ZA803250B - Substituded aromatic compounds - Google Patents

Substituded aromatic compounds

Info

Publication number
ZA803250B
ZA803250B ZA00803250A ZA803250A ZA803250B ZA 803250 B ZA803250 B ZA 803250B ZA 00803250 A ZA00803250 A ZA 00803250A ZA 803250 A ZA803250 A ZA 803250A ZA 803250 B ZA803250 B ZA 803250B
Authority
ZA
South Africa
Prior art keywords
substituded
aromatic compounds
aromatic
compounds
substituded aromatic
Prior art date
Application number
ZA00803250A
Other languages
English (en)
Inventor
D Sawyer
M Baxter
A Elphick
A Miller
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA803250(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of ZA803250B publication Critical patent/ZA803250B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
    • C07D253/0651,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/071,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075Two hetero atoms, in positions 3 and 5
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA00803250A 1979-06-01 1980-05-30 Substituded aromatic compounds ZA803250B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01

Publications (1)

Publication Number Publication Date
ZA803250B true ZA803250B (en) 1982-01-27

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00803250A ZA803250B (en) 1979-06-01 1980-05-30 Substituded aromatic compounds

Country Status (30)

Country Link
US (2) US4486354A (fr)
EP (2) EP0059987B1 (fr)
JP (2) JPS5625169A (fr)
AR (1) AR227521A1 (fr)
AT (1) AT370097B (fr)
AU (2) AU530999B2 (fr)
BG (1) BG60427B2 (fr)
CA (1) CA1112643A (fr)
CS (1) CS234018B2 (fr)
CZ (1) CZ384891A3 (fr)
DD (1) DD151309A5 (fr)
DK (1) DK153787C (fr)
ES (1) ES491998A0 (fr)
FI (1) FI67844C (fr)
GE (1) GEP19960470B (fr)
GR (1) GR68380B (fr)
HU (1) HU182086B (fr)
IE (1) IE49823B1 (fr)
IL (1) IL60201A (fr)
IT (1) IT1147087B (fr)
MX (1) MX9202962A (fr)
MY (1) MY8500062A (fr)
NL (1) NL950007I2 (fr)
NZ (1) NZ193890A (fr)
PL (1) PL124029B1 (fr)
SU (1) SU1055331A3 (fr)
UA (1) UA5576A1 (fr)
YU (1) YU145680A (fr)
ZA (1) ZA803250B (fr)
ZW (1) ZW12980A1 (fr)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1145308B (it) * 1979-08-16 1986-11-05 Wellcome Found Composti aromatici sostituiti
GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
DE3600891A1 (de) * 1986-01-15 1987-07-16 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
US4972496A (en) * 1986-07-25 1990-11-20 Grid Systems Corporation Handwritten keyboardless entry computer system
FI895821A0 (fi) 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
SK282071B6 (sk) * 1991-01-30 2001-10-08 The Wellcome Foundation Limited Tableta dispergovateľná vo vode a spôsob jej prípravy
GB9124807D0 (en) * 1991-11-22 1992-01-15 Wellcome Found Pharmaceutical formulations
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
IL105986A (en) * 1992-06-12 1998-12-06 Wellcome Found Pharmaceutical preparations containing triazine compounds for the prevention or reduction of tolerable dependence or the opposite of dependency
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
US6133299A (en) * 1993-02-25 2000-10-17 Warner-Lambert Company Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds
GB9305693D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
US5866597A (en) * 1993-03-19 1999-02-02 Glaxo Wellcome Inc. Use of triazine compounds for the treatment of memory and learning disorders
GB9305692D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
US5912345A (en) * 1994-12-30 1999-06-15 Glaxo Wellcome Inc. Process for the preparation of lamotrigine
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6202491B1 (en) 1997-07-22 2001-03-20 Skf Condition Monitoring, Inc. Digital vibration coupling stud
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US6124500A (en) * 1998-03-09 2000-09-26 Rohm And Haas Company Process for synthesizing benzoic acids
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
CA2334937C (fr) * 1998-12-14 2004-09-21 Torrent Pharmaceuticals Ltd. Procede et appareil ameliore de preparation de 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
US20020055177A1 (en) * 1999-03-10 2002-05-09 Glaxo Wellcome Inc. Compound and its use
GB9907965D0 (en) * 1999-04-09 1999-06-02 Glaxo Group Ltd Medical use
JP2002541215A (ja) * 1999-04-09 2002-12-03 ユーロ−セルティック エス. ア. ナトリウムチャネル遮断薬組成物およびその使用
AU763244B2 (en) * 2000-01-03 2003-07-17 Rpg Life Sciences Limited A process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine
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EE200300249A (et) 2000-11-30 2003-10-15 Pfizer Products Inc. GABA agonistide ja aldoosreduktaasi inhibiitoritekombinatsioon
EP1337271B1 (fr) 2000-11-30 2004-11-03 Pfizer Products Inc. Combinaison d'agonistes gaba et d'inhibiteurs de la sorbitol-deshydrogenase (sdi)
EP1390355A4 (fr) * 2001-02-27 2005-02-23 Teva Pharma Nouvelles formes crystallines de la lamotrigine et procedes pour leur prepation
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CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
ATE357217T1 (de) * 2002-04-23 2007-04-15 Teva Pharma Pharmazeutische zusammensetzung enthaltend lamotrigine-partikel mit definierter morphologie
US8637512B2 (en) 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
HU225667B1 (en) 2002-09-20 2007-05-29 Richter Gedeon Nyrt Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
ES2209639B1 (es) 2002-10-31 2005-08-01 Vita Cientifica, S.L. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
EP1603889A1 (fr) * 2003-03-17 2005-12-14 Hetero Drugs Limited Nouvelles formes cristallines de lamotrigine
WO2004085426A1 (fr) 2003-03-27 2004-10-07 Hetero Drugs Limited Nouvelles formes cristallines de candesartan cilexetil
BRPI0410271A (pt) 2003-05-16 2006-05-16 Pfizer Prod Inc combinações terapêuticas de antipsicóticos atìpicos com moduladores de gaba, anticonvulsivantes ou benzodiazepinas
WO2004103340A1 (fr) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Comprimes hydrodispersibles a base de lamotrigine
GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
CA2548917C (fr) 2003-12-11 2014-09-23 Sepracor Inc. Combinaison d'un sedatif et d'un modulateur des neurotransmetteurs, et methodes permettant d'ameliorer la qualite du sommeil et de traiter la depression
EP1737466A1 (fr) * 2004-01-29 2007-01-03 Pfizer Products Inc. COMBINAISON DE MODULATEURS D'ACIDE GAMMA-AMINOBUTYRIQUE ET D'ANTAGONISTES DU RECEPTEUR 5-HT-1b
WO2005102366A2 (fr) * 2004-04-19 2005-11-03 Philip Maxwell Satow Combinaisons de lithium et utilisations associees
PT1809271E (pt) * 2004-09-10 2010-08-30 Newron Pharm Spa Utilização de (halogenobenziloxi)benzilamino-propanamidas para o fabrico de medicamentos activos como moduladores selectivos dos canais de sódio e/ou de cálcio
US7825151B2 (en) * 2005-09-23 2010-11-02 Janssen Pharmaceutica Nv Hexahydro-cyclooctyl pyrazole cannabinoid modulators
US8378096B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
US8378117B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
RS51298B (sr) * 2005-09-23 2010-12-31 Janssen Pharmaceutica N.V. Modulatori heksahidro-ciklooktil pirazol kanabinoida
DK1937259T3 (da) * 2005-09-23 2012-02-13 Janssen Pharmaceutica Nv Hexahydro-cycloheptapyrazol-cannabinoid-modulatorer
EP1937646A1 (fr) 2005-09-23 2008-07-02 Janssen Pharmaceutica N.V. Modulateurs cannabinoïdes de type tétrahydrocyclopentylpyrazole
US20070117858A1 (en) * 2005-11-23 2007-05-24 Mingde Xia Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators
US7526911B2 (en) * 2006-02-03 2009-05-05 Rolls-Royce Corporation Gas turbine engine fuel system with fuel metering valve
WO2007095513A1 (fr) * 2006-02-14 2007-08-23 Janssen Pharmaceutica, Nv Modulateurs cannabinoides de type tetrahydro-2h-indazole pyrazole
WO2007112402A1 (fr) * 2006-03-27 2007-10-04 Janssen Pharmaceutica N.V. Modulateurs cannabinoïdes de type tétrahydro-1h-1,2,6-triazaazulènes
US20070254911A1 (en) * 2006-03-27 2007-11-01 Mingde Xia Tetrahydro-Pyrazolo[3,4-c]Pyridine Cannabinoid Modulators
WO2007122638A2 (fr) * 2006-04-26 2007-11-01 Ratnamani Bio-Chemicals & Pharmaceuticals Pvt. Ltd. Procede ameliore de preparation d'intermediaires de lamotrigine
DE602007003830D1 (de) * 2006-05-31 2010-01-28 Calaire Chimie Sas Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchlorid
GB0613836D0 (en) * 2006-07-13 2006-08-23 Univ Greenwich New medical use of triazine derivatives
US20120142919A1 (en) 2006-08-02 2012-06-07 Medichem, S.A. Method for synthesizing lamotrigine
CA2659290A1 (fr) * 2006-08-14 2008-02-21 Jean-Paul Roduit Procede de preparation de lamotrigine
WO2008090114A1 (fr) 2007-01-24 2008-07-31 Glaxo Group Limited Compositions pharmaceutiques contenant du 2-méthoxy-5- (5-trifluorométhyl-tétrazol-i-yl-benzyl) - (2s-phényl-pipéridin-3s-yl-)
US7943653B2 (en) * 2007-08-13 2011-05-17 Janssen Pharmaceutica N.V. Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators
US20090076010A1 (en) * 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched lamotrigine
US8486927B2 (en) * 2007-11-09 2013-07-16 Thar Pharmaceuticals Crystalline forms of lamotrigine
GB0800741D0 (en) * 2008-01-16 2008-02-20 Univ Greenwich Cyclic triazo and diazo sodium channel blockers
US20100190752A1 (en) * 2008-09-05 2010-07-29 Gruenenthal Gmbh Pharmaceutical Combination
MX2011012044A (es) 2009-05-13 2011-12-14 Nektar Therapeutics Compuestos de triazina aromatica sustituida que contienen oligomeros.
US20100297195A1 (en) 2009-05-20 2010-11-25 Ranbaxy Laboratories Limited Controlled release lamotrigine formulations
GB2471729A (en) 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
GB2471713A (en) 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
US20110052686A1 (en) 2009-09-03 2011-03-03 Ranbaxy Laboratories Limited Modified release lamotrigine tablets
GB201111712D0 (en) 2011-07-08 2011-08-24 Gosforth Ct Holdings Pty Ltd Pharmaceutical compositions
WO2013183985A1 (fr) 2012-06-05 2013-12-12 Erasmus University Medical Center Rotterdam Procédé de traitement d'un trouble cognitif et composés pour l'utiliser
US10189859B2 (en) 2013-12-21 2019-01-29 Nektar Therapeutics Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine
WO2016198878A1 (fr) 2015-06-12 2016-12-15 University Of Greenwich Dérivés de triazine en tant qu'inhibiteurs de l'interféron gamma
PT3554490T (pt) 2016-12-16 2022-03-17 Idorsia Pharmaceuticals Ltd Combinação farmacêutica compreendendo um bloqueador de canais de cálcio de tipo t
TWI826531B (zh) 2018-09-21 2023-12-21 南韓商愛思開生物製藥股份有限公司 具有㗁二唑之化合物及包含該化合物之醫藥組合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
BE663481A (fr) * 1964-05-05
BE722109A (fr) * 1967-10-12 1969-04-10
GB1223491A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
IT1145308B (it) * 1979-08-16 1986-11-05 Wellcome Found Composti aromatici sostituiti

Also Published As

Publication number Publication date
NL950007I1 (nl) 1995-06-16
ZW12980A1 (en) 1982-01-06
GEP19960470B (en) 1996-08-29
AU5890680A (en) 1980-12-04
EP0021121B1 (fr) 1983-05-11
DK153787B (da) 1988-09-05
MX9202962A (es) 1992-07-01
UA5576A1 (uk) 1994-12-28
IE49823B1 (en) 1985-12-25
EP0021121A1 (fr) 1981-01-07
PL124029B1 (en) 1982-12-31
ES8104993A1 (es) 1981-05-16
FI67844B (fi) 1985-02-28
EP0059987B1 (fr) 1985-08-14
DK153787C (da) 1989-01-16
SU1055331A3 (ru) 1983-11-15
IL60201A (en) 1984-05-31
YU145680A (en) 1983-02-28
AU566870B2 (en) 1987-11-05
IL60201A0 (en) 1980-07-31
BG60427B2 (bg) 1995-03-31
AU530999B2 (en) 1983-08-04
CZ384891A3 (en) 1993-10-13
IT8048848A0 (it) 1980-05-30
ES491998A0 (es) 1981-05-16
NZ193890A (en) 1984-07-06
JPS6133163A (ja) 1986-02-17
JPH0144179B2 (fr) 1989-09-26
MY8500062A (en) 1985-12-31
FI67844C (fi) 1985-06-10
IE801126L (en) 1980-12-01
JPH0144706B2 (fr) 1989-09-29
NL950007I2 (nl) 1997-02-03
IT1147087B (it) 1986-11-19
AR227521A1 (es) 1982-11-15
FI801758A (fi) 1980-12-02
DD151309A5 (de) 1981-10-14
CA1112643A (fr) 1981-11-17
PL224633A1 (fr) 1981-02-13
AT370097B (de) 1983-02-25
HU182086B (en) 1983-12-28
US4602017A (en) 1986-07-22
US4486354A (en) 1984-12-04
ATA289680A (de) 1982-07-15
GR68380B (fr) 1981-12-28
EP0059987A1 (fr) 1982-09-15
JPS5625169A (en) 1981-03-10
DK233880A (da) 1980-12-02
CS234018B2 (en) 1985-03-14

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