ZA879000B - New pyrrole derivatives,their preparation and pharmaceutical compositions which contain them - Google Patents

New pyrrole derivatives,their preparation and pharmaceutical compositions which contain them

Info

Publication number
ZA879000B
ZA879000B ZA879000A ZA879000A ZA879000B ZA 879000 B ZA879000 B ZA 879000B ZA 879000 A ZA879000 A ZA 879000A ZA 879000 A ZA879000 A ZA 879000A ZA 879000 B ZA879000 B ZA 879000B
Authority
ZA
South Africa
Prior art keywords
alkyl
unsubstituted
substituted
piperidyl
pyrrolidinyl
Prior art date
Application number
ZA879000A
Other languages
English (en)
Inventor
Bourzat Jean-Dominique
Capet Marc
Cotrel Claude
Labaudiniere Richard
Pitchen Philippe
Roussel Gerard
Original Assignee
Rhone-Poulenc Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Sante filed Critical Rhone-Poulenc Sante
Publication of ZA879000B publication Critical patent/ZA879000B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
ZA879000A 1986-12-02 1987-11-30 New pyrrole derivatives,their preparation and pharmaceutical compositions which contain them ZA879000B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8616795A FR2607503B1 (fr) 1986-12-02 1986-12-02 Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ZA879000B true ZA879000B (en) 1988-06-01

Family

ID=9341442

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA879000A ZA879000B (en) 1986-12-02 1987-11-30 New pyrrole derivatives,their preparation and pharmaceutical compositions which contain them

Country Status (23)

Country Link
US (1) US4960779A (el)
EP (1) EP0274930B1 (el)
JP (1) JP2531710B2 (el)
KR (1) KR960011775B1 (el)
AT (1) ATE66480T1 (el)
AU (1) AU600776B2 (el)
CA (1) CA1298296C (el)
DE (1) DE3772369D1 (el)
DK (1) DK168383B1 (el)
ES (1) ES2029282T3 (el)
FI (1) FI84722C (el)
FR (1) FR2607503B1 (el)
GR (1) GR3002576T3 (el)
HU (1) HU198047B (el)
IE (1) IE61088B1 (el)
IL (1) IL84657A (el)
MA (1) MA21117A1 (el)
MX (1) MX9560A (el)
NO (1) NO166036C (el)
NZ (1) NZ222751A (el)
PT (1) PT86260B (el)
SU (2) SU1577698A3 (el)
ZA (1) ZA879000B (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2607504B1 (fr) * 1986-12-02 1989-01-27 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2607506B1 (fr) * 1986-12-02 1989-01-06 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
US5273978A (en) * 1991-07-10 1993-12-28 Takeda Chemical Industries, Ltd. Optically active isoindoline derivatives, their production and use
FR2678932B1 (fr) * 1991-07-12 1993-09-24 Rhone Poulenc Rorer Sa Procede de preparation des isomeres optiques d'un derive de l'amino-2 naphtyridine.
FR2678931B1 (fr) * 1991-07-12 1993-09-24 Rhone Poulenc Rorer Sa Nouveau derive de l'amino-2 naphtyridine, sa preparation et son emploi.
FR2678933B1 (fr) * 1991-07-12 1993-09-24 Rhone Poulenc Rorer Sa Procede de preparation des isomeres optiques d'un derive de l'amino-2 naphtyridine.
FR2678934B1 (fr) * 1991-07-12 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de l'isomere dextrogyre d'un derive de l'isoindolinone.
FR2684673B1 (fr) * 1991-12-04 1994-01-21 Rhone Poulenc Rorer Sa Procede de preparation d'un derive de l'amino-2 naphtyridine racemique.
FR2685330B1 (fr) * 1991-12-20 1994-02-04 Rhone Poulenc Rorer Sa Procede de preparation des enantiomeres d'un derive de l'isoindolinone.
FR2687154B1 (fr) * 1992-02-07 1995-05-12 Rhone Poulenc Rorer Sa Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent.
FR2695389B1 (fr) * 1992-09-08 1994-11-04 Rhone Poulenc Rorer Sa Nouveau dérivé de l'isoindolinone, sa préparation et les compositions pharmaceutiques qui le contiennent.
US5498716A (en) * 1994-01-12 1996-03-12 Rhone-Poulenc Rorer S.A. 2-amino naphthyridine derivative, its preparation and its use
US6399553B1 (en) 1997-06-05 2002-06-04 The Clorox Company Reduced residue hard surface cleaner
WO2001008670A2 (en) * 1999-07-29 2001-02-08 Interneuron Pharmaceuticals, Inc. Methods and compositions for alleviating stuttering
US6855721B1 (en) 2000-07-28 2005-02-15 Indevus Pharmaceuticals, Inc. Methods and compositions for alleviating stuttering
AU783516B2 (en) 2001-04-30 2005-11-03 Warner-Lambert Company Methods, kits and compositions for using pyrrole derivatives
DK1490363T3 (da) * 2002-03-29 2006-05-15 Indevus Pharmaceuticals Inc Fremgangsmåder til fremstilling af 2-7-chlor-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxo-hexyl)1-isoindolinon
WO2005105061A2 (en) * 2004-04-14 2005-11-10 Indevus Pharmaceuticals, Inc. Transdermal patch
EP2678337A1 (en) 2011-02-25 2014-01-01 Concert Pharmaceuticals Inc. 2-amino-naphthyridine derivatives
CN112138003A (zh) * 2019-06-27 2020-12-29 中山大学 3-正丁基-异吲哚啉-1-酮在镇静、抗惊厥和抗癫痫的药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE793851A (fr) * 1972-01-10 1973-07-10 Rhone Poulenc Sa Nouveaux derives de l'isoindoline, leur preparation et les compositions medicinales qui les contiennent
US4244966A (en) * 1979-09-24 1981-01-13 American Home Products Corporation 1,3-Dihydro-3-(2-hydroxy-, 2-bromo- or 2-chloroethyl)-2H-isoindol-1-one derivatives
ATE39483T1 (de) * 1982-04-02 1989-01-15 Takeda Chemical Industries Ltd Kondensierte pyrrolinon-derivate, und ihre herstellung.
WO1984003089A1 (en) * 1983-02-05 1984-08-16 Takeda Chemical Industries Ltd Condensed pyrrolinone derivatives
JPS6169773A (ja) * 1984-09-14 1986-04-10 Takeda Chem Ind Ltd イソインドリノン誘導体
US4657913A (en) * 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
FR2607506B1 (fr) * 1986-12-02 1989-01-06 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2607504B1 (fr) * 1986-12-02 1989-01-27 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
NO875011D0 (no) 1987-12-01
KR880007516A (ko) 1988-08-27
NO166036B (no) 1991-02-11
FR2607503A1 (fr) 1988-06-03
HUT46001A (en) 1988-09-28
SU1577698A3 (ru) 1990-07-07
DE3772369D1 (de) 1991-09-26
IL84657A (en) 1991-09-16
NZ222751A (en) 1989-10-27
IL84657A0 (en) 1988-04-29
NO166036C (no) 1991-05-22
EP0274930B1 (fr) 1991-08-21
FI875298A (fi) 1988-06-03
JP2531710B2 (ja) 1996-09-04
CA1298296C (fr) 1992-03-31
PT86260B (pt) 1990-11-07
DK630687A (da) 1988-06-03
ATE66480T1 (de) 1991-09-15
ES2029282T3 (es) 1992-08-01
EP0274930A1 (fr) 1988-07-20
KR960011775B1 (ko) 1996-08-30
NO875011L (no) 1988-06-03
FI84722C (fi) 1992-01-10
FR2607503B1 (fr) 1989-02-24
DK168383B1 (da) 1994-03-21
DK630687D0 (da) 1987-12-01
PT86260A (fr) 1988-01-01
IE61088B1 (en) 1994-09-21
AU8191187A (en) 1988-06-02
GR3002576T3 (en) 1993-01-25
MA21117A1 (fr) 1988-07-01
IE873251L (en) 1988-06-02
FI875298A0 (fi) 1987-12-01
SU1630612A3 (ru) 1991-02-23
MX9560A (es) 1993-11-01
JPS63154681A (ja) 1988-06-27
FI84722B (fi) 1991-09-30
HU198047B (en) 1989-07-28
US4960779A (en) 1990-10-02
AU600776B2 (en) 1990-08-23

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