ZA200509440B - Ophthalmic compositions containing a synergistic combination of two polymers - Google Patents
Ophthalmic compositions containing a synergistic combination of two polymers Download PDFInfo
- Publication number
- ZA200509440B ZA200509440B ZA200509440A ZA200509440A ZA200509440B ZA 200509440 B ZA200509440 B ZA 200509440B ZA 200509440 A ZA200509440 A ZA 200509440A ZA 200509440 A ZA200509440 A ZA 200509440A ZA 200509440 B ZA200509440 B ZA 200509440B
- Authority
- ZA
- South Africa
- Prior art keywords
- composition
- combination
- polymers
- agents
- hydroxypropyl methylcellulose
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 88
- 229920000642 polymer Polymers 0.000 title claims description 44
- 239000011885 synergistic combination Substances 0.000 title description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 36
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 23
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 23
- 239000004615 ingredient Substances 0.000 claims description 22
- 239000000665 guar gum Substances 0.000 claims description 21
- 235000010417 guar gum Nutrition 0.000 claims description 21
- 229960002154 guar gum Drugs 0.000 claims description 21
- 229920002907 Guar gum Polymers 0.000 claims description 20
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 18
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 15
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 14
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 12
- 229920002674 hyaluronan Polymers 0.000 claims description 12
- 229960003160 hyaluronic acid Drugs 0.000 claims description 12
- 230000002195 synergetic effect Effects 0.000 claims description 10
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- -1 hydroxypropyl hydroxypropyl Chemical group 0.000 claims description 8
- 229940023490 ophthalmic product Drugs 0.000 claims description 7
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 5
- 239000004327 boric acid Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- RFIMISVNSAUMBU-UHFFFAOYSA-N 2-(hydroxymethyl)-2-(prop-2-enoxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC=C RFIMISVNSAUMBU-UHFFFAOYSA-N 0.000 claims description 4
- RFRMMZAKBNXNHE-UHFFFAOYSA-N 6-[4,6-dihydroxy-5-(2-hydroxyethoxy)-2-(hydroxymethyl)oxan-3-yl]oxy-2-(hydroxymethyl)-5-(2-hydroxypropoxy)oxane-3,4-diol Chemical compound CC(O)COC1C(O)C(O)C(CO)OC1OC1C(O)C(OCCO)C(O)OC1CO RFRMMZAKBNXNHE-UHFFFAOYSA-N 0.000 claims description 4
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- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
- 229940086737 allyl sucrose Drugs 0.000 claims description 3
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- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 2
- 206010013774 Dry eye Diseases 0.000 claims description 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims description 2
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- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 description 2
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- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
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- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 description 1
- MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 description 1
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- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical class [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 description 1
- 101000608750 Arachis hypogaea Alpha-methyl-mannoside-specific lectin Proteins 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 229920000896 Ethulose Polymers 0.000 description 1
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- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
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- QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/765—Polymers containing oxygen
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
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US47825303P | 2003-06-13 | 2003-06-13 |
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ZA200509440B true ZA200509440B (en) | 2007-04-25 |
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ZA200509440A ZA200509440B (en) | 2003-06-13 | 2004-06-08 | Ophthalmic compositions containing a synergistic combination of two polymers |
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US (1) | US7709012B2 (de) |
EP (5) | EP2526929B1 (de) |
JP (4) | JP4860475B2 (de) |
KR (5) | KR101147046B1 (de) |
CN (1) | CN100475192C (de) |
AU (2) | AU2004249137B2 (de) |
BR (1) | BRPI0411361B1 (de) |
CA (6) | CA2839930C (de) |
DK (1) | DK2116227T3 (de) |
ES (3) | ES2415738T3 (de) |
MX (1) | MXPA05013290A (de) |
PL (1) | PL2116227T3 (de) |
PT (1) | PT2116227E (de) |
SI (1) | SI2116227T1 (de) |
WO (1) | WO2004112836A2 (de) |
ZA (1) | ZA200509440B (de) |
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KR101555291B1 (ko) * | 2007-02-09 | 2015-09-30 | 알콘, 인코퍼레이티드 | 세가지 폴리머의 상승성 배합물을 함유하는 안과 조성물 |
US8759321B2 (en) * | 2007-06-13 | 2014-06-24 | Bausch & Lomb Incorporated | Ophthalmic composition with hyaluronic acid and polymeric biguanide |
EP2172224A4 (de) | 2007-06-26 | 2013-01-16 | Wakamoto Pharma Co Ltd | Wässrige zusammensetzung |
DK2193795T3 (da) | 2007-08-29 | 2014-11-03 | Wakamoto Pharma Co Ltd | Latanoprostholdig vandig farmaceutisk sammensætning |
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US8629099B2 (en) * | 2008-03-25 | 2014-01-14 | Bausch & Lomb Incorporated | Ophthalmic compositions comprising a dipeptide |
US20100286010A1 (en) * | 2008-09-03 | 2010-11-11 | Erning Xia | Ophthalmic Compositions with Hyaluronic Acid |
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US8324171B1 (en) | 2012-02-06 | 2012-12-04 | Bausch & Lomb Incorporated | Ophthalmic compositions containing diglycine |
UA113434C2 (uk) * | 2012-05-04 | 2017-01-25 | Алкон Рісерч, Лтд. | Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням |
EP3250185B1 (de) | 2015-01-26 | 2018-12-05 | Bausch & Lomb Incorporated | Ophthalmische suspensionszusammensetzung |
CN108367026A (zh) * | 2015-06-18 | 2018-08-03 | 常规制药股份公司 | 抗微生物配制品 |
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2004
- 2004-06-06 JP JP2006533590A patent/JP4860475B2/ja not_active Expired - Lifetime
- 2004-06-06 CA CA2839930A patent/CA2839930C/en not_active Expired - Fee Related
- 2004-06-06 CN CNB2004800159648A patent/CN100475192C/zh not_active Expired - Lifetime
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- 2004-06-06 KR KR1020057023409A patent/KR101147046B1/ko not_active IP Right Cessation
- 2004-06-06 KR KR1020127008027A patent/KR20120062846A/ko not_active Application Discontinuation
- 2004-06-06 CA CA2527712A patent/CA2527712C/en not_active Expired - Fee Related
- 2004-06-06 CA CA2839928A patent/CA2839928C/en not_active Expired - Fee Related
- 2004-06-06 PT PT91689208T patent/PT2116227E/pt unknown
- 2004-06-06 KR KR1020117005797A patent/KR101131056B1/ko not_active IP Right Cessation
- 2004-06-06 KR KR1020117018563A patent/KR20110098863A/ko not_active Application Discontinuation
- 2004-06-06 AU AU2004249137A patent/AU2004249137B2/en not_active Ceased
- 2004-06-06 CA CA2839898A patent/CA2839898C/en not_active Expired - Fee Related
- 2004-06-06 KR KR1020117028334A patent/KR20110134525A/ko not_active Application Discontinuation
- 2004-06-08 EP EP12173896.7A patent/EP2526929B1/de not_active Revoked
- 2004-06-08 EP EP11163662.7A patent/EP2361610B1/de not_active Expired - Lifetime
- 2004-06-08 ES ES09168920T patent/ES2415738T3/es not_active Expired - Lifetime
- 2004-06-08 PL PL09168920T patent/PL2116227T3/pl unknown
- 2004-06-08 DK DK09168920.8T patent/DK2116227T3/da active
- 2004-06-08 BR BRPI0411361A patent/BRPI0411361B1/pt not_active IP Right Cessation
- 2004-06-08 WO PCT/US2004/018068 patent/WO2004112836A2/en active Application Filing
- 2004-06-08 ES ES12173896T patent/ES2570856T3/es not_active Expired - Lifetime
- 2004-06-08 ZA ZA200509440A patent/ZA200509440B/en unknown
- 2004-06-08 EP EP09168920.8A patent/EP2116227B1/de not_active Expired - Lifetime
- 2004-06-08 US US10/863,169 patent/US7709012B2/en active Active
- 2004-06-08 EP EP16153017.5A patent/EP3028692B1/de not_active Expired - Lifetime
- 2004-06-08 ES ES11163662T patent/ES2410505T3/es not_active Expired - Lifetime
- 2004-06-08 SI SI200432047T patent/SI2116227T1/sl unknown
- 2004-06-08 EP EP04754624A patent/EP1631257A2/de not_active Withdrawn
- 2004-06-08 MX MXPA05013290A patent/MXPA05013290A/es active IP Right Grant
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2010
- 2010-01-27 AU AU2010200297A patent/AU2010200297B2/en not_active Ceased
- 2010-11-11 JP JP2010253316A patent/JP2011026354A/ja active Pending
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2011
- 2011-06-22 JP JP2011138663A patent/JP2011184463A/ja active Pending
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- 2013-02-22 JP JP2013032842A patent/JP2013100360A/ja active Pending
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