ZA201208544B - 5,7-substitute-imidazo [1,2-c] pyrimidines as inhibitors of jak kinases - Google Patents
5,7-substitute-imidazo [1,2-c] pyrimidines as inhibitors of jak kinasesInfo
- Publication number
- ZA201208544B ZA201208544B ZA2012/08544A ZA201208544A ZA201208544B ZA 201208544 B ZA201208544 B ZA 201208544B ZA 2012/08544 A ZA2012/08544 A ZA 2012/08544A ZA 201208544 A ZA201208544 A ZA 201208544A ZA 201208544 B ZA201208544 B ZA 201208544B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrimidines
- imidazo
- substitute
- inhibitors
- jak kinases
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32418610P | 2010-04-14 | 2010-04-14 | |
| PCT/US2011/031896 WO2011130146A1 (en) | 2010-04-14 | 2011-04-11 | 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of jak kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201208544B true ZA201208544B (en) | 2015-04-29 |
Family
ID=43984073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2012/08544A ZA201208544B (en) | 2010-04-14 | 2012-11-13 | 5,7-substitute-imidazo [1,2-c] pyrimidines as inhibitors of jak kinases |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8962596B2 (enExample) |
| EP (1) | EP2558468B1 (enExample) |
| JP (2) | JP2013523884A (enExample) |
| KR (1) | KR20130094710A (enExample) |
| CN (1) | CN102985424B (enExample) |
| AR (1) | AR081075A1 (enExample) |
| AU (1) | AU2011240808B2 (enExample) |
| CA (1) | CA2796388A1 (enExample) |
| CL (1) | CL2012002882A1 (enExample) |
| CO (1) | CO6630187A2 (enExample) |
| CR (1) | CR20120572A (enExample) |
| MX (1) | MX2012011941A (enExample) |
| NZ (1) | NZ603446A (enExample) |
| PH (1) | PH12012502046A1 (enExample) |
| RU (1) | RU2012148246A (enExample) |
| SG (1) | SG184870A1 (enExample) |
| TW (1) | TWI494314B (enExample) |
| UA (1) | UA109131C2 (enExample) |
| UY (1) | UY33328A (enExample) |
| WO (1) | WO2011130146A1 (enExample) |
| ZA (1) | ZA201208544B (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA116187C2 (uk) | 2005-12-13 | 2018-02-26 | Інсайт Холдінгс Корпорейшн | ГЕТЕРОАРИЛЗАМІЩЕНІ ПІРОЛО[2,3-b]ПІРИДИНИ Й ПІРОЛО[2,3-b]ПІРИМІДИНИ ЯК ІНГІБІТОРИ ЯНУС-КІНАЗИ |
| WO2008157208A2 (en) | 2007-06-13 | 2008-12-24 | Incyte Corporation | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| PE20120371A1 (es) | 2009-05-22 | 2012-05-17 | Incyte Corp | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4il)-1h-pirazol-1-il]octano o heptano-nitrilo como inhibidores de jak |
| EP2432555B1 (en) | 2009-05-22 | 2014-04-30 | Incyte Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| PL2442809T3 (pl) | 2009-06-17 | 2017-02-28 | Vertex Pharmaceuticals Incorporated | Inhibitory replikacji wirusów grypy |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| DK3354652T3 (da) | 2010-03-10 | 2020-05-18 | Incyte Holdings Corp | Piperidin-4-yl azetidinderivativer som jak1-inhibitorer |
| PE20130216A1 (es) | 2010-05-21 | 2013-02-27 | Incyte Corp | Formulacion topica para un inhibidor de jak |
| PH12013501001A1 (en) | 2010-11-19 | 2019-09-02 | Incyte Holdings Corp | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| EP2640725B1 (en) | 2010-11-19 | 2015-01-07 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
| AU2011343642A1 (en) | 2010-12-16 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| AR086983A1 (es) | 2011-06-20 | 2014-02-05 | Incyte Corp | Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| AU2012323399A1 (en) * | 2011-10-12 | 2014-05-29 | Array Biopharma Inc. | 5,7-substituted-imidazo[1,2-c]pyrimidines |
| WO2013070606A1 (en) * | 2011-11-07 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Methods for treating inflammatory diseases and pharmaceutical combinations useful therefor |
| AR091079A1 (es) | 2012-05-18 | 2014-12-30 | Incyte Corp | Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak |
| EP2912031B1 (en) | 2012-10-24 | 2017-05-31 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| NZ708157A (en) | 2012-11-15 | 2019-07-26 | Incyte Holdings Corp | Sustained-release dosage forms of ruxolitinib |
| WO2014118388A1 (en) | 2013-02-04 | 2014-08-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for assaying jak2 activity in red blood cells and uses thereof |
| SMT201900081T1 (it) * | 2013-03-06 | 2019-05-10 | Incyte Holdings Corp | Procedimenti e intermedi per produrre un inibitore di jak |
| WO2014146249A1 (en) | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors |
| US9637483B2 (en) | 2013-03-28 | 2017-05-02 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2014172639A1 (en) * | 2013-04-19 | 2014-10-23 | Ruga Corporation | Raf kinase inhibitors |
| PE20200527A1 (es) | 2013-05-17 | 2020-03-09 | Incyte Corp | Derivados del bipirazol como inhibidores jak |
| HRP20200955T1 (hr) | 2013-08-07 | 2020-10-02 | Incyte Corporation | Dozni oblici s produženim oslobađanjem za jak1 inhibitor |
| EP3421468B1 (en) | 2013-11-13 | 2020-11-04 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| LT3068776T (lt) | 2013-11-13 | 2019-08-12 | Vertex Pharmaceuticals Incorporated | Gripo virusų replikacijos inhibitoriai |
| WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| USRE49517E1 (en) | 2014-08-15 | 2023-05-02 | Janssen Pharmaceuticals, Inc. | Pyrazoles |
| RU2021102805A (ru) | 2014-12-05 | 2021-02-12 | Эррэй Биофарма Инк. | 4,6-ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ |
| CN105777754B (zh) * | 2014-12-16 | 2019-07-26 | 北京赛林泰医药技术有限公司 | 吡咯并嘧啶化合物 |
| ES2962330T3 (es) | 2015-01-20 | 2024-03-18 | Wuxi Fortune Pharmaceutical Co Ltd | Inhibidor de jak |
| PL3290418T3 (pl) * | 2015-04-29 | 2019-11-29 | Wuxi Fortune Pharmaceutical Co Ltd | Inhibitory kinaz janusowych (jak) |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| PT3305788T (pt) | 2015-05-29 | 2020-09-25 | Wuxi Fortune Pharmaceutical Co Ltd | Inibidor da janus cinase |
| AR104918A1 (es) * | 2015-06-19 | 2017-08-23 | Lilly Co Eli | Procesos e intermediarios para la preparación de {1-(etilsulfonil)-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrilo |
| CN105294699B (zh) * | 2015-12-04 | 2019-06-11 | 上海勋和医药科技有限公司 | 巴瑞替尼的制备方法 |
| EP3409673B1 (en) | 2016-01-26 | 2021-06-16 | Hangzhou Bangshun Pharmaceutical Co., Ltd. | Pyrrolopyrimidine five-membered azacyclic derivative and application thereof |
| AU2017222417B2 (en) | 2016-02-24 | 2020-07-09 | Pfizer Inc. | Pyrazolo[1,5-a]pyrazin-4-yl derivatives as JAK-inhibitors |
| KR102485731B1 (ko) | 2017-01-23 | 2023-01-05 | 상하이 롱우드 바이오파마슈티칼스 컴퍼니 리미티드 | Jak 효소 억제제 및 이의 제조 방법과 용도 |
| WO2018167283A1 (en) | 2017-03-17 | 2018-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling |
| US20200088732A1 (en) | 2017-04-13 | 2020-03-19 | INSERM (Institut National de la Santé et de la Recherche Mèdicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma |
| JP7365332B2 (ja) | 2017-08-07 | 2023-10-19 | ジョイント・ストック・カンパニー “バイオキャド” | Ｃｄｋ８／１９阻害薬としての新規ヘテロ環式化合物 |
| US11254668B2 (en) | 2017-08-14 | 2022-02-22 | Pfizer Inc. | Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives |
| AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
| IL276302B2 (en) | 2018-01-30 | 2023-11-01 | Incyte Corp | Procedures for preparing [1-(3-fluoro-2-(trifluoromethyl(isonicotinyl}piperidine-4-one) |
| KR20240157777A (ko) | 2018-02-16 | 2024-11-01 | 인사이트 코포레이션 | 사이토카인-관련 장애의 치료를 위한 jak1 경로 억제제 |
| EP4424328A3 (en) | 2018-03-30 | 2024-12-04 | Incyte Corporation | Treatment of hidradenitis suppurativa using jak inhibitors |
| US20220041588A1 (en) * | 2018-09-27 | 2022-02-10 | Fochon Pharmaceuticals, Ltd. | Substituted imidazo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine compounds as ret kinase inhibitors |
| TWI721624B (zh) | 2018-10-31 | 2021-03-11 | 美商基利科學股份有限公司 | 經取代之6-氮雜苯并咪唑化合物 |
| ES2979163T3 (es) | 2018-10-31 | 2024-09-24 | Gilead Sciences Inc | Compuestos de 6-azabenzimidazol sustituidos como inhibidores de HPK1 |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| CN111320624B (zh) * | 2018-12-14 | 2023-05-12 | 中国医药研究开发中心有限公司 | 三唑并吡啶类和咪唑并吡啶类化合物及其制备方法和医药用途 |
| ES2981909T3 (es) * | 2019-04-12 | 2024-10-11 | Primegene Beijing Co Ltd | Compuestos derivados de pirazolopirazina, composición farmacéutica y utilización de los mismos |
| US11453681B2 (en) | 2019-05-23 | 2022-09-27 | Gilead Sciences, Inc. | Substituted eneoxindoles and uses thereof |
| CN111039963B (zh) * | 2019-12-31 | 2021-03-19 | 卓和药业集团有限公司 | Wxfl10203614水溶性类似物及其合成方法 |
| BR112022024632A2 (pt) | 2020-06-02 | 2023-02-28 | Incyte Corp | Processos para preparar um inibidor de jak1 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| EP3944859A1 (en) | 2020-07-30 | 2022-02-02 | Assistance Publique Hôpitaux de Paris | Method for treating immune toxicities induced by immune checkpoint inhibitors |
| US11957661B2 (en) | 2020-12-08 | 2024-04-16 | Incyte Corporation | JAK1 pathway inhibitors for the treatment of vitiligo |
| CA3219092A1 (en) | 2021-05-03 | 2022-11-10 | Incyte Corporation | Jak1 pathway inhibitors for the treatment of prurigo nodularis |
| US20250011332A1 (en) * | 2021-11-12 | 2025-01-09 | Soter Biopharma Pte. Ltd. | Pyrazolo fused ring compound and use thereof |
| US20250263409A1 (en) * | 2022-04-25 | 2025-08-21 | Eli Lilly And Company | Fgfr2 inhibitor compounds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728536A (en) | 1993-07-29 | 1998-03-17 | St. Jude Children's Research Hospital | Jak kinases and regulation of Cytokine signal transduction |
| HUP0103386A3 (en) | 1998-08-21 | 2002-07-29 | Parker Hughes Inst St Paul | Use of quinazoline derivatives for producing pharmaceutical compositions having jak 3-inhibitor effect |
| JP2001302667A (ja) * | 2000-04-28 | 2001-10-31 | Bayer Ag | イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体 |
| WO2006044687A2 (en) * | 2004-10-15 | 2006-04-27 | Takeda San Diego, Inc. | Kinase inhibitors |
| UA116187C2 (uk) | 2005-12-13 | 2018-02-26 | Інсайт Холдінгс Корпорейшн | ГЕТЕРОАРИЛЗАМІЩЕНІ ПІРОЛО[2,3-b]ПІРИДИНИ Й ПІРОЛО[2,3-b]ПІРИМІДИНИ ЯК ІНГІБІТОРИ ЯНУС-КІНАЗИ |
| AU2007323725B2 (en) * | 2006-11-22 | 2014-02-20 | Incyte Holdings Corporation | Imidazotriazines and imidazopyrimidines as kinase inhibitors |
| DE102007012645A1 (de) * | 2007-03-16 | 2008-09-18 | Bayer Healthcare Ag | Substituierte Imidazo- und Triazolopyrimidine |
| CL2008001709A1 (es) * | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| NZ587928A (en) | 2008-03-11 | 2012-08-31 | Incyte Corp | Azetidine and cyclobutane derivatives as jak inhibitors |
| JOP20190231A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
-
2011
- 2011-04-11 CN CN201180029128.5A patent/CN102985424B/zh not_active Expired - Fee Related
- 2011-04-11 AU AU2011240808A patent/AU2011240808B2/en not_active Ceased
- 2011-04-11 CA CA2796388A patent/CA2796388A1/en not_active Abandoned
- 2011-04-11 EP EP11715818.8A patent/EP2558468B1/en active Active
- 2011-04-11 RU RU2012148246/04A patent/RU2012148246A/ru not_active Application Discontinuation
- 2011-04-11 US US13/640,099 patent/US8962596B2/en not_active Expired - Fee Related
- 2011-04-11 SG SG2012076493A patent/SG184870A1/en unknown
- 2011-04-11 UA UAA201212901A patent/UA109131C2/ru unknown
- 2011-04-11 WO PCT/US2011/031896 patent/WO2011130146A1/en not_active Ceased
- 2011-04-11 KR KR1020127029826A patent/KR20130094710A/ko not_active Withdrawn
- 2011-04-11 PH PH1/2012/502046A patent/PH12012502046A1/en unknown
- 2011-04-11 NZ NZ603446A patent/NZ603446A/en not_active IP Right Cessation
- 2011-04-11 JP JP2013504972A patent/JP2013523884A/ja not_active Ceased
- 2011-04-11 MX MX2012011941A patent/MX2012011941A/es active IP Right Grant
- 2011-04-13 UY UY0001033328A patent/UY33328A/es not_active Application Discontinuation
- 2011-04-13 AR ARP110101268A patent/AR081075A1/es not_active Application Discontinuation
- 2011-04-14 TW TW100113047A patent/TWI494314B/zh not_active IP Right Cessation
-
2012
- 2012-10-12 CL CL2012002882A patent/CL2012002882A1/es unknown
- 2012-11-09 CR CR20120572A patent/CR20120572A/es unknown
- 2012-11-13 CO CO12203751A patent/CO6630187A2/es active IP Right Grant
- 2012-11-13 ZA ZA2012/08544A patent/ZA201208544B/en unknown
-
2015
- 2015-06-26 JP JP2015128369A patent/JP2015205905A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PH12012502046A1 (en) | 2017-07-26 |
| EP2558468B1 (en) | 2015-04-01 |
| NZ603446A (en) | 2014-05-30 |
| CN102985424B (zh) | 2015-03-11 |
| AU2011240808B2 (en) | 2015-01-22 |
| CN102985424A (zh) | 2013-03-20 |
| JP2015205905A (ja) | 2015-11-19 |
| EP2558468A1 (en) | 2013-02-20 |
| TW201134827A (en) | 2011-10-16 |
| US20130131039A1 (en) | 2013-05-23 |
| JP2013523884A (ja) | 2013-06-17 |
| AU2011240808A1 (en) | 2012-11-29 |
| KR20130094710A (ko) | 2013-08-26 |
| SG184870A1 (en) | 2012-11-29 |
| CL2012002882A1 (es) | 2013-02-08 |
| WO2011130146A1 (en) | 2011-10-20 |
| US8962596B2 (en) | 2015-02-24 |
| AR081075A1 (es) | 2012-06-06 |
| TWI494314B (zh) | 2015-08-01 |
| CA2796388A1 (en) | 2011-10-20 |
| RU2012148246A (ru) | 2014-05-20 |
| CO6630187A2 (es) | 2013-03-01 |
| UY33328A (es) | 2012-10-31 |
| UA109131C2 (ru) | 2015-07-27 |
| CR20120572A (es) | 2013-02-20 |
| MX2012011941A (es) | 2013-08-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201208544B (en) | 5,7-substitute-imidazo [1,2-c] pyrimidines as inhibitors of jak kinases | |
| HRP20180829T1 (hr) | Spojevi tioacetata, pripravci i postupci za uporabu | |
| IL252952B (en) | Diaminocarboxamide and diaminocarbonitrile converted pyrimidines, their compositions and methods of treatment | |
| AP3751A (en) | Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines | |
| EP2552208A4 (en) | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS | |
| PL2536722T3 (pl) | Związki bicykliczne i ich zastosowanie jako podwójne inhibitory c-src / jak | |
| ZA201300705B (en) | Inhibitors of bruton's tyrosine kinase | |
| EP2552214A4 (en) | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | |
| ZA201100110B (en) | Pyrimidine compounds,compositions and methods of use | |
| IL207609A0 (en) | Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases | |
| EP2552211A4 (en) | INDAZOLYL-PYRIMIDINE AS KINASEHEMMER | |
| EP2445346A4 (en) | OXOHETEROCYCLIC FUSIONED PYRIMIDINE COMPOUNDS AND COMPOSITIONS AND METHOD FOR THEIR USE | |
| ZA201207636B (en) | Heteroaryl imidazoline derivatives as jak inhibitors | |
| IL220154A0 (en) | Novel pyrimidine compounds as mtor and pi3k inhibitors | |
| IL221311A0 (en) | Inhibitors of protein kinases | |
| ZA201209029B (en) | Novel pyrimidine derivatives | |
| HK1182091A (en) | 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of jak kinases | |
| ZA201209648B (en) | Crystalline forms of kinase inhibitors | |
| ZA201209647B (en) | Crystalline forms of kinase inhibitors | |
| ZA201206945B (en) | Bicyclic compounds and their uses as dual c-src/jak inhibitors | |
| GB201003949D0 (en) | Inhibitors of protein kinases | |
| ZA201105238B (en) | Levelling of supports |