ZA200704520B - Structural nucleic acid guided chemical synthesis - Google Patents

Structural nucleic acid guided chemical synthesis

Info

Publication number
ZA200704520B
ZA200704520B ZA200704520A ZA200704520A ZA200704520B ZA 200704520 B ZA200704520 B ZA 200704520B ZA 200704520 A ZA200704520 A ZA 200704520A ZA 200704520 A ZA200704520 A ZA 200704520A ZA 200704520 B ZA200704520 B ZA 200704520B
Authority
ZA
South Africa
Prior art keywords
nucleic acid
composition
chemical synthesis
reaction
structural nucleic
Prior art date
Application number
ZA200704520A
Other languages
English (en)
Inventor
Hansen Nils Jakob Vest
Blakskjaer Peter
Hansen Margit Haahr
Petersen Lars Kolster
Heitner Tara Renee
Original Assignee
Vipergen Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vipergen Aps filed Critical Vipergen Aps
Publication of ZA200704520B publication Critical patent/ZA200704520B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Electroluminescent Light Sources (AREA)
  • Luminescent Compositions (AREA)
ZA200704520A 2004-11-08 2005-11-08 Structural nucleic acid guided chemical synthesis ZA200704520B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04105597 2004-11-08

Publications (1)

Publication Number Publication Date
ZA200704520B true ZA200704520B (en) 2008-09-25

Family

ID=34929821

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200704520A ZA200704520B (en) 2004-11-08 2005-11-08 Structural nucleic acid guided chemical synthesis

Country Status (16)

Country Link
US (2) US8202823B2 (da)
EP (1) EP1809743B1 (da)
JP (1) JP4931825B2 (da)
KR (1) KR101411361B1 (da)
CN (3) CN101914528B (da)
AT (1) ATE419344T1 (da)
AU (1) AU2005300886B2 (da)
CA (1) CA2587010C (da)
DE (1) DE602005012139D1 (da)
DK (1) DK1809743T3 (da)
EA (1) EA024849B1 (da)
ES (1) ES2320361T3 (da)
IL (1) IL183013A (da)
NZ (1) NZ555698A (da)
WO (1) WO2006048025A1 (da)
ZA (1) ZA200704520B (da)

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WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
ATE414769T1 (de) 2002-03-15 2008-12-15 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
ES2640279T3 (es) 2002-10-30 2017-11-02 Nuevolution A/S Procedimiento para la síntesis de un complejo bifuncional
EP1756277B1 (en) 2002-12-19 2009-12-02 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
EP2236606B1 (en) 2003-03-20 2013-11-06 Nuevolution A/S Ligational encoding of small molecules
EP1670939B1 (en) 2003-09-18 2009-11-04 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
EP1730277B1 (en) 2004-03-22 2009-10-28 Nuevolution A/S Ligational encoding using building block oligonucleotides
US7727721B2 (en) 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
US7960357B2 (en) 2005-10-07 2011-06-14 California Institute Of Technology PKR activation via hybridization chain reaction
EP1957644B1 (en) 2005-12-01 2010-12-01 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
EP2021470A1 (en) * 2006-05-03 2009-02-11 Vipergen APS A method for preparing compounds by nucleic acid directed synthesis
US8318921B2 (en) 2007-03-01 2012-11-27 California Institute Of Technology Triggered RNAi
EP2155770B1 (en) * 2007-05-16 2013-10-16 California Institute of Technology A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
EP2241640B1 (en) * 2008-01-22 2016-06-22 Hiroshima University Nucleic acid-binding protein assay method and kit
US8497364B2 (en) 2008-02-27 2013-07-30 California Institute Of Technology Triggered RNAi
US8241854B2 (en) 2008-05-22 2012-08-14 California Institute Of Technology Triggered RNAi
SG173627A1 (en) 2009-02-13 2011-09-29 Chem Inc X Methods of creating and screening dna-encoded libraries
WO2010020892A2 (en) * 2009-07-07 2010-02-25 The Procter & Gamble Company Property-space similarity modeling
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
US8658780B2 (en) 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
US8962241B2 (en) 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
WO2012041633A1 (en) 2010-09-27 2012-04-05 Vipergen A method for making an enriched library
BR112014005205A2 (pt) 2011-09-07 2017-03-21 X-Chem Inc métodos para etiquetar bibliotecas codificadas com dna
US9078078B1 (en) * 2011-09-15 2015-07-07 Google Inc. Call forwarding methods and systems
IL236633B (en) 2012-07-13 2022-07-01 X Chem Inc DNA-encoded libraries containing a conjugate containing conjugated oligonucleotide links
US9856472B2 (en) 2013-07-01 2018-01-02 California Institute Of Technology Small conditional RNAs
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
US20180340174A1 (en) 2014-11-11 2018-11-29 Nanocore Aps Method for identification of molecules with desired characteristics
NL2013857B1 (en) * 2014-11-21 2016-10-11 Piculet Biosciences Tech B V Self-assembled bivalent ligand complex (SABLC) libraries and methods for screening such libraries.
EP3472376A4 (en) 2016-06-16 2019-12-18 Richard Edward Watts DIRECTED AND RECORDED COMBINATORY SYNTHESIS OF OLIGONUCLEOTIDES OF CODED PROBE MOLECULES
EP3943613A1 (en) 2016-07-05 2022-01-26 California Institute of Technology Fractional initiator hybridization chain reaction
IL264831B (en) 2016-08-30 2022-09-01 California Inst Of Techn Immunohistochemistry by hybridization chain reaction
WO2018204420A1 (en) 2017-05-02 2018-11-08 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
MX2020003695A (es) 2017-11-30 2020-08-03 Arrakis Therapeutics Inc Fotosondas de union a acido nucleico y usos de las mismas.
GB201817321D0 (en) 2018-10-24 2018-12-05 Nanna Therapeutics Ltd Microbeads for tagless encoded chemical library screening
GB201821109D0 (en) * 2018-12-21 2019-02-06 Philochem Ag Nucleic acid encoded chemical libraries
CA3127137A1 (en) 2019-01-22 2020-07-30 Vipergen Aps A method for screening of an in vitro display library within a cell
EP4284925A1 (en) 2021-01-26 2023-12-06 California Institute of Technology Allosteric conditional guide rnas for cell-selective regulation of crispr/cas

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0151631A1 (en) 1983-08-03 1985-08-21 The Research Foundation Of State University Of New York Nucleic acid branched junctions with precisely defined migrational mobility
US5386020A (en) 1991-01-10 1995-01-31 New York University Multiply connected, three-dimensional nucleic acid structures
US5278051A (en) 1991-12-12 1994-01-11 New York University Construction of geometrical objects from polynucleotides
US6072044A (en) 1996-04-26 2000-06-06 New York University Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules
WO2000023458A1 (en) 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
WO2000061775A1 (en) * 1999-04-08 2000-10-19 Pavel Sergeev Synthesis of biologically active compounds in cells
AU2001268228A1 (en) * 2000-06-08 2001-12-17 La Jolla Pharmaceutical Company Multivalent platform molecules comprising high molecular weight polyethylene oxide
JP4128453B2 (ja) 2001-03-19 2008-07-30 プレジデント アンド フェロウズ オブ ハーバード カレッジ 新規分子機能の進化
EP1540013B1 (en) 2002-08-19 2015-07-08 The President and Fellows of Harvard College Evolving new molecular function
AU2003260291A1 (en) * 2002-09-12 2004-04-30 Nuevolution A/S Proximity-aided synthesis of templated molecules
ES2640279T3 (es) * 2002-10-30 2017-11-02 Nuevolution A/S Procedimiento para la síntesis de un complejo bifuncional
AU2003269401A1 (en) 2002-11-01 2004-05-25 Pharmacia & Upjohn Company Llc Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
AU2002953366A0 (en) 2002-12-17 2003-01-09 Hearts And Minds Crm Pty Ltd A method of analysing a business network
EP1756277B1 (en) * 2002-12-19 2009-12-02 Nuevolution A/S Quasirandom structure and function guided synthesis methods

Also Published As

Publication number Publication date
US8202823B2 (en) 2012-06-19
DK1809743T3 (da) 2009-05-04
CN101056980B (zh) 2012-05-23
IL183013A (en) 2011-12-29
IL183013A0 (en) 2007-08-19
ATE419344T1 (de) 2009-01-15
EP1809743A1 (en) 2007-07-25
AU2005300886A1 (en) 2006-05-11
JP2008518607A (ja) 2008-06-05
CN101056980A (zh) 2007-10-17
WO2006048025A1 (en) 2006-05-11
CA2587010A1 (en) 2006-05-11
US9006150B2 (en) 2015-04-14
NZ555698A (en) 2010-07-30
AU2005300886B2 (en) 2009-11-12
KR20070085977A (ko) 2007-08-27
CN101914528A (zh) 2010-12-15
CN101914527A (zh) 2010-12-15
DE602005012139D1 (de) 2009-02-12
EA200701022A1 (ru) 2007-10-26
CN101914528B (zh) 2013-04-03
JP4931825B2 (ja) 2012-05-16
EA024849B1 (ru) 2016-10-31
EP1809743B1 (en) 2008-12-31
ES2320361T3 (es) 2009-05-21
KR101411361B1 (ko) 2014-06-25
US20130005581A1 (en) 2013-01-03
CN101914527B (zh) 2012-06-27
US20110045990A1 (en) 2011-02-24
CA2587010C (en) 2017-08-15

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