ZA201101425B - Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative deseases - Google Patents
Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative deseasesInfo
- Publication number
- ZA201101425B ZA201101425B ZA2011/01425A ZA201101425A ZA201101425B ZA 201101425 B ZA201101425 B ZA 201101425B ZA 2011/01425 A ZA2011/01425 A ZA 2011/01425A ZA 201101425 A ZA201101425 A ZA 201101425A ZA 201101425 B ZA201101425 B ZA 201101425B
- Authority
- ZA
- South Africa
- Prior art keywords
- deseases
- dimers
- proliferative
- treatment
- pyrrolobenzodiazepine
- Prior art date
Links
- 239000000539 dimer Substances 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0819095.1A GB0819095D0 (en) | 2008-10-17 | 2008-10-17 | Pyrrolobenzodiazepines |
| PCT/GB2009/002498 WO2010043880A1 (en) | 2008-10-17 | 2009-10-16 | Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201101425B true ZA201101425B (en) | 2011-10-26 |
Family
ID=40097621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2011/01425A ZA201101425B (en) | 2008-10-17 | 2011-02-23 | Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative deseases |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US8592576B2 (https=) |
| EP (1) | EP2350080B1 (https=) |
| JP (2) | JP5995441B2 (https=) |
| KR (1) | KR101755722B1 (https=) |
| CN (3) | CN105732666B (https=) |
| AU (1) | AU2009305190B2 (https=) |
| BR (1) | BRPI0918476B8 (https=) |
| CA (1) | CA2735477C (https=) |
| CY (1) | CY1117106T1 (https=) |
| DK (1) | DK2350080T3 (https=) |
| ES (1) | ES2557283T3 (https=) |
| GB (1) | GB0819095D0 (https=) |
| HR (1) | HRP20160003T1 (https=) |
| HU (1) | HUE025905T2 (https=) |
| IL (1) | IL211985A (https=) |
| MX (1) | MX2011003342A (https=) |
| NZ (1) | NZ591425A (https=) |
| PL (1) | PL2350080T3 (https=) |
| PT (1) | PT2350080E (https=) |
| SI (1) | SI2350080T1 (https=) |
| SM (1) | SMT201600017B (https=) |
| WO (1) | WO2010043880A1 (https=) |
| ZA (1) | ZA201101425B (https=) |
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