DK1809743T3 - Strukturel nukleinsyre-styret kemisk syntese - Google Patents

Strukturel nukleinsyre-styret kemisk syntese

Info

Publication number
DK1809743T3
DK1809743T3 DK05800754T DK05800754T DK1809743T3 DK 1809743 T3 DK1809743 T3 DK 1809743T3 DK 05800754 T DK05800754 T DK 05800754T DK 05800754 T DK05800754 T DK 05800754T DK 1809743 T3 DK1809743 T3 DK 1809743T3
Authority
DK
Denmark
Prior art keywords
nucleic acid
composition
chemical synthesis
reaction
structural nucleic
Prior art date
Application number
DK05800754T
Other languages
English (en)
Inventor
Nils Jakob Vest Hansen
Peter Blakskjaer
Margit Haahr Hansen
Lars Kolster Petersen
Tara Renee Heitner
Original Assignee
Vipergen Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vipergen Aps filed Critical Vipergen Aps
Application granted granted Critical
Publication of DK1809743T3 publication Critical patent/DK1809743T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Electroluminescent Light Sources (AREA)
  • Luminescent Compositions (AREA)
DK05800754T 2004-11-08 2005-11-08 Strukturel nukleinsyre-styret kemisk syntese DK1809743T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP04105597 2004-11-08
US68784905P 2005-06-07 2005-06-07
US72534705P 2005-10-11 2005-10-11
PCT/DK2005/000714 WO2006048025A1 (en) 2004-11-08 2005-11-08 Structural nucleic acid guided chemical synthesis

Publications (1)

Publication Number Publication Date
DK1809743T3 true DK1809743T3 (da) 2009-05-04

Family

ID=34929821

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05800754T DK1809743T3 (da) 2004-11-08 2005-11-08 Strukturel nukleinsyre-styret kemisk syntese

Country Status (16)

Country Link
US (2) US8202823B2 (da)
EP (1) EP1809743B1 (da)
JP (1) JP4931825B2 (da)
KR (1) KR101411361B1 (da)
CN (3) CN101914528B (da)
AT (1) ATE419344T1 (da)
AU (1) AU2005300886B2 (da)
CA (1) CA2587010C (da)
DE (1) DE602005012139D1 (da)
DK (1) DK1809743T3 (da)
EA (1) EA024849B1 (da)
ES (1) ES2320361T3 (da)
IL (1) IL183013A (da)
NZ (1) NZ555698A (da)
WO (1) WO2006048025A1 (da)
ZA (1) ZA200704520B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
EP2186897B1 (en) 2002-03-15 2016-02-17 Nuevolution A/S An improved method for synthesising templated molecules
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
ES2368215T3 (es) 2002-10-30 2011-11-15 Nuevolution A/S Codificación enzimática.
EP2175019A3 (en) 2002-12-19 2011-04-06 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US7915201B2 (en) 2003-03-20 2011-03-29 Nuevolution A/S Ligational encoding of small molecules
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
DK1730277T3 (da) 2004-03-22 2010-03-01 Nuevolution As Kodning ved ligering under anvendelse af byggebloksoligonukleotider
US7727721B2 (en) 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
ATE526975T1 (de) 2005-10-07 2011-10-15 California Inst Of Techn Pkr-aktivierung mittels hybridisierungskettenreaktion
DE602006018648D1 (de) 2005-12-01 2011-01-13 Nuevolution As Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken
WO2007124758A1 (en) * 2006-05-03 2007-11-08 Vipergen Aps A method for preparing compounds by nucleic acid directed synthesis
US8318921B2 (en) 2007-03-01 2012-11-27 California Institute Of Technology Triggered RNAi
US9217151B2 (en) 2007-05-16 2015-12-22 California Institute Of Technology Versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
WO2009093667A1 (ja) * 2008-01-22 2009-07-30 Hiroshima University 核酸結合蛋白質アッセイ法およびキット
US8497364B2 (en) 2008-02-27 2013-07-30 California Institute Of Technology Triggered RNAi
US8241854B2 (en) 2008-05-22 2012-08-14 California Institute Of Technology Triggered RNAi
NZ594420A (en) 2009-02-13 2013-06-28 Chem Inc X Methods of creating and screening dna-encoded libraries
CN102473248A (zh) * 2009-07-07 2012-05-23 宝洁公司 特性-空间相似度建模
DK2558577T3 (da) 2010-04-16 2019-04-01 Nuevolution As Bi-funktionelle komplekser og fremgangsmåder til fremstilling og anvendelse af sådanne komplekser
US8658780B2 (en) 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
US8962241B2 (en) 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly
WO2012041633A1 (en) 2010-09-27 2012-04-05 Vipergen A method for making an enriched library
EP3828271A1 (en) 2011-09-07 2021-06-02 X-Chem, Inc. Methods for tagging dna-encoded libraries
US9078078B1 (en) * 2011-09-15 2015-07-07 Google Inc. Call forwarding methods and systems
IL236633B (en) 2012-07-13 2022-07-01 X Chem Inc DNA-encoded libraries containing a conjugate containing conjugated oligonucleotide links
US9856472B2 (en) 2013-07-01 2018-01-02 California Institute Of Technology Small conditional RNAs
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
EP3218479A1 (en) 2014-11-11 2017-09-20 Nanocore ApS Method for identification of molecules with desired characteristics
NL2013857B1 (en) * 2014-11-21 2016-10-11 Piculet Biosciences Tech B V Self-assembled bivalent ligand complex (SABLC) libraries and methods for screening such libraries.
EP3472376A4 (en) 2016-06-16 2019-12-18 Richard Edward Watts DIRECTED AND RECORDED COMBINATORY SYNTHESIS OF OLIGONUCLEOTIDES OF CODED PROBE MOLECULES
IL302802A (en) 2016-07-05 2023-07-01 California Inst Of Techn Hybridization chain reaction based on a minimal initiator
IL264831B (en) 2016-08-30 2022-09-01 California Inst Of Techn Immunohistochemistry by hybridization chain reaction
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
MX2020003695A (es) 2017-11-30 2020-08-03 Arrakis Therapeutics Inc Fotosondas de union a acido nucleico y usos de las mismas.
GB201817321D0 (en) 2018-10-24 2018-12-05 Nanna Therapeutics Ltd Microbeads for tagless encoded chemical library screening
GB201821109D0 (en) * 2018-12-21 2019-02-06 Philochem Ag Nucleic acid encoded chemical libraries
EP3914704B9 (en) * 2019-01-22 2023-10-04 Vipergen APS A method for screening of an in vitro display library within a cell
EP4284925A1 (en) 2021-01-26 2023-12-06 California Institute of Technology Allosteric conditional guide rnas for cell-selective regulation of crispr/cas

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000813A1 (en) * 1983-08-03 1985-02-28 The Research Foundation Of State University Of New Nucleic acid branched junctions with precisely defined migrational mobility
US5386020A (en) * 1991-01-10 1995-01-31 New York University Multiply connected, three-dimensional nucleic acid structures
US5278051A (en) * 1991-12-12 1994-01-11 New York University Construction of geometrical objects from polynucleotides
US6072044A (en) * 1996-04-26 2000-06-06 New York University Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules
CA2346989A1 (en) 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
CA2403209A1 (en) 1999-04-08 2000-10-19 Pavel V. Sergeev Synthesis of biologically active compounds in cells
EP1292337A2 (en) * 2000-06-08 2003-03-19 La Jolla Pharmaceutical Multivalent platform molecules comprising high molecular weight polyethylene oxide
ATE335754T1 (de) 2001-03-19 2006-09-15 Harvard College Entwicklung neuer molekularer funktionen
EP1540013B1 (en) 2002-08-19 2015-07-08 The President and Fellows of Harvard College Evolving new molecular function
WO2004024929A2 (en) * 2002-09-12 2004-03-25 Nuevolution A/S Proximity-aided synthesis of templated molecules
ES2368215T3 (es) * 2002-10-30 2011-11-15 Nuevolution A/S Codificación enzimática.
WO2004039815A2 (en) 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
AU2002953366A0 (en) 2002-12-17 2003-01-09 Hearts And Minds Crm Pty Ltd A method of analysing a business network
EP2175019A3 (en) * 2002-12-19 2011-04-06 Nuevolution A/S Quasirandom structure and function guided synthesis methods

Also Published As

Publication number Publication date
NZ555698A (en) 2010-07-30
US20110045990A1 (en) 2011-02-24
CN101914527A (zh) 2010-12-15
CA2587010C (en) 2017-08-15
ATE419344T1 (de) 2009-01-15
EA024849B1 (ru) 2016-10-31
EA200701022A1 (ru) 2007-10-26
KR101411361B1 (ko) 2014-06-25
US20130005581A1 (en) 2013-01-03
CN101914528B (zh) 2013-04-03
CN101914527B (zh) 2012-06-27
AU2005300886B2 (en) 2009-11-12
CN101056980A (zh) 2007-10-17
AU2005300886A1 (en) 2006-05-11
JP2008518607A (ja) 2008-06-05
CA2587010A1 (en) 2006-05-11
IL183013A0 (en) 2007-08-19
CN101056980B (zh) 2012-05-23
ZA200704520B (en) 2008-09-25
EP1809743A1 (en) 2007-07-25
ES2320361T3 (es) 2009-05-21
CN101914528A (zh) 2010-12-15
KR20070085977A (ko) 2007-08-27
WO2006048025A1 (en) 2006-05-11
EP1809743B1 (en) 2008-12-31
US9006150B2 (en) 2015-04-14
US8202823B2 (en) 2012-06-19
DE602005012139D1 (de) 2009-02-12
IL183013A (en) 2011-12-29
JP4931825B2 (ja) 2012-05-16

Similar Documents

Publication Publication Date Title
DK1809743T3 (da) Strukturel nukleinsyre-styret kemisk syntese
WO2005002359A3 (en) Modified starch, uses, methods for production thereof
BRPI0413323A (pt) processo para a preparação de vacinas conjugadas de polissacarìdeo-proteìna
TWI365867B (en) Process for preparing cyclohexanone and cyclohexanol
WO2010066411A3 (en) Polypeptides having cellobiohydrolase ii activity
DE602006007357D1 (de) Verfahren zur reduktiven aminierung von aldehyden und ketonen durch die bildung von makrocyclischen polyimin-zwischenprodukten
WO2005016824A3 (en) Synthesis of nanoparticles by an emulsion-gas contacting process
WO2004007664A3 (en) Nucleic acid vectors
DE602005026099D1 (de) Transformierte saccharomyces cerevisiae sowie verfahren zur massenproduktion des proteins lk8 damit
DK1844144T3 (da) Fremgangsmåde til mutagenese
DE502007006479D1 (de) Integriertes verfahren zur herstellung von benzol und ammoniak ausgehend von aliphatischen kohlenwasserstoffen und stickstoff
WO2007071578A3 (de) Verfahren zur herstellung von 5 -norbornen-2-carbonsäure aus 5-norbornen-2-carbonitril unter verwendung einer arylacetonitrilase
WO2007102006A3 (en) Non-cloning vector method for generating genomic templates for cluster formation and sbs sequencing
WO2004089281A3 (en) Novel polymorphs of tolterodine tartrate
DE50002865D1 (de) Verfahren zur herstellung von benzofuranonoximen
NO20064484L (no) Isopropanol-vannopplosning av olanzapin
AU2003903132A0 (en) Plant promoter
WO2003040292A3 (de) Gene die für membransynthese- und membrantransport-proteine codieren
DE502004001550D1 (de) Verfahren zur herstellung von melamin im einphasigen rohrreaktor
UA84150C2 (ru) Йодопиразолилкарбоксанилиды, способ их получения, производные йодопиразолилкарбоновой кислоты и средство для борьбы с нежелательными микроорганизмами
TH75572B (th) กรรมวิธีการสังเคราะห์ตัวเร่งปฏิกิริยาจากผลิตผลพลอยได้ (By Product) ของกระบวนการผลิตแอสฟัลติกคอนกรีต (Asphaltic Concrete) และการใช้ตัวเร่งปฏิกิริยาดังกล่าว
UA96731C2 (en) Process for preparing cyclohexanone and cyclohexanol
TH74461A (th) กรรมวิธี
TH110369B (th) วิธีการผลิตไอโซไซยาเนทโดยใช้ไดอัลลิลกรดคาร์บอนิค
TW200712247A (en) Method of processing ferric compound by plasma technique and preparing ferric oxide