ZA200706968B - Purification of streptococcal capsular polysaccharide - Google Patents
Purification of streptococcal capsular polysaccharideInfo
- Publication number
- ZA200706968B ZA200706968B ZA200706968A ZA200706968A ZA200706968B ZA 200706968 B ZA200706968 B ZA 200706968B ZA 200706968 A ZA200706968 A ZA 200706968A ZA 200706968 A ZA200706968 A ZA 200706968A ZA 200706968 B ZA200706968 B ZA 200706968B
- Authority
- ZA
- South Africa
- Prior art keywords
- purification
- capsular polysaccharide
- streptococcal capsular
- streptococcal
- polysaccharide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Sustainable Development (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Detergent Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0502096.1A GB0502096D0 (en) | 2005-02-01 | 2005-02-01 | Purification of streptococcal capsular polysaccharide |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200706968B true ZA200706968B (en) | 2008-11-26 |
Family
ID=34307821
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200706968A ZA200706968B (en) | 2005-02-01 | 2007-08-20 | Purification of streptococcal capsular polysaccharide |
Country Status (12)
Country | Link |
---|---|
US (1) | US20100063270A1 (xx) |
EP (2) | EP2270056A3 (xx) |
JP (1) | JP2008528052A (xx) |
CN (1) | CN101146829A (xx) |
AU (1) | AU2006211049B2 (xx) |
CA (1) | CA2596653A1 (xx) |
GB (1) | GB0502096D0 (xx) |
IL (1) | IL184980A0 (xx) |
MX (1) | MX2007009276A (xx) |
NZ (1) | NZ560928A (xx) |
WO (1) | WO2006082527A2 (xx) |
ZA (1) | ZA200706968B (xx) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ560966A (en) | 2000-10-27 | 2010-06-25 | Novartis Vaccines & Diagnostic | Nucleic acids and proteins from streptococcus groups A & B |
PT1648500E (pt) | 2003-07-31 | 2014-10-10 | Novartis Vaccines & Diagnostic | Composições imunogénicas para estreptococos piogenes |
US8945589B2 (en) | 2003-09-15 | 2015-02-03 | Novartis Vaccines And Diagnostics, Srl | Immunogenic compositions for Streptococcus agalactiae |
GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
NO346529B1 (no) | 2005-12-22 | 2022-09-26 | Glaxosmithkline Biologicals Sa | Bruk av et immunogenpreparat for småbarn, omfattende 22F sakkaridkonjugat |
GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
MX2010002773A (es) | 2007-09-12 | 2010-03-31 | Novartis Ag | Antigenos mutantes de gas57 y anticuerpos de gas57. |
GB0818453D0 (en) * | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
PL2493498T3 (pl) * | 2009-10-30 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Oczyszczanie sacharydów otoczkowych staphylococcus aureus typu 5 i typu 8 |
GB201003333D0 (en) | 2010-02-26 | 2010-04-14 | Novartis Ag | Immunogenic proteins and compositions |
GB201005625D0 (en) | 2010-04-01 | 2010-05-19 | Novartis Ag | Immunogenic proteins and compositions |
GB201101665D0 (en) | 2011-01-31 | 2011-03-16 | Novartis Ag | Immunogenic compositions |
CN102653565A (zh) * | 2011-03-03 | 2012-09-05 | 天津康希诺生物技术有限公司 | 一种从荚膜细菌发酵液纯化荚膜多糖的方法 |
JP6088507B2 (ja) | 2011-07-08 | 2017-03-01 | ノバルティス アーゲー | チロシンライゲーションの方法 |
GB201114923D0 (en) | 2011-08-30 | 2011-10-12 | Novartis Ag | Immunogenic proteins and compositions |
MX354924B (es) | 2011-11-07 | 2018-03-22 | Novartis Ag | Molecula portadora que comprende un antigeno spr0096 y un spr2021. |
GB201121301D0 (en) | 2011-12-12 | 2012-01-25 | Novartis Ag | Method |
WO2013088448A1 (en) * | 2011-12-15 | 2013-06-20 | Serum Institute Of India Ltd. | A novel process of cultivating bacteria for yield improvement of capsular polyoses |
LT2890710T (lt) * | 2012-08-28 | 2017-10-25 | Novartis Ag | Antikūnų gryninimo būdai, panaudojant alifatinius alkoholius |
ES2848048T3 (es) | 2012-10-03 | 2021-08-05 | Glaxosmithkline Biologicals Sa | Composiciones inmunogénicas |
CN105593238B (zh) | 2013-07-11 | 2020-09-08 | 诺华股份有限公司 | 使用微生物转谷氨酰胺酶进行赖氨酸特异性化学酶法蛋白质修饰 |
EP2942396A1 (en) * | 2014-05-07 | 2015-11-11 | Novartis AG | Polysaccharides produced by CPSC mutants |
CN104558225B (zh) * | 2014-12-11 | 2017-02-22 | 云南沃森生物技术股份有限公司 | 一种针对肠道细菌的荚膜多糖提取方法 |
CN104530250A (zh) * | 2014-12-11 | 2015-04-22 | 北京科兴生物制品有限公司 | 一种纯化肺炎链球菌荚膜多糖的方法 |
EP3034516A1 (en) * | 2014-12-19 | 2016-06-22 | Novartis AG | Purification of streptococcal capsular polysaccharide |
CN106146679B (zh) * | 2015-04-23 | 2019-02-01 | 中国医学科学院医学生物学研究所 | 一种纯化细菌荚膜多糖的方法 |
US10836839B2 (en) | 2015-04-28 | 2020-11-17 | Biological E Limited | Method for separation of protein and other impurities from microbial capsular polysaccharides |
IL255106B2 (en) | 2015-05-04 | 2023-04-01 | Pfizer | Protein-polysaccharide conjugates of group b streptococcus, methods for preparing conjugates, immunogenic preparations containing conjugates and their uses |
WO2017175082A1 (en) | 2016-04-05 | 2017-10-12 | Gsk Vaccines S.R.L. | Immunogenic compositions |
US10751402B2 (en) | 2016-11-09 | 2020-08-25 | Pfizer Inc. | Immunogenic compositions and uses thereof |
BE1025162B9 (fr) | 2016-12-06 | 2019-01-07 | Glaxosmithkline Biologicals Sa | Procede de purification pour les polysaccharides capsulaires |
EP3619241A1 (en) * | 2017-05-05 | 2020-03-11 | Serum Institute Of India Private Limited | Method for removal of impurities from bacterial capsular polysaccharide based preparations |
US10702596B2 (en) | 2017-07-05 | 2020-07-07 | Inventprise, Llc | Polysaccharide purification for vaccine production using lytic enzymes, tangential flow filtration, and multimode chromatography |
JP7111799B2 (ja) | 2017-07-05 | 2022-08-02 | インベントプライズ リミテッド ライアビリティ カンパニー | 溶菌酵素、接線流濾過、及びマルチモードクロマトグラフィを用いたワクチン生産のための多糖精製 |
CN109336989B (zh) * | 2018-10-22 | 2022-05-13 | 北京智飞绿竹生物制药有限公司 | 一种通过粘度控制制备肺炎球菌荚膜多糖的方法 |
JP7239509B6 (ja) * | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
CA3139257A1 (en) | 2019-05-10 | 2020-11-19 | Glaxosmithkline Biologicals Sa | Conjugate production |
CN113234770A (zh) * | 2021-06-15 | 2021-08-10 | 广州知易生物科技有限公司 | 脆弱拟杆菌荚膜多糖a的制备方法 |
WO2024062494A1 (en) | 2022-09-19 | 2024-03-28 | Biological E Limited | Method for the purification of capsular polysaccharides |
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US4242501A (en) * | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
PT72812B (en) * | 1980-04-14 | 1983-02-16 | Merck & Co Inc | Process for preparing group b streptococcal capsular polysccha-rides |
US4413057A (en) * | 1980-04-14 | 1983-11-01 | Merck & Co., Inc. | Group B streptococcal capsular polysaccharides |
US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
EP0378881B1 (en) | 1989-01-17 | 1993-06-09 | ENIRICERCHE S.p.A. | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
JPH04506662A (ja) | 1989-07-14 | 1992-11-19 | アメリカン・サイアナミド・カンパニー | 接合体ワクチンのためのサイトカイニンおよびホルモンのキヤリヤー |
IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
JP2678673B2 (ja) * | 1990-02-05 | 1997-11-17 | 雪印乳業株式会社 | 新規多糖類、その製法及びその多糖類を有効成分とする抗腫瘍剤 |
SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
ATE128628T1 (de) | 1990-08-13 | 1995-10-15 | American Cyanamid Co | Faser-hemagglutinin von bordetella pertussis als träger für konjugierten impfstoff. |
US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
CA2059693C (en) * | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
ZA937034B (en) | 1992-09-24 | 1995-06-23 | Brigham & Womens Hospital | Group B streptococcus type II and type V polysaccharide-protein conjugate vaccines |
US5565204A (en) * | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
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US5714354A (en) * | 1995-06-06 | 1998-02-03 | American Home Products Corporation | Alcohol-free pneumococcal polysaccharide purification process |
HUP9802199A3 (en) | 1995-06-07 | 1999-07-28 | Smithkline Beecham Biolog | Vaccine comprising a polysaccharide antigen-carrier protein conjugate and free carrier protein and use of |
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US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
CA2284606A1 (en) | 1997-03-26 | 1998-10-01 | Brigham And Women's Hospital, Inc. | Method for generating saccharide fragments |
GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
CA2671261A1 (en) | 1997-11-06 | 1999-05-20 | Novartis Vaccines And Diagnostics S.R.L. | Neisserial antigens |
KR20010032336A (ko) | 1997-11-21 | 2001-04-16 | 브랑디 빠스깔 | 클라미디아 뉴모니아 게놈 서열과 폴리펩티드, 이의 단편및 이의 용도, 특히, 감염의 진단, 예방 및 치료 용도 |
JP2002517179A (ja) | 1997-11-28 | 2002-06-18 | ジェンセット | Chlamydiatrachomatisゲノム配列およびポリペプチド、それらのフラグメント、ならびに特に感染症の診断、予防および治療のためのそれらの使用 |
AU754256C (en) * | 1997-12-23 | 2004-05-20 | Pfizer Ireland Pharmaceuticals | Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugate vaccines |
BR9906927A (pt) | 1998-01-14 | 2001-11-20 | Chiron Spa | Proteìnas de neisseria meningitidis |
US7018637B2 (en) | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
US20020104801A1 (en) * | 1998-04-06 | 2002-08-08 | Nicolas Voute | Small dense microporous solid support materials, their preparation,and use for purification of large macromolecules and bioparticles |
NZ541361A (en) | 1998-05-01 | 2008-04-30 | Inst Genomic Research | Neisseria meningitidis antigens and compositions relating to SEQ ID Nos:2916, 2918 and 2920 |
EP1144998A3 (en) | 1998-10-09 | 2002-08-07 | Chiron Corporation | Neisseria genomic sequences and methods of their use |
US6146902A (en) | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
CH692919A5 (fr) * | 1999-01-28 | 2002-12-13 | Trb Chemedica S A | Procédé de purification de l'acide hyaluronique à poids moléculaire élevé. |
AU781027B2 (en) | 1999-04-09 | 2005-04-28 | Department Of Health & Human Services | Recombinant toxin a protein carrier for polysaccharide conjugate vaccines |
ES2507100T3 (es) | 2000-01-17 | 2014-10-14 | Novartis Vaccines And Diagnostics S.R.L. | Vacuna OMV suplementada contra meningococo |
GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
US20030180316A1 (en) | 2000-06-29 | 2003-09-25 | Dominique Boutriau | Multivalent vaccine composition |
EP1297005B1 (en) | 2000-07-03 | 2009-08-26 | Novartis Vaccines and Diagnostics S.r.l. | Immunisation against chlamydia pneumoniae |
NZ560966A (en) | 2000-10-27 | 2010-06-25 | Novartis Vaccines & Diagnostic | Nucleic acids and proteins from streptococcus groups A & B |
US20030035806A1 (en) | 2001-05-11 | 2003-02-20 | D'ambra Anello J. | Novel meningitis conjugate vaccine |
GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
GB0210128D0 (en) | 2002-05-02 | 2002-06-12 | Chiron Spa | Nucleic acids and proteins from streptococcus groups A & B |
WO2004011027A1 (en) | 2002-07-30 | 2004-02-05 | Baxter International Inc. | Chimeric multivalent polysaccharide conjugate vaccines |
US20070053924A1 (en) | 2002-08-26 | 2007-03-08 | Herve Tettelin | Conserved and specific streptococcal genomes |
US20070036828A1 (en) | 2002-09-13 | 2007-02-15 | Chiron Corporation | Group b streptococcus vaccine |
ES2341863T3 (es) * | 2003-09-11 | 2010-06-29 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws | Proceso para la produccion de un polisacarido capsular para su uso en vacunas de conjugado. |
-
2005
- 2005-02-01 GB GBGB0502096.1A patent/GB0502096D0/en not_active Ceased
-
2006
- 2006-02-01 CA CA002596653A patent/CA2596653A1/en not_active Abandoned
- 2006-02-01 EP EP10179778A patent/EP2270056A3/en not_active Withdrawn
- 2006-02-01 WO PCT/IB2006/000626 patent/WO2006082527A2/en active Application Filing
- 2006-02-01 MX MX2007009276A patent/MX2007009276A/es not_active Application Discontinuation
- 2006-02-01 AU AU2006211049A patent/AU2006211049B2/en not_active Ceased
- 2006-02-01 EP EP06710574A patent/EP1848746A2/en not_active Withdrawn
- 2006-02-01 JP JP2007553742A patent/JP2008528052A/ja active Pending
- 2006-02-01 NZ NZ560928A patent/NZ560928A/en not_active IP Right Cessation
- 2006-02-01 US US11/883,615 patent/US20100063270A1/en not_active Abandoned
- 2006-02-01 CN CNA2006800073415A patent/CN101146829A/zh active Pending
-
2007
- 2007-08-01 IL IL184980A patent/IL184980A0/en unknown
- 2007-08-20 ZA ZA200706968A patent/ZA200706968B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2006211049B2 (en) | 2012-06-07 |
CN101146829A (zh) | 2008-03-19 |
EP2270056A2 (en) | 2011-01-05 |
EP1848746A2 (en) | 2007-10-31 |
WO2006082527A2 (en) | 2006-08-10 |
CA2596653A1 (en) | 2006-08-10 |
AU2006211049A1 (en) | 2006-08-10 |
EP2270056A3 (en) | 2011-03-02 |
NZ560928A (en) | 2010-05-28 |
GB0502096D0 (en) | 2005-03-09 |
WO2006082527A3 (en) | 2006-11-16 |
JP2008528052A (ja) | 2008-07-31 |
IL184980A0 (en) | 2007-12-03 |
MX2007009276A (es) | 2007-09-19 |
US20100063270A1 (en) | 2010-03-11 |
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