ZA200506414B - Indenoncarboxylic acids derivatives and their use for the treatment of and preventing diabetes and dyslipidaemia - Google Patents

Indenoncarboxylic acids derivatives and their use for the treatment of and preventing diabetes and dyslipidaemia Download PDF

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Publication number
ZA200506414B
ZA200506414B ZA200506414A ZA200506414A ZA200506414B ZA 200506414 B ZA200506414 B ZA 200506414B ZA 200506414 A ZA200506414 A ZA 200506414A ZA 200506414 A ZA200506414 A ZA 200506414A ZA 200506414 B ZA200506414 B ZA 200506414B
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formula
optionally substituted
compound
compounds
alkyl
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ZA200506414A
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Adje Nathalie
Roche Didier
Yvon Stuphane
Contard Francis
Ferrand Gerard
Brunet Michel
Zeiller Jean-Jacques
Guyard-Dangremont Valerie
Guerrier Daniel
Bonhomme Yves
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Merck Patent Gmbh
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    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
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    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
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    • C07C211/57—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton
    • C07C211/60—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton containing a ring other than a six-membered aromatic ring forming part of at least one of the condensed ring systems
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    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
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    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
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    • C07C255/00—Carboxylic acid nitriles
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    • C07C255/40—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by doubly-bound oxygen atoms
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    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
    • C07C323/34—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a mercapto group
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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
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    • C07C69/734—Ethers
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ZA200506414A 2003-01-13 2005-08-11 Indenoncarboxylic acids derivatives and their use for the treatment of and preventing diabetes and dyslipidaemia ZA200506414B (en)

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FR0300318A FR2849849B1 (fr) 2003-01-13 2003-01-13 Nouveaux acides carboxyliques et derives pour le traitement et la prevention du diabete et des dyslipemies

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EP (1) EP1583738B1 (ja)
JP (1) JP4762551B2 (ja)
KR (1) KR20050091086A (ja)
CN (1) CN1738795A (ja)
AR (1) AR042830A1 (ja)
AU (1) AU2003294861B2 (ja)
BR (1) BR0317965A (ja)
CA (1) CA2513310C (ja)
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FR (1) FR2849849B1 (ja)
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RU (1) RU2005125635A (ja)
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FR2845087B1 (fr) * 2002-10-01 2004-12-24 Merck Sante Sas Nouveaux acides arylhexadienoiques substitues et leurs esters,utilisables dans le traitement et la prevention du diabete, des dyslipidemies,de l'atherosclerose, compositions pharmaceutiques les contenant et procedes de preparation
JP5566004B2 (ja) * 2007-11-14 2014-08-06 株式会社Ｄｎｐファインケミカル宇都宮 アルコキシインダノン誘導体の製造方法
WO2010070076A1 (en) * 2008-12-19 2010-06-24 Crystax Pharmaceuticals, S.L. Alkanoic acid derivatives and their therapeutic use as hdac inhibitors
NZ594236A (en) 2009-01-26 2014-08-29 Univ Taipei Medical Use of pterosin compounds for treating diabetes and obesity
NZ595978A (en) 2009-05-04 2013-11-29 Prometic Biosciences Inc Substituted aromatic compounds and pharmaceutical uses thereof
US10800726B2 (en) 2014-06-30 2020-10-13 The Uab Research Foundation Rexinoid compounds and methods of using rexinoid compounds for treating metabolic disorders and cancer
AU2021205974A1 (en) * 2020-01-09 2022-07-21 Senseion Therapeutics, Inc. Suppression of inflammasome activation

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AU2003294861A1 (en) 2004-08-10
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CN1738795A (zh) 2006-02-22
EP1583738A1 (en) 2005-10-12
KR20050091086A (ko) 2005-09-14
FR2849849B1 (fr) 2006-08-04
CA2513310A1 (en) 2004-07-29
FR2849849A1 (fr) 2004-07-16
WO2004063148A1 (en) 2004-07-29
BR0317965A (pt) 2005-11-29
US7482484B2 (en) 2009-01-27
CA2513310C (en) 2012-11-27
EP1583738B1 (en) 2017-05-10
JP4762551B2 (ja) 2011-08-31
JP2006513242A (ja) 2006-04-20
AR042830A1 (es) 2005-07-06
RU2005125635A (ru) 2006-02-27
MXPA05007497A (es) 2005-09-21
AU2003294861B2 (en) 2010-05-20

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