ZA883861B - (1h-azol-1-ylmethyl)substituted benzotriazole derivatives - Google Patents

(1h-azol-1-ylmethyl)substituted benzotriazole derivatives

Info

Publication number
ZA883861B
ZA883861B ZA883861A ZA883861A ZA883861B ZA 883861 B ZA883861 B ZA 883861B ZA 883861 A ZA883861 A ZA 883861A ZA 883861 A ZA883861 A ZA 883861A ZA 883861 B ZA883861 B ZA 883861B
Authority
ZA
South Africa
Prior art keywords
azol
ylmethyl
benzotriazole derivatives
substituted benzotriazole
substituted
Prior art date
Application number
ZA883861A
Other languages
English (en)
Inventor
Alfons Herman Marg Raeymaekers
Herman Margaretha Raeym Alfons
Eddy Jean Edgard Freyne
Jean Edgard Freyne Eddy
Josephus Ludovicus Hube Gelder
Ludovicus Hubertus Va Josephus
Marc Gaston Venet
Gaston Venet Marc
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA883861B publication Critical patent/ZA883861B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA883861A 1987-06-01 1988-05-30 (1h-azol-1-ylmethyl)substituted benzotriazole derivatives ZA883861B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5602187A 1987-06-01 1987-06-01

Publications (1)

Publication Number Publication Date
ZA883861B true ZA883861B (en) 1990-01-31

Family

ID=22001654

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA883861A ZA883861B (en) 1987-06-01 1988-05-30 (1h-azol-1-ylmethyl)substituted benzotriazole derivatives

Country Status (24)

Country Link
EP (1) EP0293978B1 (pt)
JP (1) JPH0662612B2 (pt)
KR (1) KR970000952B1 (pt)
CN (1) CN1022184C (pt)
AU (1) AU603446B2 (pt)
BG (2) BG50278A3 (pt)
CA (1) CA1307271C (pt)
CY (1) CY1866A (pt)
DE (1) DE3884055T2 (pt)
DK (1) DK175218B1 (pt)
ES (1) ES2059490T3 (pt)
FI (1) FI90078C (pt)
HK (1) HK114795A (pt)
HU (2) HU201056B (pt)
IE (1) IE61823B1 (pt)
IL (1) IL86551A (pt)
LT (1) LT3950B (pt)
LV (1) LV10452B (pt)
NO (1) NO169900C (pt)
NZ (1) NZ224714A (pt)
PT (1) PT87623B (pt)
RU (1) RU1838308C (pt)
UA (1) UA11192A (pt)
ZA (1) ZA883861B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
GB8827820D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
US5157046A (en) * 1988-11-29 1992-10-20 Janssen Pharmaceutica N.V. Method of treating epithelial disorders
DK0408509T3 (da) * 1989-07-14 1996-04-01 Ciba Geigy Ag Substituerede benzonitriler
US5066656A (en) * 1989-11-01 1991-11-19 Janssen Pharmaceutica N.V. Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives
CA2026792A1 (en) * 1989-11-01 1991-05-02 Michael N. Greco (6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1h-benzotriazole derivatives
NZ236440A (en) * 1989-12-15 1993-07-27 Merck & Co Inc Reversal of sexual phenotype in poultry using an inhibitor of steroid biotransformation and/or aromatase inhibitor, poultry produced by this process
EP0445073A1 (de) * 1990-02-27 1991-09-04 Ciba-Geigy Ag Benzofurane
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
TW224461B (pt) * 1990-09-18 1994-06-01 Ciba Geigy Ag
US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
TW210334B (pt) * 1990-12-12 1993-08-01 Ciba Geigy Ag
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
UA41295C2 (uk) 1991-09-02 2001-09-17 Яманугі Фармасетікл Ко., Лтд Триазолілзаміщені третинні амінні сполуки або їх солі як інгібітор ароматази та фармацевтична композиція на їх основі
US5635521A (en) * 1991-09-23 1997-06-03 Sandoz Ltd. Imidazolylmethyl-pyridines
JP2700595B2 (ja) * 1992-05-21 1998-01-21 呉羽化学工業株式会社 アゾール誘導体を含有する抗アロマターゼ剤
PL176059B1 (pl) * 1992-11-10 1999-03-31 Janssen Pharmaceutica Nv Sposób wytwarzania enancjomerycznie czystego 6-[(4-chlorofenylo) (1H-1,2,4-triazol-1-ilo)-metylo]-1-metylo-1H-benzotriazolu
US5587392A (en) * 1994-05-27 1996-12-24 Mochida Pharmaceutical Co., Ltd. Azolyl methyl phenyl derivatives having aromatase inhibitory activity
WO1997006788A1 (en) * 1995-08-14 1997-02-27 Janssen Pharmaceutica N.V. Transdermal administration of vorozole
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
EP0949242A4 (en) * 1996-12-24 2004-09-08 Chugai Seiyakukabushiki Kaisha AROMATIC AMINE DERIVATIVES HAVING AN INHIBITORY ACTION WITH RESPECT TO OUR
KR20030017511A (ko) * 2000-06-28 2003-03-03 에스에스 세야쿠 가부시키 가이샤 이미다졸 유도체 또는 그의 염 및 이를 함유하는 의약
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
WO2004078116A2 (en) * 2003-03-03 2004-09-16 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
MX2007008781A (es) 2005-01-21 2007-09-11 Astex Therapeutics Ltd Compuestos farmaceuticos.
CA2600052A1 (en) * 2005-04-29 2006-11-09 Janssen Pharmaceutica N.V. Benzotriazole derivatives as cannabinoid receptor antagonists
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
CN101291950B (zh) 2005-09-15 2013-01-02 科学与工业研究会 咪唑基取代的类固醇和茚满-1-酮衍生物
NZ570846A (en) 2006-01-31 2011-08-26 Array Biopharma Inc Kinase inhibitors and methods of use thereof
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
EP2630136A1 (en) * 2010-10-21 2013-08-28 Universität des Saarlandes Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75101B (pt) * 1980-10-23 1984-07-13 Pfizer
US4801594A (en) * 1984-06-18 1989-01-31 Eli Lilly And Company Aromatase inhibitors
EP0165781A1 (en) * 1984-06-18 1985-12-27 Eli Lilly And Company Aromatase inhibiting N-substituted imidazole derivatives
US4609666A (en) * 1984-06-18 1986-09-02 Eli Lilly And Company Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles
US4659730A (en) * 1984-06-18 1987-04-21 Eli Lilly And Company Aromatase inhibiting imidazole derivatives
US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors
DE3744589C1 (de) 1987-12-31 1988-12-29 Albrecht Josef Bohrfutter Nachspannendes Bohrfutter

Also Published As

Publication number Publication date
NO169900B (no) 1992-05-11
LTIP1625A (en) 1995-07-25
RU1838308C (ru) 1993-08-30
ES2059490T3 (es) 1994-11-16
JPH0662612B2 (ja) 1994-08-17
PT87623A (pt) 1988-06-01
KR970000952B1 (ko) 1997-01-21
AU1653788A (en) 1988-12-01
IL86551A0 (en) 1988-11-15
FI882552A (fi) 1988-12-02
EP0293978A2 (en) 1988-12-07
IE61823B1 (en) 1994-11-30
NO169900C (no) 1992-08-19
HU211482A9 (en) 1995-11-28
BG50278A3 (en) 1992-06-15
DK295288D0 (da) 1988-05-31
KR890000469A (ko) 1989-03-14
CN1022184C (zh) 1993-09-22
UA11192A (uk) 1996-12-25
CY1866A (en) 1988-05-26
AU603446B2 (en) 1990-11-15
IL86551A (en) 1992-07-15
FI90078C (fi) 1993-12-27
FI882552A0 (fi) 1988-05-31
HUT49132A (en) 1989-08-28
DE3884055D1 (de) 1993-10-21
FI90078B (fi) 1993-09-15
NZ224714A (en) 1990-03-27
EP0293978A3 (en) 1990-06-13
LV10452B (en) 1995-08-20
LV10452A (lv) 1995-02-20
LT3950B (en) 1996-05-27
EP0293978B1 (en) 1993-09-15
CN88103408A (zh) 1988-12-14
BG60429B2 (bg) 1995-03-31
HU201056B (en) 1990-09-28
DE3884055T2 (de) 1994-01-27
PT87623B (pt) 1992-09-30
DK175218B1 (da) 2004-07-12
IE881640L (en) 1988-12-01
CA1307271C (en) 1992-09-08
HK114795A (en) 1995-07-21
JPS63316775A (ja) 1988-12-26
DK295288A (da) 1988-12-02
NO882390L (no) 1988-12-02
NO882390D0 (no) 1988-05-31

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