NO20054006L - Cykliske ureaderivater, fremstillingsfremgangsmate derav og farmasoytisk anvendelse av samme som kinaseinhibitorer - Google Patents
Cykliske ureaderivater, fremstillingsfremgangsmate derav og farmasoytisk anvendelse av samme som kinaseinhibitorerInfo
- Publication number
- NO20054006L NO20054006L NO20054006A NO20054006A NO20054006L NO 20054006 L NO20054006 L NO 20054006L NO 20054006 A NO20054006 A NO 20054006A NO 20054006 A NO20054006 A NO 20054006A NO 20054006 L NO20054006 L NO 20054006L
- Authority
- NO
- Norway
- Prior art keywords
- nr5r6
- cycloalkyl
- alkyl
- alkenyl
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Foreliggende oppfinnelse angår nye produkter som har formel (I) hvori: p betegner 0 til 2; R og R1 betegner O eller NH; R2 og R3 betegner hydrogen, alkyl, alkenyl, alkynyl, sykloalkyl, aryl og heteroaryl, R2 og R3, sammen med karbonatomet til hvilket de er bundet, danner et karbosyklisk eller heterosyklisk radikal, hvor alle nevnte radikal eventuelt er substituert; A1 betegner en enkelt binding, alkyl, allyl og propynyl; Y og Y1 betegner H, OCF3, S(O)nCF3, S(O)nAlk, SO2CHF2, SO2CF2CF3, -O-CF2-CHF2, -O-CHF2, -O-CH2-CF3, SF5 og SO2NR5R6; hvori R5 og R6 er utvalgt fra hydrogen, alkyl, alkenyl, sykloalkyl, sykloalkenyl, heterosykloalkyl, aryl og heteroaryl, som eventuelt er substituert, eller R5 og R6, sammen med N til hvilket de er bundet, danner et heterosyklisk radikal; A2 betegner A1, CO og SO2; B2 betegner et heterosyklisk radikal som eventuelt er substituert med en eller flere substituenter som er valgt fra verdiene til Y2; Y2 betegner hydrogen, halogen, hydroksyl, cyano, alkyl, alkoksy, sykloalkyl, heterosykloalkyl, aryl, heteroaryl, -O-alkenyl, -O-alkynyl, O-sykloalkyl, S(O)n-alkyl, -S(O)n-alkenyl, -S(O)n-alkynyl, S(O)n-sykloalkyl, -COOR13, -OCOR13, NR5R6, CONR5R6, S(O)n-NR5R6, -NR10-CO-R13, -NR10-SO2-R13, -NHSO2-NR5R6, -NR10-CO-NR5R6, -NR10-CS-NR5R6, -NR10-COOR13, hvor alle nevnte radikaler eventuelt er substituert; n betegner et heltall på fra 0 til 2. De tidligere nevnte produktene er i alle isomere former og saltene derav for anvendelse som medikamenter.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0301098A FR2850652B1 (fr) | 2003-01-31 | 2003-01-31 | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
PCT/FR2004/000188 WO2004070050A2 (fr) | 2003-01-31 | 2004-01-28 | Derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20054006D0 NO20054006D0 (no) | 2005-08-29 |
NO20054006L true NO20054006L (no) | 2005-10-13 |
Family
ID=32696243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20054006A NO20054006L (no) | 2003-01-31 | 2005-08-29 | Cykliske ureaderivater, fremstillingsfremgangsmate derav og farmasoytisk anvendelse av samme som kinaseinhibitorer |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1599464B1 (no) |
JP (1) | JP4604020B2 (no) |
KR (1) | KR20050098286A (no) |
CN (1) | CN1768054A (no) |
AR (1) | AR042936A1 (no) |
AT (1) | ATE482207T1 (no) |
AU (1) | AU2004209319A1 (no) |
BR (1) | BRPI0407091A (no) |
CA (1) | CA2513631A1 (no) |
DE (1) | DE602004029236D1 (no) |
FR (1) | FR2850652B1 (no) |
HR (1) | HRP20050679A2 (no) |
MA (1) | MA27651A1 (no) |
ME (1) | MEP22608A (no) |
MX (1) | MXPA05007407A (no) |
NO (1) | NO20054006L (no) |
NZ (1) | NZ541270A (no) |
PE (1) | PE20040808A1 (no) |
PL (1) | PL377811A1 (no) |
RS (1) | RS20050657A (no) |
RU (1) | RU2341523C2 (no) |
TW (1) | TW200505898A (no) |
WO (1) | WO2004070050A2 (no) |
ZA (1) | ZA200505934B (no) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3081214A3 (en) | 2003-08-29 | 2016-11-16 | The Brigham And Women's Hospital, Inc. | Inhibitors of cellular necrosis |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
EP2299266A1 (en) | 2003-12-19 | 2011-03-23 | The Regents of the University of California | Methods and materials for assessing prostate cancer therapies |
AU2005232526B2 (en) | 2004-02-24 | 2011-06-23 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
EP1621535A1 (en) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
EP1621536A1 (en) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
PT2444085E (pt) | 2005-05-13 | 2015-06-11 | Univ California | Compostos de diaril-hidantoínas como antagonistas do recetor androgénio para tratamento de cancro |
US7709516B2 (en) | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
FR2896503B1 (fr) | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
FR2896504B1 (fr) * | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
EP2656842B1 (en) | 2006-03-27 | 2016-08-10 | The Regents of The University of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
EP3020706A1 (en) | 2006-03-29 | 2016-05-18 | The Regents Of The University Of California | Diarylthiohydantoin compounds useful for the treatment of a hyperproliferative disorder |
BRPI0715160A2 (pt) | 2006-08-08 | 2013-06-11 | Sanofi Aventis | imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso |
MX2009006228A (es) | 2006-12-12 | 2009-06-22 | Schering Corp | Inhibidores de aspartil proteasa. |
CA2966280A1 (en) | 2007-10-26 | 2009-04-30 | The Regents Of The University Of California | Diarylhydantoin compounds |
CN102316735A (zh) | 2008-12-23 | 2012-01-11 | 哈佛大学校长及研究员协会 | 坏死性凋亡的小分子抑制剂 |
PT3124481T (pt) | 2010-02-16 | 2018-06-18 | Aragon Pharmaceuticals Inc | Moduladores do receptor de androgénios e suas utilizações |
AU2011349525B2 (en) * | 2010-12-21 | 2015-05-21 | Cytec Technology Corp. | Microdispersions of hydroxamated polymers and methods of making and using them |
US8492556B2 (en) * | 2011-11-10 | 2013-07-23 | Allergan, Inc. | 2,5-Dioxoimidazolidin-1-yl-3-phenylurea derivatives as formyl peptide receptor like-1 (FPRL-1) receptor modulators |
EA030128B1 (ru) | 2012-09-26 | 2018-06-29 | Арагон Фармасьютикалз, Инк. | Способ лечения неметастатического кастрационно-резистентного рака простаты |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
US9725452B2 (en) | 2013-03-15 | 2017-08-08 | Presidents And Fellows Of Harvard College | Substituted indoles and pyrroles as RIP kinase inhibitors |
GB201312492D0 (en) * | 2013-07-12 | 2013-08-28 | Syngenta Ltd | Herbicidal compounds |
WO2015108881A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
GEP20196983B (en) | 2014-01-14 | 2019-06-25 | Millennium Pharm Inc | Heteroaryls and uses thereof |
EP3229807A4 (en) | 2014-12-11 | 2018-10-17 | President and Fellows of Harvard College | Inhibitors of cellular necrosis and related methods |
TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
CN107619388A (zh) * | 2016-07-13 | 2018-01-23 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
WO2018014829A1 (en) * | 2016-07-20 | 2018-01-25 | Novartis Ag | Aminopyridine derivatives and their use as selective alk-2 inhibitors |
US10702508B2 (en) | 2017-10-16 | 2020-07-07 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
EP3705474A4 (en) * | 2017-10-31 | 2021-06-09 | Pelemed Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF ACUTE MYELOIC LEUKEMIA OR METASTATIC BREAST CANCER |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2329276A1 (fr) * | 1975-10-29 | 1977-05-27 | Roussel Uclaf | Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant |
DE4228717A1 (de) * | 1992-08-28 | 1994-03-03 | Cassella Ag | Imidazolidin-Derivate |
DE19540027A1 (de) * | 1995-10-27 | 1997-04-30 | Gruenenthal Gmbh | Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe |
BR9811260A (pt) * | 1997-03-03 | 2000-08-08 | Boehringer Ingelheim Pharma | Pequenas moléculas úteis no tratamento de doença inflamatória |
DE19732928C2 (de) * | 1997-07-31 | 2000-05-18 | Gruenenthal Gmbh | Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel |
FR2796945B1 (fr) * | 1999-07-30 | 2002-06-28 | Sod Conseils Rech Applic | Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments |
WO2001092253A2 (en) * | 2000-05-31 | 2001-12-06 | Tanabe Seiyaku Co., Ltd. | Inhibitors of alpha l beta 2 mediated cell adhesion |
JP4623279B2 (ja) * | 2002-05-16 | 2011-02-02 | メリアル・リミテッド | ピリジンカルボキサミド誘導体および農薬としてのその使用 |
-
2003
- 2003-01-31 FR FR0301098A patent/FR2850652B1/fr not_active Expired - Fee Related
-
2004
- 2004-01-22 PE PE2004000090A patent/PE20040808A1/es not_active Application Discontinuation
- 2004-01-27 AR ARP040100233A patent/AR042936A1/es unknown
- 2004-01-28 CA CA002513631A patent/CA2513631A1/fr not_active Abandoned
- 2004-01-28 CN CNA2004800088356A patent/CN1768054A/zh active Pending
- 2004-01-28 RS YUP-2005/0657A patent/RS20050657A/sr unknown
- 2004-01-28 NZ NZ541270A patent/NZ541270A/en unknown
- 2004-01-28 AU AU2004209319A patent/AU2004209319A1/en not_active Abandoned
- 2004-01-28 MX MXPA05007407A patent/MXPA05007407A/es active IP Right Grant
- 2004-01-28 JP JP2006502123A patent/JP4604020B2/ja not_active Expired - Fee Related
- 2004-01-28 KR KR1020057014096A patent/KR20050098286A/ko not_active Application Discontinuation
- 2004-01-28 WO PCT/FR2004/000188 patent/WO2004070050A2/fr active Application Filing
- 2004-01-28 EP EP04705838A patent/EP1599464B1/fr not_active Expired - Lifetime
- 2004-01-28 PL PL377811A patent/PL377811A1/pl not_active Application Discontinuation
- 2004-01-28 AT AT04705838T patent/ATE482207T1/de not_active IP Right Cessation
- 2004-01-28 DE DE602004029236T patent/DE602004029236D1/de not_active Expired - Lifetime
- 2004-01-28 ME MEP-226/08A patent/MEP22608A/xx unknown
- 2004-01-28 RU RU2005127335/04A patent/RU2341523C2/ru not_active IP Right Cessation
- 2004-01-28 BR BR0407091-7A patent/BRPI0407091A/pt not_active IP Right Cessation
- 2004-01-30 TW TW093102064A patent/TW200505898A/zh unknown
-
2005
- 2005-07-22 ZA ZA200505934A patent/ZA200505934B/en unknown
- 2005-07-29 HR HR20050679A patent/HRP20050679A2/xx not_active Application Discontinuation
- 2005-07-29 MA MA28417A patent/MA27651A1/fr unknown
- 2005-08-29 NO NO20054006A patent/NO20054006L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
RS20050657A (en) | 2007-06-04 |
JP4604020B2 (ja) | 2010-12-22 |
RU2005127335A (ru) | 2006-09-10 |
PL377811A1 (pl) | 2006-02-20 |
RU2341523C2 (ru) | 2008-12-20 |
CA2513631A1 (fr) | 2004-08-19 |
NO20054006D0 (no) | 2005-08-29 |
ZA200505934B (en) | 2007-06-27 |
MEP22608A (en) | 2010-06-10 |
BRPI0407091A (pt) | 2006-01-24 |
JP2006517569A (ja) | 2006-07-27 |
EP1599464B1 (fr) | 2010-09-22 |
AU2004209319A1 (en) | 2004-08-19 |
EP1599464A2 (fr) | 2005-11-30 |
WO2004070050A2 (fr) | 2004-08-19 |
ATE482207T1 (de) | 2010-10-15 |
WO2004070050A3 (fr) | 2005-02-17 |
KR20050098286A (ko) | 2005-10-11 |
FR2850652B1 (fr) | 2008-05-30 |
CN1768054A (zh) | 2006-05-03 |
NZ541270A (en) | 2008-11-28 |
PE20040808A1 (es) | 2004-12-31 |
AR042936A1 (es) | 2005-07-06 |
MXPA05007407A (es) | 2005-09-12 |
HRP20050679A2 (en) | 2006-12-31 |
TW200505898A (en) | 2005-02-16 |
DE602004029236D1 (de) | 2010-11-04 |
FR2850652A1 (fr) | 2004-08-06 |
MA27651A1 (fr) | 2005-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20054006L (no) | Cykliske ureaderivater, fremstillingsfremgangsmate derav og farmasoytisk anvendelse av samme som kinaseinhibitorer | |
TW200617004A (en) | Novel heterocycle-substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors | |
NO20063780L (no) | Fremgangsmate for fremstilling av 2-aminitiazol-5-aromatisk karboksamid som kinase inhibitorer. | |
AR057979A1 (es) | PIRAZOLPIRIMIDINAS COMO INHIBIDORAS DE PROTEíNA QUINASA. COMPOSICIONES FARMACEUTICAS. | |
NO20080456L (no) | Nye 2,4-dianilinopyrimidinderivater, fremstilling derav og deres anvendelse som medikamenter, farmasoytiske sammensetninger og, spesielt, som IKK inhibitorer | |
NO20063446L (no) | Tiazolderivater | |
NO20072632L (no) | Oksadiazolderivater som DGAT-inhibitorer | |
AR053405A1 (es) | Derivados de urea sustituidas, composiciones farmaceuticas y metodos para el tratamiento de cardiopatias | |
NO20051223L (no) | Oksadiazoler som modulatorer av metabotropisk glutamat reseptor-5. | |
NO20055688L (no) | Organiske forbindelser | |
NO20080717L (no) | Oksimderivat og fremgangsmate for fremstilling av dette | |
CO5580747A2 (es) | Derivados e intermediarios de n-adamantilmetilo como composiciones farmaceuticas y procesos para su preparacion | |
NO20051826L (no) | Heterosyklisk substituerte piperaziner for behandling av schizofreni | |
NO20050635L (no) | Nye tricykliske spiropiperidiner eller spiropyrrolidiner | |
AR050181A1 (es) | Derivados de urea ciclicos sustituidos, su preparacion y su uso farmaceutico como inhibidores de quinasa | |
ES2333802T3 (es) | Inhibidores no nucleicos de transcriptasa inversa. | |
NO20074763L (no) | (1,5-difenyl-1H-pyrazol-3-yl)oksadiazolderivater, fremgangsmate ved fremstilling derav og anvendelse av samme i terapi | |
NO20082975L (no) | Nye cykliske ureaderivater, fremstilling derav og farmasoytisk anvendelse derav som kinaseinhibitorer | |
ZA200810739B (en) | Pesticide containing novel pyridyl-methanamine derivative or its salt | |
NO20040961L (no) | Antitumoranaloger | |
NO20023161L (no) | Substituerte piperidiner, legemidler inneholdende disse forbindelser og fremgangsmåter for fremstilling av dem | |
NO20061045L (no) | Imidazolderivater | |
NO20073811L (no) | N-(heteroaryl)-1H-indol-2-karboksamidderivater og deres anvendelse som vanilloid TRPV1 reseptorligander | |
NO20063865L (no) | Heterocyklisk substituerte 7-amino-4-kinolon-3-karboksylsyrederivater, fremgangsmate for fremstilling derav og deres anvendelse som medikamenter | |
NO20062533L (no) | 5-fluor, 5-klor- og cyanopyridin-2-yl-tetrazoler som ligander for den metabotrofe glutamatreseptor-5 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |