ZA200505934B - Cyclic urea derivatives, preparation method thereof and pharmaceutical use of same as kinase inhibitors - Google Patents
Cyclic urea derivatives, preparation method thereof and pharmaceutical use of same as kinase inhibitors Download PDFInfo
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- ZA200505934B ZA200505934B ZA200505934A ZA200505934A ZA200505934B ZA 200505934 B ZA200505934 B ZA 200505934B ZA 200505934 A ZA200505934 A ZA 200505934A ZA 200505934 A ZA200505934 A ZA 200505934A ZA 200505934 B ZA200505934 B ZA 200505934B
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- alkyl
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- 238000002360 preparation method Methods 0.000 title claims 10
- 229940043355 kinase inhibitor Drugs 0.000 title claims 2
- ZMGMDXCADSRNCX-UHFFFAOYSA-N 5,6-dihydroxy-1,3-diazepan-2-one Chemical class OC1CNC(=O)NCC1O ZMGMDXCADSRNCX-UHFFFAOYSA-N 0.000 title 1
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- 150000003254 radicals Chemical class 0.000 claims description 127
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- 150000002431 hydrogen Chemical class 0.000 claims description 69
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 62
- 239000011707 mineral Substances 0.000 claims description 62
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 58
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- 125000003118 aryl group Chemical group 0.000 claims description 56
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- WUEPMEXUMQVEGN-UHFFFAOYSA-N 2,2,2-trifluoroacetic acid;2,2,2-trifluoro-n-[2-[2-[(2,2,2-trifluoroacetyl)amino]ethylamino]ethyl]acetamide Chemical compound OC(=O)C(F)(F)F.FC(F)(F)C(=O)NCCNCCNC(=O)C(F)(F)F WUEPMEXUMQVEGN-UHFFFAOYSA-N 0.000 claims 4
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| FR0301098A FR2850652B1 (fr) | 2003-01-31 | 2003-01-31 | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
Publications (1)
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|---|---|
| ZA200505934B true ZA200505934B (en) | 2007-06-27 |
Family
ID=32696243
Family Applications (1)
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| ZA200505934A ZA200505934B (en) | 2003-01-31 | 2005-07-22 | Cyclic urea derivatives, preparation method thereof and pharmaceutical use of same as kinase inhibitors |
Country Status (24)
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| EP (1) | EP1599464B1 (xx) |
| JP (1) | JP4604020B2 (xx) |
| KR (1) | KR20050098286A (xx) |
| CN (1) | CN1768054A (xx) |
| AR (1) | AR042936A1 (xx) |
| AT (1) | ATE482207T1 (xx) |
| AU (1) | AU2004209319A1 (xx) |
| BR (1) | BRPI0407091A (xx) |
| CA (1) | CA2513631A1 (xx) |
| DE (1) | DE602004029236D1 (xx) |
| FR (1) | FR2850652B1 (xx) |
| HR (1) | HRP20050679A2 (xx) |
| MA (1) | MA27651A1 (xx) |
| ME (1) | MEP22608A (xx) |
| MX (1) | MXPA05007407A (xx) |
| NO (1) | NO20054006L (xx) |
| NZ (1) | NZ541270A (xx) |
| PE (1) | PE20040808A1 (xx) |
| PL (1) | PL377811A1 (xx) |
| RS (1) | RS20050657A (xx) |
| RU (1) | RU2341523C2 (xx) |
| TW (1) | TW200505898A (xx) |
| WO (1) | WO2004070050A2 (xx) |
| ZA (1) | ZA200505934B (xx) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7491743B2 (en) | 2003-08-29 | 2009-02-17 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| JP2007514442A (ja) | 2003-12-19 | 2007-06-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 前立腺癌治療を評価するための方法および物質 |
| US7718684B2 (en) | 2004-02-24 | 2010-05-18 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
| EP1621536A1 (en) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
| EP1621535A1 (en) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
| DK1893196T4 (en) | 2005-05-13 | 2015-10-19 | Univ California | Diarylhydantoin connection |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| US7709516B2 (en) * | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
| FR2896503B1 (fr) * | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| FR2896504B1 (fr) * | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| PL2368550T3 (pl) | 2006-03-27 | 2014-01-31 | Univ California | Modulator receptorów androgenowych do leczenia raka gruczołu krokowego i chorób związanych z receptorami androgenów |
| EP2439196A1 (en) | 2006-03-29 | 2012-04-11 | The Regents of The University of California | Diarylthiohydantoin compounds for use in a method for the treatment of a hyperproliferative disorder |
| EP2061767B1 (de) | 2006-08-08 | 2014-12-17 | Sanofi | Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung |
| US8093254B2 (en) | 2006-12-12 | 2012-01-10 | Schering Corporation | Aspartyl protease inhibitors |
| CA2966280A1 (en) | 2007-10-26 | 2009-04-30 | The Regents Of The University Of California | Diarylhydantoin compounds |
| CN104803986A (zh) | 2008-12-23 | 2015-07-29 | 哈佛大学校长及研究员协会 | 坏死性凋亡的小分子抑制剂 |
| EP3124481B1 (en) | 2010-02-16 | 2018-03-28 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and uses thereof |
| WO2012087862A2 (en) * | 2010-12-21 | 2012-06-28 | Cytec Technology Corp. | Microdispersions of hydroxamated polymers and methods of making and using them |
| US8492556B2 (en) * | 2011-11-10 | 2013-07-23 | Allergan, Inc. | 2,5-Dioxoimidazolidin-1-yl-3-phenylurea derivatives as formyl peptide receptor like-1 (FPRL-1) receptor modulators |
| CA2885415C (en) | 2012-09-26 | 2021-06-29 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
| JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
| WO2014145022A1 (en) | 2013-03-15 | 2014-09-18 | President And Fellows Of Harvard College | Hybrid necroptosis inhibitors |
| GB201312492D0 (en) * | 2013-07-12 | 2013-08-28 | Syngenta Ltd | Herbicidal compounds |
| TN2016000270A1 (en) | 2014-01-14 | 2017-10-06 | Millennium Pharm Inc | Heteroaryls and uses thereof. |
| WO2015108881A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| SG11201704764PA (en) | 2014-12-11 | 2017-07-28 | Harvard College | Inhibitors of cellular necrosis and related methods |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| CN107619388A (zh) * | 2016-07-13 | 2018-01-23 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
| WO2018014829A1 (en) * | 2016-07-20 | 2018-01-25 | Novartis Ag | Aminopyridine derivatives and their use as selective alk-2 inhibitors |
| EP3697398A1 (en) | 2017-10-16 | 2020-08-26 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
| RU2763346C2 (ru) * | 2017-10-31 | 2021-12-28 | Пелемед Ко., Лтд. | Фармацевтическая композиция для предупреждения или лечения острого миелоидного лейкоза или метастатического рака молочной железы |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2329276A1 (fr) * | 1975-10-29 | 1977-05-27 | Roussel Uclaf | Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant |
| DE4228717A1 (de) * | 1992-08-28 | 1994-03-03 | Cassella Ag | Imidazolidin-Derivate |
| DE19540027A1 (de) * | 1995-10-27 | 1997-04-30 | Gruenenthal Gmbh | Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe |
| SK117499A3 (en) * | 1997-03-03 | 2000-05-16 | Boehringer Ingelheim Pharma | Small molecules useful in the treatment of inflammatory and immune cell-mediated diseases, small molecules and pharmaceutical composition with their content |
| DE19732928C2 (de) * | 1997-07-31 | 2000-05-18 | Gruenenthal Gmbh | Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel |
| FR2796945B1 (fr) * | 1999-07-30 | 2002-06-28 | Sod Conseils Rech Applic | Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments |
| MXPA02011858A (es) * | 2000-05-31 | 2004-07-30 | Tanabe Seiyaku Co | Inhibidores de adhesion de celula mediada por alfabeta2. |
| ES2572808T3 (es) * | 2002-05-16 | 2016-06-02 | Merial, Inc. | Derivados de piridincarboxamida y su utilización como plaguicidas |
-
2003
- 2003-01-31 FR FR0301098A patent/FR2850652B1/fr not_active Expired - Fee Related
-
2004
- 2004-01-22 PE PE2004000090A patent/PE20040808A1/es not_active Application Discontinuation
- 2004-01-27 AR ARP040100233A patent/AR042936A1/es unknown
- 2004-01-28 JP JP2006502123A patent/JP4604020B2/ja not_active Expired - Fee Related
- 2004-01-28 CN CNA2004800088356A patent/CN1768054A/zh active Pending
- 2004-01-28 CA CA002513631A patent/CA2513631A1/fr not_active Abandoned
- 2004-01-28 RU RU2005127335/04A patent/RU2341523C2/ru not_active IP Right Cessation
- 2004-01-28 KR KR1020057014096A patent/KR20050098286A/ko not_active Application Discontinuation
- 2004-01-28 DE DE602004029236T patent/DE602004029236D1/de not_active Expired - Lifetime
- 2004-01-28 EP EP04705838A patent/EP1599464B1/fr not_active Expired - Lifetime
- 2004-01-28 ME MEP-226/08A patent/MEP22608A/xx unknown
- 2004-01-28 AT AT04705838T patent/ATE482207T1/de not_active IP Right Cessation
- 2004-01-28 MX MXPA05007407A patent/MXPA05007407A/es active IP Right Grant
- 2004-01-28 PL PL377811A patent/PL377811A1/pl not_active Application Discontinuation
- 2004-01-28 BR BR0407091-7A patent/BRPI0407091A/pt not_active IP Right Cessation
- 2004-01-28 AU AU2004209319A patent/AU2004209319A1/en not_active Abandoned
- 2004-01-28 RS YUP-2005/0657A patent/RS20050657A/sr unknown
- 2004-01-28 WO PCT/FR2004/000188 patent/WO2004070050A2/fr active Application Filing
- 2004-01-28 NZ NZ541270A patent/NZ541270A/en unknown
- 2004-01-30 TW TW093102064A patent/TW200505898A/zh unknown
-
2005
- 2005-07-22 ZA ZA200505934A patent/ZA200505934B/en unknown
- 2005-07-29 MA MA28417A patent/MA27651A1/fr unknown
- 2005-07-29 HR HR20050679A patent/HRP20050679A2/xx not_active Application Discontinuation
- 2005-08-29 NO NO20054006A patent/NO20054006L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20050098286A (ko) | 2005-10-11 |
| PE20040808A1 (es) | 2004-12-31 |
| WO2004070050A3 (fr) | 2005-02-17 |
| NO20054006L (no) | 2005-10-13 |
| ATE482207T1 (de) | 2010-10-15 |
| JP4604020B2 (ja) | 2010-12-22 |
| MXPA05007407A (es) | 2005-09-12 |
| NZ541270A (en) | 2008-11-28 |
| HRP20050679A2 (en) | 2006-12-31 |
| CN1768054A (zh) | 2006-05-03 |
| FR2850652A1 (fr) | 2004-08-06 |
| RS20050657A (xx) | 2007-06-04 |
| EP1599464B1 (fr) | 2010-09-22 |
| EP1599464A2 (fr) | 2005-11-30 |
| CA2513631A1 (fr) | 2004-08-19 |
| TW200505898A (en) | 2005-02-16 |
| AU2004209319A1 (en) | 2004-08-19 |
| PL377811A1 (pl) | 2006-02-20 |
| MA27651A1 (fr) | 2005-12-01 |
| JP2006517569A (ja) | 2006-07-27 |
| NO20054006D0 (no) | 2005-08-29 |
| MEP22608A (en) | 2010-06-10 |
| FR2850652B1 (fr) | 2008-05-30 |
| RU2005127335A (ru) | 2006-09-10 |
| BRPI0407091A (pt) | 2006-01-24 |
| RU2341523C2 (ru) | 2008-12-20 |
| WO2004070050A2 (fr) | 2004-08-19 |
| AR042936A1 (es) | 2005-07-06 |
| DE602004029236D1 (de) | 2010-11-04 |
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