CA2245823A1 - Farnesyl transferase inhibitors - Google Patents

Farnesyl transferase inhibitors

Info

Publication number
CA2245823A1
CA2245823A1 CA002245823A CA2245823A CA2245823A1 CA 2245823 A1 CA2245823 A1 CA 2245823A1 CA 002245823 A CA002245823 A CA 002245823A CA 2245823 A CA2245823 A CA 2245823A CA 2245823 A1 CA2245823 A1 CA 2245823A1
Authority
CA
Canada
Prior art keywords
farnesyl transferase
transferase inhibitors
farnesyl
inhibitors
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002245823A
Other languages
French (fr)
Other versions
CA2245823C (en
Inventor
Thomas D. Gordon
Barry A. Morgan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Biomeasure, Incorporated
Thomas D. Gordon
Barry A. Morgan
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S .
Ipsen Pharma S.A.S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/752,546 external-priority patent/US6673927B2/en
Application filed by Biomeasure, Incorporated, Thomas D. Gordon, Barry A. Morgan, Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S ., Ipsen Pharma S.A.S filed Critical Biomeasure, Incorporated
Publication of CA2245823A1 publication Critical patent/CA2245823A1/en
Application granted granted Critical
Publication of CA2245823C publication Critical patent/CA2245823C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A family of compounds capable of inhibiting the activity of farnesyl transferase.
CA002245823A 1996-02-16 1997-02-14 Farnesyl transferase inhibitors Expired - Fee Related CA2245823C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US60243896A 1996-02-16 1996-02-16
US08/602,438 1996-02-16
US08/752,546 1996-11-20
US08/752,546 US6673927B2 (en) 1996-02-16 1996-11-20 Farnesyl transferase inhibitors
PCT/US1997/002651 WO1997030053A1 (en) 1996-02-16 1997-02-14 Farnesyl transferase inhibitors

Publications (2)

Publication Number Publication Date
CA2245823A1 true CA2245823A1 (en) 1997-08-21
CA2245823C CA2245823C (en) 2006-08-01

Family

ID=36764344

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002245823A Expired - Fee Related CA2245823C (en) 1996-02-16 1997-02-14 Farnesyl transferase inhibitors

Country Status (1)

Country Link
CA (1) CA2245823C (en)

Also Published As

Publication number Publication date
CA2245823C (en) 2006-08-01

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed