ZA887900B - Therapeutic heterocyclic compounds - Google Patents
Therapeutic heterocyclic compoundsInfo
- Publication number
- ZA887900B ZA887900B ZA887900A ZA887900A ZA887900B ZA 887900 B ZA887900 B ZA 887900B ZA 887900 A ZA887900 A ZA 887900A ZA 887900 A ZA887900 A ZA 887900A ZA 887900 B ZA887900 B ZA 887900B
- Authority
- ZA
- South Africa
- Prior art keywords
- aryl
- alkyl
- group
- benzyl
- independently selected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878724912A GB8724912D0 (en) | 1987-10-23 | 1987-10-23 | Indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA887900B true ZA887900B (en) | 1990-06-27 |
Family
ID=10625806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA887900A ZA887900B (en) | 1987-10-23 | 1988-10-21 | Therapeutic heterocyclic compounds |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0313397B1 (fr) |
| JP (1) | JP2501631B2 (fr) |
| CN (1) | CN1035113A (fr) |
| AT (1) | ATE90089T1 (fr) |
| AU (1) | AU604165B2 (fr) |
| DD (1) | DD283140A5 (fr) |
| DE (1) | DE3881472T2 (fr) |
| DK (1) | DK586588A (fr) |
| ES (1) | ES2054825T3 (fr) |
| FI (1) | FI884879A (fr) |
| GB (1) | GB8724912D0 (fr) |
| HU (1) | HU202230B (fr) |
| IL (1) | IL88122A0 (fr) |
| MC (1) | MC1983A1 (fr) |
| NZ (1) | NZ226671A (fr) |
| PL (1) | PL158305B1 (fr) |
| PT (1) | PT88829B (fr) |
| ZA (1) | ZA887900B (fr) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT95899A (pt) * | 1989-11-17 | 1991-09-13 | Glaxo Group Ltd | Processo para a preparacao de derivados indole |
| IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
| DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
| NZ238424A (en) * | 1990-06-07 | 1993-12-23 | Wellcome Found | 3,5-substituted indole derivatives; medicaments and preparatory processes. |
| EP0494774A1 (fr) * | 1991-01-11 | 1992-07-15 | MERCK SHARP & DOHME LTD. | Composés hétéroaromatiques à 5 chaînons substitués par l'indazole |
| US5317103A (en) * | 1991-01-15 | 1994-05-31 | Merck Sharp & Dohme Limited | Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists |
| CZ283018B6 (cs) * | 1991-02-01 | 1997-12-17 | Merck Sharp And Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi |
| TW263508B (fr) * | 1991-02-12 | 1995-11-21 | Pfizer | |
| GB9104136D0 (en) * | 1991-02-27 | 1991-04-17 | Merck Sharp & Dohme | Therapeutic agents |
| KR0184911B1 (ko) * | 1991-11-25 | 1999-05-01 | 알렌 제이. 스피겔 | 인돌유도체 |
| EP0545478A1 (fr) * | 1991-12-03 | 1993-06-09 | MERCK SHARP & DOHME LTD. | Composés hétérocycliques comme tachykinine antagonistes |
| US5409941A (en) * | 1992-02-03 | 1995-04-25 | Pfizer Inc. | 5-heteroyl indole derivatives |
| TW288010B (fr) * | 1992-03-05 | 1996-10-11 | Pfizer | |
| EP0630374B1 (fr) * | 1992-03-13 | 2001-09-05 | MERCK SHARP & DOHME LTD. | Derives d'imidazole, de triazole et de tetrazole |
| GB9207396D0 (en) * | 1992-04-03 | 1992-05-13 | Merck Sharp & Dohme | Therapeutic agents |
| JP2644088B2 (ja) | 1992-04-07 | 1997-08-25 | フアイザー・インコーポレイテツド | ５−ｈｔ１作動薬としてのインドール誘導体 |
| US6380233B1 (en) | 1992-04-07 | 2002-04-30 | Pfizer Inc | Indole derivatives as 5-HT1 agonists |
| GB9207930D0 (en) * | 1992-04-10 | 1992-05-27 | Pfizer Ltd | Indoles |
| NZ251047A (en) * | 1992-04-10 | 1996-09-25 | Pfizer | Acylaminoindole derivatives and medicaments |
| GB9208463D0 (en) * | 1992-04-16 | 1992-06-03 | Merck Sharp & Dohme | Therapeutic agents |
| GB9210400D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| HUT71403A (en) * | 1992-06-05 | 1995-11-28 | Merck Sharp & Dohme | The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy |
| GB9215526D0 (en) * | 1992-07-22 | 1992-09-02 | Merck Sharp & Dohme | Chemical process |
| AU672802B2 (en) * | 1992-07-24 | 1996-10-17 | Merck Sharp & Dohme Limited | Imidazole, triazole and tetrazole derivatives |
| IL106445A (en) * | 1992-07-30 | 1998-01-04 | Merck Sharp & Dohme | History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them |
| TW251284B (fr) * | 1992-11-02 | 1995-07-11 | Pfizer | |
| GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| LT3594B (en) | 1993-07-29 | 1995-12-27 | Merck Sharp & Dohme | Imidazole,triazole and tetrazole derivatives |
| ES2070087B1 (es) * | 1993-08-13 | 1996-02-16 | Pfizer | Derivados de indol |
| US6423731B2 (en) | 1994-01-06 | 2002-07-23 | Zeneca Limited | Indole derivatives as prodrugs of 5-HT1-like receptor agonists |
| GB9401436D0 (en) * | 1994-01-26 | 1994-03-23 | Wellcome Found | Therapeutic heterocyclic compounds |
| GB9407447D0 (en) * | 1994-04-14 | 1994-06-08 | Glaxo Group Ltd | Chemical compounds |
| AU2621995A (en) * | 1994-06-01 | 1995-12-21 | Zeneca Limited | Indole derivatives as prodrugs of 5-ht1-like receptor agonists |
| WO1996003400A1 (fr) * | 1994-07-26 | 1996-02-08 | Pfizer Inc. | Derives 4-indole utilises comme agonistes et antagonistes de la serotonine |
| EP0796258A1 (fr) * | 1994-12-06 | 1997-09-24 | MERCK SHARP & DOHME LTD. | Derives de l'azetidine, de la pyrrolidine et de la piperidine utilises comme agonistes des recepteurs 5-ht1 |
| GB9516143D0 (en) | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
| US6909005B1 (en) | 1995-08-07 | 2005-06-21 | Astrazeneca Uk Limited | One post synthesis of 2-oxazolidinone derivatives |
| GB9516145D0 (en) * | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
| US5998438A (en) * | 1996-11-26 | 1999-12-07 | Allelix Biopharmaceuticals, Inc. | 5-cyclo indole compounds |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| WO2000000490A2 (fr) * | 1998-06-26 | 2000-01-06 | Eli Lilly And Company | Agonistes de 5-ht¿1f? |
| AU2003249582B2 (en) | 2002-06-21 | 2006-08-03 | Suven Life Sciences Limited | Tetracyclic arylsulfonyl indoles having serotonin receptor affinity |
| BR0312175A (pt) | 2002-06-21 | 2005-04-05 | Suven Life Sciences Ltd | Composto, composição farmacêutica, uso de um composto, método para o tratamento e método para reduzir a morbidez e a mortalidade associadas com o excesso de peso |
| KR100776118B1 (ko) | 2002-11-28 | 2007-11-15 | 수벤 라이프 사이언시스 리미티드 | 엔-아릴술포닐-3-아미노알콕시인돌 |
| ES2310243T3 (es) | 2002-11-28 | 2009-01-01 | Suven Life Sciences Limited | Indoles n-aril-3-sulfonil sustituidos que tienen afinidad por receptores de serotonina, proceso para su preparacion y composicion farmaceutica que los contiene. |
| JP4571507B2 (ja) | 2002-12-18 | 2010-10-27 | スベン ライフ サイエンシズ リミティド | セロトニン受容体親和性を有する四環系３−置換インドール |
| DE102005018191A1 (de) * | 2005-04-19 | 2006-10-26 | Grünenthal GmbH | Substituierte zyklische Harnstoff-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| EP3407869A1 (fr) | 2016-01-27 | 2018-12-05 | Instar Technologies A.S. | Supports nanofibreux oromumuqueux pour traitement thérapeutique |
| CN112759550A (zh) * | 2019-11-04 | 2021-05-07 | 上海科技大学 | 一种平滑受体拮抗剂 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4833153A (en) | 1985-11-08 | 1989-05-23 | Glaxo Group Limited | Indole derivatives |
| GB8600397D0 (en) | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
-
1987
- 1987-10-23 GB GB878724912A patent/GB8724912D0/en active Pending
-
1988
- 1988-10-21 CN CN88108816A patent/CN1035113A/zh active Pending
- 1988-10-21 HU HU885431A patent/HU202230B/hu unknown
- 1988-10-21 FI FI884879A patent/FI884879A/fi not_active Application Discontinuation
- 1988-10-21 DE DE88309943T patent/DE3881472T2/de not_active Expired - Fee Related
- 1988-10-21 MC MC882012A patent/MC1983A1/fr unknown
- 1988-10-21 JP JP63265917A patent/JP2501631B2/ja not_active Expired - Lifetime
- 1988-10-21 DD DD88320940A patent/DD283140A5/de not_active IP Right Cessation
- 1988-10-21 AT AT88309943T patent/ATE90089T1/de not_active IP Right Cessation
- 1988-10-21 IL IL88122A patent/IL88122A0/xx unknown
- 1988-10-21 PT PT88829A patent/PT88829B/pt not_active IP Right Cessation
- 1988-10-21 DK DK586588A patent/DK586588A/da not_active Application Discontinuation
- 1988-10-21 NZ NZ226671A patent/NZ226671A/xx unknown
- 1988-10-21 PL PL1988275423A patent/PL158305B1/pl unknown
- 1988-10-21 EP EP88309943A patent/EP0313397B1/fr not_active Expired - Lifetime
- 1988-10-21 ZA ZA887900A patent/ZA887900B/xx unknown
- 1988-10-21 ES ES88309943T patent/ES2054825T3/es not_active Expired - Lifetime
- 1988-10-24 AU AU24181/88A patent/AU604165B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DK586588A (da) | 1989-04-24 |
| CN1035113A (zh) | 1989-08-30 |
| ATE90089T1 (de) | 1993-06-15 |
| DD283140A5 (de) | 1990-10-03 |
| FI884879A0 (fi) | 1988-10-21 |
| AU604165B2 (en) | 1990-12-06 |
| PL275423A1 (en) | 1989-08-07 |
| DK586588D0 (da) | 1988-10-21 |
| PL158305B1 (en) | 1992-08-31 |
| AU2418188A (en) | 1989-04-27 |
| HUT50163A (en) | 1989-12-28 |
| EP0313397B1 (fr) | 1993-06-02 |
| FI884879A (fi) | 1989-04-24 |
| DE3881472T2 (de) | 1993-12-16 |
| PT88829B (pt) | 1993-01-29 |
| EP0313397A1 (fr) | 1989-04-26 |
| IL88122A0 (en) | 1989-06-30 |
| JP2501631B2 (ja) | 1996-05-29 |
| HU202230B (en) | 1991-02-28 |
| GB8724912D0 (en) | 1987-11-25 |
| DE3881472D1 (de) | 1993-07-08 |
| ES2054825T3 (es) | 1994-08-16 |
| NZ226671A (en) | 1991-09-25 |
| JPH01146882A (ja) | 1989-06-08 |
| MC1983A1 (fr) | 1989-11-23 |
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