ZA200902711B - Compositions and methods for modulating c-kit and PDGFR receptors - Google Patents
Compositions and methods for modulating c-kit and PDGFR receptorsInfo
- Publication number
- ZA200902711B ZA200902711B ZA200902711A ZA200902711A ZA200902711B ZA 200902711 B ZA200902711 B ZA 200902711B ZA 200902711 A ZA200902711 A ZA 200902711A ZA 200902711 A ZA200902711 A ZA 200902711A ZA 200902711 B ZA200902711 B ZA 200902711B
- Authority
- ZA
- South Africa
- Prior art keywords
- modulating
- kit
- compositions
- methods
- pdgfr receptors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86243006P | 2006-10-20 | 2006-10-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200902711B true ZA200902711B (en) | 2010-05-26 |
Family
ID=39027274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200902711A ZA200902711B (en) | 2006-10-20 | 2009-04-20 | Compositions and methods for modulating c-kit and PDGFR receptors |
Country Status (25)
Country | Link |
---|---|
US (2) | US7678792B2 (de) |
EP (1) | EP2076513A1 (de) |
JP (1) | JP2010506948A (de) |
KR (1) | KR101079520B1 (de) |
CN (1) | CN101528744A (de) |
AR (1) | AR063343A1 (de) |
AU (1) | AU2007309279B2 (de) |
BR (1) | BRPI0718162A2 (de) |
CA (1) | CA2667010A1 (de) |
CL (1) | CL2007003005A1 (de) |
CO (1) | CO6170361A2 (de) |
CR (1) | CR10717A (de) |
EA (1) | EA200900573A1 (de) |
EC (1) | ECSP099353A (de) |
IL (1) | IL197875A0 (de) |
MA (1) | MA30888B1 (de) |
MX (1) | MX2009004141A (de) |
NI (1) | NI200900061A (de) |
NO (1) | NO20091949L (de) |
PE (1) | PE20081262A1 (de) |
SM (1) | SMP200900027B (de) |
TN (1) | TN2009000145A1 (de) |
TW (1) | TW200825081A (de) |
WO (1) | WO2008051757A1 (de) |
ZA (1) | ZA200902711B (de) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2003078448A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
US8221804B2 (en) | 2005-02-03 | 2012-07-17 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
US7897762B2 (en) | 2006-09-14 | 2011-03-01 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of proliferative diseases |
US8188113B2 (en) * | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
CA2668814A1 (en) | 2006-11-09 | 2008-06-05 | Alcon Research, Ltd. | Water insoluble polymer matrix for drug delivery |
TWI498115B (zh) * | 2007-12-27 | 2015-09-01 | Daiichi Sankyo Co Ltd | 咪唑羰基化合物 |
US8278452B2 (en) * | 2008-02-22 | 2012-10-02 | Irm Llc | Heterocyclic compounds and compositions as c-kit and PDGFR kinase inhibitors |
JP5607025B2 (ja) | 2008-04-21 | 2014-10-15 | シグナム バイオサイエンシーズ, インコーポレイテッド | 化合物、組成物およびそれらを作製する方法 |
FR2930552B1 (fr) * | 2008-04-24 | 2012-10-12 | Centre Nat Rech Scient | N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog |
JP2011524365A (ja) * | 2008-06-11 | 2011-09-01 | アイアールエム・リミテッド・ライアビリティ・カンパニー | マラリアの処置に有用な化合物および組成物 |
CA2733010A1 (en) * | 2008-08-05 | 2010-02-11 | George Mason Intellectual Properties, Inc. | Signal pathway alterations and drug target elevations in primary metachronous metastatic colorectal cancer compared to non-metastatic disease |
CA2742007C (en) * | 2008-10-29 | 2014-07-08 | Deciphera Pharmaceuticals, Llc | Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities |
AR074776A1 (es) * | 2008-12-18 | 2011-02-09 | Sanofi Aventis | Metodo para tratar la degeneracion macular; modulando el sistema inmunitario del paciente |
WO2010071846A2 (en) | 2008-12-19 | 2010-06-24 | Afraxis, Inc. | Compounds for treating neuropsychiatric conditions |
EA201101188A1 (ru) * | 2009-02-13 | 2012-04-30 | Фовеа Фармасьютикалз | [1,2,4]триазоло[1,5-а]пиридины в качестве ингибиторов киназы |
JP2013507395A (ja) | 2009-10-09 | 2013-03-04 | アフラクシス・インコーポレイテッド | Cns障害治療用の8−エチル−6−(アリール)ピリド[2,3−d]ピリミジン−7(8h)−オン |
CA2786245A1 (en) | 2010-01-29 | 2011-08-04 | Boehringer Ingelheim International Gmbh | Substituted naphthyridines and their use as syk kinase inhibitors |
CN102770426B (zh) * | 2010-02-05 | 2016-03-23 | 诺瓦提斯公司 | 作为蛋白激酶抑制剂的化合物和组合物 |
WO2012103165A2 (en) * | 2011-01-26 | 2012-08-02 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
EP2701510B1 (de) | 2011-04-25 | 2017-02-15 | Usher III Initiative | Pyrazolopyridazine und verfahren zur behandlung von degenerativen netzhauterkrankungen und hörverlust mit usher-syndrom |
MX336224B (es) * | 2011-07-26 | 2016-01-12 | Boehringer Ingelheim Int | Quinolinas sustituidas y su uso como medicamentos. |
SG11201401084TA (en) * | 2011-09-30 | 2014-04-28 | Kineta Inc | Anti-viral compounds |
PL2900637T3 (pl) | 2012-05-15 | 2018-01-31 | Novartis Ag | Pirymidyna podstawiona tiazolem lub imidazolem, amidowe pochodne pirazyny i pirydyny i powiązane związki takie jak inhibitory abl1, abl2 i bcr-abl1 do leczenia nowotworu, specyficznych infekcji wirusowych i specyficznych zaburzeń cns |
CA2871715A1 (en) | 2012-05-15 | 2013-11-21 | Novartis Ag | Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1 |
ES2670667T3 (es) | 2012-05-15 | 2018-05-31 | Novartis Ag | Derivados de benzamida para inhibir la actividad de ABL1, ABL2 y BCR-ABL1 |
DK2861579T5 (da) | 2012-05-15 | 2022-10-24 | Novartis Ag | Benzamidderivater til at hæmme aktiviteten af ABL1, ABL2 og BCR-ABL1 |
ES2663605T3 (es) * | 2012-06-07 | 2018-04-16 | Deciphera Pharmaceuticals, Llc | Dihidronaftiridinas y compuestos relacionados útiles como inhibidores de quinasas para el tratamiento de enfermedades proliferativas |
US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
EP4063391A1 (de) | 2012-07-25 | 2022-09-28 | Celldex Therapeutics, Inc. | Anti-kit-antikörper und verwendungen davon |
US9227976B2 (en) | 2012-10-25 | 2016-01-05 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
CA2915975A1 (en) * | 2013-06-26 | 2014-12-31 | Proteostasis Therapeutics, Inc. | Methods of modulating cftr activity |
GB201401886D0 (en) | 2014-02-04 | 2014-03-19 | Lytix Biopharma As | Neurodegenerative therapies |
EP3116870A1 (de) | 2014-03-13 | 2017-01-18 | Proteostasis Therapeutics, Inc. | Verbindungen, zusammensetzungen und verfahren zur steigerung der cftr-aktivität |
WO2015138909A1 (en) | 2014-03-13 | 2015-09-17 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
US10239943B2 (en) | 2014-05-23 | 2019-03-26 | Celldex Therapeutics, Inc. | Treatment of eosinophil or mast cell related disorders |
EP3157917B1 (de) | 2014-06-19 | 2020-03-18 | Proteostasis Therapeutics, Inc. | Verbindungen, zusammensetzungen und verfahren zur steigerung der cftr-aktivität |
CN105085489B (zh) | 2014-11-05 | 2019-03-01 | 益方生物科技(上海)有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
US10392378B2 (en) | 2014-12-23 | 2019-08-27 | Proteostasis Therapeutics, Inc. | Derivatives of 5-phenyl- or 5-heteroarylathiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
US10738011B2 (en) | 2014-12-23 | 2020-08-11 | Proteostasis Therapeutics, Inc. | Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
WO2016105468A1 (en) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
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AU2001292320A1 (en) | 2000-10-02 | 2002-04-15 | Tanabe Seiyaku Co., Ltd. | Benzylamine compound, process for producing the same, and intermediate therefor |
CN1863774B (zh) * | 2003-10-08 | 2010-12-15 | Irm责任有限公司 | 用作蛋白激酶抑制剂的化合物和组合物 |
AU2005325676A1 (en) | 2004-12-23 | 2006-08-03 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
JP5197016B2 (ja) * | 2004-12-23 | 2013-05-15 | デシファラ ファーマスーティカルズ, エルエルシー | 酵素モジュレータ及び治療 |
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JP5357763B2 (ja) * | 2006-11-06 | 2013-12-04 | トレロ ファーマシューティカルズ, インコーポレイテッド | イミダゾ[1,2−b]ピリダジン誘導体およびピラゾロ[1,5−a]ピリダジン誘導体およびプロテインキナーゼインヒビターとしてのこれらの使用 |
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2007
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- 2007-10-16 WO PCT/US2007/081538 patent/WO2008051757A1/en active Application Filing
- 2007-10-16 CA CA002667010A patent/CA2667010A1/en not_active Abandoned
- 2007-10-16 BR BRPI0718162-0A patent/BRPI0718162A2/pt not_active IP Right Cessation
- 2007-10-16 KR KR1020097008062A patent/KR101079520B1/ko not_active IP Right Cessation
- 2007-10-16 MX MX2009004141A patent/MX2009004141A/es active IP Right Grant
- 2007-10-16 AU AU2007309279A patent/AU2007309279B2/en not_active Ceased
- 2007-10-16 JP JP2009533484A patent/JP2010506948A/ja active Pending
- 2007-10-16 CN CNA2007800390373A patent/CN101528744A/zh active Pending
- 2007-10-16 EA EA200900573A patent/EA200900573A1/ru unknown
- 2007-10-16 US US11/873,196 patent/US7678792B2/en not_active Expired - Fee Related
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2009
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- 2009-04-17 CO CO09039151A patent/CO6170361A2/es not_active Application Discontinuation
- 2009-04-17 TN TNP2009000145A patent/TN2009000145A1/fr unknown
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US20080176846A1 (en) | 2008-07-24 |
WO2008051757A1 (en) | 2008-05-02 |
CR10717A (es) | 2009-07-02 |
IL197875A0 (en) | 2009-12-24 |
TN2009000145A1 (en) | 2010-10-18 |
CL2007003005A1 (es) | 2008-05-23 |
US7678792B2 (en) | 2010-03-16 |
AU2007309279B2 (en) | 2011-03-24 |
PE20081262A1 (es) | 2008-10-29 |
CN101528744A (zh) | 2009-09-09 |
MX2009004141A (es) | 2009-05-01 |
AU2007309279A1 (en) | 2008-05-02 |
EP2076513A1 (de) | 2009-07-08 |
EA200900573A1 (ru) | 2009-10-30 |
JP2010506948A (ja) | 2010-03-04 |
NO20091949L (no) | 2009-05-19 |
CO6170361A2 (es) | 2010-06-18 |
SMAP200900027A (it) | 2009-07-14 |
AR063343A1 (es) | 2009-01-21 |
US20100081656A1 (en) | 2010-04-01 |
SMP200900027B (it) | 2010-01-19 |
NI200900061A (es) | 2010-03-10 |
CA2667010A1 (en) | 2008-05-02 |
ECSP099353A (es) | 2009-06-30 |
US8106068B2 (en) | 2012-01-31 |
TW200825081A (en) | 2008-06-16 |
KR101079520B1 (ko) | 2011-11-03 |
BRPI0718162A2 (pt) | 2013-11-26 |
MA30888B1 (fr) | 2009-11-02 |
KR20090054477A (ko) | 2009-05-29 |
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