ATE532783T1 - Pyridinmethylenzolidinone und ihre verwendung als phosphoinositid-hemmer - Google Patents
Pyridinmethylenzolidinone und ihre verwendung als phosphoinositid-hemmerInfo
- Publication number
- ATE532783T1 ATE532783T1 AT05797231T AT05797231T ATE532783T1 AT E532783 T1 ATE532783 T1 AT E532783T1 AT 05797231 T AT05797231 T AT 05797231T AT 05797231 T AT05797231 T AT 05797231T AT E532783 T1 ATE532783 T1 AT E532783T1
- Authority
- AT
- Austria
- Prior art keywords
- diseases
- pyridinmethylenenzolidinones
- phosphoinositide
- inhibitors
- phosphoinositide inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003906 phosphoinositides Chemical class 0.000 title 1
- HAIALLMLSNZDAL-UHFFFAOYSA-N 3-methylidenepyrrolidin-2-one;pyridine Chemical class C1=CC=NC=C1.C=C1CCNC1=O HAIALLMLSNZDAL-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000004852 Lung Injury Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 231100000515 lung injury Toxicity 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60737404P | 2004-09-03 | 2004-09-03 | |
| EP04104259 | 2004-09-03 | ||
| PCT/EP2005/054339 WO2006024666A1 (en) | 2004-09-03 | 2005-09-02 | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE532783T1 true ATE532783T1 (de) | 2011-11-15 |
Family
ID=35457295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05797231T ATE532783T1 (de) | 2004-09-03 | 2005-09-02 | Pyridinmethylenzolidinone und ihre verwendung als phosphoinositid-hemmer |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7842698B2 (de) |
| EP (1) | EP1786812B1 (de) |
| JP (1) | JP5209311B2 (de) |
| KR (1) | KR101229647B1 (de) |
| CN (1) | CN101052640B (de) |
| AT (1) | ATE532783T1 (de) |
| AU (1) | AU2005279156B2 (de) |
| BR (1) | BRPI0515627A (de) |
| CA (1) | CA2576765C (de) |
| CY (1) | CY1112316T1 (de) |
| EA (1) | EA012178B1 (de) |
| HR (1) | HRP20110834T1 (de) |
| IL (1) | IL181415A (de) |
| MX (1) | MX2007002604A (de) |
| NO (1) | NO20071605L (de) |
| PL (1) | PL1786812T3 (de) |
| SI (1) | SI1786812T1 (de) |
| WO (1) | WO2006024666A1 (de) |
| ZA (1) | ZA200701666B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1648452B1 (de) | 2003-07-28 | 2009-07-22 | Merck Serono SA | 2-imino-4-(thio)oxo-5-polycyclovinylazoline zur verwendung als pi3-kinase-inhibtoren |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
| US20090215818A1 (en) * | 2006-07-24 | 2009-08-27 | Smithkline Beecham Corporation | Thiozolidinedione derivatives as pi3 kinase inhibitors |
| EA201001687A1 (ru) * | 2008-04-29 | 2011-06-30 | Новартис Аг | Производные имидазопиридина в качестве ингибиторов активиноподобной рецепторной киназы ( alk-4 или alk-5 ) |
| US20100061982A1 (en) * | 2008-09-10 | 2010-03-11 | Wyeth | 3-substituted-1h-indole, 3-substituted-1h-pyrrolo[2,3-b]pyridine and 3-substituted-1h-pyrrolo[3,2-b]pyridine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| WO2010091996A1 (en) * | 2009-02-12 | 2010-08-19 | Merck Serono S.A. | 2-morpholino-pyrido[3,2-d]pyrimidines |
| PL2509602T3 (pl) * | 2009-12-04 | 2017-08-31 | Senhwa Biosciences, Inc. | Pirazolopirymidyny i podobne heterocykle jako inhibitory ck2 |
| CN102884062B (zh) | 2009-12-23 | 2016-08-03 | 嘉世高制药公司 | 氨基嘧啶激酶抑制剂 |
| EP2699569B1 (de) * | 2011-04-22 | 2017-08-30 | Jasco Pharmaceuticals, LLC | Aminopyrimidinkinasehemmer |
| RU2615767C2 (ru) * | 2011-09-15 | 2017-04-11 | Тайпей Медикл Юнивесити | Способ лечения сердечной недостаточности и поражения нервных клеток |
| WO2013051672A1 (ja) * | 2011-10-04 | 2013-04-11 | 株式会社ヤクルト本社 | チアゾリジン誘導体又はその塩を有効成分とする医薬品 |
| RU2674017C2 (ru) | 2011-11-04 | 2018-12-04 | ДЖАСКО ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Аминопиримидиновые ингибиторы киназ |
| KR101684955B1 (ko) | 2012-07-23 | 2016-12-12 | 주식회사유한양행 | 퓨란-함유 융합 고리 화합물 또는 그의 염 및 이를 포함하는 약학 조성물 |
| US9737521B2 (en) | 2012-11-08 | 2017-08-22 | Rhizen Pharmaceuticals Sa | Pharmaceutical compositions containing a PDE4 inhibitor and a PI3 delta or dual PI3 delta-gamma kinase inhibitor |
| CA2984305C (en) | 2015-04-29 | 2021-12-28 | Janssen Pharmaceutica Nv | Indolone compounds and their use as ampa receptor modulators |
| CN107567452B (zh) | 2015-04-29 | 2020-07-07 | 詹森药业有限公司 | 咪唑并哌嗪和吡唑并嘧啶以及它们作为ampa受体调节剂的用途 |
| KR20170141767A (ko) | 2015-04-29 | 2017-12-26 | 얀센 파마슈티카 엔.브이. | 벤즈이미다졸론 및 벤조티아졸론 화합물 및 ampa 수용체 조절제로서의 이들의 용도 |
| HUE053943T2 (hu) | 2015-04-29 | 2021-08-30 | Janssen Pharmaceutica Nv | Azabenzimidazolok és ampa receptor modulátorokként való alkalmazásuk |
| WO2018013430A2 (en) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus infection |
| CN106588909B (zh) * | 2017-01-06 | 2019-08-27 | 广东工业大学 | 一种喹啉类衍生物的制备及其在抗炎中的应用 |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| EP4434972A1 (de) | 2023-03-22 | 2024-09-25 | Eberhard-Karls-Universität Tübingen | Atm-kinase-inhibitoren |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05000453A (es) * | 2002-07-10 | 2005-03-23 | Applied Research Systems | Derivados de benceno fusionados a azolidinona-vinilo. |
| AU2003280188A1 (en) | 2002-12-06 | 2004-06-30 | Warner-Lambert Company Llc | Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k |
| MXPA05006742A (es) | 2002-12-20 | 2005-09-08 | Warner Lambert Co | Benzoxazinas y derivados de las mismas como inhibidores de fosfoinositido-3-quinasas. |
| US7202363B2 (en) * | 2003-07-24 | 2007-04-10 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
| EP1648452B1 (de) * | 2003-07-28 | 2009-07-22 | Merck Serono SA | 2-imino-4-(thio)oxo-5-polycyclovinylazoline zur verwendung als pi3-kinase-inhibtoren |
| JP2008503469A (ja) * | 2004-06-17 | 2008-02-07 | ワイス | ゴナドトロピン放出ホルモン受容体アンタゴニスト |
| BRPI0517416A (pt) | 2004-10-12 | 2008-10-07 | Serono Lab | inibidores de pi3 quinase gama para o tratamento de anemia |
| BRPI0615654A2 (pt) | 2005-09-07 | 2011-05-24 | Serono Lab | inibidores da pi3k para o tratamento de endometriose |
| PE20071020A1 (es) * | 2006-03-07 | 2007-12-11 | Smithkline Beecham Corp | Compuestos derivados de glicina n-sustituidos como inhibidores de prolil hidroxilasa |
| EP2057168A2 (de) * | 2006-08-31 | 2009-05-13 | Array Biopharma, Inc. | Raf-hemmende verbindungen und anwendungsverfahren dafür |
| JP5568471B2 (ja) * | 2007-07-12 | 2014-08-06 | ユニヴァーシティ オブ サウス フロリダ | 抗腫瘍活性を有するａｋｔ／ｐｋｂの阻害剤 |
| US7932251B2 (en) * | 2007-07-16 | 2011-04-26 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
-
2005
- 2005-09-02 CA CA2576765A patent/CA2576765C/en not_active Expired - Fee Related
- 2005-09-02 JP JP2007528883A patent/JP5209311B2/ja not_active Expired - Fee Related
- 2005-09-02 CN CN200580037159XA patent/CN101052640B/zh not_active Expired - Fee Related
- 2005-09-02 HR HR20110834T patent/HRP20110834T1/hr unknown
- 2005-09-02 AT AT05797231T patent/ATE532783T1/de active
- 2005-09-02 SI SI200531418T patent/SI1786812T1/sl unknown
- 2005-09-02 WO PCT/EP2005/054339 patent/WO2006024666A1/en not_active Ceased
- 2005-09-02 KR KR1020077007588A patent/KR101229647B1/ko not_active Expired - Fee Related
- 2005-09-02 EA EA200700541A patent/EA012178B1/ru not_active IP Right Cessation
- 2005-09-02 PL PL05797231T patent/PL1786812T3/pl unknown
- 2005-09-02 AU AU2005279156A patent/AU2005279156B2/en not_active Ceased
- 2005-09-02 US US11/574,613 patent/US7842698B2/en not_active Expired - Fee Related
- 2005-09-02 BR BRPI0515627-0A patent/BRPI0515627A/pt not_active IP Right Cessation
- 2005-09-02 ZA ZA200701666A patent/ZA200701666B/en unknown
- 2005-09-02 MX MX2007002604A patent/MX2007002604A/es active IP Right Grant
- 2005-09-02 EP EP05797231A patent/EP1786812B1/de not_active Expired - Lifetime
-
2007
- 2007-02-19 IL IL181415A patent/IL181415A/en not_active IP Right Cessation
- 2007-03-27 NO NO20071605A patent/NO20071605L/no not_active Application Discontinuation
-
2010
- 2010-10-18 US US12/906,729 patent/US8058289B2/en not_active Expired - Fee Related
-
2012
- 2012-02-02 CY CY20121100119T patent/CY1112316T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005279156B2 (en) | 2011-06-02 |
| SI1786812T1 (sl) | 2011-12-30 |
| EA200700541A1 (ru) | 2007-08-31 |
| CY1112316T1 (el) | 2015-12-09 |
| EA012178B1 (ru) | 2009-08-28 |
| US20110034458A1 (en) | 2011-02-10 |
| HRP20110834T1 (hr) | 2011-12-31 |
| JP5209311B2 (ja) | 2013-06-12 |
| EP1786812A1 (de) | 2007-05-23 |
| CN101052640A (zh) | 2007-10-10 |
| CA2576765A1 (en) | 2006-03-09 |
| MX2007002604A (es) | 2007-04-25 |
| HK1106773A1 (en) | 2008-03-20 |
| AU2005279156A1 (en) | 2006-03-09 |
| IL181415A (en) | 2012-09-24 |
| US20080269227A1 (en) | 2008-10-30 |
| PL1786812T3 (pl) | 2012-04-30 |
| ZA200701666B (en) | 2008-07-30 |
| CN101052640B (zh) | 2011-05-11 |
| KR101229647B1 (ko) | 2013-02-05 |
| BRPI0515627A (pt) | 2008-07-29 |
| CA2576765C (en) | 2013-05-28 |
| NO20071605L (no) | 2007-05-31 |
| US7842698B2 (en) | 2010-11-30 |
| WO2006024666A1 (en) | 2006-03-09 |
| KR20070053315A (ko) | 2007-05-23 |
| EP1786812B1 (de) | 2011-11-09 |
| US8058289B2 (en) | 2011-11-15 |
| IL181415A0 (en) | 2007-07-04 |
| JP2008511589A (ja) | 2008-04-17 |
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