AU2011240808B2 - 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of JAK kinases - Google Patents

5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of JAK kinases Download PDF

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Publication number
AU2011240808B2
AU2011240808B2 AU2011240808A AU2011240808A AU2011240808B2 AU 2011240808 B2 AU2011240808 B2 AU 2011240808B2 AU 2011240808 A AU2011240808 A AU 2011240808A AU 2011240808 A AU2011240808 A AU 2011240808A AU 2011240808 B2 AU2011240808 B2 AU 2011240808B2
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Australia
Prior art keywords
pyrazol
imidazo
pyrimidin
methyl
alkyl
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Ceased
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AU2011240808A1 (en
Inventor
Mark Laurence Boys
Laurence E. Burgess
Robert D. Groneberg
Darren M. Harvey
Lily Huang
Timothy Kercher
Christopher F. Kraser
Ellen Laird
Eugene Tarlton
Qian Zhao
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Array Biopharma Inc
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Array Biopharma Inc
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Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2011240808A 2010-04-14 2011-04-11 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of JAK kinases Ceased AU2011240808B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2015201991A AU2015201991A1 (en) 2010-04-14 2015-04-21 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of JAK kinases

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32418610P 2010-04-14 2010-04-14
US61/324,186 2010-04-14
PCT/US2011/031896 WO2011130146A1 (en) 2010-04-14 2011-04-11 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of jak kinases

Related Child Applications (1)

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AU2015201991A Division AU2015201991A1 (en) 2010-04-14 2015-04-21 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of JAK kinases

Publications (2)

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AU2011240808A1 AU2011240808A1 (en) 2012-11-29
AU2011240808B2 true AU2011240808B2 (en) 2015-01-22

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AU2011240808A Ceased AU2011240808B2 (en) 2010-04-14 2011-04-11 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of JAK kinases

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Country Link
US (1) US8962596B2 (enExample)
EP (1) EP2558468B1 (enExample)
JP (2) JP2013523884A (enExample)
KR (1) KR20130094710A (enExample)
CN (1) CN102985424B (enExample)
AR (1) AR081075A1 (enExample)
AU (1) AU2011240808B2 (enExample)
CA (1) CA2796388A1 (enExample)
CL (1) CL2012002882A1 (enExample)
CO (1) CO6630187A2 (enExample)
CR (1) CR20120572A (enExample)
MX (1) MX2012011941A (enExample)
NZ (1) NZ603446A (enExample)
PH (1) PH12012502046A1 (enExample)
RU (1) RU2012148246A (enExample)
SG (1) SG184870A1 (enExample)
TW (1) TWI494314B (enExample)
UA (1) UA109131C2 (enExample)
UY (1) UY33328A (enExample)
WO (1) WO2011130146A1 (enExample)
ZA (1) ZA201208544B (enExample)

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UY33328A (es) 2012-10-31
CN102985424A (zh) 2013-03-20
NZ603446A (en) 2014-05-30
CO6630187A2 (es) 2013-03-01
CL2012002882A1 (es) 2013-02-08
KR20130094710A (ko) 2013-08-26
US8962596B2 (en) 2015-02-24
RU2012148246A (ru) 2014-05-20
AU2011240808A1 (en) 2012-11-29
MX2012011941A (es) 2013-08-27
SG184870A1 (en) 2012-11-29
JP2015205905A (ja) 2015-11-19
TW201134827A (en) 2011-10-16
US20130131039A1 (en) 2013-05-23
PH12012502046A1 (en) 2017-07-26
CR20120572A (es) 2013-02-20
CN102985424B (zh) 2015-03-11
CA2796388A1 (en) 2011-10-20
EP2558468B1 (en) 2015-04-01
UA109131C2 (ru) 2015-07-27
EP2558468A1 (en) 2013-02-20
WO2011130146A1 (en) 2011-10-20
JP2013523884A (ja) 2013-06-17
ZA201208544B (en) 2015-04-29
AR081075A1 (es) 2012-06-06
TWI494314B (zh) 2015-08-01

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