NO20055376D0 - Benzoksazinyl-amidosyklopentyl-heterosykliske modulatorer av chemokin-reseptorer - Google Patents

Benzoksazinyl-amidosyklopentyl-heterosykliske modulatorer av chemokin-reseptorer

Info

Publication number
NO20055376D0
NO20055376D0 NO20055376A NO20055376A NO20055376D0 NO 20055376 D0 NO20055376 D0 NO 20055376D0 NO 20055376 A NO20055376 A NO 20055376A NO 20055376 A NO20055376 A NO 20055376A NO 20055376 D0 NO20055376 D0 NO 20055376D0
Authority
NO
Norway
Prior art keywords
compounds
benzoxazinyl
amidocyclopentyl
chemokine receptors
diseases
Prior art date
Application number
NO20055376A
Other languages
English (en)
Other versions
NO20055376L (no
Inventor
Lihu Yang
Sander G Mills
Stephen D Goble
Alexander Pasternak
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20055376D0 publication Critical patent/NO20055376D0/no
Publication of NO20055376L publication Critical patent/NO20055376L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
NO20055376A 2003-04-15 2005-11-14 Benzoksazinyl-amidosyklopentyl-heterosykliske modulatorer av chemokin-reseptorer NO20055376L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46311103P 2003-04-15 2003-04-15
PCT/US2004/011281 WO2004092124A2 (en) 2003-04-15 2004-04-09 Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors

Publications (2)

Publication Number Publication Date
NO20055376D0 true NO20055376D0 (no) 2005-11-14
NO20055376L NO20055376L (no) 2006-01-13

Family

ID=33300038

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055376A NO20055376L (no) 2003-04-15 2005-11-14 Benzoksazinyl-amidosyklopentyl-heterosykliske modulatorer av chemokin-reseptorer

Country Status (23)

Country Link
US (1) US7700591B2 (no)
EP (1) EP1615699B1 (no)
JP (1) JP4440257B2 (no)
KR (1) KR20060003353A (no)
CN (1) CN1802187B (no)
AT (1) ATE461929T1 (no)
AU (1) AU2004231087B2 (no)
BR (1) BRPI0409393A8 (no)
CA (1) CA2521950C (no)
CY (1) CY1110155T1 (no)
DE (1) DE602004026166D1 (no)
DK (1) DK1615699T3 (no)
ES (1) ES2342776T3 (no)
IS (1) IS8056A (no)
MX (1) MXPA05011160A (no)
NO (1) NO20055376L (no)
NZ (1) NZ543287A (no)
PL (1) PL1615699T3 (no)
PT (1) PT1615699E (no)
RU (1) RU2301802C2 (no)
SI (1) SI1615699T1 (no)
WO (1) WO2004092124A2 (no)
ZA (1) ZA200507796B (no)

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AU2005206791A1 (en) * 2004-01-20 2005-08-04 Merck Sharp & Dohme Corp. 2,6-disubstituted piperidines as modulators of chemokine receptor activity
US20070238723A1 (en) * 2004-10-15 2007-10-11 Goble Stephen D Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
AU2006204038A1 (en) * 2005-01-06 2006-07-13 Merck & Co., Inc. Drug combination therapy and pharmaceutical compositions for treating inflammatory disorders
TW200738701A (en) * 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
WO2007122103A1 (en) * 2006-04-20 2007-11-01 F. Hoffmann-La Roche Ag Diazepan derivatives modulators of chemokine receptors
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
AU2008329070B2 (en) * 2007-11-30 2014-11-20 Noxxon Pharma Ag MCP-I binding nucleic acids and use thereof
KR100904535B1 (ko) * 2009-03-09 2009-06-29 한세이엔씨(주) 교량의 박스거더 내부 안전진단장치
CN102439007A (zh) 2009-03-17 2012-05-02 第一三共株式会社 酰胺衍生物
EA020825B1 (ru) * 2009-04-07 2015-02-27 Эмерити Фарма Аб Аналоги изоксазол-3(2h)-она в качестве терапевтических агентов
UA107938C2 (en) 2009-08-12 2015-03-10 Syngenta Participations Ag Heterocycles with microbicidal properties
US9040526B2 (en) 2010-02-09 2015-05-26 Bristol-Myers Squibb Company Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
CN103694220A (zh) * 2013-12-30 2014-04-02 张磊 新型吡唑-3-甲酸酯及合成方法
RU2564440C1 (ru) * 2014-06-03 2015-10-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" 3-ароил-2-гидрокси-2-(2-оксоциклоалкил)пирроло[2,1-с][1,4]бензоксазин-1,4(2н)-дионы, проявляющие анальгетическую активность, и способ их получения
JP6660393B2 (ja) 2015-01-16 2020-03-11 バイエル・クロップサイエンス・アクチェンゲゼルシャフト ４−シアノピペリジン塩酸塩を調製する方法
BR112017018991B1 (pt) * 2015-03-05 2022-02-15 Bayer Cropscience Aktiengesellschaft Processo para preparação de hidrocloreto de piperidina-4-carbotioamida
AU2016263579B2 (en) * 2015-05-21 2020-12-03 Chemocentryx, Inc. CCR2 modulators
EP3325533B1 (en) 2015-07-23 2023-09-13 Huntsman Advanced Materials Americas LLC Curable benzoxazine compositions
CN111712242B (zh) 2017-09-25 2023-11-24 凯莫森特里克斯股份有限公司 使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗
WO2019136368A2 (en) 2018-01-08 2019-07-11 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
US11352357B2 (en) * 2019-11-27 2022-06-07 Sumitomo Dainippon Pharma Co., Ltd. Cycloalkylurea derivative
CN116730855B (zh) * 2023-08-08 2023-10-20 苏州开元民生科技股份有限公司 3-氨基-4-氯苯甲酸十六酯的合成方法

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US3647804A (en) 1970-02-27 1972-03-07 Upjohn Co Cycloalkanecarboxamides
US3772308A (en) 1972-06-02 1973-11-13 Lilly Co Eli Cyclopentanecetamides and cyclopentaneacetonitriles
GB9812037D0 (en) 1998-06-04 1998-07-29 Pfizer Ltd Piperidones
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
AU5473400A (en) * 1999-06-11 2001-01-02 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
WO2002070523A1 (en) 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
NZ536477A (en) * 2002-04-29 2005-05-27 Merck & Co Inc Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
AU2003223755B2 (en) * 2002-04-29 2008-08-21 Merck Sharp & Dohme Corp. Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
US20060205761A1 (en) 2003-06-06 2006-09-14 Catherine Abbadie Ccr-2 antagonists for treatment of neuropathic pain
US20070238723A1 (en) * 2004-10-15 2007-10-11 Goble Stephen D Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
AU2006204038A1 (en) * 2005-01-06 2006-07-13 Merck & Co., Inc. Drug combination therapy and pharmaceutical compositions for treating inflammatory disorders

Also Published As

Publication number Publication date
PL1615699T3 (pl) 2010-08-31
US20060069088A1 (en) 2006-03-30
RU2301802C2 (ru) 2007-06-27
NO20055376L (no) 2006-01-13
BRPI0409393A8 (pt) 2018-05-08
AU2004231087B2 (en) 2007-01-04
ES2342776T3 (es) 2010-07-14
RU2005135432A (ru) 2006-04-27
CY1110155T1 (el) 2015-01-14
JP2006523702A (ja) 2006-10-19
EP1615699A4 (en) 2008-03-19
CA2521950C (en) 2009-11-17
SI1615699T1 (sl) 2010-07-30
EP1615699A2 (en) 2006-01-18
ZA200507796B (en) 2007-02-28
DK1615699T3 (da) 2010-07-19
IS8056A (is) 2005-09-29
PT1615699E (pt) 2010-05-21
ATE461929T1 (de) 2010-04-15
MXPA05011160A (es) 2005-12-14
US7700591B2 (en) 2010-04-20
EP1615699B1 (en) 2010-03-24
KR20060003353A (ko) 2006-01-10
DE602004026166D1 (de) 2010-05-06
NZ543287A (en) 2008-08-29
CA2521950A1 (en) 2004-10-28
CN1802187A (zh) 2006-07-12
AU2004231087A1 (en) 2004-10-28
CN1802187B (zh) 2011-09-14
JP4440257B2 (ja) 2010-03-24
WO2004092124A3 (en) 2005-04-14
WO2004092124A2 (en) 2004-10-28
WO2004092124A8 (en) 2010-02-25
BRPI0409393A (pt) 2006-04-18

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