ZA200701666B - Pyridine méthylène azolidinones and use thereof phospho-inositide inhibitors - Google Patents
Pyridine méthylène azolidinones and use thereof phospho-inositide inhibitors Download PDFInfo
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- ZA200701666B ZA200701666B ZA200701666A ZA200701666A ZA200701666B ZA 200701666 B ZA200701666 B ZA 200701666B ZA 200701666 A ZA200701666 A ZA 200701666A ZA 200701666 A ZA200701666 A ZA 200701666A ZA 200701666 B ZA200701666 B ZA 200701666B
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- South Africa
- Prior art keywords
- pyridine
- derivative according
- imidazo
- alkyl
- diseases
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title claims description 10
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- HAIALLMLSNZDAL-UHFFFAOYSA-N 3-methylidenepyrrolidin-2-one;pyridine Chemical class C1=CC=NC=C1.C=C1CCNC1=O HAIALLMLSNZDAL-UHFFFAOYSA-N 0.000 claims abstract description 27
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60737404P | 2004-09-03 | 2004-09-03 | |
| EP04104259 | 2004-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200701666B true ZA200701666B (en) | 2008-07-30 |
Family
ID=35457295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200701666A ZA200701666B (en) | 2004-09-03 | 2005-09-02 | Pyridine méthylène azolidinones and use thereof phospho-inositide inhibitors |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7842698B2 (sl) |
| EP (1) | EP1786812B1 (sl) |
| JP (1) | JP5209311B2 (sl) |
| KR (1) | KR101229647B1 (sl) |
| CN (1) | CN101052640B (sl) |
| AT (1) | ATE532783T1 (sl) |
| AU (1) | AU2005279156B2 (sl) |
| BR (1) | BRPI0515627A (sl) |
| CA (1) | CA2576765C (sl) |
| CY (1) | CY1112316T1 (sl) |
| EA (1) | EA012178B1 (sl) |
| HK (1) | HK1106773A1 (sl) |
| HR (1) | HRP20110834T1 (sl) |
| IL (1) | IL181415A (sl) |
| MX (1) | MX2007002604A (sl) |
| NO (1) | NO20071605L (sl) |
| PL (1) | PL1786812T3 (sl) |
| SI (1) | SI1786812T1 (sl) |
| WO (1) | WO2006024666A1 (sl) |
| ZA (1) | ZA200701666B (sl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005011686A1 (en) | 2003-07-28 | 2005-02-10 | Applied Research Systems Ars Holding N.V. | 2-imino-4-(thio) oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors |
| EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| US20090215818A1 (en) * | 2006-07-24 | 2009-08-27 | Smithkline Beecham Corporation | Thiozolidinedione derivatives as pi3 kinase inhibitors |
| ES2399175T3 (es) * | 2008-04-29 | 2013-03-26 | Novartis Ag | Derivados de imidazo-piridina como inhibidores de quinasa del receptor tipo activina (alk4 o alk5) |
| WO2010030727A1 (en) * | 2008-09-10 | 2010-03-18 | Wyeth Llc | 3-substituted-1h-indole, 3-substituted-1h-pyrrolo[2,3-b]pyridine and 3-substituted-1h-pyrrolo[3,2-b]pyridine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| CA2751501C (en) * | 2009-02-12 | 2018-01-16 | Merck Serono S.A. | 2-morpholino-pyrido[3,2-d]pyrimidines |
| EP2509602B9 (en) * | 2009-12-04 | 2017-11-01 | Senhwa Biosciences, Inc. | Pyrazolopyrimidines and related heterocycles as ck2 inhibitors |
| CN102884062B (zh) | 2009-12-23 | 2016-08-03 | 嘉世高制药公司 | 氨基嘧啶激酶抑制剂 |
| WO2012145617A2 (en) | 2011-04-22 | 2012-10-26 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
| MX355015B (es) * | 2011-09-15 | 2018-04-02 | Univ Taipei Medical | Uso de hidroxamatos de indolilo e indolinilo para tratar insuficiencia cardiaca o lesión neuronal. |
| JP6057907B2 (ja) * | 2011-10-04 | 2017-01-11 | 株式会社ヤクルト本社 | チアゾリジン誘導体又はその塩を有効成分とする医薬品 |
| ES2629690T3 (es) | 2011-11-04 | 2017-08-14 | Jasco Pharmaceuticals, LLC | Inhibidores de aminopirimidina quinasa |
| WO2014017802A1 (ko) | 2012-07-23 | 2014-01-30 | 주식회사 유한양행 | 퓨란-함유 융합 고리 화합물 또는 그의 염 및 이를 포함하는 약학 조성물 |
| KR20210010958A (ko) | 2012-11-08 | 2021-01-28 | 리젠 파마슈티컬스 소시에떼 아노님 | Pde4 억제제 및 pi3 델타 또는 이중 pi3 델타-감마 키나아제 억제제를 함유하는 약제학적 조성물 |
| JP6804469B2 (ja) | 2015-04-29 | 2020-12-23 | ヤンセン ファーマシューティカ エヌ．ベー． | ベンゾイミダゾロン及びベンゾチアゾロン化合物並びにａｍｐａ受容体調節因子としてのそれらの使用 |
| US10604484B2 (en) | 2015-04-29 | 2020-03-31 | Janssen Pharmaceutica Nv | Indolone compounds and their use as AMPA receptor modulators |
| EP3288940B9 (en) * | 2015-04-29 | 2021-07-21 | Janssen Pharmaceutica NV | Azabenzimidazoles and their use as ampa receptor modulators |
| US10513523B2 (en) | 2015-04-29 | 2019-12-24 | Janssen Pharmaceutica Nv | Imidazopyrazines and pyrazolopyrimidines and their use as AMPA receptor modulators |
| WO2018013430A2 (en) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus infection |
| CN106588909B (zh) * | 2017-01-06 | 2019-08-27 | 广东工业大学 | 一种喹啉类衍生物的制备及其在抗炎中的应用 |
| CN109575435A (zh) | 2017-09-14 | 2019-04-05 | 株式会社日化精密科技 | 聚丙烯树脂组合物、聚丙烯树脂成形体以及聚丙烯树脂成形体的制造方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4782564B2 (ja) * | 2002-07-10 | 2011-09-28 | メルク セローノ ソシエテ アノニム | アゾリジノン−ビニル縮合−ベンゼン誘導体 |
| BR0316386A (pt) * | 2002-12-06 | 2005-09-27 | Warner Lambert Co | Benzoxazin-3-onas e seus derivados como inibidores de p13k |
| AU2003303231A1 (en) | 2002-12-20 | 2004-07-14 | Warner-Lambert Company Llc | Benzoxazines and derivatives thereof as inhibitors of pi3ks |
| US7202363B2 (en) * | 2003-07-24 | 2007-04-10 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
| WO2005011686A1 (en) | 2003-07-28 | 2005-02-10 | Applied Research Systems Ars Holding N.V. | 2-imino-4-(thio) oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors |
| CN101006078A (zh) * | 2004-06-17 | 2007-07-25 | 惠氏公司 | 促性腺素释放激素受体拮抗剂 |
| JP2008515955A (ja) * | 2004-10-12 | 2008-05-15 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 貧血の治療のためのＰＩ３キナーゼγ阻害剤 |
| BRPI0615654A2 (pt) * | 2005-09-07 | 2011-05-24 | Serono Lab | inibidores da pi3k para o tratamento de endometriose |
| TW200808793A (en) * | 2006-03-07 | 2008-02-16 | Smithkline Beecham Corp | Prolyl hydroxylase inhibitors |
| CN101553492A (zh) * | 2006-08-31 | 2009-10-07 | 阵列生物制药公司 | Raf抑制剂化合物及其使用方法 |
| US8183249B2 (en) * | 2007-07-12 | 2012-05-22 | University Of South Florida | Inhibitors of AKT/PKB with anti-tumor activity |
| US7932251B2 (en) * | 2007-07-16 | 2011-04-26 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
-
2005
- 2005-09-02 EP EP05797231A patent/EP1786812B1/en active Active
- 2005-09-02 ZA ZA200701666A patent/ZA200701666B/en unknown
- 2005-09-02 PL PL05797231T patent/PL1786812T3/pl unknown
- 2005-09-02 KR KR1020077007588A patent/KR101229647B1/ko not_active IP Right Cessation
- 2005-09-02 MX MX2007002604A patent/MX2007002604A/es active IP Right Grant
- 2005-09-02 EA EA200700541A patent/EA012178B1/ru not_active IP Right Cessation
- 2005-09-02 AU AU2005279156A patent/AU2005279156B2/en not_active Ceased
- 2005-09-02 AT AT05797231T patent/ATE532783T1/de active
- 2005-09-02 BR BRPI0515627-0A patent/BRPI0515627A/pt not_active IP Right Cessation
- 2005-09-02 WO PCT/EP2005/054339 patent/WO2006024666A1/en active Application Filing
- 2005-09-02 JP JP2007528883A patent/JP5209311B2/ja not_active Expired - Fee Related
- 2005-09-02 CA CA2576765A patent/CA2576765C/en not_active Expired - Fee Related
- 2005-09-02 US US11/574,613 patent/US7842698B2/en not_active Expired - Fee Related
- 2005-09-02 CN CN200580037159XA patent/CN101052640B/zh not_active Expired - Fee Related
- 2005-09-02 SI SI200531418T patent/SI1786812T1/sl unknown
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2007
- 2007-02-19 IL IL181415A patent/IL181415A/en not_active IP Right Cessation
- 2007-03-27 NO NO20071605A patent/NO20071605L/no not_active Application Discontinuation
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2008
- 2008-01-16 HK HK08100536.3A patent/HK1106773A1/xx not_active IP Right Cessation
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2010
- 2010-10-18 US US12/906,729 patent/US8058289B2/en not_active Expired - Fee Related
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2011
- 2011-11-11 HR HR20110834T patent/HRP20110834T1/hr unknown
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2012
- 2012-02-02 CY CY20121100119T patent/CY1112316T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1106773A1 (en) | 2008-03-20 |
| HRP20110834T1 (hr) | 2011-12-31 |
| EA012178B1 (ru) | 2009-08-28 |
| JP5209311B2 (ja) | 2013-06-12 |
| JP2008511589A (ja) | 2008-04-17 |
| AU2005279156B2 (en) | 2011-06-02 |
| AU2005279156A1 (en) | 2006-03-09 |
| EA200700541A1 (ru) | 2007-08-31 |
| KR20070053315A (ko) | 2007-05-23 |
| EP1786812A1 (en) | 2007-05-23 |
| BRPI0515627A (pt) | 2008-07-29 |
| WO2006024666A1 (en) | 2006-03-09 |
| KR101229647B1 (ko) | 2013-02-05 |
| ATE532783T1 (de) | 2011-11-15 |
| IL181415A (en) | 2012-09-24 |
| SI1786812T1 (sl) | 2011-12-30 |
| EP1786812B1 (en) | 2011-11-09 |
| MX2007002604A (es) | 2007-04-25 |
| CA2576765A1 (en) | 2006-03-09 |
| CA2576765C (en) | 2013-05-28 |
| US20080269227A1 (en) | 2008-10-30 |
| IL181415A0 (en) | 2007-07-04 |
| PL1786812T3 (pl) | 2012-04-30 |
| CN101052640A (zh) | 2007-10-10 |
| US7842698B2 (en) | 2010-11-30 |
| US8058289B2 (en) | 2011-11-15 |
| CN101052640B (zh) | 2011-05-11 |
| NO20071605L (no) | 2007-05-31 |
| CY1112316T1 (el) | 2015-12-09 |
| US20110034458A1 (en) | 2011-02-10 |
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