containing heterocyclic derivatives their preparation and pharmaceutical compositions containing them
CA2118985A1 (en) * 1993-04-02 1994-10-03 Dinesh V. Patel Heterocyclic inhibitors of farnesyl protein transferase
US5408385A (en) * 1993-04-30 1995-04-18 Robertshaw Controls Company Control device and method of making the same
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5439918A (en) * 1994-03-14 1995-08-08 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2155448A1 (en) * 1994-08-11 1996-02-12 Katerina Leftheris Inhibitors of farnesyl protein transferase
US5491164A (en) * 1994-09-29 1996-02-13 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2207252C (en) * 1995-01-12 2014-02-25 University Of Pittsburgh Inhibitors of prenyl transferases

Also Published As

Publication number Publication date
ATE380797T1 (de) 2007-12-15
US5773455A (en) 1998-06-30
IL127574A (en) 2002-12-01
CN1081187C (zh) 2002-03-20
PL330908A1 (en) 1999-06-07
JP2000514056A (ja) 2000-10-24
CA2254759A1 (en) 1998-01-08
ES2296309T3 (es) 2008-04-16
TW415945B (en) 2000-12-21
EP0932606B1 (en) 2007-12-12
WO1998000409A1 (en) 1998-01-08
DE69738373D1 (de) 2008-01-24
PL189835B1 (pl) 2005-09-30
CA2254759C (en) 2007-02-13
AU726784B2 (en) 2000-11-23
CZ295437B6 (cs) 2005-08-17
EP0932606A4 (en) 2000-01-19
CZ418098A3 (cs) 1999-05-12
IL127574A0 (en) 1999-10-28
NZ332559A (en) 2000-05-26
RU2186776C2 (ru) 2002-08-10
EP0932606A1 (en) 1999-08-04
AU2998897A (en) 1998-01-21
DE69738373T2 (de) 2008-12-04
CN1223642A (zh) 1999-07-21

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