ZA816080B - 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridine-3-carboxylic acids,processes for their preparation and antibacterial agents containing these compounds - Google Patents
7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridine-3-carboxylic acids,processes for their preparation and antibacterial agents containing these compoundsInfo
- Publication number
- ZA816080B ZA816080B ZA816080A ZA816080A ZA816080B ZA 816080 B ZA816080 B ZA 816080B ZA 816080 A ZA816080 A ZA 816080A ZA 816080 A ZA816080 A ZA 816080A ZA 816080 B ZA816080 B ZA 816080B
- Authority
- ZA
- South Africa
- Prior art keywords
- naphthyridine
- cyclopropyl
- dihydro
- oxo
- amino
- Prior art date
Links
- UZSCYVLTFUBAGG-UHFFFAOYSA-N 7-amino-1-cyclopropyl-4-oxo-1,8-naphthyridine-3-carboxylic acid Chemical class N=1C(N)=CC=C(C(C(C(O)=O)=C2)=O)C=1N2C1CC1 UZSCYVLTFUBAGG-UHFFFAOYSA-N 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Quinoline Compounds (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803033157 DE3033157A1 (de) | 1980-09-03 | 1980-09-03 | 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA816080B true ZA816080B (en) | 1982-08-25 |
Family
ID=6111041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA816080A ZA816080B (en) | 1980-09-03 | 1981-09-02 | 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridine-3-carboxylic acids,processes for their preparation and antibacterial agents containing these compounds |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0049355B1 (no) |
JP (3) | JPS5777683A (no) |
KR (1) | KR870000441B1 (no) |
AR (1) | AR227063A1 (no) |
AT (1) | ATE9803T1 (no) |
AU (1) | AU540242B2 (no) |
CY (1) | CY1301A (no) |
DE (2) | DE3033157A1 (no) |
DK (1) | DK161460C (no) |
ES (1) | ES8206523A1 (no) |
HK (1) | HK61485A (no) |
IE (1) | IE51541B1 (no) |
KE (1) | KE3545A (no) |
MY (1) | MY8700363A (no) |
NL (2) | NL930033I1 (no) |
SG (1) | SG44685G (no) |
ZA (1) | ZA816080B (no) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4855292A (en) * | 1986-02-25 | 1989-08-08 | Otsuka Pharmaceutical Company, Limited | 1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3142854A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
JPS5925391A (ja) * | 1982-07-30 | 1984-02-09 | Dainippon Pharmaceut Co Ltd | ピリジルナフチリジン誘導体およびその塩 |
US4665079A (en) * | 1984-02-17 | 1987-05-12 | Warner-Lambert Company | Antibacterial agents |
US5281612A (en) * | 1982-09-09 | 1994-01-25 | Warner-Lambert Company | Naphthyridine antibacterial agents |
DE3248506A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3248505A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(4- (oxoalkyl)-1-piperazinyl/-3-chinolincarbonsaeuren und ihre derivate, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3248507A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | Mikrobizide mittel auf chinoloncarbonsaeure basis |
DE3306771A1 (de) * | 1983-02-25 | 1984-08-30 | Bayer Ag, 5090 Leverkusen | Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3306772A1 (de) * | 1983-02-25 | 1984-08-30 | Bayer Ag, 5090 Leverkusen | Chinolonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3308909A1 (de) * | 1983-03-12 | 1984-09-13 | Bayer Ag, 5090 Leverkusen | Bakterizide mittel auf chinoloncarbonsaeure-basis |
DE3308908A1 (de) * | 1983-03-12 | 1984-09-13 | Bayer Ag, 5090 Leverkusen | Bakterizide mittel |
DE3318145A1 (de) * | 1983-05-18 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
JPS6056959A (ja) * | 1983-07-18 | 1985-04-02 | アボツト ラボラトリ−ズ | キノリン抗菌性化合物 |
DE3326190A1 (de) * | 1983-07-20 | 1985-01-31 | Bayer Ag, 5090 Leverkusen | 5-cyclopropyl-5,8-dihydro-8-oxo-1,3-dioxolo-(4,5-g) chinolin-7-carbonsaeure, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
JPS60260577A (ja) * | 1984-06-06 | 1985-12-23 | Dainippon Pharmaceut Co Ltd | 1,8−ナフチリジン誘導体 |
CS274601B2 (en) * | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
JPS6028978A (ja) * | 1983-07-27 | 1985-02-14 | Dainippon Pharmaceut Co Ltd | 1,8−ナフチリジン誘導体 |
JPS6032790A (ja) * | 1983-08-01 | 1985-02-19 | Dainippon Pharmaceut Co Ltd | 1,8−ナフチリジン類 |
AU553415B2 (en) * | 1983-09-19 | 1986-07-17 | Abbott Japan Co., Ltd. | 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids |
JPS6089480A (ja) * | 1983-10-21 | 1985-05-20 | Dainippon Pharmaceut Co Ltd | ピリドンカルボン酸誘導体 |
US4551456A (en) * | 1983-11-14 | 1985-11-05 | Merck & Co., Inc. | Ophthalmic use of norfloxacin and related antibiotics |
JPS60126284A (ja) * | 1983-12-09 | 1985-07-05 | Dainippon Pharmaceut Co Ltd | ピリドンカルボン酸誘導体およびその塩 |
EP0160578B1 (en) * | 1984-02-17 | 1989-11-23 | Daiichi Seiyaku Co., Ltd. | 1,8-naphthyridine derivatives |
CA1285279C (en) * | 1984-02-17 | 1991-06-25 | Joseph P. Sanchez | 7-amine derivatives of 1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acids and 1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine- 3-carboxylic acidsas antibacterial agents |
JPS60228479A (ja) * | 1984-04-26 | 1985-11-13 | Toyama Chem Co Ltd | 1,4−ジヒドロ−4−オキソナフチリジン誘導体およびその塩 |
US4732311A (en) * | 1984-05-31 | 1988-03-22 | Nippondenso Co., Ltd. | Process of producing lightweight and corrosion-resistant heat exchanger |
US5468861A (en) * | 1984-06-04 | 1995-11-21 | Bayer Aktiengesellschaft | 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof |
DE3420770A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3420798A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren |
DE3420743A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
IE58742B1 (en) * | 1984-07-20 | 1993-11-05 | Warner Lambert Co | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds |
IN162769B (no) * | 1984-11-13 | 1988-07-09 | Kyorin Seiyaku Kk | |
JPS61118370A (ja) * | 1985-10-30 | 1986-06-05 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸とその製造方法 |
JPS61180771A (ja) * | 1985-01-05 | 1986-08-13 | バイエル・アクチエンゲゼルシヤフト | 安定な抗バクテリア剤水溶液 |
DE3517709A1 (de) * | 1985-01-05 | 1986-07-10 | Bayer Ag | Basische zubereitungen von chinoloncarbonsaeuren |
DE3508816A1 (de) * | 1985-01-10 | 1986-07-10 | Bayer Ag, 5090 Leverkusen | 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren |
DE3504643A1 (de) * | 1985-02-12 | 1986-08-14 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl)-3-chinolin carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3509546A1 (de) * | 1985-03-16 | 1986-09-25 | Bayer Ag, 5090 Leverkusen | 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
IT1200470B (it) * | 1985-05-10 | 1989-01-18 | Schering Spa | Composti ad attivita' antibatterica,loro preparazione e composizioni farmaceutiche relative |
GB8512143D0 (en) * | 1985-05-14 | 1985-06-19 | Beecham Group Plc | Method of treatment |
DE3519286A1 (de) * | 1985-05-30 | 1986-12-04 | Bayer Ag, 5090 Leverkusen | 7-azolyl-1-cyclopropyl-1,4-dihydro-4-oxo-3- chinolincarbonsaeuren und -1,8-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3608745A1 (de) * | 1985-07-24 | 1987-01-29 | Bayer Ag | Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin |
AU594983B2 (en) * | 1985-10-29 | 1990-03-22 | Dainippon Pharmaceutical Co. Ltd. | Novel quinoline derivatives and processes for preparation thereof |
EP0224121A3 (en) * | 1985-11-19 | 1987-11-11 | ROTTAPHARM S.p.A. | 7-[4-amino-piperazinyl]- or 7-[4-chloro-piperazinyl]quinolinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them |
DE3542002A1 (de) * | 1985-11-28 | 1987-06-04 | Bayer Ag | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
US4668680A (en) * | 1985-12-12 | 1987-05-26 | Warner-Lambert Company | 5-amino-6,8-difluoroquinolones as antibacterial agents |
US5286754A (en) * | 1986-01-21 | 1994-02-15 | Bayer Aktiengesellschaft | Pharmaceutical formulations of ciprofloxacin |
DE3601566A1 (de) * | 1986-01-21 | 1987-07-23 | Bayer Ag | Pharmazeutische zubereitungen von ciprofloxacin |
US4692454A (en) * | 1986-02-03 | 1987-09-08 | Warner-Lambert Company | Opthalmic use of quinolone antibiotics |
HU198709B (en) * | 1987-04-08 | 1989-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing quinoline-carboxylic acid derivatives |
DE3713672A1 (de) * | 1987-04-24 | 1988-11-17 | Bayer Ag | Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren |
DE3719764A1 (de) * | 1987-06-13 | 1988-12-22 | Bayer Ag | Ionenaustauscherharze beladen mit chinoloncarbonsaeurederivaten, ihre herstellung und verwendung |
DE3902079A1 (de) * | 1988-04-15 | 1989-10-26 | Bayer Ag | I.m. injektionsformen von gyrase-inhibitoren |
ES2158963T3 (es) | 1995-02-09 | 2001-09-16 | Bayer Ag | Derivados de acidos 1,6-naftiridoncarboxilicos. |
DE19519822A1 (de) * | 1995-05-31 | 1996-12-05 | Bayer Ag | Neue antibakterielle Mittel |
IT1280428B1 (it) * | 1995-07-14 | 1998-01-20 | R R A S R L | Composizione farmaceutica per uso topico |
JP4694669B2 (ja) | 1999-03-17 | 2011-06-08 | 第一三共株式会社 | 医薬組成物 |
SE9904108D0 (sv) * | 1999-11-15 | 1999-11-15 | New Pharma Research Ab | Nya föreningar |
JP4290381B2 (ja) * | 2002-04-11 | 2009-07-01 | 学校法人 聖マリアンナ医科大学 | ピリドンカルボン酸化合物含有エマルション |
NZ541681A (en) | 2003-02-10 | 2009-02-28 | Bayer Healthcare Ag | Treatment of bacterial diseases of the respiratory organs by locally applying ciprofloxacin and its salts |
DE102007004732A1 (de) | 2007-01-31 | 2008-08-07 | Bayer Healthcare Ag | Enrofloxacin-Hexahydrat |
WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
EP2957561A1 (en) | 2014-06-18 | 2015-12-23 | Université Paris 6 Pierre et Marie Curie UPMC | Novel fluoroquinolones and use thereof to treat bacterial infections |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4843508A (no) * | 1971-10-05 | 1973-06-23 | ||
JPS5635188B2 (no) * | 1974-02-12 | 1981-08-15 | ||
JPS5732059B2 (no) * | 1974-02-09 | 1982-07-08 | ||
JPS587626B2 (ja) * | 1974-02-13 | 1983-02-10 | 大日本製薬株式会社 | ナフチリジン オヨビ キノリンユウドウタイノセイホウ |
JPS5437151A (en) * | 1977-08-29 | 1979-03-19 | Mizusawa Industrial Chem | Method of improving basic lead sulfate |
SE444566B (sv) * | 1977-09-20 | 1986-04-21 | Bellon Labor Sa Roger | 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav |
JPS5466686A (en) * | 1977-09-20 | 1979-05-29 | Dainippon Pharmaceut Co Ltd | Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same |
DE2808070A1 (de) * | 1978-02-24 | 1979-08-30 | Bayer Ag | Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten |
JPS5845426B2 (ja) * | 1978-09-29 | 1983-10-08 | 杏林製薬株式会社 | 置換キノリンカルボン酸誘導体 |
DE2903850A1 (de) * | 1979-02-01 | 1980-08-07 | Bayer Ag | 2-amino-8-cyclopropyl-5-oxo-5,8- dihydro-pyrido eckige klammer auf 2,3-d eckige klammer zu -pyrimidin-6-carnonsaeuren, verfahren zu ihrer herstellung sowie ihrer verwendung als antibakterielle mittel |
-
1980
- 1980-09-03 DE DE19803033157 patent/DE3033157A1/de not_active Withdrawn
-
1981
- 1981-08-21 DE DE8181106511T patent/DE3166619D1/de not_active Expired
- 1981-08-21 CY CY1301A patent/CY1301A/xx unknown
- 1981-08-21 AT AT81106511T patent/ATE9803T1/de active
- 1981-08-21 EP EP81106511A patent/EP0049355B1/de not_active Expired
- 1981-08-27 AU AU74680/81A patent/AU540242B2/en not_active Expired
- 1981-09-01 JP JP56136224A patent/JPS5777683A/ja active Granted
- 1981-09-02 IE IE2032/81A patent/IE51541B1/en not_active IP Right Cessation
- 1981-09-02 ZA ZA816080A patent/ZA816080B/xx unknown
- 1981-09-02 DK DK387781A patent/DK161460C/da not_active IP Right Cessation
- 1981-09-02 ES ES505138A patent/ES8206523A1/es not_active Expired
- 1981-09-03 KR KR1019810003285A patent/KR870000441B1/ko active
-
1982
- 1982-01-01 AR AR227063D patent/AR227063A1/es active
-
1985
- 1985-06-11 SG SG44685A patent/SG44685G/en unknown
- 1985-06-19 KE KE3545A patent/KE3545A/xx unknown
- 1985-08-15 HK HK614/85A patent/HK61485A/xx not_active IP Right Cessation
-
1987
- 1987-01-16 JP JP62006271A patent/JPS62161763A/ja active Granted
- 1987-01-16 JP JP62006272A patent/JPS62161728A/ja active Granted
- 1987-12-30 MY MY363/87A patent/MY8700363A/xx unknown
-
1993
- 1993-05-24 NL NL930033C patent/NL930033I1/nl unknown
- 1993-05-24 NL NL930032C patent/NL930032I2/nl unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4855292A (en) * | 1986-02-25 | 1989-08-08 | Otsuka Pharmaceutical Company, Limited | 1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives |
US4874764A (en) * | 1986-02-25 | 1989-10-17 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
US4880806A (en) * | 1986-02-25 | 1989-11-14 | Otsuka Pharmaceutical Company, Limited | 1-Cyclopropyl-6-fluoro-7-piperazinyl-1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid derivatives |
US4935420A (en) * | 1986-02-25 | 1990-06-19 | Otsuka Pharmaceutical Company, Ltd. | Benzoheterocyclic compounds |
Also Published As
Publication number | Publication date |
---|---|
DK161460C (da) | 1991-12-16 |
NL930032I2 (nl) | 1997-03-03 |
KR870000441B1 (ko) | 1987-03-10 |
IE812032L (en) | 1982-03-03 |
EP0049355A1 (de) | 1982-04-14 |
JPS6356224B2 (no) | 1988-11-07 |
JPH0316344B2 (no) | 1991-03-05 |
ATE9803T1 (de) | 1984-10-15 |
JPS62161763A (ja) | 1987-07-17 |
DK387781A (da) | 1982-03-04 |
NL930032I1 (nl) | 1993-08-02 |
AU7468081A (en) | 1982-03-11 |
MY8700363A (en) | 1987-12-31 |
ES505138A0 (es) | 1982-08-16 |
AR227063A1 (es) | 1982-09-15 |
AU540242B2 (en) | 1984-11-08 |
ES8206523A1 (es) | 1982-08-16 |
JPH0314811B2 (no) | 1991-02-27 |
JPS62161728A (ja) | 1987-07-17 |
CY1301A (en) | 1985-12-06 |
JPS5777683A (en) | 1982-05-15 |
DE3033157A1 (de) | 1982-04-01 |
KR830007642A (ko) | 1983-11-04 |
KE3545A (en) | 1985-07-19 |
IE51541B1 (en) | 1987-01-07 |
NL930033I1 (nl) | 1993-08-02 |
HK61485A (en) | 1985-08-23 |
DK161460B (da) | 1991-07-08 |
DE3166619D1 (en) | 1984-11-15 |
EP0049355B1 (de) | 1984-10-10 |
SG44685G (en) | 1986-01-17 |
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