ZA8860B - Pancreatic secretory trypsin inhibitor and variants thereof produced by a recombinant host,process,expression vector and recombinant host therefor and pharmaceutical use thereof - Google Patents
Pancreatic secretory trypsin inhibitor and variants thereof produced by a recombinant host,process,expression vector and recombinant host therefor and pharmaceutical use thereofInfo
- Publication number
- ZA8860B ZA8860B ZA8860A ZA8860A ZA8860B ZA 8860 B ZA8860 B ZA 8860B ZA 8860 A ZA8860 A ZA 8860A ZA 8860 A ZA8860 A ZA 8860A ZA 8860 B ZA8860 B ZA 8860B
- Authority
- ZA
- South Africa
- Prior art keywords
- recombinant host
- variants
- pharmaceutical use
- trypsin inhibitor
- produced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8135—Kazal type inhibitors, e.g. pancreatic secretory inhibitor, ovomucoid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08700204A GB2199582A (en) | 1987-01-07 | 1987-01-07 | Analogues of pancreatic secretory trypsin inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA8860B true ZA8860B (en) | 1988-10-26 |
Family
ID=10610323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA8860A ZA8860B (en) | 1987-01-07 | 1988-01-06 | Pancreatic secretory trypsin inhibitor and variants thereof produced by a recombinant host,process,expression vector and recombinant host therefor and pharmaceutical use thereof |
Country Status (15)
Country | Link |
---|---|
US (1) | US5126322A (fr) |
EP (1) | EP0278112B1 (fr) |
JP (2) | JPS63169994A (fr) |
KR (1) | KR960010949B1 (fr) |
CN (1) | CN1030999C (fr) |
AT (1) | ATE97421T1 (fr) |
AU (1) | AU592486B2 (fr) |
DE (1) | DE3788216D1 (fr) |
DK (1) | DK3688A (fr) |
ES (1) | ES2059356T3 (fr) |
FI (1) | FI97139C (fr) |
GB (1) | GB2199582A (fr) |
HU (1) | HUT46068A (fr) |
IL (1) | IL85020A (fr) |
ZA (1) | ZA8860B (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU8172787A (en) * | 1986-10-30 | 1988-05-25 | Synergen Biologicals, Inc. | Human pancreatic secretory trypsin inhibitors produced by recombinant dna methods and processes for the production of same |
JPS6427473A (en) * | 1987-07-23 | 1989-01-30 | Mochida Pharm Co Ltd | Human pancreas-secreting trypsin inhibitor and production thereof |
GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
US5591603A (en) * | 1987-08-28 | 1997-01-07 | Novo Nordisk A/S | Process for preparing aprotinin and aprotinin analogs in yeast cells |
ES2063161T3 (es) * | 1988-03-07 | 1995-01-01 | Ciba Geigy Ag | Proteinas modificadas. |
US5180667A (en) * | 1988-03-07 | 1993-01-19 | Ciba-Geigy Corporation | Genes encoding eglin C mutants |
JPH07102137B2 (ja) * | 1988-07-19 | 1995-11-08 | 塩野義製薬株式会社 | 修飾ヒトpsti |
DE3907492A1 (de) * | 1989-03-08 | 1990-09-13 | Biotechnolog Forschung Gmbh | Verfahren zur isolierung und reinigung von hpsti und hpsti-varianten |
US5231010A (en) * | 1989-09-13 | 1993-07-27 | Bayer Aktiengesellschaft | Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof |
IL104314A0 (en) * | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them |
EP0699750A1 (fr) * | 1994-06-07 | 1996-03-06 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Une collection de phagemides, une collection de soudas d'escherichia coli portant ces phagemides, une collection de particule des phagemides produit par cette deuxième collection et des particules de phagemides obtenus par ce procédé |
JPH09124698A (ja) | 1995-10-27 | 1997-05-13 | Sagami Chem Res Center | ヒトpec−60様蛋白質およびそれをコードするdna |
US6703201B1 (en) | 1995-10-27 | 2004-03-09 | Sagami Chemical Research Center | Human PEC-60-like protein and DNA encoding this protein |
US5851987A (en) * | 1997-04-14 | 1998-12-22 | Incyte Pharmaceuticals, Inc. | Human tumor-associated Kazal inhibitor-like polypeptides and encoding polynucleotides |
WO2008052238A1 (fr) * | 2006-11-01 | 2008-05-08 | The University Of Sydney | Traitement du cancer urologique |
DK2109457T3 (en) | 2007-02-12 | 2016-04-11 | Csl Behring Gmbh | THERAPEUTIC USE OF KAZAL TYPE SERINE PROTEASE INHIBITORS |
FI20105572A0 (fi) | 2010-05-24 | 2010-05-24 | Prevab R Lcc | Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt |
AU2015247382B2 (en) | 2014-04-17 | 2020-04-23 | Theriva Biologics, Inc. | Beta-lactamases with improved properties for therapy |
CN106574273B (zh) | 2014-08-28 | 2021-07-02 | 合成生物制品有限公司 | β-内酰胺酶的基于大肠杆菌的生产 |
CN107148473B (zh) | 2014-10-08 | 2021-08-06 | 合成生物制品有限公司 | β-内酰胺酶制剂及其用途 |
WO2016105498A1 (fr) | 2014-12-23 | 2016-06-30 | Synthetic Biologics, Inc. | Méthodes et compositions pour inhiber ou prévenir les effets néfastes des antibiotiques oraux |
JP6810697B2 (ja) | 2015-02-23 | 2021-01-13 | シンセティック・バイオロジクス・インコーポレイテッド | 腸内マイクロバイオームの保護のために抗生物質と共に使用するカルバペネマーゼ |
US10709773B2 (en) | 2015-03-06 | 2020-07-14 | Synthetic Biologics, Inc. | Safe and effective beta-lactamase dosing for microbiome protection |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2701890C2 (de) * | 1977-01-19 | 1983-08-04 | Hoechst Ag, 6230 Frankfurt | Peptielischer Glycosidhydrolase-Inhibitor aus einem Streptomyceten und seine Verwendung |
AU560584B2 (en) * | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
DE3429430A1 (de) * | 1984-08-10 | 1986-02-20 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens |
US4760130A (en) * | 1984-12-06 | 1988-07-26 | Synergen Biologicals, Inc. | Serine protease inhibitors and methods for isolation of same |
DE3587875T3 (de) * | 1984-12-06 | 2003-01-02 | Amgen Inc.(N.D.Ges D. Staates Delaware), Thousand Oaks | Rekombinantverfahren zur herstellung von serinproteaseinhibitoren, sowie dns-sequenzen dazu. |
DE3786870T2 (de) * | 1986-10-14 | 1993-11-11 | Shionogi Seiyaku Kk | Methode zur Herstellung von Proteinen. |
JPH0616716B2 (ja) * | 1986-10-14 | 1994-03-09 | 塩野義製薬株式会社 | 酵母におけるヒトpstiの製造法 |
AU8172787A (en) * | 1986-10-30 | 1988-05-25 | Synergen Biologicals, Inc. | Human pancreatic secretory trypsin inhibitors produced by recombinant dna methods and processes for the production of same |
-
1987
- 1987-01-07 GB GB08700204A patent/GB2199582A/en active Pending
- 1987-12-24 DE DE87119221T patent/DE3788216D1/de not_active Expired - Lifetime
- 1987-12-24 EP EP87119221A patent/EP0278112B1/fr not_active Expired - Lifetime
- 1987-12-24 ES ES87119221T patent/ES2059356T3/es not_active Expired - Lifetime
- 1987-12-24 AT AT87119221T patent/ATE97421T1/de not_active IP Right Cessation
-
1988
- 1988-01-04 IL IL85020A patent/IL85020A/xx not_active IP Right Cessation
- 1988-01-05 AU AU10038/88A patent/AU592486B2/en not_active Ceased
- 1988-01-05 FI FI880017A patent/FI97139C/fi not_active IP Right Cessation
- 1988-01-05 HU HU8817A patent/HUT46068A/hu unknown
- 1988-01-06 DK DK003688A patent/DK3688A/da not_active Application Discontinuation
- 1988-01-06 ZA ZA8860A patent/ZA8860B/xx unknown
- 1988-01-06 JP JP63000445A patent/JPS63169994A/ja active Pending
- 1988-01-07 CN CN88100146A patent/CN1030999C/zh not_active Expired - Fee Related
- 1988-01-07 KR KR1019880000044A patent/KR960010949B1/ko not_active IP Right Cessation
-
1991
- 1991-04-16 US US07/685,798 patent/US5126322A/en not_active Expired - Fee Related
-
1997
- 1997-07-30 JP JP9218307A patent/JPH10117786A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU592486B2 (en) | 1990-01-11 |
KR960010949B1 (ko) | 1996-08-14 |
EP0278112A3 (en) | 1990-01-10 |
US5126322A (en) | 1992-06-30 |
FI97139C (fi) | 1996-10-25 |
ATE97421T1 (de) | 1993-12-15 |
GB2199582A (en) | 1988-07-13 |
HUT46068A (en) | 1988-09-28 |
EP0278112B1 (fr) | 1993-11-18 |
CN88100146A (zh) | 1988-08-31 |
IL85020A (en) | 1993-02-21 |
IL85020A0 (en) | 1988-06-30 |
FI880017A0 (fi) | 1988-01-05 |
CN1030999C (zh) | 1996-02-14 |
FI97139B (fi) | 1996-07-15 |
ES2059356T3 (es) | 1994-11-16 |
JPS63169994A (ja) | 1988-07-13 |
DE3788216D1 (de) | 1993-12-23 |
KR880009125A (ko) | 1988-09-14 |
AU1003888A (en) | 1988-09-01 |
EP0278112A2 (fr) | 1988-08-17 |
GB8700204D0 (en) | 1987-02-11 |
DK3688D0 (da) | 1988-01-06 |
DK3688A (da) | 1988-07-08 |
JPH10117786A (ja) | 1998-05-12 |
FI880017A (fi) | 1988-07-08 |
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