DE602005012139D1 - Strukturelle nukleinsäure-geführte chemische synthese - Google Patents

Strukturelle nukleinsäure-geführte chemische synthese

Info

Publication number
DE602005012139D1
DE602005012139D1 DE602005012139T DE602005012139T DE602005012139D1 DE 602005012139 D1 DE602005012139 D1 DE 602005012139D1 DE 602005012139 T DE602005012139 T DE 602005012139T DE 602005012139 T DE602005012139 T DE 602005012139T DE 602005012139 D1 DE602005012139 D1 DE 602005012139D1
Authority
DE
Germany
Prior art keywords
nucleic acid
composition
chemical synthesis
reaction
structural nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005012139T
Other languages
English (en)
Inventor
Nils Jakob Vest Hansen
Peter Blakskjar
Margit Haahr Hansen
Lars Kolster Petersen
Tara Renee Heitner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vipergen ApS
Original Assignee
Vipergen ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vipergen ApS filed Critical Vipergen ApS
Publication of DE602005012139D1 publication Critical patent/DE602005012139D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Electroluminescent Light Sources (AREA)
  • Luminescent Compositions (AREA)
DE602005012139T 2004-11-08 2005-11-08 Strukturelle nukleinsäure-geführte chemische synthese Active DE602005012139D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP04105597 2004-11-08
US68784905P 2005-06-07 2005-06-07
US72534705P 2005-10-11 2005-10-11
PCT/DK2005/000714 WO2006048025A1 (en) 2004-11-08 2005-11-08 Structural nucleic acid guided chemical synthesis

Publications (1)

Publication Number Publication Date
DE602005012139D1 true DE602005012139D1 (de) 2009-02-12

Family

ID=34929821

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005012139T Active DE602005012139D1 (de) 2004-11-08 2005-11-08 Strukturelle nukleinsäure-geführte chemische synthese

Country Status (16)

Country Link
US (2) US8202823B2 (de)
EP (1) EP1809743B1 (de)
JP (1) JP4931825B2 (de)
KR (1) KR101411361B1 (de)
CN (3) CN101056980B (de)
AT (1) ATE419344T1 (de)
AU (1) AU2005300886B2 (de)
CA (1) CA2587010C (de)
DE (1) DE602005012139D1 (de)
DK (1) DK1809743T3 (de)
EA (1) EA024849B1 (de)
ES (1) ES2320361T3 (de)
IL (1) IL183013A (de)
NZ (1) NZ555698A (de)
WO (1) WO2006048025A1 (de)
ZA (1) ZA200704520B (de)

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WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
AU2003214031A1 (en) 2002-03-15 2003-09-29 Nuevolution A/S An improved method for synthesising templated molecules
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
CN102838654B (zh) 2002-10-30 2016-05-18 纽韦卢森公司 合成双功能复合物的方法
AU2003291964A1 (en) 2002-12-19 2004-07-14 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
EP1608748B1 (de) 2003-03-20 2009-03-04 Nuevolution A/S Ligationsvermittelnde codierung von kleinen molekülen
DK1670939T3 (da) 2003-09-18 2010-03-01 Nuevolution As Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser
EP1730277B1 (de) 2004-03-22 2009-10-28 Nuevolution A/S Ligationscodierung unter verwendung von oligonukleotidbausteinen
US7727721B2 (en) 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
EP1931806B1 (de) 2005-10-07 2011-10-05 California Institute Of Technology Pkr-aktivierung mittels hybridisierungskettenreaktion
SI3305900T1 (sl) 2005-12-01 2022-02-28 Nuevolution A/S Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic
EP2021470A1 (de) 2006-05-03 2009-02-11 Vipergen APS Verfahren zur herstellung von verbindungen durch nukleinsäuregesteuerte synthese
WO2008106658A2 (en) 2007-03-01 2008-09-04 California Institute Of Technology TRIGGERED RNAi
WO2008144562A1 (en) 2007-05-16 2008-11-27 California Institute Of Technology A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
EP2241640B1 (de) * 2008-01-22 2016-06-22 Hiroshima University Nukleinsäurebindungsprotein-testverfahren und -kit
US8497364B2 (en) 2008-02-27 2013-07-30 California Institute Of Technology Triggered RNAi
US8241854B2 (en) 2008-05-22 2012-08-14 California Institute Of Technology Triggered RNAi
US9359601B2 (en) 2009-02-13 2016-06-07 X-Chem, Inc. Methods of creating and screening DNA-encoded libraries
EP2452294A2 (de) * 2009-07-07 2012-05-16 The Procter & Gamble Company Ähnlichkeitsmodellierung von vermögensräumen
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
US8658780B2 (en) 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
US8962241B2 (en) 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly
EP3399035B1 (de) * 2010-09-27 2021-02-17 Vipergen Verfahren zur herstellung einer angereicherten bibliothek
IN2014CN02574A (de) 2011-09-07 2015-06-26 Chem Inc X
US9078078B1 (en) * 2011-09-15 2015-07-07 Google Inc. Call forwarding methods and systems
AU2013289993B2 (en) 2012-07-13 2018-05-10 X-Chem, Inc. DNA-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
US9856472B2 (en) 2013-07-01 2018-01-02 California Institute Of Technology Small conditional RNAs
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
EP3218479A1 (de) 2014-11-11 2017-09-20 Nanocore ApS Verfahren zur identifizierung von molekülen mit gewünschten eigenschaften
NL2013857B1 (en) * 2014-11-21 2016-10-11 Piculet Biosciences Tech B V Self-assembled bivalent ligand complex (SABLC) libraries and methods for screening such libraries.
US11186836B2 (en) 2016-06-16 2021-11-30 Haystack Sciences Corporation Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
ES2908919T3 (es) 2016-07-05 2022-05-04 California Inst Of Techn Reacción en cadena de hibridación de iniciador fraccionario
US10815519B2 (en) 2016-08-30 2020-10-27 California Institute Of Technology Immunohistochemistry via hybridization chain reaction
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
IL297543A (en) 2017-11-30 2022-12-01 Arrakis Therapeutics Inc Nucleic acid-binding photoprobes and their uses
GB201817321D0 (en) 2018-10-24 2018-12-05 Nanna Therapeutics Ltd Microbeads for tagless encoded chemical library screening
GB201821109D0 (en) * 2018-12-21 2019-02-06 Philochem Ag Nucleic acid encoded chemical libraries
WO2020152028A1 (en) * 2019-01-22 2020-07-30 Vipergen Aps A method for screening of an in vitro display library within a cell
WO2022164796A1 (en) 2021-01-26 2022-08-04 California Institute Of Technology Allosteric conditional guide rnas for cell-selective regulation of crispr/cas

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0151631A1 (de) * 1983-08-03 1985-08-21 The Research Foundation Of State University Of New York Verzweigte verbindungen von nukleinsäure mit einer präzise bestimmten migration
US5386020A (en) * 1991-01-10 1995-01-31 New York University Multiply connected, three-dimensional nucleic acid structures
US5278051A (en) * 1991-12-12 1994-01-11 New York University Construction of geometrical objects from polynucleotides
US6072044A (en) * 1996-04-26 2000-06-06 New York University Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules
US7479472B1 (en) 1998-10-19 2009-01-20 The Board Of Trustees Of The Leland Stanford Junior University DNA-templated combinatorial library chemistry
WO2000061775A1 (en) * 1999-04-08 2000-10-19 Pavel Sergeev Synthesis of biologically active compounds in cells
EP1292337A2 (de) * 2000-06-08 2003-03-19 La Jolla Pharmaceutical Polyethylenoxid mit hohem molekulargewicht enthaltende multivalenz-plattformmoleküle
EP2332896A3 (de) 2001-03-19 2012-09-26 President and Fellows of Harvard College Entwicklung neuer molekularer Funktionen
JP4657919B2 (ja) 2002-08-19 2011-03-23 プレジデント アンド フェローズ オブ ハーバード カレッジ 進化する新しい分子機能
WO2004024929A2 (en) * 2002-09-12 2004-03-25 Nuevolution A/S Proximity-aided synthesis of templated molecules
CN102838654B (zh) * 2002-10-30 2016-05-18 纽韦卢森公司 合成双功能复合物的方法
BR0315056A (pt) 2002-11-01 2005-08-16 Pharmacia & Upjohn Co Llc Compostos tendo tanto atividade agonista nicotìnica de alfa7 quanto atividade antagonista de 5ht3 para o tratamento de doenças do sistema nervoso central
AU2002953366A0 (en) 2002-12-17 2003-01-09 Hearts And Minds Crm Pty Ltd A method of analysing a business network
AU2003291964A1 (en) * 2002-12-19 2004-07-14 Nuevolution A/S Quasirandom structure and function guided synthesis methods

Also Published As

Publication number Publication date
EP1809743B1 (de) 2008-12-31
CN101914528A (zh) 2010-12-15
CN101056980A (zh) 2007-10-17
JP4931825B2 (ja) 2012-05-16
EP1809743A1 (de) 2007-07-25
CA2587010A1 (en) 2006-05-11
IL183013A (en) 2011-12-29
EA024849B1 (ru) 2016-10-31
US8202823B2 (en) 2012-06-19
CN101914527A (zh) 2010-12-15
US9006150B2 (en) 2015-04-14
ES2320361T3 (es) 2009-05-21
WO2006048025A1 (en) 2006-05-11
CN101914528B (zh) 2013-04-03
NZ555698A (en) 2010-07-30
US20110045990A1 (en) 2011-02-24
AU2005300886B2 (en) 2009-11-12
CN101056980B (zh) 2012-05-23
ZA200704520B (en) 2008-09-25
ATE419344T1 (de) 2009-01-15
EA200701022A1 (ru) 2007-10-26
CA2587010C (en) 2017-08-15
IL183013A0 (en) 2007-08-19
AU2005300886A1 (en) 2006-05-11
US20130005581A1 (en) 2013-01-03
KR101411361B1 (ko) 2014-06-25
JP2008518607A (ja) 2008-06-05
KR20070085977A (ko) 2007-08-27
CN101914527B (zh) 2012-06-27
DK1809743T3 (da) 2009-05-04

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