ZA904446B - Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof - Google Patents

Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof

Info

Publication number
ZA904446B
ZA904446B ZA904446A ZA904446A ZA904446B ZA 904446 B ZA904446 B ZA 904446B ZA 904446 A ZA904446 A ZA 904446A ZA 904446 A ZA904446 A ZA 904446A ZA 904446 B ZA904446 B ZA 904446B
Authority
ZA
South Africa
Prior art keywords
salts
amino
hydroxybutylidene
preparing
bisphosphonic acid
Prior art date
Application number
ZA904446A
Other languages
English (en)
Inventor
Gerald R Kieczykowski
R Kieczykowski Gerald
David G Melillo
G Melillo David
Ronald B Jobson
B Jobson Ronald
Gerald S Brenner
S Brenner Gerald
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23431886&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA904446(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA904446B publication Critical patent/ZA904446B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA904446A 1989-06-09 1990-06-08 Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof ZA904446B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/363,820 US4922007A (en) 1989-06-09 1989-06-09 Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof

Publications (1)

Publication Number Publication Date
ZA904446B true ZA904446B (en) 1992-06-24

Family

ID=23431886

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA904446A ZA904446B (en) 1989-06-09 1990-06-08 Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof

Country Status (23)

Country Link
US (1) US4922007A (pt)
EP (1) EP0402152B1 (pt)
JP (2) JPH0662651B2 (pt)
KR (1) KR0137455B1 (pt)
AT (1) ATE129713T1 (pt)
AU (1) AU625704C (pt)
CA (1) CA2018477C (pt)
CH (1) CH0402152H1 (pt)
CY (1) CY1894A (pt)
DE (1) DE69023280T2 (pt)
DK (1) DK0402152T3 (pt)
ES (1) ES2080116T3 (pt)
FI (1) FI93219C (pt)
GR (1) GR3018379T3 (pt)
HK (1) HK69596A (pt)
HU (1) HU211908A9 (pt)
IE (1) IE69564B1 (pt)
IL (1) IL94612A (pt)
LV (1) LV11472B (pt)
NO (2) NO177997C (pt)
NZ (1) NZ233972A (pt)
PT (1) PT94306B (pt)
ZA (1) ZA904446B (pt)

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NO177997B (no) 1995-09-25
ES2080116T3 (es) 1996-02-01
HK69596A (en) 1996-04-26
LV11472B (en) 1996-12-20
NO177997C (no) 1996-01-03
IL94612A (en) 1995-03-30
NZ233972A (en) 1992-05-26
AU625704C (en) 2001-07-26
US4922007A (en) 1990-05-01
DE69023280D1 (de) 1995-12-07
KR0137455B1 (ko) 1998-05-01
NO178228C (no) 1996-02-14
IE902073L (en) 1990-12-09
NO941726L (no) 1990-12-10
EP0402152A3 (en) 1991-07-03
LV11472A (lv) 1996-08-20
AU625704B2 (en) 1992-07-16
KR910000768A (ko) 1991-01-30
IL94612A0 (en) 1991-04-15
NO902559L (no) 1990-12-10
NO941726D0 (no) 1994-05-09
FI902845A0 (fi) 1990-06-07
PT94306A (pt) 1991-02-08
PT94306B (pt) 1997-05-28
NO178228B (no) 1995-11-06
EP0402152B1 (en) 1995-11-02
FI93219B (fi) 1994-11-30
JPH0662651B2 (ja) 1994-08-17
AU5701990A (en) 1990-12-13
DK0402152T3 (da) 1995-12-04
FI93219C (fi) 1995-03-10
CY1894A (en) 1990-06-08
JPH03101684A (ja) 1991-04-26
IE69564B1 (en) 1996-10-02
JPH0748391A (ja) 1995-02-21
DE69023280T2 (de) 1996-06-20
EP0402152A2 (en) 1990-12-12
ATE129713T1 (de) 1995-11-15
NO902559D0 (no) 1990-06-08
GR3018379T3 (en) 1996-03-31
CH0402152H1 (fr) 2006-02-28
CA2018477A1 (en) 1990-12-09
CA2018477C (en) 1995-08-01
HU211908A9 (en) 1996-01-29

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