ZA200610637B - Process for the preparation of 4,4-difluoro-3-oxobutanoic acid esters - Google Patents
Process for the preparation of 4,4-difluoro-3-oxobutanoic acid esters Download PDFInfo
- Publication number
- ZA200610637B ZA200610637B ZA200610637A ZA200610637A ZA200610637B ZA 200610637 B ZA200610637 B ZA 200610637B ZA 200610637 A ZA200610637 A ZA 200610637A ZA 200610637 A ZA200610637 A ZA 200610637A ZA 200610637 B ZA200610637 B ZA 200610637B
- Authority
- ZA
- South Africa
- Prior art keywords
- process according
- solvent
- ethyl
- difluoro
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 27
- 230000008569 process Effects 0.000 title claims description 23
- 238000002360 preparation method Methods 0.000 title claims description 13
- HQZSNVHMLLTTRA-UHFFFAOYSA-N 4,4-difluoro-3-oxobutanoic acid Chemical class OC(=O)CC(=O)C(F)F HQZSNVHMLLTTRA-UHFFFAOYSA-N 0.000 title description 4
- 239000002585 base Substances 0.000 claims description 16
- -1 alkali metal alkoxide Chemical class 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 13
- 150000002168 ethanoic acid esters Chemical class 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical group [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims description 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 10
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 125000002723 alicyclic group Chemical group 0.000 claims description 7
- 150000001412 amines Chemical group 0.000 claims description 7
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 claims description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 5
- 229910052783 alkali metal Inorganic materials 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 239000003849 aromatic solvent Substances 0.000 claims description 2
- 229910052792 caesium Inorganic materials 0.000 claims description 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 27
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 10
- 229940093499 ethyl acetate Drugs 0.000 description 9
- 235000019439 ethyl acetate Nutrition 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 150000002148 esters Chemical class 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 6
- CBDPWKVOPADMJC-UHFFFAOYSA-N ethyl 4,4-difluoro-3-oxobutanoate Chemical compound CCOC(=O)CC(=O)C(F)F CBDPWKVOPADMJC-UHFFFAOYSA-N 0.000 description 5
- 238000006277 sulfonation reaction Methods 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000012267 brine Substances 0.000 description 4
- 239000005457 ice water Substances 0.000 description 4
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
- 150000004703 alkoxides Chemical class 0.000 description 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 3
- 239000006184 cosolvent Substances 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 125000004494 ethyl ester group Chemical group 0.000 description 3
- 239000000417 fungicide Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 229910000104 sodium hydride Inorganic materials 0.000 description 3
- 239000012312 sodium hydride Substances 0.000 description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 description 3
- 235000011152 sodium sulphate Nutrition 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- UOMXIKXHYRRODT-UHFFFAOYSA-N 2,2-dichloro-n,n-dimethylacetamide Chemical compound CN(C)C(=O)C(Cl)Cl UOMXIKXHYRRODT-UHFFFAOYSA-N 0.000 description 2
- IUEWOPMXNADAEB-UHFFFAOYSA-N 2,2-difluoro-n,n-dimethylacetamide Chemical compound CN(C)C(=O)C(F)F IUEWOPMXNADAEB-UHFFFAOYSA-N 0.000 description 2
- BUWFFJSRMUPAEJ-UHFFFAOYSA-N 5-fluoro-4-(fluoromethyl)-3-oxopentanoic acid Chemical class OC(=O)CC(=O)C(CF)CF BUWFFJSRMUPAEJ-UHFFFAOYSA-N 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 150000008064 anhydrides Chemical class 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- WMZYZYFPPQOFKY-UHFFFAOYSA-N n-phenyl-1h-pyrazole-3-carboxamide Chemical compound C1=CNN=C1C(=O)NC1=CC=CC=C1 WMZYZYFPPQOFKY-UHFFFAOYSA-N 0.000 description 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 239000012044 organic layer Substances 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- 239000011698 potassium fluoride Substances 0.000 description 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- IYXUFOCLMOXQSL-UHFFFAOYSA-N (2,2-difluoroacetyl) 2,2-difluoroacetate Chemical compound FC(F)C(=O)OC(=O)C(F)F IYXUFOCLMOXQSL-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- BHKKSKOHRFHHIN-MRVPVSSYSA-N 1-[[2-[(1R)-1-aminoethyl]-4-chlorophenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one Chemical compound N[C@H](C)C1=C(CN2C(NC(C3=C2C=CN3)=O)=S)C=CC(=C1)Cl BHKKSKOHRFHHIN-MRVPVSSYSA-N 0.000 description 1
- KURKJXZWCPWPFX-UHFFFAOYSA-N 2,2-difluoroacetyl chloride Chemical class FC(F)C(Cl)=O KURKJXZWCPWPFX-UHFFFAOYSA-N 0.000 description 1
- RLOHOBNEYHBZID-UHFFFAOYSA-N 3-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid Chemical compound CN1C=C(C(O)=O)C(C(F)F)=N1 RLOHOBNEYHBZID-UHFFFAOYSA-N 0.000 description 1
- LIQBKSIZAXKCPA-UHFFFAOYSA-N 4,4,4-trifluoro-3-oxobutanoic acid Chemical class OC(=O)CC(=O)C(F)(F)F LIQBKSIZAXKCPA-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- IGQNDARULCASRN-UHFFFAOYSA-N Fluxapyroxad (bas 700 f)-tp cscd465008 Chemical class OC(=O)C1=CNN=C1C(F)F IGQNDARULCASRN-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- DVECBJCOGJRVPX-UHFFFAOYSA-N butyryl chloride Chemical compound CCCC(Cl)=O DVECBJCOGJRVPX-UHFFFAOYSA-N 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- WCGGWVOVFQNRRS-UHFFFAOYSA-N dichloroacetamide Chemical class NC(=O)C(Cl)Cl WCGGWVOVFQNRRS-UHFFFAOYSA-N 0.000 description 1
- FBCCMZVIWNDFMO-UHFFFAOYSA-N dichloroacetyl chloride Chemical compound ClC(Cl)C(Cl)=O FBCCMZVIWNDFMO-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- NVFHNBDIBRFUEI-UHFFFAOYSA-N ethyl 2-ethyl-4,4-difluoro-3-oxobutanoate Chemical compound CCOC(=O)C(CC)C(=O)C(F)F NVFHNBDIBRFUEI-UHFFFAOYSA-N 0.000 description 1
- WGHDTFLIIVIHGM-UHFFFAOYSA-N ethyl 5-fluoro-4-(fluoromethyl)-3-oxopentanoate Chemical compound CCOC(=O)CC(=O)C(CF)CF WGHDTFLIIVIHGM-UHFFFAOYSA-N 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000003682 fluorination reaction Methods 0.000 description 1
- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- VSVHALAPOBOPOJ-UHFFFAOYSA-N methyl 2-ethyl-4,4-difluoro-3-oxobutanoate Chemical compound COC(=O)C(CC)C(=O)C(F)F VSVHALAPOBOPOJ-UHFFFAOYSA-N 0.000 description 1
- OHTZSGZMMOMLKA-UHFFFAOYSA-N methyl 4,4-difluoro-3-oxobutanoate Chemical compound COC(=O)CC(=O)C(F)F OHTZSGZMMOMLKA-UHFFFAOYSA-N 0.000 description 1
- CRXATJZTRIHWMN-UHFFFAOYSA-N methyl 5-fluoro-4-(fluoromethyl)-3-oxopentanoate Chemical compound COC(=O)CC(=O)C(CF)CF CRXATJZTRIHWMN-UHFFFAOYSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- HDZGCSFEDULWCS-UHFFFAOYSA-N monomethylhydrazine Chemical compound CNN HDZGCSFEDULWCS-UHFFFAOYSA-N 0.000 description 1
- KRJKJVSLOIGMGA-UHFFFAOYSA-N n,n-diethyl-2,2-difluoroacetamide Chemical compound CCN(CC)C(=O)C(F)F KRJKJVSLOIGMGA-UHFFFAOYSA-N 0.000 description 1
- 229960005235 piperonyl butoxide Drugs 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0415764.0A GB0415764D0 (en) | 2004-07-14 | 2004-07-14 | Chemical process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200610637B true ZA200610637B (en) | 2008-07-30 |
Family
ID=32893564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200610637A ZA200610637B (en) | 2004-07-14 | 2006-12-18 | Process for the preparation of 4,4-difluoro-3-oxobutanoic acid esters |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7355065B2 (de) |
| EP (1) | EP1765764B1 (de) |
| JP (1) | JP5021470B2 (de) |
| CN (1) | CN100532345C (de) |
| AR (1) | AR049668A1 (de) |
| AU (1) | AU2005261777B2 (de) |
| BR (1) | BRPI0513299B1 (de) |
| CA (1) | CA2572896C (de) |
| EA (1) | EA011019B1 (de) |
| GB (1) | GB0415764D0 (de) |
| IL (1) | IL180311A (de) |
| MX (1) | MX2007000347A (de) |
| TW (1) | TWI366562B (de) |
| UA (1) | UA84950C2 (de) |
| WO (1) | WO2006005612A1 (de) |
| ZA (1) | ZA200610637B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006039909A1 (de) * | 2006-08-25 | 2008-03-13 | Bayer Cropscience Ag | Verfahren zum Herstellen von 3-Dihalomethyl-pyrazol-4-carbonsäurederivaten |
| DE102007005296A1 (de) * | 2007-02-02 | 2008-08-07 | Bayer Cropscience Ag | Verfahren zum Herstellen von Dihaloacetessigsäurealkylestern |
| JP5340287B2 (ja) * | 2007-08-16 | 2013-11-13 | ソルヴェイ（ソシエテ アノニム） | ４−フルオロ置換３−オキソ−アルカン酸のエステル類の調製方法 |
| AR083482A1 (es) | 2010-10-21 | 2013-02-27 | Syngenta Ltd | Concentrados agroquimicos con isopirazam |
| CN102875379A (zh) * | 2012-11-01 | 2013-01-16 | 上海品沃化工有限公司 | 一种二氟乙酸酯的工业化合成方法 |
| US20140130657A1 (en) * | 2012-11-05 | 2014-05-15 | Gordon Holdings, Inc. | High strength, light weight composite structure, method of manufacture and use thereof |
| US8871947B2 (en) | 2013-02-04 | 2014-10-28 | KingChem LLC | Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester |
| US9139507B2 (en) | 2013-12-09 | 2015-09-22 | KingChem LLC. | Process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate and its analogs |
| WO2016128999A1 (en) * | 2015-02-11 | 2016-08-18 | Srf Limited | Process of preparation of compounds having chf 2c(o) group |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07242587A (ja) * | 1994-03-04 | 1995-09-19 | Asahi Glass Co Ltd | ジフルオロ酢酸およびジフルオロ酢酸アミドの製造方法 |
| US5493025A (en) | 1994-07-27 | 1996-02-20 | Rohm And Haas Company | Process for preparation of fluorinated beta-keto ester |
| US5498624A (en) | 1995-05-03 | 1996-03-12 | Monsanto Company | Selected pyrazolyl derivatives |
| JP3564982B2 (ja) * | 1997-12-12 | 2004-09-15 | 宇部興産株式会社 | ４−フルオロ−３−オキソカルボン酸エステル及びその製法 |
| PL354102A1 (en) | 1999-12-09 | 2003-12-29 | Syngenta Participations Agsyngenta Participations Ag | Pyrazolecarboxamide and pyrazolethioamide as fungicide |
-
2004
- 2004-07-14 GB GBGB0415764.0A patent/GB0415764D0/en not_active Ceased
-
2005
- 2005-07-12 TW TW094123595A patent/TWI366562B/zh not_active IP Right Cessation
- 2005-07-12 AR ARP050102874A patent/AR049668A1/es not_active Application Discontinuation
- 2005-07-13 EA EA200700064A patent/EA011019B1/ru not_active IP Right Cessation
- 2005-07-13 CN CNB2005800235839A patent/CN100532345C/zh active Active
- 2005-07-13 WO PCT/EP2005/007635 patent/WO2006005612A1/en active Application Filing
- 2005-07-13 CA CA2572896A patent/CA2572896C/en not_active Expired - Fee Related
- 2005-07-13 MX MX2007000347A patent/MX2007000347A/es active IP Right Grant
- 2005-07-13 UA UAA200701400A patent/UA84950C2/ru unknown
- 2005-07-13 JP JP2007520754A patent/JP5021470B2/ja not_active Expired - Fee Related
- 2005-07-13 EP EP05770697.0A patent/EP1765764B1/de active Active
- 2005-07-13 US US11/572,053 patent/US7355065B2/en active Active
- 2005-07-13 AU AU2005261777A patent/AU2005261777B2/en not_active Ceased
- 2005-07-13 BR BRPI0513299-1A patent/BRPI0513299B1/pt active IP Right Grant
-
2006
- 2006-12-18 ZA ZA200610637A patent/ZA200610637B/en unknown
- 2006-12-25 IL IL180311A patent/IL180311A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0513299B1 (pt) | 2015-03-10 |
| BRPI0513299A (pt) | 2008-05-06 |
| CA2572896A1 (en) | 2006-01-19 |
| AR049668A1 (es) | 2006-08-23 |
| EP1765764B1 (de) | 2014-05-21 |
| GB0415764D0 (en) | 2004-08-18 |
| EA200700064A1 (ru) | 2007-08-31 |
| EP1765764A1 (de) | 2007-03-28 |
| AU2005261777A1 (en) | 2006-01-19 |
| CN1984865A (zh) | 2007-06-20 |
| JP5021470B2 (ja) | 2012-09-05 |
| US7355065B2 (en) | 2008-04-08 |
| IL180311A0 (en) | 2007-06-03 |
| TW200604161A (en) | 2006-02-01 |
| AU2005261777B2 (en) | 2008-06-26 |
| WO2006005612A1 (en) | 2006-01-19 |
| TWI366562B (en) | 2012-06-21 |
| IL180311A (en) | 2011-02-28 |
| CA2572896C (en) | 2013-02-26 |
| JP2008506650A (ja) | 2008-03-06 |
| UA84950C2 (ru) | 2008-12-10 |
| EA011019B1 (ru) | 2008-12-30 |
| US20080004465A1 (en) | 2008-01-03 |
| MX2007000347A (es) | 2007-03-07 |
| CN100532345C (zh) | 2009-08-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2005261777B2 (en) | Process for the preparation of 4,4-difluoro-3-oxobutanoic acid esters | |
| WO2006125964A1 (en) | A process for the dynamic resolution of (substituted) (r) - or (s) -mandelic acid | |
| WO2021209269A1 (en) | A process for preparation of substituted enamine compounds | |
| EP0990647B1 (de) | Verfahren zur herstellung von chinolinderivaten | |
| KR101200294B1 (ko) | 4,4-디플루오로-3-옥소부탄산 에스테르의 제조방법 | |
| CA2233617A1 (en) | Process for the preparation of 4-methylenepiperidine | |
| JP5186115B2 (ja) | ２‐置換ベンジル‐３，３‐ジフルオロアクリル酸エステル誘導体及びそれらの製造方法 | |
| JPH0853395A (ja) | フッ素化β−ケトエステルの製造方法 | |
| RU2232754C2 (ru) | Способ получения производных 1-фенилпиразолин-3-карбоновой кислоты | |
| US5508446A (en) | Method for producing alkyl 3-phthalidylideneacetate | |
| JPH0361664B2 (de) | ||
| JP2007254293A (ja) | α−メチレン−β−アルキル−γ−ブチロラクトンの製造法 | |
| EP3191441B1 (de) | Neuartiges verfahren zur herstellung von spiro[2,5]octan-5,7-dion und spiro[3,5]nonan-6,8-dion | |
| WO2015177179A1 (en) | Improved process for preparing substituted crotonic acids | |
| WO2022218734A1 (en) | A process for preparation of substituted enamine compounds | |
| EP0943600A1 (de) | Verfahren zur herstellung von dicarbonsäuremonoestern | |
| EP2514738B1 (de) | Verfahren zur herstellung von alkyl-5-methyl-5-hexenoaten | |
| JP2002226431A (ja) | 液晶化合物の製造方法 | |
| JP2002201184A (ja) | 芳香族炭化水素を用いた２，４−オキサゾリジンジオン類金属塩の製造方法 | |
| JPH0477454A (ja) | アセチレンジカルボン酸エステルの製造方法 |