ZA200507796B - Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors - Google Patents

Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors

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Publication number
ZA200507796B
ZA200507796B ZA200507796A ZA200507796A ZA200507796B ZA 200507796 B ZA200507796 B ZA 200507796B ZA 200507796 A ZA200507796 A ZA 200507796A ZA 200507796 A ZA200507796 A ZA 200507796A ZA 200507796 B ZA200507796 B ZA 200507796B
Authority
ZA
South Africa
Prior art keywords
compounds
benzoxazinyl
amidocyclopentyl
chemokine receptors
diseases
Prior art date
Application number
ZA200507796A
Other languages
English (en)
Inventor
Stephen D Goble
Sander G Mills
Yang Lihu
Pasternak Alexander
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA200507796B publication Critical patent/ZA200507796B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA200507796A 2003-04-15 2005-09-27 Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors ZA200507796B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46311103P 2003-04-15 2003-04-15

Publications (1)

Publication Number Publication Date
ZA200507796B true ZA200507796B (en) 2007-02-28

Family

ID=33300038

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200507796A ZA200507796B (en) 2003-04-15 2005-09-27 Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors

Country Status (23)

Country Link
US (1) US7700591B2 (pt)
EP (1) EP1615699B1 (pt)
JP (1) JP4440257B2 (pt)
KR (1) KR20060003353A (pt)
CN (1) CN1802187B (pt)
AT (1) ATE461929T1 (pt)
AU (1) AU2004231087B2 (pt)
BR (1) BRPI0409393A8 (pt)
CA (1) CA2521950C (pt)
CY (1) CY1110155T1 (pt)
DE (1) DE602004026166D1 (pt)
DK (1) DK1615699T3 (pt)
ES (1) ES2342776T3 (pt)
IS (1) IS8056A (pt)
MX (1) MXPA05011160A (pt)
NO (1) NO20055376L (pt)
NZ (1) NZ543287A (pt)
PL (1) PL1615699T3 (pt)
PT (1) PT1615699E (pt)
RU (1) RU2301802C2 (pt)
SI (1) SI1615699T1 (pt)
WO (1) WO2004092124A2 (pt)
ZA (1) ZA200507796B (pt)

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EP1732552A4 (en) * 2004-01-20 2007-12-19 Merck & Co Inc 2,6-DISUBSTITUTED PIPERIDINES, MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
US20070238723A1 (en) * 2004-10-15 2007-10-11 Goble Stephen D Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
EP1855673A4 (en) * 2005-01-06 2008-03-12 Merck & Co Inc COMBINED THERAPY AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
WO2007053498A1 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
AU2007242883B2 (en) * 2006-04-20 2012-09-27 F. Hoffmann-La Roche Ag Diazepan derivatives modulators of chemokine receptors
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
KR20100092463A (ko) * 2007-11-30 2010-08-20 녹손 파르마 아게 Ｍｃｐ-1 결합형 핵산 및 이의 용도
KR100904535B1 (ko) * 2009-03-09 2009-06-29 한세이엔씨(주) 교량의 박스거더 내부 안전진단장치
BRPI1014125A2 (pt) 2009-03-17 2016-04-12 Daiichi Sankyo Co Ltd composto, composição farmacêutica, e, uso de um composto.
EP2417131A4 (en) * 2009-04-07 2014-08-27 Astrazeneca Ab ISOXAZOL-3 (2H) -ONE ANALOGUE AS THERAPEUTIC
UA107938C2 (en) * 2009-08-12 2015-03-10 Syngenta Participations Ag Heterocycles with microbicidal properties
US9040526B2 (en) 2010-02-09 2015-05-26 Bristol-Myers Squibb Company Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
CN103694220A (zh) * 2013-12-30 2014-04-02 张磊 新型吡唑-3-甲酸酯及合成方法
RU2564440C1 (ru) * 2014-06-03 2015-10-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" 3-ароил-2-гидрокси-2-(2-оксоциклоалкил)пирроло[2,1-с][1,4]бензоксазин-1,4(2н)-дионы, проявляющие анальгетическую активность, и способ их получения
WO2016113277A1 (en) 2015-01-16 2016-07-21 Bayer Cropscience Aktiengesellschaft Method for preparing 4-cyanopiperidine hydrochloride
DK3265444T3 (en) * 2015-03-05 2019-03-18 Bayer Cropscience Ag PROCEDURE FOR PIPERIDIN-4-CARBOTHIOAMIDE HYDROCHLORIDE PREPARATION
CN108135168B (zh) * 2015-05-21 2021-07-20 凯莫森特里克斯股份有限公司 Ccr2调节剂
AU2016296886B2 (en) * 2015-07-23 2020-04-30 Huntsman Advanced Materials Americas Llc Curable benzoxazine compositions
MX2020003192A (es) 2017-09-25 2020-07-29 Chemocentryx Inc Terapia de combinacion usando un antagonista del receptor de quimiocina tipo 2 (ccr2) y un inhibidor de pd-1/pd-l1.
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
JP7442141B2 (ja) 2018-01-08 2024-03-04 ケモセントリックス，インコーポレイティド Ｃｃｒ２アンタゴニストによる固形腫瘍の治療方法
US11352357B2 (en) * 2019-11-27 2022-06-07 Sumitomo Dainippon Pharma Co., Ltd. Cycloalkylurea derivative
CN116730855B (zh) * 2023-08-08 2023-10-20 苏州开元民生科技股份有限公司 3-氨基-4-氯苯甲酸十六酯的合成方法

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DK1501507T3 (da) * 2002-04-29 2008-09-29 Merck & Co Inc Tetrahydropyranyl-cyclopentyl-tertrahydropyridopyrindin-modulatorer af kemokin-receptor-aktivitet
JP4459807B2 (ja) * 2002-04-29 2010-04-28 メルク エンド カムパニー インコーポレーテッド テトラヒドロピラニルシクロペンチルテトラヒドロイソキノリン系のケモカイン受容体活性調節剤
US20060205761A1 (en) 2003-06-06 2006-09-14 Catherine Abbadie Ccr-2 antagonists for treatment of neuropathic pain
US20070238723A1 (en) * 2004-10-15 2007-10-11 Goble Stephen D Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
EP1855673A4 (en) * 2005-01-06 2008-03-12 Merck & Co Inc COMBINED THERAPY AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY DISORDERS

Also Published As

Publication number Publication date
WO2004092124A2 (en) 2004-10-28
NO20055376D0 (no) 2005-11-14
EP1615699A4 (en) 2008-03-19
BRPI0409393A8 (pt) 2018-05-08
US7700591B2 (en) 2010-04-20
JP4440257B2 (ja) 2010-03-24
EP1615699B1 (en) 2010-03-24
AU2004231087A1 (en) 2004-10-28
CA2521950C (en) 2009-11-17
PT1615699E (pt) 2010-05-21
JP2006523702A (ja) 2006-10-19
ATE461929T1 (de) 2010-04-15
AU2004231087B2 (en) 2007-01-04
IS8056A (is) 2005-09-29
CA2521950A1 (en) 2004-10-28
SI1615699T1 (sl) 2010-07-30
DE602004026166D1 (de) 2010-05-06
MXPA05011160A (es) 2005-12-14
WO2004092124A8 (en) 2010-02-25
PL1615699T3 (pl) 2010-08-31
NZ543287A (en) 2008-08-29
WO2004092124A3 (en) 2005-04-14
DK1615699T3 (da) 2010-07-19
CY1110155T1 (el) 2015-01-14
US20060069088A1 (en) 2006-03-30
CN1802187B (zh) 2011-09-14
EP1615699A2 (en) 2006-01-18
ES2342776T3 (es) 2010-07-14
NO20055376L (no) 2006-01-13
RU2005135432A (ru) 2006-04-27
KR20060003353A (ko) 2006-01-10
CN1802187A (zh) 2006-07-12
BRPI0409393A (pt) 2006-04-18
RU2301802C2 (ru) 2007-06-27

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