ZA828546B - 2-(4-((4,4-dialkyl-2,6-piperidinedion-1-yl)butyl)-1-piperazinyl)pyridines - Google Patents

2-(4-((4,4-dialkyl-2,6-piperidinedion-1-yl)butyl)-1-piperazinyl)pyridines

Info

Publication number
ZA828546B
ZA828546B ZA828546A ZA828546A ZA828546B ZA 828546 B ZA828546 B ZA 828546B ZA 828546 A ZA828546 A ZA 828546A ZA 828546 A ZA828546 A ZA 828546A ZA 828546 B ZA828546 B ZA 828546B
Authority
ZA
South Africa
Prior art keywords
piperidinedion
pyridines
piperazinyl
dialkyl
butyl
Prior art date
Application number
ZA828546A
Other languages
English (en)
Inventor
Davis L Temple
Joseph P Yevich
Walter G Lobeck
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ZA828546B publication Critical patent/ZA828546B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
ZA828546A 1981-12-28 1982-11-19 2-(4-((4,4-dialkyl-2,6-piperidinedion-1-yl)butyl)-1-piperazinyl)pyridines ZA828546B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/334,689 US4361565A (en) 1981-12-28 1981-12-28 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines

Publications (1)

Publication Number Publication Date
ZA828546B true ZA828546B (en) 1983-09-28

Family

ID=23308356

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA828546A ZA828546B (en) 1981-12-28 1982-11-19 2-(4-((4,4-dialkyl-2,6-piperidinedion-1-yl)butyl)-1-piperazinyl)pyridines

Country Status (27)

Country Link
US (1) US4361565A (sv)
JP (1) JPS58118583A (sv)
KR (1) KR880002011B1 (sv)
AT (1) AT380880B (sv)
AU (1) AU560667B2 (sv)
BE (1) BE895505A (sv)
CA (1) CA1237722A (sv)
CH (1) CH653682A5 (sv)
CY (1) CY1378A (sv)
DE (1) DE3248138A1 (sv)
DK (1) DK162284C (sv)
ES (1) ES518511A0 (sv)
FI (1) FI70892C (sv)
FR (1) FR2518994B1 (sv)
GB (1) GB2114121B (sv)
GR (1) GR77101B (sv)
HK (1) HK5188A (sv)
HU (1) HU190827B (sv)
IE (1) IE54620B1 (sv)
IT (1) IT1158040B (sv)
KE (1) KE3714A (sv)
LU (1) LU84562A1 (sv)
NL (1) NL8204974A (sv)
PT (1) PT76037B (sv)
SE (1) SE449748B (sv)
SG (1) SG29687G (sv)
ZA (1) ZA828546B (sv)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387221B (de) * 1980-09-08 1988-12-27 Bristol Myers Co Verfahren zur herstellung des neuen
AT387773B (de) * 1983-09-12 1989-03-10 Bristol Myers Co Verfahren zur herstellung von 1-heteroaryl-4-((2,5-pyrrolidindion-1-yl)aklyl) iperazin-derivaten
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4619930A (en) * 1985-01-16 1986-10-28 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
CA1278792C (en) * 1985-05-06 1991-01-08 Joseph P. Yevich Antipsychotic fused-ring pyridinylpiperazine derivatives
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
US4757073A (en) * 1986-09-30 1988-07-12 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylipiperazin-1-yl) pyridines, compositions and use
US4855430A (en) * 1987-11-12 1989-08-08 American Home Products Corporation Polycyclicamine with psychotropic activity
EP0348460A4 (en) * 1987-11-12 1991-11-27 American Home Products Corporation Polycyclicamines with psychotropic activity
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US5116970A (en) * 1988-02-18 1992-05-26 New James S Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
DK0482696T3 (da) * 1990-10-23 1996-05-20 Akzo Nobel Nv 4-(4- eller 6-(trifluormethyl-2-pyridinyl))-1-piperazinylalkyl-substituerede lactamer
EP0564520A1 (en) * 1990-12-24 1993-10-13 Merrell Dow Pharmaceuticals Inc. Use of certain glutarimide derivatives in the treatment of depression and mania
SE9201138D0 (sv) * 1992-04-09 1992-04-09 Astra Ab Novel phthalimidoalkylpiperazines
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
ATE274510T1 (de) 1998-06-19 2004-09-15 Chiron Corp Glycogen synthase kinase 3 inhibitoren
CA2686525C (en) * 2007-03-29 2012-05-29 Obschestvo S Ogranishennoi Otvetstvennostu "Farmving" An antihistamine antiallergic agent and a method of deriving it

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
AU521110B2 (en) * 1978-06-20 1982-03-18 Synthelabo Phenylpiperazine derivatives
US4305944A (en) * 1980-09-08 1981-12-15 Mead Johnson & Company N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones

Also Published As

Publication number Publication date
IE823068L (en) 1983-06-28
KE3714A (en) 1987-04-16
JPH0567637B2 (sv) 1993-09-27
HK5188A (en) 1988-01-29
GR77101B (sv) 1984-09-06
FI70892B (fi) 1986-07-18
SG29687G (en) 1987-07-17
IT8249720A0 (it) 1982-12-22
DK573282A (da) 1983-06-29
DE3248138A1 (de) 1983-07-07
US4361565A (en) 1982-11-30
SE8207426D0 (sv) 1982-12-27
KR840002826A (ko) 1984-07-21
CA1237722A (en) 1988-06-07
FR2518994B1 (fr) 1986-09-05
AU9108482A (en) 1983-07-07
ES8402832A1 (es) 1984-03-01
PT76037A (en) 1983-01-01
GB2114121B (en) 1985-11-27
GB2114121A (en) 1983-08-17
CY1378A (en) 1987-08-07
AU560667B2 (en) 1987-04-16
IE54620B1 (en) 1989-12-20
JPS58118583A (ja) 1983-07-14
DK162284C (da) 1992-03-16
KR880002011B1 (ko) 1988-10-12
NL8204974A (nl) 1983-07-18
AT380880B (de) 1986-07-25
DK162284B (da) 1991-10-07
HU190827B (en) 1986-11-28
CH653682A5 (de) 1986-01-15
ES518511A0 (es) 1984-03-01
IT1158040B (it) 1987-02-18
LU84562A1 (fr) 1983-09-08
SE8207426L (sv) 1983-06-29
FR2518994A1 (fr) 1983-07-01
FI824443A0 (fi) 1982-12-23
SE449748B (sv) 1987-05-18
FI70892C (fi) 1986-10-27
ATA467682A (de) 1985-12-15
BE895505A (fr) 1983-06-28
PT76037B (en) 1985-12-16
DE3248138C2 (sv) 1992-12-10
FI824443L (fi) 1983-06-29

Similar Documents

Publication Publication Date Title
KE3709A (en) 2-(4-((4,4-dialkyl-2,6-piperidinedion-1-yl)butyl)-1-piperazinyl)pyrimidines
SG29687G (en) 2-(4-((4, 4-dialkyl-2, 6-piperidinedion-1-yl) butyl)-1-piperazinyl) pyridines
DE3486121D1 (en) 4-((bicyclische heterocyclyl)methyl und -hetero)-piperidine.
DE3268733D1 (en) 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds
AU556084B2 (en) 4-(2-fluoro-4-halo-5-substituted phenyl)-urazols
JPS5791980A (en) 2,4-disubstituted thiazole derivatives
AU591740B2 (en) 2-((3,5-dihalo-4-aminobenzyl)) imidazolines
AU8793182A (en) Omega-(4-(2-pyridyl)-piperazino)alkanoylanilide derivatives
AU548671B2 (en) 1,2-dimydro-6-methyl-2-oxo-5-(pyridinyl) nicotinonitriles
AU550614B2 (en) 2-phenyl-2-(pyridyloxy)-ethylamines
JPS56138170A (en) 2-(1-piperazinyl)-2,4,6-cycloheptatriene-1-one derivative
AU544794B2 (en) 4-(2,2-dialkyl-indane-1-ylidene)-piperidines
GB2078222B (en) 4-(3-iodopropargyloxy)pyrimidines
GB2159154B (en) Methyl 2-(2-hydroperoxy-2-propyl)naphthalene-6-carboxylate
YU240282A (en) Process for preparing 4-(3-methly-2-butenyl)1,2-diphenyl-3,5-dioxopyrazolidine
IE871642L (en) 4-(3'trifluoromethylphenoxy)-benzoylacetic acid derivatives.
IE810824L (en) 2-(1-piperazinyl)-4-pyrimidinamines
AU540657B2 (en) 2-(1-piperazinyl)-2,4,6-cycloheptatriene-1-one derivative
GB2102417B (en) Micronised 2-(4-chlorophenyl)-s-triazolo]5,1-aisoquinolin
AU600073C (en) 2-(1,2,4-triazol-1-yl)methyl- tetrahydro-furans
PH17535A (en) 2-(4-hydroxyalkyl-1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives
IE811864L (en) 2-(substituted-thio)-penem compounds
IE812090L (en) 2-(1, 4-benzodioxan-2-ylalkyl) imidazoles
AU7669881A (en) 4-(2,4-dichloro-3-methylbenzoyl)-1,3-dimethyl-5-phenacyloxy- pyrazoles
IE861024L (en) 2-(n-alkynyl-n-phenylamino) imidazoline compounds.