ZA943100B - Benzofuranyl- and -thiophenyl-alkanecarboxyclic acid derivatives - Google Patents
Benzofuranyl- and -thiophenyl-alkanecarboxyclic acid derivativesInfo
- Publication number
- ZA943100B ZA943100B ZA943100A ZA943100A ZA943100B ZA 943100 B ZA943100 B ZA 943100B ZA 943100 A ZA943100 A ZA 943100A ZA 943100 A ZA943100 A ZA 943100A ZA 943100 B ZA943100 B ZA 943100B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzofuranyl
- thiophenyl
- acid derivatives
- alkanecarboxyclic
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939309324A GB9309324D0 (en) | 1993-05-06 | 1993-05-06 | Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA943100B true ZA943100B (en) | 1995-01-09 |
Family
ID=10735023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA943100A ZA943100B (en) | 1993-05-06 | 1994-05-05 | Benzofuranyl- and -thiophenyl-alkanecarboxyclic acid derivatives |
Country Status (21)
Country | Link |
---|---|
US (1) | US5504213A (fr) |
EP (1) | EP0623607B1 (fr) |
JP (1) | JP3452088B2 (fr) |
CN (1) | CN1097749A (fr) |
AT (1) | ATE168373T1 (fr) |
AU (1) | AU678814B2 (fr) |
CA (1) | CA2122788A1 (fr) |
CZ (1) | CZ112994A3 (fr) |
DE (1) | DE69411625T2 (fr) |
DK (1) | DK0623607T3 (fr) |
ES (1) | ES2118283T3 (fr) |
FI (1) | FI942049A (fr) |
GB (1) | GB9309324D0 (fr) |
GR (1) | GR3027787T3 (fr) |
HU (1) | HUT67847A (fr) |
IL (1) | IL109526A0 (fr) |
NO (1) | NO941662L (fr) |
NZ (1) | NZ260445A (fr) |
RU (1) | RU2125564C1 (fr) |
SK (1) | SK53194A3 (fr) |
ZA (1) | ZA943100B (fr) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5721233A (en) * | 1992-04-06 | 1998-02-24 | Merrell Pharmaceuticals Inc. | Derivatives of 2,3-dihydro benzofuranols |
GB9312853D0 (en) | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
EP0685475B1 (fr) * | 1994-05-31 | 1999-01-13 | Bayer Ag | Dérivés de aminobenzofuryle et -thienyle |
GB9410877D0 (en) * | 1994-05-31 | 1994-07-20 | Bayer Ag | Heterocyclycarbonyl substituted benzoduranyl-and-thiophenyl-alkanecarboxyclic acid derivatives |
HRP950288A2 (en) * | 1994-05-31 | 1997-08-31 | Bayer Ag | Oxalylamino-benzofuran- and benzothienyl-derivatives |
US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
US5591776A (en) | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
AU714054B2 (en) * | 1995-01-06 | 1999-12-16 | Toray Industries, Inc. | Benzene-fused heterocyclic derivatives and use of the same |
GB9504460D0 (en) * | 1995-03-06 | 1995-04-26 | Bayer Ag | N-(3-Benzofuranyl)urea-derivatives |
US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
US6075016A (en) | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
US5972936A (en) * | 1996-05-20 | 1999-10-26 | Darwin Discover Limited | Benzofuran carboxamides and their therapeutic use |
GB9614718D0 (en) * | 1996-07-12 | 1996-09-04 | Bayer Ag | 3-ureido-pyridofurans and -pyridothiophenes |
DE19642451A1 (de) * | 1996-10-15 | 1998-04-16 | Merck Patent Gmbh | Aminothiophencarbonsäureamide |
DE19706396A1 (de) * | 1996-12-09 | 1998-06-10 | Bayer Ag | Verfahren zur Herstellung von 3-(l-Hydroxiphenyl-l-alkoximinomethyl)dioxazinen |
GB2350109A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active benzofuranyl sulfonates |
GB2350111A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives |
TR200201317T2 (tr) | 1999-08-21 | 2002-11-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Sinerjistik kombinasyon. |
JP4615826B2 (ja) | 2001-01-29 | 2011-01-19 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 置換インドールおよびインテグリンアンタゴニストとしてのそれらの使用 |
US6872730B2 (en) * | 2001-04-27 | 2005-03-29 | 3-Dimensional Pharmaceuticals, Inc. | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists |
WO2002094321A1 (fr) | 2001-05-23 | 2002-11-28 | Tanabe Seiyaku Co., Ltd. | Compositions favorisant la guérison d'une fracture osseuse |
CN1537018A (zh) | 2001-05-23 | 2004-10-13 | 田边制药株式会社 | 一种用于软骨疾病再生治疗的组合物 |
US7144885B2 (en) * | 2002-02-22 | 2006-12-05 | Bayer Pharmaceuticals Corporation | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders |
ES2271537T3 (es) * | 2002-02-22 | 2007-04-16 | Bayer Pharmaceuticals Corporation | Derivados de benzofurano y benzotiofeno utiles en el tratamiento de trastornos hiperproliferativos. |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
MXPA05010373A (es) | 2003-04-01 | 2005-12-05 | Applied Research Systems | Inhibidores de fosfodiesterasas en infertilidad. |
WO2004106317A1 (fr) * | 2003-05-29 | 2004-12-09 | The New Industry Research Organization | Compose a base de benzofurane et composition medicinale contenant ce compose |
JP2005008631A (ja) * | 2003-05-29 | 2005-01-13 | New Industry Research Organization | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
JP2007504228A (ja) * | 2003-09-02 | 2007-03-01 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症を治療するための眼組成物 |
AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
CL2007001873A1 (es) * | 2006-06-27 | 2008-01-04 | Takeda Pharmaceutical | Acido((3s))-6-((¨2,6-dimetil-4-(3-(metilsulfonil)-propoxi)bifenil-3-il)metoxi-2,3-dihidro-1-benzofuran-3-il)acetico o una sal del mismo |
EP2056817A1 (fr) * | 2006-09-01 | 2009-05-13 | Bayer HealthCare AG | Dérivés de benzofurane et de benzothiophène utiles dans le traitement de cancers du système nerveux central |
MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
ES2627848T3 (es) | 2008-06-04 | 2017-07-31 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CN103764672A (zh) | 2011-03-01 | 2014-04-30 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
EP2958577A2 (fr) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Agonistes du recepteur de la guanylate cyclase pour l'utilisation dans l'irrigation du colon |
US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP2970384A1 (fr) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonistes de la guanylate cyclase et leurs utilisations |
KR102272746B1 (ko) | 2013-06-05 | 2021-07-08 | 보슈 헬스 아일랜드 리미티드 | 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법 |
CA2920856A1 (fr) | 2013-08-09 | 2015-02-12 | Ardelyx, Inc. | Composes modulant le ph pour diminuer l'absorption gastro-intestinale dephosphate |
US9890132B2 (en) | 2013-08-25 | 2018-02-13 | Council Of Scientific & Industrial Research | Process for the preparation of anti-inflammatory aroylbenzofuran compounds |
BR112016019549B1 (pt) * | 2014-02-25 | 2022-08-02 | Ecolab Usa Inc | Composição e solução de limpeza sanitária aquosa, método para limpar uma superfície sanitária, e, uso de uma composição de limpeza sanitária ou uma solução de limpeza sanitária aquosa |
CN105254611B (zh) * | 2015-11-09 | 2017-10-31 | 江西仁明医药化工有限公司 | 苯并噻吩‑2‑羧酸的制备方法 |
CN107935972B (zh) * | 2017-11-14 | 2020-06-02 | 沈阳药科大学 | 5-[2-羟基-3-(异丙胺基)丙氧基]苯并呋喃类衍生物及其应用 |
CN107857748B (zh) * | 2017-11-14 | 2020-06-02 | 沈阳药科大学 | 5-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用 |
CN107827849B (zh) * | 2017-11-14 | 2020-06-02 | 沈阳药科大学 | 6-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用 |
JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス, インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
CN110938035B (zh) * | 2019-10-28 | 2022-07-01 | 广西师范大学 | 9-苯磺酸-10-咪蒽腙及其合成方法和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0019955A1 (fr) * | 1979-05-16 | 1980-12-10 | Shell Internationale Researchmaatschappij B.V. | Dérivés d'acide benzofuranne-carboxylique, leur préparation et leur utilisation dans des compositions inhibant la lipogenèse |
US4663347A (en) * | 1983-10-31 | 1987-05-05 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis |
EP0146243A1 (fr) * | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Inhibiteurs de la lipoxygénase |
US4482772A (en) * | 1983-11-03 | 1984-11-13 | Mobil Oil Corporation | Multistage process for converting oxygenates to hydrocarbons |
-
1993
- 1993-05-06 GB GB939309324A patent/GB9309324D0/en active Pending
-
1994
- 1994-04-19 AU AU60558/94A patent/AU678814B2/en not_active Ceased
- 1994-04-22 DE DE69411625T patent/DE69411625T2/de not_active Expired - Fee Related
- 1994-04-22 AT AT94106320T patent/ATE168373T1/de active
- 1994-04-22 ES ES94106320T patent/ES2118283T3/es not_active Expired - Lifetime
- 1994-04-22 DK DK94106320T patent/DK0623607T3/da active
- 1994-04-22 EP EP94106320A patent/EP0623607B1/fr not_active Expired - Lifetime
- 1994-04-29 US US08/236,796 patent/US5504213A/en not_active Expired - Fee Related
- 1994-05-02 JP JP11592394A patent/JP3452088B2/ja not_active Expired - Fee Related
- 1994-05-03 IL IL10952694A patent/IL109526A0/xx unknown
- 1994-05-03 NZ NZ260445A patent/NZ260445A/en unknown
- 1994-05-03 CA CA002122788A patent/CA2122788A1/fr not_active Abandoned
- 1994-05-04 FI FI942049A patent/FI942049A/fi unknown
- 1994-05-05 NO NO941662A patent/NO941662L/no unknown
- 1994-05-05 ZA ZA943100A patent/ZA943100B/xx unknown
- 1994-05-05 RU RU94015838A patent/RU2125564C1/ru active
- 1994-05-06 CN CN94104909A patent/CN1097749A/zh active Pending
- 1994-05-06 HU HU9401415A patent/HUT67847A/hu unknown
- 1994-05-06 CZ CZ941129A patent/CZ112994A3/cs unknown
- 1994-05-06 SK SK531-94A patent/SK53194A3/sk unknown
-
1998
- 1998-08-31 GR GR980401965T patent/GR3027787T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69411625D1 (de) | 1998-08-20 |
NO941662D0 (no) | 1994-05-05 |
CZ112994A3 (en) | 1994-11-16 |
AU678814B2 (en) | 1997-06-12 |
RU94015838A (ru) | 1997-02-20 |
AU6055894A (en) | 1994-11-10 |
JPH06329652A (ja) | 1994-11-29 |
IL109526A0 (en) | 1994-08-26 |
FI942049A0 (fi) | 1994-05-04 |
DK0623607T3 (da) | 1999-04-19 |
JP3452088B2 (ja) | 2003-09-29 |
GR3027787T3 (en) | 1998-11-30 |
HUT67847A (en) | 1995-05-29 |
DE69411625T2 (de) | 1998-11-05 |
EP0623607B1 (fr) | 1998-07-15 |
ATE168373T1 (de) | 1998-08-15 |
SK53194A3 (en) | 1995-02-08 |
CA2122788A1 (fr) | 1994-11-07 |
RU2125564C1 (ru) | 1999-01-27 |
EP0623607A1 (fr) | 1994-11-09 |
FI942049A (fi) | 1994-11-07 |
CN1097749A (zh) | 1995-01-25 |
US5504213A (en) | 1996-04-02 |
ES2118283T3 (es) | 1998-09-16 |
GB9309324D0 (en) | 1993-06-16 |
NO941662L (no) | 1994-11-07 |
NZ260445A (en) | 1995-08-28 |
HU9401415D0 (en) | 1994-08-29 |
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