ZA782816B - Therapeutic agents - Google Patents
Therapeutic agentsInfo
- Publication number
- ZA782816B ZA782816B ZA00782816A ZA782816A ZA782816B ZA 782816 B ZA782816 B ZA 782816B ZA 00782816 A ZA00782816 A ZA 00782816A ZA 782816 A ZA782816 A ZA 782816A ZA 782816 B ZA782816 B ZA 782816B
- Authority
- ZA
- South Africa
- Prior art keywords
- therapeutic agents
- therapeutic
- agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/800,264 US4122274A (en) | 1977-05-25 | 1977-05-25 | 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA782816B true ZA782816B (en) | 1979-05-30 |
Family
ID=25177928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA00782816A ZA782816B (en) | 1977-05-25 | 1978-05-17 | Therapeutic agents |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4122274A (no) |
| JP (1) | JPS6050197B2 (no) |
| AT (1) | AT365187B (no) |
| AU (1) | AU521211B2 (no) |
| BE (1) | BE867295A (no) |
| CA (1) | CA1098520A (no) |
| CH (1) | CH642656A5 (no) |
| CY (1) | CY1218A (no) |
| DE (1) | DE2822544A1 (no) |
| DK (1) | DK160279C (no) |
| FI (1) | FI64594C (no) |
| FR (1) | FR2401159A1 (no) |
| GB (1) | GB1596476A (no) |
| GR (1) | GR71887B (no) |
| HK (1) | HK25884A (no) |
| IE (1) | IE46849B1 (no) |
| IT (1) | IT1105040B (no) |
| KE (1) | KE3357A (no) |
| LU (1) | LU79694A1 (no) |
| MY (1) | MY8500305A (no) |
| NL (1) | NL190702C (no) |
| NO (1) | NO150361C (no) |
| SE (1) | SE437830B (no) |
| SG (1) | SG73383G (no) |
| YU (2) | YU42163B (no) |
| ZA (1) | ZA782816B (no) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4495189A (en) * | 1975-11-27 | 1985-01-22 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | Condensed pyrimidines |
| HU173438B (hu) * | 1975-11-27 | 1979-05-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom |
| HU180439B (en) * | 1977-12-29 | 1983-03-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 9-amino-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives |
| US4192944A (en) * | 1978-04-03 | 1980-03-11 | Bristol-Myers Company | Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents |
| US4223031A (en) * | 1978-05-05 | 1980-09-16 | Mead Johnson & Company | Azolopyrimidinones |
| US4491587A (en) * | 1978-05-05 | 1985-01-01 | Mead Johnson & Company | Tetrazole derivatives |
| US4282360A (en) * | 1979-10-12 | 1981-08-04 | Hoffmann-La Roche Inc. | 7-Methylthio or methylsulfinyl-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid |
| US4419357A (en) * | 1982-01-18 | 1983-12-06 | The Dow Chemical Company | 3-(1H-Tetrazol-5-yl)-4(3H)-quinazolinones |
| US4476130A (en) * | 1982-09-09 | 1984-10-09 | Riker Laboratories, Inc. | 3-(1H-Tetrazol-5-yl)-4H-pyrimido[2,1-b]benzoxazol-4-one compounds exhibiting anti-allergic activity |
| US4474953A (en) * | 1982-09-09 | 1984-10-02 | Riker Laboratories, Inc. | Process and intermediates for the preparation of 3(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-ones |
| US4507477A (en) * | 1982-09-09 | 1985-03-26 | Riker Laboratories, Inc. | Process for tetrazolyl-pyrimidinone derivatives |
| US4457932A (en) * | 1983-07-22 | 1984-07-03 | Bristol-Myers Company | Anti-ulcer agents |
| DK169580B1 (da) * | 1985-09-25 | 1994-12-12 | Shionogi & Co | 9-(substitueret thio)-4H-pyrido[1,2-a]pyrimidin-4-on-derivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende sådanne derivater |
| JPS63183581A (ja) * | 1985-10-03 | 1988-07-28 | Tokyo Tanabe Co Ltd | ピリド〔１，２−ａ〕ピリミジン誘導体、その製造法及びそれを有効成分とするアレルギ−疾患治療薬 |
| JPS62242682A (ja) * | 1986-04-16 | 1987-10-23 | Tokyo Tanabe Co Ltd | 新規なピリド［１，２―ａ］ピリミジン誘導体及びその製造法 |
| JP2504788B2 (ja) * | 1987-11-10 | 1996-06-05 | 東京田辺製薬株式会社 | ９−メチル−３−（１Ｈ−テトラゾ―ル−５−イル）−４Ｈ−ピリド［１，２−ａ］ピリミジン−４−オンカリウム塩の水性製剤 |
| US5034230A (en) * | 1987-12-25 | 1991-07-23 | Santen Pharmaceutical Co., Ltd. | Anti-allergic ophthalmics |
| CA2010336C (en) * | 1989-02-27 | 1996-11-19 | Atsunori Sano | Process for producing pyrido[1,2-a]pyrimidine derivative |
| HU209793B (en) * | 1990-09-25 | 1994-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for the production of pyrido[1,2-a]pyrimidine-derivatives and pharmaceutical compositions containing the same |
| AU674016B2 (en) | 1992-07-30 | 1996-12-05 | Mitsubishi-Tokyo Pharmaceuticals, Inc. | Remedy for inflammatory intestinal diseases |
| US5527802A (en) * | 1992-10-01 | 1996-06-18 | Bristol-Myers Squibb Company | New uses of 3-tetrazolo -5,6,7,8- substituted-pyrido (1,2-a) pyrimidin-4-ones |
| JPH0892093A (ja) * | 1994-11-10 | 1996-04-09 | Tokyo Tanabe Co Ltd | ９−メチル−３−（１Ｈ−テトラゾール−５−イル）−４Ｈ−ピリド［１，２−ａ］ピリミジン−４−オンの水性製剤 |
| JP4171303B2 (ja) * | 2001-02-26 | 2008-10-22 | 田辺三菱製薬株式会社 | 腎疾患・腎不全の予防剤及び／又は治療剤 |
| ITMI20011764A1 (it) * | 2001-08-10 | 2003-02-10 | Dinamite Dipharma Spa | Metodo per l'ottenimento del pemirolast ad elevata purezza |
| GB0316546D0 (en) * | 2003-07-15 | 2003-08-20 | Novartis Ag | Process for the manufacture of organic compounds |
| MX2009006507A (es) * | 2006-12-18 | 2009-08-18 | Cardoz Ab | Nueva combinacion para usarse en el tratamiento de trastornos inflamatorios. |
| ATE543501T1 (de) * | 2006-12-20 | 2012-02-15 | Cardoz Ab | Kombination von pemirolast und ramatroban zur verwendung bei der behandlung von entzündlichen erkrankungen |
| US20100184783A1 (en) * | 2007-07-11 | 2010-07-22 | Johan Raud | Combination for use in the treatment of inflammatory atherosclerosis comprising a mast cell inhibitor and a ppar gamma agonist |
| WO2009007675A2 (en) * | 2007-07-11 | 2009-01-15 | Cardoz Ab | Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and a p2 gamma 12 antagonist |
| WO2009007679A2 (en) * | 2007-07-11 | 2009-01-15 | Cardoz Ab | Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and a thromboxane a2 antagonist |
| EP2303251B1 (en) * | 2008-04-07 | 2012-05-16 | Cardoz AB | New combination for use in the treatment of inflammatory disorders |
| US20120157415A1 (en) * | 2009-06-16 | 2012-06-21 | Cardoz Ab | New Crystalline Form of Pemirolast |
| USD661900S1 (en) | 2010-02-22 | 2012-06-19 | Bajer Design & Marketing, Inc. | Collapsible structure |
| PE20142364A1 (es) * | 2012-02-10 | 2015-01-10 | Hoffmann La Roche | Compuestos para tratar atrofia muscular espinal |
| KR102099997B1 (ko) | 2012-03-01 | 2020-04-13 | 피티씨 테라퓨틱스, 인크. | 척수성 근위축증을 치료하기 위한 화합물 |
| EA028382B1 (ru) | 2012-03-23 | 2017-11-30 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Соединения для лечения спинальной мышечной атрофии |
| EP3082820B1 (en) | 2013-12-19 | 2022-07-20 | PTC Therapeutics, Inc. | Methods for modulating the amount of rna transcripts |
| WO2016063085A1 (en) | 2014-10-23 | 2016-04-28 | Rspr Pharma Ab | Use of pemirolast in the treatment of acute asthma |
| WO2016102941A1 (en) | 2014-12-22 | 2016-06-30 | Rspr Pharma Ab | New combination of pemirolast and montelukast |
| EP3298017B1 (en) * | 2015-05-20 | 2019-08-14 | H. Hoffnabb-La Roche Ag | Compounds for treating spinal muscular atrophy |
| EP4249472A3 (en) | 2015-05-30 | 2023-12-13 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| GB201518831D0 (en) | 2015-10-23 | 2015-12-09 | Rspr Pharma Ab | New use |
| IL281633B (en) | 2015-12-10 | 2022-07-01 | Ptc Therapeutics Inc | Methods for treating Huntington's disease |
| GB201601138D0 (en) * | 2016-01-21 | 2016-03-09 | Rspr Pharma Ab | New use |
| EP3544435A4 (en) | 2016-11-28 | 2020-11-04 | PTC Therapeutics, Inc. | RNA SPLICE MODULATION PROCESSES |
| EP3634953B1 (en) | 2017-06-05 | 2024-01-03 | PTC Therapeutics, Inc. | Compounds for treating huntington's disease |
| CN111372611A (zh) | 2017-06-14 | 2020-07-03 | Ptc医疗公司 | 修饰rna剪接的方法 |
| US11395822B2 (en) | 2017-06-28 | 2022-07-26 | Ptc Therapeutics, Inc. | Methods for treating Huntington's disease |
| CA3067591A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Methods for treating huntington's disease |
| CA3094703A1 (en) | 2018-03-27 | 2019-10-03 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| WO2020005873A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heterocyclic and heteroaryl compounds for treating huntington's disease |
| US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3072485A (en) * | 1960-08-24 | 1963-01-08 | Eastman Kodak Co | Optically sensitized azido polymers for photomechanical resist compositions |
| AT286990B (de) * | 1966-11-02 | 1971-01-11 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung von neuen Homopyrimidazol-Derivaten sowie von deren Salzen |
| US3960847A (en) * | 1972-04-17 | 1976-06-01 | E. R. Squibb & Sons, Inc. | 9-Substituted-4-oxopyrido(1,2-α)pyrimidine-3-carboxylic acids and derivatives thereof |
| US3929787A (en) * | 1974-04-22 | 1975-12-30 | Squibb & Sons Inc | 6,7,8,9-Tetrahydro-pyrido(1,2-a)pyrimidin-4-ones |
| US3960863A (en) * | 1974-06-25 | 1976-06-01 | Sankyo Company Limited | Pyrido[1,2-a]pyrimidinone derivatives |
| US4017625A (en) * | 1975-08-01 | 1977-04-12 | Pfizer Inc. | Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor |
| US4012387A (en) * | 1975-09-18 | 1977-03-15 | Warner-Lambert Company | Benzo-[g]pyrido[2,1-b]quinazolinones |
-
1977
- 1977-05-25 US US05/800,264 patent/US4122274A/en not_active Expired - Lifetime
-
1978
- 1978-05-15 GR GR56238A patent/GR71887B/el unknown
- 1978-05-17 ZA ZA00782816A patent/ZA782816B/xx unknown
- 1978-05-19 CA CA303,794A patent/CA1098520A/en not_active Expired
- 1978-05-19 BE BE187888A patent/BE867295A/xx not_active IP Right Cessation
- 1978-05-22 NL NL7805534A patent/NL190702C/xx not_active IP Right Cessation
- 1978-05-22 AU AU36319/78A patent/AU521211B2/en not_active Expired
- 1978-05-22 FI FI781614A patent/FI64594C/fi not_active IP Right Cessation
- 1978-05-23 DE DE19782822544 patent/DE2822544A1/de active Granted
- 1978-05-23 LU LU79694A patent/LU79694A1/xx unknown
- 1978-05-23 AT AT0373278A patent/AT365187B/de not_active IP Right Cessation
- 1978-05-23 DK DK228878A patent/DK160279C/da active
- 1978-05-23 NO NO781786A patent/NO150361C/no unknown
- 1978-05-24 IE IE1036/78A patent/IE46849B1/en not_active IP Right Cessation
- 1978-05-24 CY CY1218A patent/CY1218A/xx unknown
- 1978-05-24 YU YU1236/78A patent/YU42163B/xx unknown
- 1978-05-24 FR FR7815398A patent/FR2401159A1/fr active Granted
- 1978-05-24 IT IT49523/78A patent/IT1105040B/it active
- 1978-05-24 SE SE7805954A patent/SE437830B/sv not_active IP Right Cessation
- 1978-05-24 GB GB22090/78A patent/GB1596476A/en not_active Expired
- 1978-05-25 CH CH572378A patent/CH642656A5/de not_active IP Right Cessation
- 1978-05-25 JP JP53061768A patent/JPS6050197B2/ja not_active Expired
-
1982
- 1982-10-15 YU YU2330/82A patent/YU44212B/xx unknown
-
1983
- 1983-11-25 SG SG733/83A patent/SG73383G/en unknown
- 1983-12-15 KE KE3357A patent/KE3357A/xx unknown
-
1984
- 1984-03-22 HK HK258/84A patent/HK25884A/xx not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY305/85A patent/MY8500305A/xx unknown
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