ZA200704520B - Structural nucleic acid guided chemical synthesis - Google Patents

Structural nucleic acid guided chemical synthesis

Info

Publication number
ZA200704520B
ZA200704520B ZA200704520A ZA200704520A ZA200704520B ZA 200704520 B ZA200704520 B ZA 200704520B ZA 200704520 A ZA200704520 A ZA 200704520A ZA 200704520 A ZA200704520 A ZA 200704520A ZA 200704520 B ZA200704520 B ZA 200704520B
Authority
ZA
South Africa
Prior art keywords
nucleic acid
composition
chemical synthesis
reaction
structural nucleic
Prior art date
Application number
ZA200704520A
Other languages
English (en)
Inventor
Hansen Nils Jakob Vest
Blakskjaer Peter
Hansen Margit Haahr
Petersen Lars Kolster
Heitner Tara Renee
Original Assignee
Vipergen Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vipergen Aps filed Critical Vipergen Aps
Publication of ZA200704520B publication Critical patent/ZA200704520B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Luminescent Compositions (AREA)
  • Electroluminescent Light Sources (AREA)
ZA200704520A 2004-11-08 2005-11-08 Structural nucleic acid guided chemical synthesis ZA200704520B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04105597 2004-11-08

Publications (1)

Publication Number Publication Date
ZA200704520B true ZA200704520B (en) 2008-09-25

Family

ID=34929821

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200704520A ZA200704520B (en) 2004-11-08 2005-11-08 Structural nucleic acid guided chemical synthesis

Country Status (16)

Country Link
US (2) US8202823B2 (xx)
EP (1) EP1809743B1 (xx)
JP (1) JP4931825B2 (xx)
KR (1) KR101411361B1 (xx)
CN (3) CN101914527B (xx)
AT (1) ATE419344T1 (xx)
AU (1) AU2005300886B2 (xx)
CA (1) CA2587010C (xx)
DE (1) DE602005012139D1 (xx)
DK (1) DK1809743T3 (xx)
EA (1) EA024849B1 (xx)
ES (1) ES2320361T3 (xx)
IL (1) IL183013A (xx)
NZ (1) NZ555698A (xx)
WO (1) WO2006048025A1 (xx)
ZA (1) ZA200704520B (xx)

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DE60324778D1 (de) 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
CN106337046B (zh) 2002-10-30 2021-03-23 纽韦卢森公司 合成双功能复合物的方法
EP2175019A3 (en) 2002-12-19 2011-04-06 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597395A2 (en) 2003-02-21 2005-11-23 Nuevolution A/S Method for producing second-generation library
DE602004019764D1 (de) 2003-03-20 2009-04-16 Nuevolution As Ligationsvermittelnde codierung von kleinen molekülen
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
US7704925B2 (en) 2004-03-22 2010-04-27 Nuevolution A/S Ligational encoding using building block oligonucleotides
US7727721B2 (en) 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
WO2007044727A2 (en) 2005-10-07 2007-04-19 California Institute Of Technology Pkr activation via hybridization chain reaction
PT3305900T (pt) 2005-12-01 2021-10-27 Nuevolution As Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes
WO2007124758A1 (en) * 2006-05-03 2007-11-08 Vipergen Aps A method for preparing compounds by nucleic acid directed synthesis
US8318921B2 (en) 2007-03-01 2012-11-27 California Institute Of Technology Triggered RNAi
US9217151B2 (en) 2007-05-16 2015-12-22 California Institute Of Technology Versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
WO2009093667A1 (ja) * 2008-01-22 2009-07-30 Hiroshima University 核酸結合蛋白質アッセイ法およびキット
US8497364B2 (en) 2008-02-27 2013-07-30 California Institute Of Technology Triggered RNAi
US8241854B2 (en) 2008-05-22 2012-08-14 California Institute Of Technology Triggered RNAi
KR102091207B1 (ko) 2009-02-13 2020-03-20 엑스-켐, 인크. Ｄｎａ―코딩된 라이브러리의 생성 및 스크리닝 방법
CN102473248A (zh) * 2009-07-07 2012-05-23 宝洁公司 特性-空间相似度建模
EP3540059A1 (en) 2010-04-16 2019-09-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
US8658780B2 (en) 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
US8962241B2 (en) 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
DK3399035T3 (da) 2010-09-27 2021-05-17 Vipergen Aps Fremgangsmåde til fremstilling af et beriget bibliotek
EA032438B1 (ru) 2011-09-07 2019-05-31 Икс-Чем, Инк. Способы мечения днк-кодированных библиотек
US9078078B1 (en) * 2011-09-15 2015-07-07 Google Inc. Call forwarding methods and systems
NZ739931A (en) 2012-07-13 2019-08-30 X Chem Inc Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
US9856472B2 (en) 2013-07-01 2018-01-02 California Institute Of Technology Small conditional RNAs
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
US20180340174A1 (en) 2014-11-11 2018-11-29 Nanocore Aps Method for identification of molecules with desired characteristics
NL2013857B1 (en) * 2014-11-21 2016-10-11 Piculet Biosciences Tech B V Self-assembled bivalent ligand complex (SABLC) libraries and methods for screening such libraries.
EP3472376A4 (en) 2016-06-16 2019-12-18 Richard Edward Watts DIRECTED AND RECORDED COMBINATORY SYNTHESIS OF OLIGONUCLEOTIDES OF CODED PROBE MOLECULES
EP3943613A1 (en) 2016-07-05 2022-01-26 California Institute of Technology Fractional initiator hybridization chain reaction
AU2017321492A1 (en) 2016-08-30 2019-03-14 California Institute Of Technology Immunohistochemistry via hybridization chain reaction
EP3619340A4 (en) 2017-05-02 2021-01-20 Haystack Sciences Corporation MOLECULES FOR THE VERIFICATION OF OLIGONUCLEOTIDE DIRECTED COMBINATIONAL SYNTHESIS AND METHOD OF MANUFACTURING AND USING THEREOF
RU2020112854A (ru) 2017-11-30 2021-12-30 Арракис Терапьютикс, Инк. Фотозонды, связывающие нуклеиновые кислоты, и способы их применения
GB201817321D0 (en) 2018-10-24 2018-12-05 Nanna Therapeutics Ltd Microbeads for tagless encoded chemical library screening
GB201821109D0 (en) * 2018-12-21 2019-02-06 Philochem Ag Nucleic acid encoded chemical libraries
SG11202107913VA (en) 2019-01-22 2021-08-30 Vipergen Aps A method for screening of an in vitro display library within a cell
US11873485B2 (en) 2021-01-26 2024-01-16 California Institute Of Technology Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas

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US5386020A (en) * 1991-01-10 1995-01-31 New York University Multiply connected, three-dimensional nucleic acid structures
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US6072044A (en) * 1996-04-26 2000-06-06 New York University Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules
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EP1208219A1 (en) 1999-04-08 2002-05-29 Pavel Sergeev Synthesis of biologically active compounds in cells
CN1434726A (zh) * 2000-06-08 2003-08-06 拉卓拉药物公司 包含高分子量聚环氧乙烷的多价平台分子
PT1423400E (pt) 2001-03-19 2006-12-29 Harvard College Evolução de nova função molecular
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WO2004024929A2 (en) * 2002-09-12 2004-03-25 Nuevolution A/S Proximity-aided synthesis of templated molecules
CN106337046B (zh) * 2002-10-30 2021-03-23 纽韦卢森公司 合成双功能复合物的方法
EP1562959A2 (en) 2002-11-01 2005-08-17 Pharmacia & Upjohn Company LLC Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
AU2002953366A0 (en) 2002-12-17 2003-01-09 Hearts And Minds Crm Pty Ltd A method of analysing a business network
EP2175019A3 (en) * 2002-12-19 2011-04-06 Nuevolution A/S Quasirandom structure and function guided synthesis methods

Also Published As

Publication number Publication date
US20130005581A1 (en) 2013-01-03
IL183013A (en) 2011-12-29
KR101411361B1 (ko) 2014-06-25
EP1809743A1 (en) 2007-07-25
KR20070085977A (ko) 2007-08-27
DK1809743T3 (da) 2009-05-04
CN101056980A (zh) 2007-10-17
US20110045990A1 (en) 2011-02-24
EA200701022A1 (ru) 2007-10-26
CA2587010C (en) 2017-08-15
DE602005012139D1 (de) 2009-02-12
EP1809743B1 (en) 2008-12-31
ES2320361T3 (es) 2009-05-21
ATE419344T1 (de) 2009-01-15
CN101914527B (zh) 2012-06-27
AU2005300886A1 (en) 2006-05-11
EA024849B1 (ru) 2016-10-31
IL183013A0 (en) 2007-08-19
US8202823B2 (en) 2012-06-19
AU2005300886B2 (en) 2009-11-12
CN101914527A (zh) 2010-12-15
WO2006048025A1 (en) 2006-05-11
CN101914528A (zh) 2010-12-15
JP2008518607A (ja) 2008-06-05
JP4931825B2 (ja) 2012-05-16
CN101056980B (zh) 2012-05-23
CN101914528B (zh) 2013-04-03
US9006150B2 (en) 2015-04-14
CA2587010A1 (en) 2006-05-11
NZ555698A (en) 2010-07-30

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