ZA200500622B - Polypeptides with a signal sequence comprising an fivsi motif and olynucleotides encoding therefor - Google Patents
Polypeptides with a signal sequence comprising an fivsi motif and olynucleotides encoding thereforInfo
- Publication number
- ZA200500622B ZA200500622B ZA200500622A ZA200500622A ZA200500622B ZA 200500622 B ZA200500622 B ZA 200500622B ZA 200500622 A ZA200500622 A ZA 200500622A ZA 200500622 A ZA200500622 A ZA 200500622A ZA 200500622 B ZA200500622 B ZA 200500622B
- Authority
- ZA
- South Africa
- Prior art keywords
- motif
- sequence
- leader sequence
- fivsi
- olynucleotides
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108010076504 Protein Sorting Signals Proteins 0.000 title 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 3
- 235000004279 alanine Nutrition 0.000 abstract 3
- 229930182817 methionine Natural products 0.000 abstract 3
- 239000004474 valine Substances 0.000 abstract 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 2
- 229960000310 isoleucine Drugs 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 210000005253 yeast cell Anatomy 0.000 abstract 1
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0217033A GB0217033D0 (en) | 2002-07-23 | 2002-07-23 | Gene and polypeptide sequences |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200500622B true ZA200500622B (en) | 2007-07-25 |
Family
ID=9940938
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200500622A ZA200500622B (en) | 2002-07-23 | 2003-07-23 | Polypeptides with a signal sequence comprising an fivsi motif and olynucleotides encoding therefor |
| ZA200703235A ZA200703235B (en) | 2002-07-23 | 2007-04-19 | Polypeptides with a signal sequence comprising an fivsi motif and olynucleotides encoding therefor |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200703235A ZA200703235B (en) | 2002-07-23 | 2007-04-19 | Polypeptides with a signal sequence comprising an fivsi motif and olynucleotides encoding therefor |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8258102B2 (fr) |
| EP (2) | EP2390333B1 (fr) |
| JP (1) | JP4597668B2 (fr) |
| KR (1) | KR101246040B1 (fr) |
| CN (1) | CN1681930B (fr) |
| AT (1) | ATE527364T1 (fr) |
| AU (1) | AU2003254495B2 (fr) |
| CA (1) | CA2493432A1 (fr) |
| DK (1) | DK2390333T3 (fr) |
| GB (2) | GB0217033D0 (fr) |
| HK (1) | HK1071909A1 (fr) |
| NZ (1) | NZ537779A (fr) |
| WO (1) | WO2004009819A2 (fr) |
| ZA (2) | ZA200500622B (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0217033D0 (en) * | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
| EP1831375B1 (fr) | 2004-12-23 | 2014-07-16 | Novozymes Biopharma DK A/S | Technique d'expression genetique |
| CA2605078C (fr) | 2005-04-15 | 2013-01-08 | Human Matrix Sciences, Llc | Ligands de proteine de liaison a l'elastine derives de plantes et leurs procedes d'utilisation |
| JP5088688B2 (ja) * | 2005-09-30 | 2012-12-05 | Ｔｄｋラムダ株式会社 | 電池パック |
| JP2010183885A (ja) * | 2009-02-13 | 2010-08-26 | Kobe Univ | タンパク質の製造方法およびそれに用いる発現ベクター |
| BR112018012851A2 (pt) | 2015-12-22 | 2018-12-26 | Albumedix Ltd | cepas de expressão de proteína melhoradas |
| EP3443001A4 (fr) | 2016-04-11 | 2020-04-29 | Obsidian Therapeutics, Inc. | Systèmes de biocircuits régulés |
| AU2018286919B2 (en) | 2017-06-20 | 2022-10-06 | Albumedix Ltd. | Improved protein expression strains |
| EP3806888B1 (fr) | 2018-06-12 | 2024-01-31 | Obsidian Therapeutics, Inc. | Constructions régulatrices dérivées de pde5 et procédés d'utilisation en immunothérapie |
| EP3870600A1 (fr) | 2018-10-24 | 2021-09-01 | Obsidian Therapeutics, Inc. | Régulation de protéine accordable par er |
| JP2022524081A (ja) | 2019-03-08 | 2022-04-27 | オブシディアン セラピューティクス， インコーポレイテッド | 調整可能な制御のためのヒトカルボニックアンヒドラーゼ２組成物及び方法 |
| EP3983538A1 (fr) | 2019-06-12 | 2022-04-20 | Obsidian Therapeutics, Inc. | Compositions de ca2 et procédés de régulation ajustable |
| WO2020252404A1 (fr) | 2019-06-12 | 2020-12-17 | Obsidian Therapeutics, Inc. | Compositions de ca2 et procédés de régulation accordable |
| WO2021046451A1 (fr) | 2019-09-06 | 2021-03-11 | Obsidian Therapeutics, Inc. | Compositions et méthodes de régulation de protéine accordable dhfr |
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
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|---|---|---|---|---|
| GB9019919D0 (en) | 1990-09-12 | 1990-10-24 | Delta Biotechnology Ltd | Purification of proteins |
| US4440859A (en) | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| ES8105035A1 (es) | 1978-12-22 | 1981-05-16 | Biogen Nv | Un metodo para producir al menos un polipeptido que muestra antigenicidad de hbv |
| US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
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| JPS6041487A (ja) | 1983-04-25 | 1985-03-05 | ジエネンテツク・インコ−ポレイテツド | 酵母発現系でのアルフア因子配列の使用 |
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| US4810648A (en) | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
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| WO1988008027A1 (fr) | 1987-04-09 | 1988-10-20 | Delta Biotechnology Limited | Vecteur de levure |
| JPH0754720B2 (ja) | 1987-04-10 | 1995-06-07 | フレキシブルプリント回路板用電気接続端子 | |
| SE459586B (sv) | 1987-09-14 | 1989-07-17 | Mta Szegedi Biolog Koezponti | Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning |
| GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
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| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
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| JPH0671432B2 (ja) | 1991-03-20 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
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| WO1999053051A2 (fr) * | 1998-04-09 | 1999-10-21 | Genset | Etiquettes de sequences exprimees (est) des 5' et proteines humaines codees |
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| AU2002240882A1 (en) * | 2000-12-29 | 2002-07-16 | Rhein Biotech Gesellschaft Fur Neue Biotechnologische Prozesse Und Produkte Mbh | Method for producing heterologous proteins in a homothallic fungus of the sordariaceae family |
| CA2447212A1 (fr) | 2001-03-29 | 2002-10-24 | Incyte Genomics, Inc. | Molecules secretoires |
| US20060241027A1 (en) * | 2002-02-07 | 2006-10-26 | Hans-Peter Hauser | Hiv inhibiting proteins |
| JP2005530484A (ja) * | 2002-02-07 | 2005-10-13 | デルタ バイオテクノロジー リミテッド | アルブミン融合抗血管形成ペプチド |
| GB0217033D0 (en) * | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
-
2002
- 2002-07-23 GB GB0217033A patent/GB0217033D0/en not_active Ceased
-
2003
- 2003-07-23 JP JP2004522368A patent/JP4597668B2/ja not_active Expired - Lifetime
- 2003-07-23 AU AU2003254495A patent/AU2003254495B2/en not_active Ceased
- 2003-07-23 DK DK10193560.9T patent/DK2390333T3/en active
- 2003-07-23 ZA ZA200500622A patent/ZA200500622B/xx unknown
- 2003-07-23 CA CA 2493432 patent/CA2493432A1/fr not_active Abandoned
- 2003-07-23 WO PCT/GB2003/003273 patent/WO2004009819A2/fr active Application Filing
- 2003-07-23 AT AT03765208T patent/ATE527364T1/de not_active IP Right Cessation
- 2003-07-23 KR KR1020057001329A patent/KR101246040B1/ko active IP Right Grant
- 2003-07-23 GB GB0501988A patent/GB2406571B/en not_active Expired - Lifetime
- 2003-07-23 NZ NZ537779A patent/NZ537779A/en not_active IP Right Cessation
- 2003-07-23 CN CN038221470A patent/CN1681930B/zh not_active Expired - Fee Related
- 2003-07-23 US US10/522,074 patent/US8258102B2/en not_active Expired - Fee Related
- 2003-07-23 EP EP10193560.9A patent/EP2390333B1/fr not_active Expired - Lifetime
- 2003-07-23 EP EP03765208A patent/EP1530639B1/fr not_active Expired - Lifetime
-
2005
- 2005-06-15 HK HK05105012A patent/HK1071909A1/xx not_active IP Right Cessation
-
2007
- 2007-04-19 ZA ZA200703235A patent/ZA200703235B/en unknown
-
2012
- 2012-08-08 US US13/569,697 patent/US9133265B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200703235B (en) | 2009-08-26 |
| EP2390333B1 (fr) | 2015-10-21 |
| CN1681930B (zh) | 2012-09-26 |
| AU2003254495B2 (en) | 2009-03-26 |
| KR20050059046A (ko) | 2005-06-17 |
| GB2406571A (en) | 2005-04-06 |
| WO2004009819A3 (fr) | 2004-03-25 |
| CA2493432A1 (fr) | 2004-01-29 |
| EP2390333A1 (fr) | 2011-11-30 |
| EP1530639B1 (fr) | 2011-10-05 |
| HK1071909A1 (en) | 2005-08-05 |
| US20060183187A1 (en) | 2006-08-17 |
| JP2006501818A (ja) | 2006-01-19 |
| US20130059785A1 (en) | 2013-03-07 |
| US9133265B2 (en) | 2015-09-15 |
| GB2406571B (en) | 2007-02-21 |
| CN1681930A (zh) | 2005-10-12 |
| GB0501988D0 (en) | 2005-03-09 |
| JP4597668B2 (ja) | 2010-12-15 |
| ATE527364T1 (de) | 2011-10-15 |
| GB0217033D0 (en) | 2002-08-28 |
| US8258102B2 (en) | 2012-09-04 |
| WO2004009819A2 (fr) | 2004-01-29 |
| DK2390333T3 (en) | 2015-12-14 |
| EP1530639A2 (fr) | 2005-05-18 |
| KR101246040B1 (ko) | 2013-03-27 |
| NZ537779A (en) | 2008-06-30 |
| AU2003254495A1 (en) | 2004-02-09 |
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