ZA200501174B - COX-2 inhibiting pyridine derivatives - Google Patents
COX-2 inhibiting pyridine derivativesInfo
- Publication number
- ZA200501174B ZA200501174B ZA200501174A ZA200501174A ZA200501174B ZA 200501174 B ZA200501174 B ZA 200501174B ZA 200501174 A ZA200501174 A ZA 200501174A ZA 200501174 A ZA200501174 A ZA 200501174A ZA 200501174 B ZA200501174 B ZA 200501174B
- Authority
- ZA
- South Africa
- Prior art keywords
- cox
- pyridine derivatives
- inhibiting
- inhibiting pyridine
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0221443.5A GB0221443D0 (en) | 2002-09-16 | 2002-09-16 | Pyridine derivates |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200501174B true ZA200501174B (en) | 2006-11-29 |
Family
ID=9944138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200501174A ZA200501174B (en) | 2002-09-16 | 2005-02-09 | COX-2 inhibiting pyridine derivatives |
Country Status (24)
Country | Link |
---|---|
US (1) | US7446117B2 (de) |
EP (1) | EP1546107B1 (de) |
JP (1) | JP4630063B2 (de) |
KR (1) | KR20050046782A (de) |
CN (1) | CN1681788A (de) |
AR (1) | AR041246A1 (de) |
AT (1) | ATE462694T1 (de) |
AU (1) | AU2003276063A1 (de) |
BR (1) | BR0313718A (de) |
CA (1) | CA2493497A1 (de) |
DE (1) | DE60331931D1 (de) |
ES (1) | ES2343316T3 (de) |
GB (1) | GB0221443D0 (de) |
IL (1) | IL166460A0 (de) |
IS (1) | IS7659A (de) |
MA (1) | MA27436A1 (de) |
MX (1) | MXPA05002886A (de) |
NO (1) | NO20050662L (de) |
NZ (1) | NZ538201A (de) |
PL (1) | PL376023A1 (de) |
RU (1) | RU2005103618A (de) |
TW (1) | TW200404541A (de) |
WO (1) | WO2004024691A1 (de) |
ZA (1) | ZA200501174B (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006500372A (ja) | 2002-08-19 | 2006-01-05 | グラクソ グループ リミテッド | 選択的cox−2阻害物質としてのピリミジン誘導体 |
GB0221443D0 (en) | 2002-09-16 | 2002-10-23 | Glaxo Group Ltd | Pyridine derivates |
WO2005007627A1 (ja) * | 2003-07-18 | 2005-01-27 | Nihon Nohyaku Co., Ltd. | フェニルピリジン誘導体、その中間体及びこれを有効成分とする除草剤 |
SI2395002T1 (sl) | 2005-11-08 | 2014-10-30 | Vertex Pharmaceuticals Incorporated | Farmacevtski sestavek, vsebujoč heterociklični modulator prenašalcev z ATP-vezavno kaseto |
JP5497633B2 (ja) | 2007-05-09 | 2014-05-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | Cftrのモジュレーター |
KR20120102117A (ko) * | 2007-12-04 | 2012-09-17 | 에프. 호프만-라 로슈 아게 | 아이속사졸로-피리딘 유도체 |
AU2008335440B2 (en) | 2007-12-07 | 2013-11-07 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
WO2009073757A1 (en) | 2007-12-07 | 2009-06-11 | Vertex Pharmaceuticals Incorporated | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid |
US8299099B2 (en) | 2008-02-28 | 2012-10-30 | Vertex Pharmaceuticals Incorporated | Heteroaryl derivatives as CFTR modulators |
US8012976B2 (en) | 2008-08-06 | 2011-09-06 | Biomarin Pharmaceutical Inc. | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) |
WO2010046780A2 (en) * | 2008-10-22 | 2010-04-29 | Institut Pasteur Korea | Anti viral compounds |
CN102869258A (zh) | 2010-02-03 | 2013-01-09 | 生物马林药物股份有限公司 | 用于pten基因缺失相关疾病的治疗的聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂 |
PT2533640T (pt) | 2010-02-08 | 2017-01-03 | Medivation Technologies Inc | Processos de síntese de derivados de di-hidropiridoftalazinona |
WO2011127241A2 (en) | 2010-04-07 | 2011-10-13 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof |
TWI557123B (zh) | 2010-10-21 | 2016-11-11 | 梅迪維新技術公司 | 結晶型(8S,9R)-5-氟-8-(4-氟苯基)-9-(1-甲基-1H-1,2,4-三唑-5-基)-8,9-二氫-2H-吡啶并[4,3,2-de]呔-3(7H)-酮甲苯磺酸鹽 |
CN102464652B (zh) | 2010-11-02 | 2013-08-28 | 北京欧博方医药科技有限公司 | 咪唑衍生物、制备方法及用途 |
US8604062B2 (en) | 2011-10-20 | 2013-12-10 | Hoffman-La Roche Inc. | Process for the preparation of isoxazolyl-methoxy nicotinic acids |
TW201605814A (zh) * | 2013-11-07 | 2016-02-16 | 拜奧馬林製藥公司 | 用於合成經保護之n-烷基三唑甲醛的三唑中間體 |
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-
2002
- 2002-09-16 GB GBGB0221443.5A patent/GB0221443D0/en not_active Ceased
-
2003
- 2003-09-12 MX MXPA05002886A patent/MXPA05002886A/es not_active Application Discontinuation
- 2003-09-12 US US10/527,799 patent/US7446117B2/en not_active Expired - Fee Related
- 2003-09-12 KR KR1020057004428A patent/KR20050046782A/ko not_active Application Discontinuation
- 2003-09-12 AT AT03795019T patent/ATE462694T1/de not_active IP Right Cessation
- 2003-09-12 BR BR0313718-0A patent/BR0313718A/pt not_active IP Right Cessation
- 2003-09-12 WO PCT/EP2003/011065 patent/WO2004024691A1/en active Application Filing
- 2003-09-12 CA CA002493497A patent/CA2493497A1/en not_active Abandoned
- 2003-09-12 ES ES03795019T patent/ES2343316T3/es not_active Expired - Lifetime
- 2003-09-12 JP JP2004535518A patent/JP4630063B2/ja not_active Expired - Fee Related
- 2003-09-12 RU RU2005103618/04A patent/RU2005103618A/ru not_active Application Discontinuation
- 2003-09-12 NZ NZ538201A patent/NZ538201A/en unknown
- 2003-09-12 PL PL03376023A patent/PL376023A1/xx not_active Application Discontinuation
- 2003-09-12 AU AU2003276063A patent/AU2003276063A1/en not_active Abandoned
- 2003-09-12 AR ARP030103312A patent/AR041246A1/es not_active Application Discontinuation
- 2003-09-12 CN CNA038218496A patent/CN1681788A/zh active Pending
- 2003-09-12 DE DE60331931T patent/DE60331931D1/de not_active Expired - Lifetime
- 2003-09-12 EP EP03795019A patent/EP1546107B1/de not_active Expired - Lifetime
- 2003-09-15 TW TW092125337A patent/TW200404541A/zh unknown
-
2005
- 2005-01-20 IS IS7659A patent/IS7659A/is unknown
- 2005-01-24 IL IL16646005A patent/IL166460A0/xx unknown
- 2005-02-08 NO NO20050662A patent/NO20050662L/no not_active Application Discontinuation
- 2005-02-09 ZA ZA200501174A patent/ZA200501174B/xx unknown
- 2005-03-16 MA MA28149A patent/MA27436A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
NO20050662L (no) | 2005-04-15 |
MXPA05002886A (es) | 2005-05-27 |
TW200404541A (en) | 2004-04-01 |
MA27436A1 (fr) | 2005-07-01 |
DE60331931D1 (de) | 2010-05-12 |
KR20050046782A (ko) | 2005-05-18 |
JP2006507247A (ja) | 2006-03-02 |
AR041246A1 (es) | 2005-05-11 |
US7446117B2 (en) | 2008-11-04 |
ATE462694T1 (de) | 2010-04-15 |
JP4630063B2 (ja) | 2011-02-09 |
CN1681788A (zh) | 2005-10-12 |
IS7659A (is) | 2005-01-20 |
NZ538201A (en) | 2007-03-30 |
US20060040988A1 (en) | 2006-02-23 |
ES2343316T3 (es) | 2010-07-28 |
EP1546107A1 (de) | 2005-06-29 |
BR0313718A (pt) | 2005-07-12 |
RU2005103618A (ru) | 2005-10-27 |
EP1546107B1 (de) | 2010-03-31 |
CA2493497A1 (en) | 2004-03-25 |
AU2003276063A1 (en) | 2004-04-30 |
PL376023A1 (en) | 2005-12-12 |
GB0221443D0 (en) | 2002-10-23 |
WO2004024691A1 (en) | 2004-03-25 |
IL166460A0 (en) | 2006-01-15 |
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