ATE532783T1 - Pyridinmethylenzolidinone und ihre verwendung als phosphoinositid-hemmer - Google Patents
Pyridinmethylenzolidinone und ihre verwendung als phosphoinositid-hemmerInfo
- Publication number
- ATE532783T1 ATE532783T1 AT05797231T AT05797231T ATE532783T1 AT E532783 T1 ATE532783 T1 AT E532783T1 AT 05797231 T AT05797231 T AT 05797231T AT 05797231 T AT05797231 T AT 05797231T AT E532783 T1 ATE532783 T1 AT E532783T1
- Authority
- AT
- Austria
- Prior art keywords
- diseases
- pyridinmethylenenzolidinones
- phosphoinositide
- inhibitors
- phosphoinositide inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003906 phosphoinositides Chemical class 0.000 title 1
- HAIALLMLSNZDAL-UHFFFAOYSA-N 3-methylidenepyrrolidin-2-one;pyridine Chemical class C1=CC=NC=C1.C=C1CCNC1=O HAIALLMLSNZDAL-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000004852 Lung Injury Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 231100000515 lung injury Toxicity 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60737404P | 2004-09-03 | 2004-09-03 | |
| EP04104259 | 2004-09-03 | ||
| PCT/EP2005/054339 WO2006024666A1 (en) | 2004-09-03 | 2005-09-02 | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE532783T1 true ATE532783T1 (de) | 2011-11-15 |
Family
ID=35457295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05797231T ATE532783T1 (de) | 2004-09-03 | 2005-09-02 | Pyridinmethylenzolidinone und ihre verwendung als phosphoinositid-hemmer |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7842698B2 (de) |
| EP (1) | EP1786812B1 (de) |
| JP (1) | JP5209311B2 (de) |
| KR (1) | KR101229647B1 (de) |
| CN (1) | CN101052640B (de) |
| AT (1) | ATE532783T1 (de) |
| AU (1) | AU2005279156B2 (de) |
| BR (1) | BRPI0515627A (de) |
| CA (1) | CA2576765C (de) |
| CY (1) | CY1112316T1 (de) |
| EA (1) | EA012178B1 (de) |
| HR (1) | HRP20110834T1 (de) |
| IL (1) | IL181415A (de) |
| MX (1) | MX2007002604A (de) |
| NO (1) | NO20071605L (de) |
| PL (1) | PL1786812T3 (de) |
| SI (1) | SI1786812T1 (de) |
| WO (1) | WO2006024666A1 (de) |
| ZA (1) | ZA200701666B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4908210B2 (ja) | 2003-07-28 | 2012-04-04 | メルク セローノ ソシエテ アノニム | Ｐｉ３キナーゼ阻害剤として使用するための２−イミノ−４−（チオ）オキソ−５−ポリシクロビニルアゾリン類 |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
| WO2008014219A2 (en) * | 2006-07-24 | 2008-01-31 | Smithkline Beecham Corporation | Thiozolidinedione derivatives as p13 kinase inhibitors |
| CN102015691B (zh) * | 2008-04-29 | 2014-01-08 | 诺华股份有限公司 | 作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物 |
| WO2010030727A1 (en) * | 2008-09-10 | 2010-03-18 | Wyeth Llc | 3-substituted-1h-indole, 3-substituted-1h-pyrrolo[2,3-b]pyridine and 3-substituted-1h-pyrrolo[3,2-b]pyridine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| AU2010213014B2 (en) * | 2009-02-12 | 2016-02-25 | Merck Serono S.A. | 2-morpholino-pyrido[3,2-d]pyrimidines |
| RU2607453C2 (ru) * | 2009-12-04 | 2017-01-10 | Сенхва Байосайенсиз, Инк. | Пиразолопиримидины и родственные гетероциклы как ск2 ингибиторы |
| BR112012015248B1 (pt) * | 2009-12-23 | 2022-01-04 | Jasco Pharmaceuticals, LLC | Composto |
| WO2012145617A2 (en) * | 2011-04-22 | 2012-10-26 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
| CA2848877A1 (en) * | 2011-09-15 | 2013-03-21 | Taipei Medical University | Use of indolyl and indolinvl hvdroxamates for treating heart failure or neuronal injury |
| TW201319063A (zh) * | 2011-10-04 | 2013-05-16 | Yakult Honsha Kk | 以四氫噻唑衍生物或其鹽為有效成分之醫藥品 |
| EP2776432B1 (de) | 2011-11-04 | 2017-03-29 | Jasco Pharmaceuticals LLC | Aminopyrimidinkinasehemmer |
| WO2014017803A1 (ko) | 2012-07-23 | 2014-01-30 | 주식회사 유한양행 | 퓨란-함유 융합 고리 화합물 또는 그의 염 및 이를 포함하는 약학 조성물 |
| WO2014072937A1 (en) | 2012-11-08 | 2014-05-15 | Rhizen Pharmaceuticals Sa | Pharmaceutical compositions containing a pde4 inhibitor and a pi3 delta or dual pi3 delta-gamma kinase inhibitor |
| AU2016255431B2 (en) | 2015-04-29 | 2020-05-07 | Janssen Pharmaceutica Nv | Imidazopyrazines and pyrazolopyrimidines and their use as AMPA receptor modulators |
| HRP20210403T1 (hr) | 2015-04-29 | 2021-10-29 | Janssen Pharmaceutica Nv | Azabenzimidazoli i njihova uporaba kao modulatora ampa receptora |
| ES2767707T3 (es) | 2015-04-29 | 2020-06-18 | Janssen Pharmaceutica Nv | Compuestos de indolona y su uso como moduladores de receptor AMPA |
| WO2016176449A1 (en) | 2015-04-29 | 2016-11-03 | Janssen Pharmaceutica Nv | Benzimidazolone and benzothiazolone compounds and their use as ampa receptor modulators |
| US11352328B2 (en) | 2016-07-12 | 2022-06-07 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus |
| CN106588909B (zh) * | 2017-01-06 | 2019-08-27 | 广东工业大学 | 一种喹啉类衍生物的制备及其在抗炎中的应用 |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| EP4434972A1 (de) | 2023-03-22 | 2024-09-25 | Eberhard-Karls-Universität Tübingen | Atm-kinase-inhibitoren |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA011807B1 (ru) | 2002-07-10 | 2009-06-30 | Лаборатуар Сероно Са | Азолидинонвинильные производные конденсированного бензола |
| JP2006510661A (ja) | 2002-12-06 | 2006-03-30 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | Ｐｉ３ｋの阻害剤としてのベンズオキサジン−３−オン類及びその誘導体 |
| AU2003303231A1 (en) | 2002-12-20 | 2004-07-14 | Warner-Lambert Company Llc | Benzoxazines and derivatives thereof as inhibitors of pi3ks |
| US7202363B2 (en) * | 2003-07-24 | 2007-04-10 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
| JP4908210B2 (ja) * | 2003-07-28 | 2012-04-04 | メルク セローノ ソシエテ アノニム | Ｐｉ３キナーゼ阻害剤として使用するための２−イミノ−４−（チオ）オキソ−５−ポリシクロビニルアゾリン類 |
| WO2006009734A1 (en) * | 2004-06-17 | 2006-01-26 | Wyeth | Gonadotropin releasing hormone receptor antagonists |
| MX2007004302A (es) | 2004-10-12 | 2007-06-07 | Applied Research Systems | Inhibidores de pi3 cinasa gamma para el tratamiento de anemia. |
| NZ565748A (en) | 2005-09-07 | 2011-04-29 | Serono Lab | PI3K inhibitors for the treatment of endometriosis |
| AR059733A1 (es) * | 2006-03-07 | 2008-04-23 | Smithkline Beecham Corp | Compuesto derivado de glicina n- sustituida con heteroaromaticos bicicicos, composicion farmaceutica que lo comprende, uso para preparar un medicamento para tratar la anemia y proceso para su preparacion |
| CA2662285A1 (en) * | 2006-08-31 | 2008-03-06 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| CA2695330C (en) * | 2007-07-12 | 2017-06-13 | University Of South Florida | Inhibitors of akt/pkb with anti-tumor activity |
| US7932251B2 (en) * | 2007-07-16 | 2011-04-26 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
-
2005
- 2005-09-02 JP JP2007528883A patent/JP5209311B2/ja not_active Expired - Fee Related
- 2005-09-02 SI SI200531418T patent/SI1786812T1/sl unknown
- 2005-09-02 PL PL05797231T patent/PL1786812T3/pl unknown
- 2005-09-02 WO PCT/EP2005/054339 patent/WO2006024666A1/en not_active Ceased
- 2005-09-02 CA CA2576765A patent/CA2576765C/en not_active Expired - Fee Related
- 2005-09-02 EA EA200700541A patent/EA012178B1/ru not_active IP Right Cessation
- 2005-09-02 ZA ZA200701666A patent/ZA200701666B/en unknown
- 2005-09-02 AU AU2005279156A patent/AU2005279156B2/en not_active Ceased
- 2005-09-02 CN CN200580037159XA patent/CN101052640B/zh not_active Expired - Fee Related
- 2005-09-02 US US11/574,613 patent/US7842698B2/en not_active Expired - Fee Related
- 2005-09-02 MX MX2007002604A patent/MX2007002604A/es active IP Right Grant
- 2005-09-02 EP EP05797231A patent/EP1786812B1/de not_active Expired - Lifetime
- 2005-09-02 AT AT05797231T patent/ATE532783T1/de active
- 2005-09-02 HR HR20110834T patent/HRP20110834T1/hr unknown
- 2005-09-02 KR KR1020077007588A patent/KR101229647B1/ko not_active Expired - Fee Related
- 2005-09-02 BR BRPI0515627-0A patent/BRPI0515627A/pt not_active IP Right Cessation
-
2007
- 2007-02-19 IL IL181415A patent/IL181415A/en not_active IP Right Cessation
- 2007-03-27 NO NO20071605A patent/NO20071605L/no not_active Application Discontinuation
-
2010
- 2010-10-18 US US12/906,729 patent/US8058289B2/en not_active Expired - Fee Related
-
2012
- 2012-02-02 CY CY20121100119T patent/CY1112316T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5209311B2 (ja) | 2013-06-12 |
| HRP20110834T1 (hr) | 2011-12-31 |
| SI1786812T1 (sl) | 2011-12-30 |
| EA012178B1 (ru) | 2009-08-28 |
| EP1786812A1 (de) | 2007-05-23 |
| CN101052640A (zh) | 2007-10-10 |
| US7842698B2 (en) | 2010-11-30 |
| AU2005279156A1 (en) | 2006-03-09 |
| WO2006024666A1 (en) | 2006-03-09 |
| US20080269227A1 (en) | 2008-10-30 |
| CA2576765C (en) | 2013-05-28 |
| IL181415A (en) | 2012-09-24 |
| HK1106773A1 (en) | 2008-03-20 |
| JP2008511589A (ja) | 2008-04-17 |
| CA2576765A1 (en) | 2006-03-09 |
| EP1786812B1 (de) | 2011-11-09 |
| ZA200701666B (en) | 2008-07-30 |
| AU2005279156B2 (en) | 2011-06-02 |
| NO20071605L (no) | 2007-05-31 |
| KR101229647B1 (ko) | 2013-02-05 |
| PL1786812T3 (pl) | 2012-04-30 |
| CY1112316T1 (el) | 2015-12-09 |
| BRPI0515627A (pt) | 2008-07-29 |
| CN101052640B (zh) | 2011-05-11 |
| US8058289B2 (en) | 2011-11-15 |
| US20110034458A1 (en) | 2011-02-10 |
| MX2007002604A (es) | 2007-04-25 |
| IL181415A0 (en) | 2007-07-04 |
| EA200700541A1 (ru) | 2007-08-31 |
| KR20070053315A (ko) | 2007-05-23 |
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