WO1996022305A3 - Peptides modifies - Google Patents

Peptides modifies Download PDF

Info

Publication number
WO1996022305A3
WO1996022305A3 PCT/GB1996/000057 GB9600057W WO9622305A3 WO 1996022305 A3 WO1996022305 A3 WO 1996022305A3 GB 9600057 W GB9600057 W GB 9600057W WO 9622305 A3 WO9622305 A3 WO 9622305A3
Authority
WO
WIPO (PCT)
Prior art keywords
modified peptides
compounds
prophylaxis
formula
treatment
Prior art date
Application number
PCT/GB1996/000057
Other languages
English (en)
Other versions
WO1996022305A2 (fr
Inventor
Alejandro Jose Daniels
Dennis Heyer
Johann Jakob Leban
Original Assignee
Wellcome Found
Alejandro Jose Daniels
Dennis Heyer
Johann Jakob Leban
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found, Alejandro Jose Daniels, Dennis Heyer, Johann Jakob Leban filed Critical Wellcome Found
Priority to AU43943/96A priority Critical patent/AU4394396A/en
Publication of WO1996022305A2 publication Critical patent/WO1996022305A2/fr
Publication of WO1996022305A3 publication Critical patent/WO1996022305A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La présente invention se rapporte à des composés de la formule (I), à l'utilisation de tels composés en médecine, notamment dans le traitement ou la prophylaxie d'états associés à des troubles de la nutrition, ainsi qu'à des compositions pharmaceutiques contenant ces composés.
PCT/GB1996/000057 1995-01-12 1996-01-12 Peptides modifies WO1996022305A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU43943/96A AU4394396A (en) 1995-01-12 1996-01-12 Modified peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9500601.1 1995-01-12
GBGB9500601.1A GB9500601D0 (en) 1995-01-12 1995-01-12 Modified peptides

Publications (2)

Publication Number Publication Date
WO1996022305A2 WO1996022305A2 (fr) 1996-07-25
WO1996022305A3 true WO1996022305A3 (fr) 1996-09-06

Family

ID=10767945

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/000057 WO1996022305A2 (fr) 1995-01-12 1996-01-12 Peptides modifies

Country Status (3)

Country Link
AU (1) AU4394396A (fr)
GB (1) GB9500601D0 (fr)
WO (1) WO1996022305A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2814367B1 (fr) * 2000-09-25 2008-12-26 Inst Nat Sante Rech Med Ligands du recepteur npff pour le traitement de la douleur et des hyperalgies
SE0103476D0 (sv) * 2001-10-18 2001-10-18 Markus Heilig New use
DE602004026289D1 (de) 2003-05-05 2010-05-12 Probiodrug Ag Glutaminylcyclase-hemmer
ZA200603165B (en) 2003-11-03 2007-07-25 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
AU2005210004B2 (en) 2004-02-05 2010-10-28 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
WO2008055945A1 (fr) 2006-11-09 2008-05-15 Probiodrug Ag Dérivés 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one utiles en tant qu' inhibiteurs de la glutaminyl-cyclase dans le traitement des ulcères, du cancer et d'autres maladies
WO2008065141A1 (fr) 2006-11-30 2008-06-05 Probiodrug Ag Nouveaux inhibiteurs de glutaminylcyclase
ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
MX2012002993A (es) 2009-09-11 2012-04-19 Probiodrug Ag Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
MX2012010470A (es) 2010-03-10 2012-10-09 Probiodrug Ag Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
WO2012123563A1 (fr) 2011-03-16 2012-09-20 Probiodrug Ag Dérivés de benzimidazole en tant qu'inhibiteurs de la glutaminyl cyclase
EP3461819B1 (fr) 2017-09-29 2020-05-27 Probiodrug AG Inhibiteurs de la glutaminyl-cyclase

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017035A1 (fr) * 1993-01-20 1994-08-04 Dr. Karl Thomae Gmbh Derives d'amino-acides, medicaments contenant ces composes et procede permettant de les preparer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017035A1 (fr) * 1993-01-20 1994-08-04 Dr. Karl Thomae Gmbh Derives d'amino-acides, medicaments contenant ces composes et procede permettant de les preparer

Also Published As

Publication number Publication date
WO1996022305A2 (fr) 1996-07-25
AU4394396A (en) 1996-08-07
GB9500601D0 (en) 1995-03-01

Similar Documents

Publication Publication Date Title
WO2000047568A3 (fr) Nouvelles benzothiazepines-1,2 presentant une activite d'inhibition de transport d'acide biliaire ileal et d'absorption de taurocholate
BG101118A (en) Therapeutical compounds
CA2163361A1 (fr) Derives de substitution de guanidines, agents therapeutiques
TW352384B (en) Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
UA39158C2 (uk) Похідні n4-оксикарбоніл-5'-дезокси-5-фторцитидину та фармацевтичний препарат на їх основі
CA2100212A1 (fr) Utilisation d'inhibiteurs du complement dans la preparation d'un produit pharmaceutique pour la prophylaxie et le traitement des affections inflammatoires de l'intestin et de la peau ainsi que du purpura
MY128654A (en) Liquid pharmaceutical composition containing an erythropoietin derivative
WO1996022305A3 (fr) Peptides modifies
WO1994007479A3 (fr) Agents immunopotentialisateurs
AU5669198A (en) Cyclosporin derivative, its preparation and pharmaceutical compositions containing same
MX9709238A (es) Formulaciones farmaceuticas y de dieta para la profilaxis y tratamiento de trastornos gastrointestinales.
ZA965294B (en) Substituted 4-phenylaminothiazoles, their process of preparation and the pharmaceutical compositions containing them.
CA2338600A1 (fr) Nouveaux composes de thiazolopyrimidine
WO1996021468A3 (fr) Interferent chimiquement modifie
MY120976A (en) 2-amino-6-(2-substituted-4-phenoxy)- substituted- pyridines
CA2343732A1 (fr) .delta.-lactones .gamma.-phenyl-substituees, leurs analogues, et leurs utilisations
BG102250A (en) The use of marigold-extracted glycosides for the treatment of psoriasis
TW268937B (fr)
AU7575394A (en) Substituted 1-naphthyl-3-pyrazolecarboxamides which are active on neurotensin, their preparation and pharmaceutical compositions containing them
IL126235A (en) Compounds with growth hormone releasing properties, pharmaceutical compositions comprising them and their use
MXPA94009086A (es) Guanidinas sustituidas terapeuticas.
AU6415994A (en) Substituted caprolactams and derivatives thereof useful for treatment of hiv disease
CA2047802A1 (fr) Compositions pharmaceutiques
AU1604592A (en) New 2-amino-5-cyano-1,4-dihydropyridines, processes for their preparation and their use in medicaments
AU7812794A (en) Pharmaceutical compositions containing n-acetylcarnosine for the treatment of cataract

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AZ BY KZ RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase