ZA200501897B - Solid formulations comprising an indolinone compound. - Google Patents
Solid formulations comprising an indolinone compound. Download PDFInfo
- Publication number
- ZA200501897B ZA200501897B ZA200501897A ZA200501897A ZA200501897B ZA 200501897 B ZA200501897 B ZA 200501897B ZA 200501897 A ZA200501897 A ZA 200501897A ZA 200501897 A ZA200501897 A ZA 200501897A ZA 200501897 B ZA200501897 B ZA 200501897B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- alkyl
- hydrogen
- heteroaryl
- aryl
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 47
- 238000009472 formulation Methods 0.000 title claims description 45
- 239000007787 solid Substances 0.000 title claims description 11
- -1 indolinone compound Chemical class 0.000 title claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 114
- 229910052739 hydrogen Inorganic materials 0.000 claims description 98
- 239000001257 hydrogen Substances 0.000 claims description 98
- 150000002431 hydrogen Chemical class 0.000 claims description 87
- 125000001072 heteroaryl group Chemical group 0.000 claims description 78
- 125000003118 aryl group Chemical group 0.000 claims description 77
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 52
- 125000003545 alkoxy group Chemical group 0.000 claims description 44
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 26
- 229910052736 halogen Inorganic materials 0.000 claims description 18
- 125000001475 halogen functional group Chemical group 0.000 claims description 18
- 150000002367 halogens Chemical group 0.000 claims description 18
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 17
- 125000004953 trihalomethyl group Chemical group 0.000 claims description 16
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 claims description 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 9
- 125000004966 cyanoalkyl group Chemical group 0.000 claims description 9
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 9
- 125000004104 aryloxy group Chemical group 0.000 claims description 8
- 239000011230 binding agent Substances 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 6
- 239000007884 disintegrant Substances 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 5
- 150000004701 malic acid derivatives Chemical class 0.000 claims description 4
- 239000003623 enhancer Substances 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 4
- 229930195725 Mannitol Natural products 0.000 claims 4
- 235000019359 magnesium stearate Nutrition 0.000 claims 4
- 239000000594 mannitol Substances 0.000 claims 4
- 235000010355 mannitol Nutrition 0.000 claims 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 239000011734 sodium Substances 0.000 claims 4
- 229910052708 sodium Inorganic materials 0.000 claims 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 3
- 229940069328 povidone Drugs 0.000 claims 3
- GRFOHUBBUMAJMM-UHFFFAOYSA-N 3-(2-aminoquinolin-3-yl)-n-cyclohexyl-n-methylpropanamide Chemical compound C=1C2=CC=CC=C2N=C(N)C=1CCC(=O)N(C)C1CCCCC1 GRFOHUBBUMAJMM-UHFFFAOYSA-N 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 3
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004859 neutralization-reionization mass spectrometry Methods 0.000 description 1
- 229940100691 oral capsule Drugs 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42113302P | 2002-09-10 | 2002-09-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200501897B true ZA200501897B (en) | 2005-09-07 |
Family
ID=31994326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200501897A ZA200501897B (en) | 2002-09-10 | 2005-03-04 | Solid formulations comprising an indolinone compound. |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20040229930A1 (fr) |
| EP (1) | EP1536783B2 (fr) |
| JP (1) | JP2006503032A (fr) |
| KR (1) | KR20050059170A (fr) |
| CN (1) | CN1688304A (fr) |
| AR (1) | AR041193A1 (fr) |
| AT (1) | ATE403425T1 (fr) |
| AU (1) | AU2003280108B2 (fr) |
| BR (1) | BR0314182A (fr) |
| CA (1) | CA2498415C (fr) |
| DE (1) | DE60322720D1 (fr) |
| DK (1) | DK1536783T3 (fr) |
| DO (1) | DOP2003000708A (fr) |
| ES (1) | ES2309363T5 (fr) |
| GT (1) | GT200300193A (fr) |
| HN (1) | HN2003000272A (fr) |
| MX (1) | MXPA05002690A (fr) |
| MY (1) | MY136767A (fr) |
| NL (1) | NL1024261C (fr) |
| NO (1) | NO20051670L (fr) |
| NZ (1) | NZ538636A (fr) |
| PA (1) | PA8581801A1 (fr) |
| PE (1) | PE20040989A1 (fr) |
| PL (1) | PL375978A1 (fr) |
| PT (1) | PT1536783E (fr) |
| RU (1) | RU2005110663A (fr) |
| SI (1) | SI1536783T1 (fr) |
| TW (1) | TW200418836A (fr) |
| UY (1) | UY27969A1 (fr) |
| WO (1) | WO2004024127A2 (fr) |
| ZA (1) | ZA200501897B (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06003661A (es) | 2003-10-02 | 2006-06-05 | Pharmacia & Upjohn Co Llc | Sales y polimorfos de un compuesto de indolinona sustituido con pirrol. |
| EP1928462A1 (fr) * | 2005-09-20 | 2008-06-11 | Pfizer Products Incorporated | Formes de dosage et procedes de traitement utilisant un inhibiteur de la tyrosine kinase |
| CN101007801A (zh) * | 2006-01-27 | 2007-08-01 | 上海恒瑞医药有限公司 | 吡咯取代的2－二氢吲哚酮衍生物、其制法与医药上的用途 |
| TWI482772B (zh) * | 2006-08-21 | 2015-05-01 | Astrazeneca Ab | 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物 |
| WO2008024044A1 (fr) * | 2006-08-21 | 2008-02-28 | Astrazeneca Ab | Compositions pour administration orale comprenant un dérivé de triazolo [4, 5] pyrimidine |
| US20090004213A1 (en) | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
| CA2699306A1 (fr) * | 2007-11-21 | 2009-05-28 | Teva Pharmaceutical Industries Ltd. | Hemi-l-malate de sunitinib, polymorphes et leur preparation, polymorphes de malate de sunitinib racemique, compositions contenant une base de sunitinib et de l'acide malique et leur preparation |
| EP2113248A1 (fr) | 2008-04-29 | 2009-11-04 | Ratiopharm GmbH | Composition pharmaceutique comportant du N-[2-(diethylamino)ethyl]-5-[5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2-dimethyl-1H-pyrrole-3-carboxamide |
| EP2090306A1 (fr) | 2008-02-13 | 2009-08-19 | Ratiopharm GmbH | Compositions pharmaceutiques comportant du N-[2-(diethylamino)ethyl]-5-[5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide |
| WO2009100929A1 (fr) * | 2008-02-13 | 2009-08-20 | Ratiopharm Gmbh | Compositions pharmaceutiques comprenant du n-[2-(diéthylamino)éthyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidène)méthyl]-2,4-diméthyl-1h-pyrrole-3-carboxamide |
| EP2138167A1 (fr) * | 2008-06-24 | 2009-12-30 | ratiopharm GmbH | Compositions pharmaceutiques comportant du N-[2-(diethylamino)ethyl]-5-[5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide |
| US8618309B2 (en) | 2008-07-24 | 2013-12-31 | Teva Pharmaceutical Industries Ltd. | Sunitinib and salts thereof and their polymorphs |
| CA2704448A1 (fr) * | 2008-09-30 | 2010-04-08 | Teva Pharmaceutical Industries Ltd. | Compositions amorphes d'une base de sunitinib et d'acide l-malique |
| WO2012042421A1 (fr) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Procédé de traitement de la croissance cellulaire anormale |
| CN103301116A (zh) * | 2012-03-16 | 2013-09-18 | 大鹏药品工业株式会社 | 口服医药组合物 |
| CN105457021A (zh) | 2012-05-04 | 2016-04-06 | 辉瑞公司 | 前列腺相关抗原及基于疫苗的免疫治疗疗法 |
| CN104069076A (zh) * | 2013-03-29 | 2014-10-01 | 浙江九洲药业股份有限公司 | 一种无定型的舒尼替尼与pvp的组合物 |
| ES2715890T3 (es) | 2013-11-01 | 2019-06-06 | Pfizer | Vectores de expresión de antígenos asociados a la próstata |
| WO2015110952A1 (fr) | 2014-01-21 | 2015-07-30 | Wockhardt Limited | Compositions pharmaceutiques orales solides comprenant du ticagrelor ou un sel de ce dernier |
| CN104829596B (zh) * | 2014-02-10 | 2017-02-01 | 石家庄以岭药业股份有限公司 | 吡咯取代吲哚酮类衍生物、其制备方法、包含该衍生物的组合物、及其用途 |
| EP3539536A1 (fr) | 2018-03-15 | 2019-09-18 | MH10 Spolka z ograniczona odpowiedzialnoscia | Composition pharmaceutique de sunitinib ou de son sel dans sa forme polymorphe i |
| KR20210113290A (ko) | 2019-01-09 | 2021-09-15 | 셀진 코포레이션 | (s)-4-(4-(4-(((2-(2,6-다이옥소피페리딘-3-일)-1-옥소아이소인돌린-4-일)옥시)메틸)벤질)피페라진-1-일)-3-플루오로벤조나이트릴을 포함하는 약제학적 조성물 및 이의 사용 방법 |
| WO2022006512A1 (fr) * | 2020-07-02 | 2022-01-06 | The Board Of Regents Of The University Of Texas System | Méthodes de traitement du mélanome |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4609675A (en) * | 1984-08-17 | 1986-09-02 | The Upjohn Company | Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing |
| US6077533A (en) * | 1994-05-25 | 2000-06-20 | Purdue Pharma L.P. | Powder-layered oral dosage forms |
| AU1928501A (en) * | 1999-11-24 | 2001-06-04 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
| DE19956598A1 (de) * | 1999-11-25 | 2001-06-13 | Bosch Gmbh Robert | Ventil zum Steuern von Flüssigkeiten |
| DE122010000004I1 (de) * | 2000-02-15 | 2010-04-15 | Sugen Inc | Pyrrol substituierte indolin-2-on protein kinase inhibitoren |
| CA2455050C (fr) * | 2001-08-15 | 2007-02-20 | Pharmacia & Upjohn Company | Cristaux comprenant un sel d'acide malique de n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide, procedes de preparation associes et compositions correspondantes |
| TWI259081B (en) * | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
-
2003
- 2003-09-09 TW TW092124905A patent/TW200418836A/zh unknown
- 2003-09-09 HN HN2003000272A patent/HN2003000272A/es unknown
- 2003-09-10 NL NL1024261A patent/NL1024261C/nl not_active IP Right Cessation
- 2003-09-10 GT GT200300193A patent/GT200300193A/es unknown
- 2003-09-10 UY UY27969A patent/UY27969A1/es not_active IP Right Cessation
- 2003-09-10 JP JP2004535803A patent/JP2006503032A/ja active Pending
- 2003-09-10 DE DE60322720T patent/DE60322720D1/de not_active Expired - Lifetime
- 2003-09-10 AU AU2003280108A patent/AU2003280108B2/en not_active Ceased
- 2003-09-10 MX MXPA05002690A patent/MXPA05002690A/es not_active Application Discontinuation
- 2003-09-10 DO DO2003000708A patent/DOP2003000708A/es unknown
- 2003-09-10 ES ES03772489T patent/ES2309363T5/es not_active Expired - Lifetime
- 2003-09-10 EP EP03772489A patent/EP1536783B2/fr not_active Expired - Lifetime
- 2003-09-10 CN CNA038238500A patent/CN1688304A/zh active Pending
- 2003-09-10 PA PA20038581801A patent/PA8581801A1/es unknown
- 2003-09-10 RU RU2005110663/15A patent/RU2005110663A/ru not_active Application Discontinuation
- 2003-09-10 CA CA002498415A patent/CA2498415C/fr not_active Expired - Lifetime
- 2003-09-10 PE PE2003000913A patent/PE20040989A1/es not_active Application Discontinuation
- 2003-09-10 SI SI200331328T patent/SI1536783T1/sl unknown
- 2003-09-10 WO PCT/IB2003/005293 patent/WO2004024127A2/fr active IP Right Grant
- 2003-09-10 MY MYPI20033418A patent/MY136767A/en unknown
- 2003-09-10 US US10/658,801 patent/US20040229930A1/en not_active Abandoned
- 2003-09-10 NZ NZ538636A patent/NZ538636A/en unknown
- 2003-09-10 PL PL03375978A patent/PL375978A1/xx not_active Application Discontinuation
- 2003-09-10 AT AT03772489T patent/ATE403425T1/de not_active IP Right Cessation
- 2003-09-10 BR BR0314182-9A patent/BR0314182A/pt not_active IP Right Cessation
- 2003-09-10 DK DK03772489T patent/DK1536783T3/da active
- 2003-09-10 PT PT03772489T patent/PT1536783E/pt unknown
- 2003-09-10 AR ARP030103269A patent/AR041193A1/es not_active Application Discontinuation
- 2003-09-10 KR KR1020057004142A patent/KR20050059170A/ko not_active Application Discontinuation
-
2005
- 2005-03-04 ZA ZA200501897A patent/ZA200501897B/en unknown
- 2005-04-04 NO NO20051670A patent/NO20051670L/no not_active Application Discontinuation
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