ZA200810709B - Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof - Google Patents

Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof

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Publication number
ZA200810709B
ZA200810709B ZA200810709A ZA200810709A ZA200810709B ZA 200810709 B ZA200810709 B ZA 200810709B ZA 200810709 A ZA200810709 A ZA 200810709A ZA 200810709 A ZA200810709 A ZA 200810709A ZA 200810709 B ZA200810709 B ZA 200810709B
Authority
ZA
South Africa
Prior art keywords
preparations
substituted
diphenylpropane derivatives
diphenylpropane
derivatives
Prior art date
Application number
ZA200810709A
Other languages
English (en)
Inventor
Jean-Francois Delhomel
Remy Hanf
Karine Caumont-Bertrand
Original Assignee
Genfit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit filed Critical Genfit
Publication of ZA200810709B publication Critical patent/ZA200810709B/xx

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    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/45—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms doubly-bound to the carbon skeleton
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    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
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    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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    • C07C69/734—Ethers
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    • C07C69/734—Ethers
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans

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  • Hematology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
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  • Toxicology (AREA)
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  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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ZA200810709A 2006-06-21 2008-12-19 Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof ZA200810709B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0605540A FR2902789A1 (fr) 2006-06-21 2006-06-21 Derives de 1,3-diphenylpropane substitues, preparations et utilisations

Publications (1)

Publication Number Publication Date
ZA200810709B true ZA200810709B (en) 2009-12-30

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ZA200810709A ZA200810709B (en) 2006-06-21 2008-12-19 Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof

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US (2) US8188148B2 (ja)
EP (2) EP2046715B1 (ja)
JP (2) JP5350231B2 (ja)
KR (2) KR101416257B1 (ja)
CN (3) CN101506138B (ja)
AU (2) AU2007262939B2 (ja)
BR (1) BRPI0713600B1 (ja)
CA (2) CA2655744C (ja)
CY (2) CY1115082T1 (ja)
DK (2) DK2046715T5 (ja)
EA (1) EA018437B1 (ja)
ES (2) ES2466268T3 (ja)
FR (1) FR2902789A1 (ja)
IL (2) IL196071A0 (ja)
MX (1) MX2008016239A (ja)
NO (1) NO341866B1 (ja)
NZ (1) NZ573674A (ja)
PL (2) PL2046715T3 (ja)
PT (2) PT2046715E (ja)
SI (2) SI2046715T1 (ja)
WO (2) WO2007147879A1 (ja)
ZA (1) ZA200810709B (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2902789A1 (fr) * 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations
FR2917084B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl propanoique activateurs des recpteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
US9221751B2 (en) 2009-11-26 2015-12-29 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
US10722575B2 (en) 2009-11-26 2020-07-28 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
JP5833016B2 (ja) * 2009-11-26 2015-12-16 ジェンフィＧｅｎｆｉｔ 肝障害を処置するための１，３−ジフェニルプロパ−２−エン−１−オン誘導体の使用
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
AU2011254670B2 (en) 2010-05-17 2014-09-25 Genfit Improved preparation of chalcone derivatives
MX2013000391A (es) * 2010-07-12 2013-03-08 Hoffmann La Roche 1-hidroxiimino-3-fenil-propanos.
WO2013072265A1 (en) * 2011-11-14 2013-05-23 F. Hoffmann-La Roche Ag 1-pyridazinyl-hydroxyimino- 3- phenyl- propanes as gpbar1 agonists
US9115073B2 (en) * 2011-12-28 2015-08-25 Genfit 1,3-diphenylpropane derivatives, preparations and uses thereof
US10442761B2 (en) 2016-02-16 2019-10-15 Concert Pharmaceuticals, Inc. Deuterated GFT-505
IT201600098338A1 (it) * 2016-09-30 2018-03-30 Univ Degli Studi Padova Composti 1-fenilpropanone e loro impiego
RU186145U1 (ru) * 2018-08-08 2019-01-11 Общество с ограниченной ответственностью "Научно-производственное объединение "Центротех" (ООО "НПО "Центротех") Каркас виброрамы вибросита
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
WO2021160519A1 (en) 2020-02-10 2021-08-19 Genfit Treatment of primary biliary cholangitis with elafibranor
CN114901641A (zh) * 2020-02-28 2022-08-12 四川科伦博泰生物医药股份有限公司 芳香族化合物及其药物组合物和用途
CA3176020A1 (en) 2020-05-18 2021-11-25 Alice Roudot Elafibranor for the treatment of primary sclerosing cholangitis
EP4203934A1 (en) 2020-08-26 2023-07-05 Genfit Compositions and methods for the treatment of primary biliary cholangitis
WO2022238445A1 (en) 2021-05-11 2022-11-17 Genfit Ppar-agonists for use in the treatment of liver failure
WO2022238451A1 (en) 2021-05-11 2022-11-17 Genfit Elafibranor and 2-[2,6-dimethyl-4-[3-[4-(methylthio)phenyl]-3-oxo-propyl] phenoxy]-2-methylpropanoic acid analog as ppar-agonists for use in the treatment of sepsis

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CY1115414T1 (el) 2017-01-04
DK2046715T3 (da) 2014-06-02
EA200900044A1 (ru) 2009-06-30
SI2046716T1 (sl) 2014-02-28
NO341866B1 (no) 2018-02-12
EP2046716A1 (fr) 2009-04-15
JP2009541269A (ja) 2009-11-26
MX2008016239A (es) 2009-02-25
DK2046716T3 (da) 2013-11-04
CN104193660A (zh) 2014-12-10
JP5350230B2 (ja) 2013-11-27
PL2046716T3 (pl) 2014-03-31
CN104193660B (zh) 2018-10-19
PT2046716E (pt) 2013-11-11
EA018437B1 (ru) 2013-08-30
CA2655744C (fr) 2016-03-22
CA2655643C (fr) 2016-03-22
IL196071A0 (en) 2009-09-01
BRPI0713600A2 (pt) 2012-11-06
US8258182B2 (en) 2012-09-04
EP2046715A1 (fr) 2009-04-15
CA2655643A1 (fr) 2007-12-27
KR101416262B1 (ko) 2014-07-16
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SI2046715T1 (sl) 2014-08-29
WO2007147879A1 (fr) 2007-12-27
AU2007262938A1 (en) 2007-12-27
EP2046716B1 (fr) 2013-08-14
CN101506138B (zh) 2014-02-19
AU2007262939B2 (en) 2012-04-05
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