ZA200506411B - Peptide inhibitors of toxins derived from LL-37 - Google Patents

Peptide inhibitors of toxins derived from LL-37 Download PDF

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Publication number
ZA200506411B
ZA200506411B ZA200506411A ZA200506411A ZA200506411B ZA 200506411 B ZA200506411 B ZA 200506411B ZA 200506411 A ZA200506411 A ZA 200506411A ZA 200506411 A ZA200506411 A ZA 200506411A ZA 200506411 B ZA200506411 B ZA 200506411B
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ZA
South Africa
Prior art keywords
compound
acid sequence
terminal part
amino acids
compounds
Prior art date
Application number
ZA200506411A
Other languages
English (en)
Inventor
Johannes J Grote
Jan W Drijfhout
Original Assignee
Academisch Ziekenhuis Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academisch Ziekenhuis Leiden filed Critical Academisch Ziekenhuis Leiden
Publication of ZA200506411B publication Critical patent/ZA200506411B/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723Cationic antimicrobial peptides, e.g. defensins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA200506411A 2003-01-28 2005-08-11 Peptide inhibitors of toxins derived from LL-37 ZA200506411B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03075274 2003-01-28

Publications (1)

Publication Number Publication Date
ZA200506411B true ZA200506411B (en) 2006-04-26

Family

ID=32798944

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200506411A ZA200506411B (en) 2003-01-28 2005-08-11 Peptide inhibitors of toxins derived from LL-37

Country Status (20)

Country Link
US (1) US7807617B2 (es)
EP (1) EP1587830B1 (es)
JP (1) JP4471968B2 (es)
KR (1) KR100856819B1 (es)
CN (1) CN1798764B (es)
AT (1) ATE435870T1 (es)
AU (1) AU2004207118B2 (es)
BR (1) BRPI0407022A (es)
CA (1) CA2514584C (es)
CR (1) CR7926A (es)
DE (1) DE602004021901D1 (es)
DK (1) DK1587830T3 (es)
ES (1) ES2328571T3 (es)
HK (1) HK1088613A1 (es)
MX (1) MXPA05008080A (es)
NZ (1) NZ541657A (es)
PT (1) PT1587830E (es)
RU (1) RU2346950C2 (es)
WO (1) WO2004067563A1 (es)
ZA (1) ZA200506411B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1621205A1 (en) * 2004-07-28 2006-02-01 OctoPlus Technologies B.V. Antimicrobial peptides derived from CAP18
US7465784B2 (en) 2006-10-26 2008-12-16 Board Of Regents Of The University Of Nebraska Antimicrobial peptides and methods of identifying the same
CA2694440A1 (en) 2007-07-25 2009-01-29 Biolex Therapeutics, Inc. Controlled release interferon drug products and treatment of hcv infection using same
CA2790818A1 (en) * 2010-02-25 2011-09-01 University Of Manitoba Modulation of cytokine-induced chronic inflammatory responses
US10723764B2 (en) 2011-11-21 2020-07-28 Board Of Regents Of The University Of Nebraska Anti-microbial peptides and methods of use thereof
US9580472B2 (en) 2011-11-21 2017-02-28 Board Of Regents Of The University Of Nebraska Anti-microbial peptides and methods of use thereof
RU2018128393A (ru) * 2012-09-17 2019-03-14 Мадригал Фармасьютикалз, Инк. Способ синтеза аналогов гормонов щитовидной железы и их полиморфов
SG11201703428SA (en) 2014-11-10 2017-05-30 Hoffmann La Roche Bispecific antibodies and methods of use in ophthalmology
RU2584089C1 (ru) * 2015-06-15 2016-05-20 Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Медицинский Университет Имени В.И. Разумовского" Министерства Здравоохранения Российской Федерации Способ снижения летального эффекта бактериального липополисахарида in vitro
CN105859867A (zh) * 2016-05-30 2016-08-17 黄石市中心医院 一种人源抗菌肽ll-37突变体及其应用
CN108892719B (zh) * 2018-07-09 2021-07-30 珠海中科先进技术研究院有限公司 一种新型人源抗菌肽ll-37衍生物及其应用
CN113116811A (zh) * 2020-01-14 2021-07-16 中国科学院上海药物研究所 可注射长效镇痛药物组合物及其制备方法和用途
WO2021143745A1 (zh) * 2020-01-14 2021-07-22 中国科学院上海药物研究所 一种长效罗哌卡因药物组合物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103888A (en) * 1992-07-17 2000-08-15 Panorama Research, Inc. Mammalian cationic proteins having lipopolysaccharide binding and anti-coagulant activity
JP4037525B2 (ja) * 1998-03-25 2008-01-23 生化学工業株式会社 新規抗菌性ペプチド

Also Published As

Publication number Publication date
JP4471968B2 (ja) 2010-06-02
CN1798764A (zh) 2006-07-05
WO2004067563A1 (en) 2004-08-12
EP1587830A1 (en) 2005-10-26
PT1587830E (pt) 2009-09-23
WO2004067563A8 (en) 2004-12-02
EP1587830B1 (en) 2009-07-08
BRPI0407022A (pt) 2006-01-10
RU2346950C2 (ru) 2009-02-20
KR20060012261A (ko) 2006-02-07
HK1088613A1 (en) 2006-11-10
CA2514584A1 (en) 2004-08-12
CA2514584C (en) 2012-05-29
MXPA05008080A (es) 2006-02-08
JP2007528696A (ja) 2007-10-18
AU2004207118B2 (en) 2009-12-17
DE602004021901D1 (de) 2009-08-20
CN1798764B (zh) 2010-05-12
AU2004207118A1 (en) 2004-08-12
DK1587830T3 (da) 2009-10-26
CR7926A (es) 2006-02-07
KR100856819B1 (ko) 2008-09-05
NZ541657A (en) 2009-01-31
ES2328571T3 (es) 2009-11-16
US20060223755A1 (en) 2006-10-05
ATE435870T1 (de) 2009-07-15
RU2005127076A (ru) 2006-01-20
US7807617B2 (en) 2010-10-05

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