ZA201404675B - Anti-lrp5 antibodies and methods of use - Google Patents
Anti-lrp5 antibodies and methods of useInfo
- Publication number
- ZA201404675B ZA201404675B ZA2014/04675A ZA201404675A ZA201404675B ZA 201404675 B ZA201404675 B ZA 201404675B ZA 2014/04675 A ZA2014/04675 A ZA 2014/04675A ZA 201404675 A ZA201404675 A ZA 201404675A ZA 201404675 B ZA201404675 B ZA 201404675B
- Authority
- ZA
- South Africa
- Prior art keywords
- methods
- lrp5 antibodies
- lrp5
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Ophthalmology & Optometry (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261588100P | 2012-01-18 | 2012-01-18 | |
| PCT/US2013/022045 WO2013109819A1 (en) | 2012-01-18 | 2013-01-18 | Anti-lrp5 antibodies and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201404675B true ZA201404675B (en) | 2016-11-30 |
Family
ID=47604271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2014/04675A ZA201404675B (en) | 2012-01-18 | 2014-06-25 | Anti-lrp5 antibodies and methods of use |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US9200072B2 (https=) |
| EP (1) | EP2804629A1 (https=) |
| JP (1) | JP6242813B2 (https=) |
| KR (1) | KR20140116490A (https=) |
| CN (1) | CN104066449B (https=) |
| AR (1) | AR089752A1 (https=) |
| AU (1) | AU2013209707A1 (https=) |
| BR (1) | BR112014017518A2 (https=) |
| CA (1) | CA2862422A1 (https=) |
| CL (1) | CL2014001888A1 (https=) |
| CO (1) | CO7000747A2 (https=) |
| CR (1) | CR20140382A (https=) |
| EA (1) | EA028202B1 (https=) |
| IL (1) | IL233317A0 (https=) |
| IN (1) | IN2014DN05885A (https=) |
| MA (1) | MA35898B1 (https=) |
| MX (1) | MX2014008157A (https=) |
| NZ (1) | NZ626520A (https=) |
| PE (1) | PE20141561A1 (https=) |
| PH (1) | PH12014501605A1 (https=) |
| SG (2) | SG11201404198TA (https=) |
| TW (1) | TW201335187A (https=) |
| WO (1) | WO2013109819A1 (https=) |
| ZA (1) | ZA201404675B (https=) |
Families Citing this family (23)
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| SG193209A1 (en) * | 2008-09-10 | 2013-09-30 | Genentech Inc | Methods for inhibiting ocular angiogenesis |
| JP5861469B2 (ja) * | 2012-01-23 | 2016-02-16 | 日本電気硝子株式会社 | ガラス管の清浄切断装置と清浄切断方法 |
| CN106488775A (zh) | 2014-07-11 | 2017-03-08 | 基因泰克公司 | Notch途径抑制 |
| AU2015314771B2 (en) | 2014-09-12 | 2021-04-01 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt signaling agonist molecules |
| KR20180063885A (ko) * | 2015-09-24 | 2018-06-12 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 전이 감소를 위한 방법 및 조성물 |
| CN106367517A (zh) * | 2016-09-28 | 2017-02-01 | 湖北工业大学 | 一种低密度脂蛋白受体相关蛋白5基因突变检测的试剂及应用 |
| WO2018204909A2 (en) * | 2017-05-05 | 2018-11-08 | Wendelin Dailey | Norrin induced expression of genes and use thereof to treat disease |
| EP3630816B1 (en) | 2017-05-31 | 2024-03-20 | Boehringer Ingelheim International GmbH | Polypeptides antagonizing wnt signaling in tumor cells |
| CN117946267A (zh) | 2017-12-19 | 2024-04-30 | 瑟罗泽恩奥普瑞汀公司 | 抗卷曲蛋白抗体和使用方法 |
| CN111699003B (zh) | 2017-12-19 | 2024-05-03 | 瑟罗泽恩奥普瑞汀公司 | 抗lrp5/6抗体和使用方法 |
| US11773171B2 (en) | 2017-12-19 | 2023-10-03 | Surrozen Operating, Inc. | WNT surrogate molecules and uses thereof |
| EP3731864A1 (en) * | 2017-12-29 | 2020-11-04 | F. Hoffmann-La Roche SA | Anti-vegf antibodies and methods of use |
| JP7550647B2 (ja) | 2018-02-14 | 2024-09-20 | アントレラ セラピューティクス インコーポレイテッド | Ｗｎｔシグナル伝達を活性化する多価結合分子およびその使用 |
| JP7840842B2 (ja) * | 2019-08-14 | 2026-04-06 | アントレラ セラピューティクス インコーポレイテッド | Ｌｒｐ５タンパク質に結合する抗体および使用方法 |
| JP2023529557A (ja) * | 2020-05-04 | 2023-07-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 抗ｅｎｐｐ１抗体の阻害 |
| CN111909935B (zh) * | 2020-07-17 | 2022-11-15 | 武汉纽福斯生物科技有限公司 | 重组人卷曲蛋白受体4(fzd4)的表达载体及其应用 |
| KR102536092B1 (ko) * | 2020-09-29 | 2023-05-24 | 조선대학교산학협력단 | Lrp5 발현 또는 활성 억제제를 포함하는 허혈성 심장질환의 예방 또는 치료용 약학적 조성물 |
| CA3204321A1 (en) | 2020-12-18 | 2022-06-23 | Antlera Therapeutics Inc. | Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof |
| WO2023250402A2 (en) * | 2022-06-22 | 2023-12-28 | Antlera Therapeutics Inc. | Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| CN118599000A (zh) * | 2024-05-11 | 2024-09-06 | 中山大学附属第三医院 | Lrp5作为靶向分子在治疗糖尿病肾病中的应用 |
| US20260092125A1 (en) | 2024-09-06 | 2026-04-02 | Eyebiotech Limited | Multivalent fzd4, wnt co-receptor, and vegf binding molecules and uses thereof |
| WO2026055308A1 (en) | 2024-09-06 | 2026-03-12 | Merck Sharp & Dohme Llc | Multivalent fzd4, wnt co-receptor, and vegf receptor molecules and uses thereof |
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