ZA894068B - Novel alpha-glucosidase inhibitors - Google Patents
Novel alpha-glucosidase inhibitorsInfo
- Publication number
- ZA894068B ZA894068B ZA894068A ZA894068A ZA894068B ZA 894068 B ZA894068 B ZA 894068B ZA 894068 A ZA894068 A ZA 894068A ZA 894068 A ZA894068 A ZA 894068A ZA 894068 B ZA894068 B ZA 894068B
- Authority
- ZA
- South Africa
- Prior art keywords
- glucosidase inhibitors
- novel alpha
- alpha
- novel
- glucosidase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP88401340A EP0344383A1 (en) | 1988-06-02 | 1988-06-02 | Novel alpha-Glucosidase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA894068B true ZA894068B (en) | 1990-09-26 |
Family
ID=8200392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA894068A ZA894068B (en) | 1988-06-02 | 1989-05-29 | Novel alpha-glucosidase inhibitors |
Country Status (22)
Country | Link |
---|---|
US (1) | US5157116A (hu) |
EP (1) | EP0344383A1 (hu) |
JP (1) | JP2791419B2 (hu) |
KR (1) | KR0155541B1 (hu) |
CN (1) | CN1023803C (hu) |
AR (1) | AR247890A1 (hu) |
AT (1) | ATE129716T1 (hu) |
AU (1) | AU608711B2 (hu) |
CA (1) | CA1339740C (hu) |
DE (1) | DE68924670T2 (hu) |
DK (1) | DK267489A (hu) |
ES (1) | ES2081857T3 (hu) |
FI (1) | FI92934C (hu) |
GR (1) | GR3018354T3 (hu) |
HU (1) | HU203559B (hu) |
IE (1) | IE68455B1 (hu) |
IL (1) | IL90463A0 (hu) |
NO (1) | NO170023C (hu) |
NZ (1) | NZ229337A (hu) |
PH (1) | PH25908A (hu) |
PT (1) | PT90713B (hu) |
ZA (1) | ZA894068B (hu) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3936295A1 (de) * | 1989-11-01 | 1991-05-02 | Bayer Ag | Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine |
US5504078A (en) * | 1990-06-08 | 1996-04-02 | Merrell Dow Pharmaceuticals Inc. | α-glucosidase inhibitors |
US5844102A (en) * | 1994-07-07 | 1998-12-01 | University Of Maryland Baltimore County | Glycohydrolase inhibitors, their preparation and use thereof |
JP3580900B2 (ja) * | 1995-04-20 | 2004-10-27 | ホクレン農業協同組合連合会 | α−グルコシダーゼ阻害剤を含む糖を主体とする組成物を有効成分とする食品及び飼料 |
AU4335997A (en) * | 1996-09-09 | 1998-03-26 | Wisconsin Alumni Research Foundation | Human salivary proteins and fragments thereof having alpha-glucosidase inhibitory activity |
JP3553086B2 (ja) * | 1997-04-15 | 2004-08-11 | シーエスアイアール | 食欲抑制活性を有する医薬組成物 |
HUP0003362A3 (en) * | 1997-05-06 | 2001-04-28 | Novo Nordisk As | Piperidine derivatives and pharmaceutical compositions containing them |
GB2355657B (en) * | 1999-10-27 | 2004-07-28 | Phytopharm Plc | Inhibitors Of Gastric Acid Secretion |
GB2363985B (en) * | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
JP4486792B2 (ja) * | 2003-06-12 | 2010-06-23 | 学校法人近畿大学 | 環状オニウム化合物およびグルコシダーゼ阻害剤 |
US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
WO2005092334A2 (en) * | 2004-03-25 | 2005-10-06 | David Priestman | Use of n-substituted imino sugars for appetite suppression |
US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
MX2007005137A (es) * | 2004-11-23 | 2007-06-22 | Warner Lambert Co | Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia. |
CN101228174A (zh) * | 2005-06-08 | 2008-07-23 | 阿米库斯治疗学公司 | 晶体糖组合物及其制备方法 |
BRPI0613222A2 (pt) * | 2005-06-08 | 2010-12-28 | Amicus Therapeutic Inc | método para purificação de um açúcar bruto contendo nitrogênio e método para purificar d-l-deoxigalactonojirimicina bruta (dgj) |
WO2006133448A1 (en) * | 2005-06-08 | 2006-12-14 | Amicus Therapeutics, Inc. | Stabilization of triflated compounds |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
CN101663262B (zh) | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物 |
ES2371393T3 (es) | 2007-03-12 | 2011-12-30 | Zadec Aps | Extracto antidiabético de rooibos. |
DK2170930T3 (da) | 2007-06-04 | 2012-11-05 | Synergy Pharmaceuticals Inc | Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
US20130072519A1 (en) | 2010-05-21 | 2013-03-21 | Edward Lee Conn | 2-phenyl benzoylamides |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP2680874A2 (en) | 2011-03-04 | 2014-01-08 | Pfizer Inc | Edn3-like peptides and uses thereof |
US20150050371A1 (en) | 2012-03-09 | 2015-02-19 | Biotropics Malaysia Berhad | Extract Formulations of Rhodamnia Cinerea And Uses Thereof |
US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
CN105143203A (zh) | 2013-04-17 | 2015-12-09 | 辉瑞大药厂 | 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物 |
KR102272746B1 (ko) | 2013-06-05 | 2021-07-08 | 보슈 헬스 아일랜드 리미티드 | 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법 |
DK3186242T3 (da) | 2014-08-29 | 2021-12-20 | Tes Pharma S R L | Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
EP3526199B1 (en) | 2016-10-14 | 2022-04-13 | Tes Pharma S.r.l. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
AR117122A1 (es) | 2018-11-20 | 2021-07-14 | Tes Pharma S R L | INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA |
CN113574055B (zh) | 2019-01-18 | 2024-07-23 | 阿斯利康(瑞典)有限公司 | Pcsk9抑制剂及其使用方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
DE2830469A1 (de) * | 1978-07-11 | 1980-01-24 | Bayer Ag | Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten |
DE2922760A1 (de) * | 1979-06-05 | 1980-12-11 | Bayer Ag | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
GB2064527B (en) * | 1979-12-08 | 1984-05-02 | Nippon Shinyaku Co Ltd | Moranoline derivatives and process for preparation thereof |
DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
JPS61115093A (ja) * | 1984-11-09 | 1986-06-02 | Nippon Shinyaku Co Ltd | モラノリン誘導体の製法 |
US4634765A (en) * | 1984-12-18 | 1987-01-06 | Merrell Dow Pharmaceuticals Inc. | Homodisaccharide hypoglycemic agents |
GB2181729B (en) * | 1985-10-12 | 1990-04-04 | Nippon Shinyaku Co Ltd | Glucosylmoranoline derivatives and production thereof |
DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
-
1988
- 1988-06-02 EP EP88401340A patent/EP0344383A1/en not_active Withdrawn
-
1989
- 1989-04-28 ES ES89401227T patent/ES2081857T3/es not_active Expired - Lifetime
- 1989-04-28 DE DE68924670T patent/DE68924670T2/de not_active Expired - Fee Related
- 1989-04-28 AT AT89401227T patent/ATE129716T1/de not_active IP Right Cessation
- 1989-05-29 ZA ZA894068A patent/ZA894068B/xx unknown
- 1989-05-29 AR AR89314032A patent/AR247890A1/es active
- 1989-05-30 AU AU35801/89A patent/AU608711B2/en not_active Ceased
- 1989-05-30 CA CA000601196A patent/CA1339740C/en not_active Expired - Fee Related
- 1989-05-30 IL IL90463A patent/IL90463A0/xx not_active IP Right Cessation
- 1989-05-30 NZ NZ229337A patent/NZ229337A/en unknown
- 1989-05-31 HU HU892791A patent/HU203559B/hu not_active IP Right Cessation
- 1989-06-01 PH PH38729A patent/PH25908A/en unknown
- 1989-06-01 NO NO892230A patent/NO170023C/no not_active IP Right Cessation
- 1989-06-01 PT PT90713A patent/PT90713B/pt not_active IP Right Cessation
- 1989-06-01 KR KR1019890007498A patent/KR0155541B1/ko not_active IP Right Cessation
- 1989-06-01 DK DK267489A patent/DK267489A/da not_active Application Discontinuation
- 1989-06-01 FI FI892682A patent/FI92934C/fi not_active IP Right Cessation
- 1989-06-01 CN CN89103723A patent/CN1023803C/zh not_active Expired - Fee Related
- 1989-06-02 JP JP1139401A patent/JP2791419B2/ja not_active Expired - Fee Related
- 1989-06-12 IE IE179889A patent/IE68455B1/en not_active IP Right Cessation
-
1992
- 1992-02-18 US US07/839,014 patent/US5157116A/en not_active Expired - Fee Related
-
1995
- 1995-12-08 GR GR950403473T patent/GR3018354T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CN1040032A (zh) | 1990-02-28 |
NO170023C (no) | 1992-09-02 |
CN1023803C (zh) | 1994-02-16 |
JP2791419B2 (ja) | 1998-08-27 |
US5157116A (en) | 1992-10-20 |
NO170023B (no) | 1992-05-25 |
AR247890A1 (es) | 1995-04-28 |
IL90463A0 (en) | 1990-01-18 |
IE891798L (en) | 1989-12-02 |
DE68924670D1 (de) | 1995-12-07 |
ATE129716T1 (de) | 1995-11-15 |
JPH0225498A (ja) | 1990-01-26 |
FI92934C (fi) | 1995-01-25 |
FI92934B (fi) | 1994-10-14 |
HUT50191A (en) | 1989-12-28 |
DK267489D0 (da) | 1989-06-01 |
PH25908A (en) | 1991-12-19 |
KR910000776A (ko) | 1991-01-30 |
HU203559B (en) | 1991-08-28 |
NO892230D0 (no) | 1989-06-01 |
AU608711B2 (en) | 1991-04-11 |
ES2081857T3 (es) | 1996-03-16 |
PT90713B (pt) | 1993-09-30 |
KR0155541B1 (ko) | 1998-10-15 |
FI892682A (fi) | 1989-12-03 |
DE68924670T2 (de) | 1996-05-23 |
FI892682A0 (fi) | 1989-06-01 |
PT90713A (pt) | 1989-12-29 |
GR3018354T3 (en) | 1996-03-31 |
IE68455B1 (en) | 1996-06-26 |
AU3580189A (en) | 1990-02-01 |
DK267489A (da) | 1989-12-03 |
NO892230L (no) | 1989-12-04 |
EP0344383A1 (en) | 1989-12-06 |
NZ229337A (en) | 1990-12-21 |
CA1339740C (en) | 1998-03-17 |
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