ZA919773B - Anti-atherosclerotic aryl compounds. - Google Patents
Anti-atherosclerotic aryl compounds.Info
- Publication number
- ZA919773B ZA919773B ZA919773A ZA919773A ZA919773B ZA 919773 B ZA919773 B ZA 919773B ZA 919773 A ZA919773 A ZA 919773A ZA 919773 A ZA919773 A ZA 919773A ZA 919773 B ZA919773 B ZA 919773B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- atoms
- group
- alkoxy
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Indole Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909027023A GB9027023D0 (en) | 1990-12-12 | 1990-12-12 | Anti-atherosclerotic aryl compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA919773B true ZA919773B (en) | 1993-06-11 |
Family
ID=10686924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA919773A ZA919773B (en) | 1990-12-12 | 1991-12-11 | Anti-atherosclerotic aryl compounds. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5658944A (ja) |
| EP (1) | EP0639178B1 (ja) |
| JP (1) | JP2951402B2 (ja) |
| KR (1) | KR930703246A (ja) |
| AT (1) | ATE157651T1 (ja) |
| AU (1) | AU647859B2 (ja) |
| CA (1) | CA2098122C (ja) |
| DE (1) | DE69127556D1 (ja) |
| GB (1) | GB9027023D0 (ja) |
| HU (1) | HUT64514A (ja) |
| IE (1) | IE914304A1 (ja) |
| IL (1) | IL100331A (ja) |
| NZ (1) | NZ240935A (ja) |
| TW (1) | TW275065B (ja) |
| WO (1) | WO1992010468A1 (ja) |
| ZA (1) | ZA919773B (ja) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4401893A1 (de) * | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
| SE9401353D0 (sv) * | 1994-04-21 | 1994-04-21 | Pharmacia Ab | Novel antitumour compounds with antimitotic activity |
| HRP950558A2 (en) * | 1994-11-15 | 1997-12-31 | Scott M. Wilhelm | Substituted 4-biarylbutric or biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors |
| DE4443891A1 (de) * | 1994-12-09 | 1996-06-13 | Bayer Ag | Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide |
| GB9606805D0 (en) * | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
| US5866609A (en) * | 1996-08-09 | 1999-02-02 | Ss Pharmaceutical Co., Ltd. | Substituted vinylurea derivatives and medicine containing the same |
| KR100610578B1 (ko) | 1999-04-28 | 2006-08-09 | 닥터 레디스 레보러터리즈 리미티드 | 치환된 이원 헤테로고리, 비만증 및 고콜레스테롤증치료제로서의 그 용도 |
| AU2001277723A1 (en) | 2000-08-11 | 2002-02-25 | Nippon Chemiphar Co., Ltd. | Ppardelta activators |
| AU2002224139A1 (en) * | 2000-12-05 | 2002-06-18 | Nippon Chemiphar Co. Ltd. | Ppar (peroxisome proliferator activated receptor) activators |
| MXPA03007284A (es) * | 2001-02-15 | 2003-12-04 | Pfizer Prod Inc | Agonistas de receptor activador del proliferador de peroxisomas. |
| WO2002064130A1 (en) * | 2001-02-15 | 2002-08-22 | Pfizer Products Inc. | Proliferative activator receptor (ppar) compounds |
| US6548538B2 (en) | 2001-05-22 | 2003-04-15 | Bayer Aktiengesellschaft | Propionic acid derivatives |
| EP1399426A2 (en) * | 2001-06-12 | 2004-03-24 | Active Pass Pharmaceuticals, Inc. | Compounds, compositions and methods for modulating beta-amyloid production |
| US20030191144A1 (en) * | 2001-06-12 | 2003-10-09 | Active Pass Pharmaceuticals, Inc. | Compounds, compositions and methods for modulating beta-amyloid production |
| PT1424330E (pt) | 2001-08-10 | 2011-12-22 | Nippon Chemiphar Co | Activador do receptor ä responsivo a proliferadores peroxissomais |
| DE60232739D1 (de) | 2001-10-12 | 2009-08-06 | Nippon Chemiphar Co | Aktivator des peroxisomproliferator-aktivierten rezeptors delta |
| US7015345B2 (en) * | 2002-02-21 | 2006-03-21 | Asahi Kasei Pharma Corporation | Propionic acid derivatives |
| CA2488972A1 (en) | 2002-06-19 | 2003-12-31 | Eli Lilly And Company | Amide linker peroxisome proliferator activated receptor modulators |
| EP1388352A1 (en) | 2002-08-08 | 2004-02-11 | Laboratoires Fournier S.A. | Use of a ppar-alpha agonist to treat patients suffering from weight gain associated with a ppar-gamma agonist treatment |
| RS52079B (sr) | 2002-10-21 | 2012-06-30 | Janssen Pharmaceutica N.V. | Supstituisani tetralini i indani i njihova primena |
| CA2507465C (en) | 2002-11-26 | 2009-04-28 | Pfizer Products Inc. | Phenyl substituted piperidine compounds for use as ppar activators |
| US7399866B2 (en) | 2003-01-14 | 2008-07-15 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| US6987118B2 (en) | 2003-05-21 | 2006-01-17 | Pfizer Inc. | Tetrahydroisoquinoline derivatives as PPAR-alpha activators |
| US8110595B2 (en) | 2004-06-17 | 2012-02-07 | Cytokinetics, Inc. | Ureas and their use in the treatment of heart failure |
| US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
| US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
| ES2419007T3 (es) | 2005-12-15 | 2013-08-19 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y procedimientos |
| US7718657B2 (en) | 2005-12-16 | 2010-05-18 | Cytokinetics, Inc. | Certain indanyl urea modulators of the cardiac sarcomere |
| EP1962852B1 (en) | 2005-12-19 | 2017-01-25 | Cytokinetics, Inc. | Compounds, compositions and methods |
| CN101466687B (zh) | 2006-04-18 | 2012-04-11 | 日本化学医药株式会社 | 过氧化物酶体增殖剂激活受体δ的激活剂 |
| CA2721339C (en) | 2008-04-15 | 2017-01-24 | Nippon Chemiphar Co., Ltd. | Activating agent for peroxisome proliferator activated receptor |
| US9187411B2 (en) | 2012-01-10 | 2015-11-17 | Eli Lilly And Company | Leukotriene B4 antagonist compound |
| WO2013169648A1 (en) | 2012-05-07 | 2013-11-14 | Novartis Ag | Pharmaceutical combinations comprising a dgat1 inhibtor and a triglyceride lowering drug |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2614045A1 (de) * | 1976-04-01 | 1977-10-06 | Boehringer Mannheim Gmbh | Neue phenoxyalkylcarbonsaeuren und verfahren zur herstellung derselben |
| US4387106A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas |
| US4623662A (en) * | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
| US4397868A (en) * | 1982-01-26 | 1983-08-09 | American Cyanamid Company | Method of treating atherosclerosis with trisubstituted ureas |
| JPH02503797A (ja) * | 1987-06-15 | 1990-11-08 | ラレザリ、イラジ | 脂質の減少、酸素に対するヘモグロビンの親和力の修正ならびに血小板凝集の抑制を行うための化合物、組成物および方法 |
| US4921997A (en) * | 1988-06-15 | 1990-05-01 | Montefiore Medical Center | Method of synthesis and novel compounds for pharmaceutical uses |
| GB8827152D0 (en) * | 1988-11-21 | 1988-12-29 | Wellcome Found | Anti-atherosclerotic diaryl compounds |
-
1990
- 1990-12-12 GB GB909027023A patent/GB9027023D0/en active Pending
-
1991
- 1991-12-11 WO PCT/GB1991/002195 patent/WO1992010468A1/en active IP Right Grant
- 1991-12-11 ZA ZA919773A patent/ZA919773B/xx unknown
- 1991-12-11 JP JP4501716A patent/JP2951402B2/ja not_active Expired - Lifetime
- 1991-12-11 CA CA002098122A patent/CA2098122C/en not_active Expired - Fee Related
- 1991-12-11 AT AT92900716T patent/ATE157651T1/de not_active IP Right Cessation
- 1991-12-11 IL IL10033191A patent/IL100331A/en not_active IP Right Cessation
- 1991-12-11 NZ NZ240935A patent/NZ240935A/en unknown
- 1991-12-11 DE DE69127556T patent/DE69127556D1/de not_active Expired - Lifetime
- 1991-12-11 AU AU90560/91A patent/AU647859B2/en not_active Ceased
- 1991-12-11 EP EP92900716A patent/EP0639178B1/en not_active Expired - Lifetime
- 1991-12-11 IE IE430491A patent/IE914304A1/en unknown
- 1991-12-11 HU HU9301709A patent/HUT64514A/hu unknown
- 1991-12-11 KR KR1019930701756A patent/KR930703246A/ko not_active Application Discontinuation
-
1992
- 1992-01-24 TW TW081100492A patent/TW275065B/zh active
-
1995
- 1995-04-14 US US08/421,997 patent/US5658944A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0639178A1 (en) | 1995-02-22 |
| JPH06507151A (ja) | 1994-08-11 |
| TW275065B (ja) | 1996-05-01 |
| AU647859B2 (en) | 1994-03-31 |
| JP2951402B2 (ja) | 1999-09-20 |
| CA2098122C (en) | 2003-09-23 |
| US5658944A (en) | 1997-08-19 |
| ATE157651T1 (de) | 1997-09-15 |
| HU9301709D0 (en) | 1993-09-28 |
| GB9027023D0 (en) | 1991-01-30 |
| CA2098122A1 (en) | 1992-06-13 |
| WO1992010468A1 (en) | 1992-06-25 |
| IE914304A1 (en) | 1992-06-17 |
| KR930703246A (ko) | 1993-11-29 |
| IL100331A (en) | 1996-09-12 |
| IL100331A0 (en) | 1992-09-06 |
| EP0639178B1 (en) | 1997-09-03 |
| NZ240935A (en) | 1994-11-25 |
| DE69127556D1 (de) | 1997-10-09 |
| HUT64514A (en) | 1994-01-28 |
| AU9056091A (en) | 1992-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW275065B (ja) | ||
| CA2282890A1 (en) | Therapeutic heterocyclic compounds | |
| GR3020510T3 (en) | Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them | |
| MY102866A (en) | Amide derivatives. | |
| IL98502A0 (en) | Aminoalkane phosphinic acid derivatives,process for their preparation and pharmaceutical compositions containing them | |
| ATE79376T1 (de) | Dithioacetal-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
| ZA935276B (en) | 3-(hydroxybenzylidenyl)-indolin-2-ones processes for their preparation and pharmaceutical compositions containing them | |
| GR3002051T3 (en) | 3-oxadiazolyl and 3-carboxylic-acid beta-carboline derivatives, their preparation and their use as medicaments | |
| ZA872254B (en) | Phenoxyalkylcarboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing them | |
| ZA873884B (en) | 2-thiazolyl imidazo(1,2-a)pyrimidines and their salts,their process of preparation,their application as medicaments and compositions containing them | |
| PT82032A (en) | Process for the preparation of anticonvulsant amino acid derivatives and of pharmaceutical compositions containing the same | |
| ES8501410A1 (es) | Un procedimiento para la preparacion de nuevos derivados de fosfolipidos. | |
| FR2709306B1 (fr) | Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
| HK56597A (en) | 3-aminochromane derivatives procedure for their preparation and pharmaceutical compositions containing them | |
| IE893956L (en) | Novel compounds | |
| ATE92315T1 (de) | Aminosaeurederivate enthaltende antikonvulsive zusammensetzungen und verwendung dieser aminosaeurederivate. | |
| IL79233A0 (en) | 11-substituted 5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin-6-ones,their preparation and pharmaceutical compositions containing them | |
| ES8105319A1 (es) | Procedimiento de preparacion de derivados pirazolo (1,5-c) quinazolinos y de sus sales de adicion acidas | |
| EP0305298A3 (en) | Imidazobenzodiazepines and their acid addition salts, process and intermediates for their preparation, their use as medicaments and compositions containing them | |
| EP0090681A3 (en) | Novel 1,2-dihydropyrido-(3,4-b)pyrazines | |
| ES2002427A6 (es) | Procedimient para la preparacion de nuevos analogos de gonadoliberina | |
| ES8701176A1 (es) | Un procedimiento para preparar nuevas amidas de acidos indo-lo-quinolizin-carboxilicos |