ZA943744B - Therapeutic substituted guanidines - Google Patents
Therapeutic substituted guanidinesInfo
- Publication number
- ZA943744B ZA943744B ZA943744A ZA943744A ZA943744B ZA 943744 B ZA943744 B ZA 943744B ZA 943744 A ZA943744 A ZA 943744A ZA 943744 A ZA943744 A ZA 943744A ZA 943744 B ZA943744 B ZA 943744B
- Authority
- ZA
- South Africa
- Prior art keywords
- substituted guanidines
- guanidines
- therapeutic substituted
- therapeutic
- utilize
- Prior art date
Links
- 150000002357 guanidines Chemical class 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
- C07C317/42—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6852293A | 1993-05-27 | 1993-05-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA943744B true ZA943744B (en) | 1995-04-26 |
Family
ID=22083114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA943744A ZA943744B (en) | 1993-05-27 | 1994-05-27 | Therapeutic substituted guanidines |
Country Status (13)
Country | Link |
---|---|
US (2) | US6153604A (fr) |
EP (1) | EP0705100B1 (fr) |
JP (2) | JP3610368B2 (fr) |
KR (1) | KR20030097618A (fr) |
CN (1) | CN1188121C (fr) |
AT (1) | ATE245977T1 (fr) |
CA (1) | CA2163361C (fr) |
DE (1) | DE69432984T2 (fr) |
DK (1) | DK0705100T3 (fr) |
ES (1) | ES2204920T3 (fr) |
PT (1) | PT705100E (fr) |
WO (1) | WO1994027591A1 (fr) |
ZA (1) | ZA943744B (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1912595A (en) | 1994-02-03 | 1995-08-21 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
US6787569B1 (en) | 1994-02-03 | 2004-09-07 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
US6143791A (en) * | 1994-02-03 | 2000-11-07 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
US7351743B1 (en) | 1994-02-03 | 2008-04-01 | Wyeth | Therapeutic guanidines |
US6025355A (en) | 1997-05-19 | 2000-02-15 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
US6756389B2 (en) * | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
JP2001519393A (ja) * | 1997-10-10 | 2001-10-23 | ケンブリッジ・ニューロサイエンス・インコーポレイティッド | 医薬活性化合物および使用方法 |
US6774263B1 (en) | 1997-10-10 | 2004-08-10 | Cambridge Neuroscience, Inc. | Pharmaceutically active compound and methods of use |
US7041702B1 (en) | 1997-10-21 | 2006-05-09 | Scion Pharmaceuticals, Inc. | Pharmaceutically active compounds and methods of use |
US20030199574A1 (en) | 2000-03-02 | 2003-10-23 | Vitreo-Retinal Technologies, Inc. | Treatment of ophthalmic disorders using urea and urea derivatives |
MXPA04007802A (es) * | 2002-02-13 | 2005-04-19 | Vitreo Retinal Technologies In | Tratamiento de desordenes oftalmicos utilizando urea o derivados de urea. |
GB0216621D0 (en) * | 2002-07-17 | 2002-08-28 | Imaging Res Solutions Ltd | Imaging compounds |
EP1732883A1 (fr) * | 2004-03-29 | 2006-12-20 | Neurosearch A/S | Nouveaux dérivés d'urea et leur utilisation médicale |
EP1940389A2 (fr) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation de la neurogenese par inhibition de la pde |
CA2625210A1 (fr) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Modulation de la neurogenese dont la mediation est assuree par recepteur gaba |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
MX2009002496A (es) * | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
EP1908464A1 (fr) * | 2006-10-04 | 2008-04-09 | Centre National De La Recherche Scientifique (Cnrs) | Utilisation de dérivés de chlorine guanabenz pour le traitement de maladies à expansion de polyglutamine |
WO2010048164A2 (fr) * | 2008-10-20 | 2010-04-29 | University Of South Florida | Traitement avec la n,n'-di-p-bromophénylguanidine pour un accident cérébrovasculaire à des temps différés |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
GB201008047D0 (en) * | 2010-05-14 | 2010-06-30 | Ge Healthcare Ltd | Method of synthesis |
NL2006875C2 (en) * | 2011-05-31 | 2012-12-03 | Vereniging Voor Christelijk Hoger Onderwijs | N,n-substituted guanidine compound. |
GB201117786D0 (en) | 2011-10-14 | 2011-11-30 | Ge Healthcare Ltd | Eluent vial |
GB201117785D0 (en) | 2011-10-14 | 2011-11-30 | Ge Healthcare Ltd | Improved radiosynthesis method |
WO2015002150A1 (fr) | 2013-07-03 | 2015-01-08 | 株式会社新日本科学 | Nouveau composé, agent de détection du transporteur de cations organiques 3 et inhibiteur de l'activité du transporteur de cations organiques 3 |
CN111548313A (zh) * | 2019-02-11 | 2020-08-18 | 绍兴从零医药科技有限公司 | 预防和治疗慢性疼痛药物的胍类化合物 |
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DE2133056C3 (de) * | 1971-07-02 | 1980-10-23 | Vsesojuznyj Nautschno-Issledovatelskij Institut Chimitscheskich Sredstv Zaschtschity Rastenij, Moskau | Verwendung von NJS-di-alkyl-N'arylsubstituierten Guanidinen zur Bekämpfung von Mehltaupilzen und Grauschimmel der Pflanzen |
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NL7315350A (nl) * | 1973-11-09 | 1975-05-13 | Akzo Nv | Nieuwe aminoguanidine verbindingen. |
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DE3501383A1 (de) * | 1985-01-17 | 1986-07-17 | Akzo Gmbh, 5600 Wuppertal | Verfahren zur herstellung von n,n'-disubstituierten guanidinen |
EP0259371B1 (fr) * | 1986-01-28 | 1992-05-13 | JOHN WYETH & BROTHER LIMITED | Preparation de 3-dimethylamino-7-methyl-1,2,4-benzotriazine-1-oxyde et d'azapropazone |
US5093525A (en) * | 1986-07-10 | 1992-03-03 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists |
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US4906779A (en) * | 1986-07-10 | 1990-03-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists |
US5190976A (en) * | 1986-07-10 | 1993-03-02 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And University Of Oregon | N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists |
US4709094A (en) * | 1986-07-10 | 1987-11-24 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Sigma brain receptor ligands and their use |
US5478863A (en) * | 1986-07-10 | 1995-12-26 | State Of Oregon, Oregon Health Sciences University Of Oregon | Substituted guanidines having high binding to the sigma receptor and the use thereof |
US4837218A (en) * | 1987-10-23 | 1989-06-06 | Washington University | Alkylated bicycloalkaneamines for treatment of neurotoxic injury |
US4891185A (en) * | 1988-01-22 | 1990-01-02 | Goldin Stanley M | High resolution monitoring device |
US5011834A (en) * | 1989-04-14 | 1991-04-30 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | PCP receptor ligands and the use thereof |
ATE110265T1 (de) * | 1989-05-02 | 1994-09-15 | Oregon State | Verwendung von sigma-rezeptor-liganden zur herstellung eines anxiolytikums. |
US5262568A (en) * | 1990-03-02 | 1993-11-16 | State Of Oregon | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists |
SG73414A1 (en) * | 1990-03-02 | 2000-06-20 | Oregon State | Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists |
US5336689A (en) * | 1990-03-02 | 1994-08-09 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists |
EP0532642A1 (fr) * | 1990-05-25 | 1993-03-24 | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON | Guanidines substituees ayant un coefficient de liaison eleve avec le recepteur sigma et utilisation de ces substances |
WO1992004054A1 (fr) * | 1990-08-30 | 1992-03-19 | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITY, PORTLAND, OREGON, and THE UNIVERSITY OF OREGON, EUGENE, OREGON, Johnson Hall, University of Oregon | Amidines substituees ayant une forte affinite avec le recepteur sigma et utilisations desdites amidines |
DE69233479T2 (de) * | 1991-02-08 | 2006-03-16 | Scion Pharmaceuticals, Inc., Medford | Substituierte Guanidine und Derivate hiervon als Modulatoren der Freisetzung von Neurotransmittern und neue Methode zur Identifizierung von Inhibitoren der Neurotransmitter-Freisetzung |
US5298657A (en) * | 1992-03-20 | 1994-03-29 | Cambridge Neuroscience Inc. | Preparation of substituted guanidines |
DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
AU1912595A (en) * | 1994-02-03 | 1995-08-21 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
-
1994
- 1994-05-27 ES ES94919275T patent/ES2204920T3/es not_active Expired - Lifetime
- 1994-05-27 DE DE69432984T patent/DE69432984T2/de not_active Expired - Fee Related
- 1994-05-27 CA CA002163361A patent/CA2163361C/fr not_active Expired - Fee Related
- 1994-05-27 PT PT94919275T patent/PT705100E/pt unknown
- 1994-05-27 JP JP50098895A patent/JP3610368B2/ja not_active Expired - Fee Related
- 1994-05-27 EP EP94919275A patent/EP0705100B1/fr not_active Expired - Lifetime
- 1994-05-27 ZA ZA943744A patent/ZA943744B/xx unknown
- 1994-05-27 DK DK94919275T patent/DK0705100T3/da active
- 1994-05-27 WO PCT/US1994/006008 patent/WO1994027591A1/fr active IP Right Grant
- 1994-05-27 AT AT94919275T patent/ATE245977T1/de not_active IP Right Cessation
- 1994-05-27 CN CNB941926109A patent/CN1188121C/zh not_active Expired - Fee Related
- 1994-05-27 KR KR1020027015816A patent/KR20030097618A/ko not_active Application Discontinuation
-
1995
- 1995-06-02 US US08/458,803 patent/US6153604A/en not_active Expired - Fee Related
- 1995-06-02 US US08/458,741 patent/US6147063A/en not_active Expired - Fee Related
-
2004
- 2004-05-11 JP JP2004140658A patent/JP2004285073A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ES2204920T3 (es) | 2004-05-01 |
AU7047394A (en) | 1994-12-20 |
CN1126434A (zh) | 1996-07-10 |
JP3610368B2 (ja) | 2005-01-12 |
US6147063A (en) | 2000-11-14 |
KR20030097618A (ko) | 2003-12-31 |
AU695337B2 (en) | 1998-08-13 |
JP2004285073A (ja) | 2004-10-14 |
CA2163361A1 (fr) | 1994-12-08 |
CA2163361C (fr) | 2008-06-17 |
JPH08510754A (ja) | 1996-11-12 |
WO1994027591A1 (fr) | 1994-12-08 |
PT705100E (pt) | 2003-12-31 |
EP0705100B1 (fr) | 2003-07-30 |
ATE245977T1 (de) | 2003-08-15 |
DK0705100T3 (da) | 2003-11-17 |
EP0705100A1 (fr) | 1996-04-10 |
DE69432984D1 (de) | 2003-09-04 |
DE69432984T2 (de) | 2004-05-27 |
US6153604A (en) | 2000-11-28 |
EP0705100A4 (fr) | 1996-05-29 |
CN1188121C (zh) | 2005-02-09 |
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