ZA200805694B - Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis - Google Patents
Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesisInfo
- Publication number
- ZA200805694B ZA200805694B ZA200805694A ZA200805694A ZA200805694B ZA 200805694 B ZA200805694 B ZA 200805694B ZA 200805694 A ZA200805694 A ZA 200805694A ZA 200805694 A ZA200805694 A ZA 200805694A ZA 200805694 B ZA200805694 B ZA 200805694B
- Authority
- ZA
- South Africa
- Prior art keywords
- angiogenesis
- amino
- substituted
- diseases associated
- proliferative disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74215105P | 2005-12-02 | 2005-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200805694B true ZA200805694B (en) | 2009-11-25 |
Family
ID=38092821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200805694A ZA200805694B (en) | 2005-12-02 | 2008-06-30 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8133995B2 (de) |
| EP (2) | EP1957077B1 (de) |
| JP (1) | JP5199882B2 (de) |
| KR (1) | KR101404290B1 (de) |
| CN (2) | CN101365454B (de) |
| AR (1) | AR057991A1 (de) |
| AU (1) | AU2006320480B2 (de) |
| BR (1) | BRPI0619153B8 (de) |
| CA (1) | CA2631775C (de) |
| DO (1) | DOP2006000269A (de) |
| ES (1) | ES2459016T3 (de) |
| HK (1) | HK1129305A1 (de) |
| IL (1) | IL191864A (de) |
| PE (1) | PE20070855A1 (de) |
| TW (1) | TWI388560B (de) |
| UY (1) | UY29983A1 (de) |
| WO (1) | WO2007064883A2 (de) |
| ZA (1) | ZA200805694B (de) |
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| UY28931A1 (es) * | 2004-06-03 | 2005-12-30 | Bayer Pharmaceuticals Corp | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis |
| PE20070855A1 (es) * | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
| US8143393B2 (en) * | 2005-12-02 | 2012-03-27 | Bayer Healthcare Llc | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
| WO2009042543A1 (en) * | 2007-09-25 | 2009-04-02 | Bayer Healthcare Llc | Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase |
| ES2398684T3 (es) | 2008-04-23 | 2013-03-21 | Gilead Sciences, Inc. | Análogos de carbanucleósido para el tratamiento antiviral |
| AR074830A1 (es) | 2008-12-19 | 2011-02-16 | Cephalon Inc | Pirrolotriazinas como inhibidores de alk y jak2 |
| MX2012003126A (es) | 2009-09-21 | 2012-06-19 | Gilead Sciences Inc | Procesos e intermedios para la preparacion de analogos de 1'-carbonucleosidos sustituidos. |
| WO2011130194A2 (en) | 2010-04-12 | 2011-10-20 | Supernus Pharmaceuticals Inc. | Methods for producing viloxazine salts and novel polymorphs thereof |
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| CA2852275C (en) * | 2011-11-18 | 2021-06-29 | F. Hoffmann-La Roche Ag | Release reagent for vitamin d compounds |
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| US9598416B2 (en) | 2011-12-15 | 2017-03-21 | Bayer Intellectual Property Gmbh | Substituted benzothienyl-pyrrolotriazines and uses thereof in the treatment cancer |
| US9475815B2 (en) | 2012-02-23 | 2016-10-25 | Bayer Intelletual Property Gmbh | Substituted benzothienyl-pyrrolotriazines and uses thereof |
| CN107652289B (zh) | 2012-06-13 | 2020-07-21 | 因塞特控股公司 | 作为fgfr抑制剂的取代的三环化合物 |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| WO2014113932A1 (en) * | 2013-01-23 | 2014-07-31 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| US20140206681A1 (en) | 2013-01-23 | 2014-07-24 | Ronald M. Kim | Btk inhibitors |
| JP6449244B2 (ja) | 2013-04-19 | 2019-01-09 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｆｇｆｒ抑制剤としての二環式複素環 |
| WO2015083008A1 (en) | 2013-12-05 | 2015-06-11 | Acerta Pharma B.V. | Therapeutic combination of a pi3k inhibitor and a btk inhibitor |
| WO2015095099A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| EP3082811B1 (de) | 2013-12-20 | 2020-01-15 | Merck Sharp & Dohme Corp. | Btk-hemmer |
| US9937171B2 (en) | 2014-04-11 | 2018-04-10 | Acerta Pharma B.V. | Methods of blocking the CXCR-4/SDF-1 signaling pathway with inhibitors of bruton's tyrosine kinase |
| US9949971B2 (en) | 2014-06-17 | 2018-04-24 | Acerta Pharma B.V. | Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor |
| HRP20211813T1 (hr) | 2014-08-11 | 2022-03-04 | Acerta Pharma B.V. | Terapeutske kombinacije inhibitora btk i inhibitora bcl-2 |
| EP3209664B1 (de) * | 2014-10-22 | 2020-06-03 | Bristol-Myers Squibb Company | Bicyclische heteroarylaminverbindungen als pi3k-hemmer |
| ES2749679T3 (es) | 2014-10-22 | 2020-03-23 | Bristol Myers Squibb Co | Compuestos de pirrolotriazina amina sustituidos como inhibidores de PI3k |
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| BR112018012914B1 (pt) | 2015-12-22 | 2023-04-18 | SHY Therapeutics LLC | Composto, uso de um composto e composição farmacêutica |
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| CN109928976A (zh) * | 2019-02-26 | 2019-06-25 | 泰州亿腾景昂药业有限公司 | 一种工业化生产eoc317的方法 |
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| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
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| CN112830930B (zh) * | 2020-12-18 | 2022-06-07 | 泰州亿腾景昂药业股份有限公司 | Eoc317的晶型及其制备方法与应用 |
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| PE20070855A1 (es) * | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
| WO2009042543A1 (en) | 2007-09-25 | 2009-04-02 | Bayer Healthcare Llc | Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase |
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2006
- 2006-11-29 PE PE2006001518A patent/PE20070855A1/es not_active Application Discontinuation
- 2006-11-30 JP JP2008543485A patent/JP5199882B2/ja active Active
- 2006-11-30 KR KR1020087016147A patent/KR101404290B1/ko active IP Right Grant
- 2006-11-30 ES ES06838778.6T patent/ES2459016T3/es active Active
- 2006-11-30 EP EP06838778.6A patent/EP1957077B1/de active Active
- 2006-11-30 CN CN200680052185.4A patent/CN101365454B/zh active Active
- 2006-11-30 BR BRPI0619153A patent/BRPI0619153B8/pt not_active IP Right Cessation
- 2006-11-30 CN CN201510873113.7A patent/CN105732634A/zh active Pending
- 2006-11-30 EP EP12159004A patent/EP2465505A1/de not_active Withdrawn
- 2006-11-30 AU AU2006320480A patent/AU2006320480B2/en not_active Ceased
- 2006-11-30 WO PCT/US2006/045996 patent/WO2007064883A2/en active Application Filing
- 2006-11-30 US US12/085,879 patent/US8133995B2/en not_active Expired - Fee Related
- 2006-11-30 CA CA2631775A patent/CA2631775C/en active Active
- 2006-11-30 UY UY29983A patent/UY29983A1/es not_active Application Discontinuation
- 2006-11-30 DO DO2006000269A patent/DOP2006000269A/es unknown
- 2006-12-01 TW TW095144567A patent/TWI388560B/zh not_active IP Right Cessation
- 2006-12-01 AR ARP060105324A patent/AR057991A1/es active IP Right Grant
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2008
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- 2008-06-30 ZA ZA200805694A patent/ZA200805694B/xx unknown
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2009
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2012
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