AU2001275267A1 - Leader peptides for enhancing secretion of recombinant protein from a host cell - Google Patents
Leader peptides for enhancing secretion of recombinant protein from a host cellInfo
- Publication number
- AU2001275267A1 AU2001275267A1 AU2001275267A AU7526701A AU2001275267A1 AU 2001275267 A1 AU2001275267 A1 AU 2001275267A1 AU 2001275267 A AU2001275267 A AU 2001275267A AU 7526701 A AU7526701 A AU 7526701A AU 2001275267 A1 AU2001275267 A1 AU 2001275267A1
- Authority
- AU
- Australia
- Prior art keywords
- leader peptides
- host cell
- recombinant protein
- enhancing secretion
- secretion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Novel synthetic leader peptides have been identified. The leader peptides have use in a method of enhancing the secretion of a recombinant polypeptide produced in a host cell. Polynucleotides encoding the novel leader peptides and a method of designing the polynucleotides are described.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20951700P | 2000-06-05 | 2000-06-05 | |
US60/209,517 | 2000-06-05 | ||
PCT/US2001/018222 WO2001094418A2 (en) | 2000-06-05 | 2001-06-05 | Leader peptides for enhancing secretion of recombinant protein from a host cell |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001275267A1 true AU2001275267A1 (en) | 2001-12-17 |
Family
ID=22779048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001275267A Abandoned AU2001275267A1 (en) | 2000-06-05 | 2001-06-05 | Leader peptides for enhancing secretion of recombinant protein from a host cell |
Country Status (9)
Country | Link |
---|---|
US (1) | US6875590B2 (en) |
EP (1) | EP1290197B1 (en) |
JP (1) | JP2004510410A (en) |
AT (1) | ATE321870T1 (en) |
AU (1) | AU2001275267A1 (en) |
CA (1) | CA2412374A1 (en) |
DE (1) | DE60118370T2 (en) |
ES (1) | ES2263626T3 (en) |
WO (1) | WO2001094418A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003099996A2 (en) * | 2002-05-22 | 2003-12-04 | Biogen Idec Ma Inc. | Detection of secreted polypeptides |
EP2316857A1 (en) * | 2004-02-12 | 2011-05-04 | Morphotek, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
PL3540062T3 (en) | 2004-11-16 | 2021-12-27 | Humanigen, Inc. | Immunoglobulin variable region cassette exchange |
CA2600505C (en) | 2005-03-10 | 2016-05-03 | Morphotek, Inc. | Anti-mesothelin antibodies |
JP5167813B2 (en) * | 2005-05-12 | 2013-03-21 | 味の素株式会社 | Protein production method |
US7393671B2 (en) | 2006-03-30 | 2008-07-01 | E.I. Du Pont De Nemours And Company | Mutant carotenoid ketolases |
DE102006044841A1 (en) * | 2006-09-22 | 2008-04-03 | Wacker Chemie Ag | Signal peptide for the production of recombinant proteins |
NZ590619A (en) * | 2008-07-03 | 2012-08-31 | Pfenex Inc | High throughput screening method and use thereof to identify a production platform for a multifunctional binding protein |
WO2010033229A2 (en) * | 2008-09-22 | 2010-03-25 | Calmune Corporation | Methods and vectors for display of molecules and displayed molecules and collections |
MY159680A (en) * | 2009-11-17 | 2017-01-13 | Janssen Biotech Inc | Improved bacterial membrane protein secrection |
JP2014045730A (en) * | 2012-08-31 | 2014-03-17 | Meiji Univ | Polypeptide, gene, expression vector, method for transporting protein to endoplasmic reticulum, and method for designing signal peptide |
WO2016130667A1 (en) | 2015-02-10 | 2016-08-18 | Ohio State Innovation Foundation | Chlamydia-activated b cell platforms and methods thereof |
US10835601B2 (en) | 2015-11-10 | 2020-11-17 | Ohio State Innovation Foundation | Methods and compositions related to accelerated humoral affinity |
AU2018237338A1 (en) * | 2017-03-23 | 2019-10-10 | Ohio State Innovation Foundation | Recombinant |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4757013A (en) | 1983-07-25 | 1988-07-12 | The Research Foundation Of State University Of New York | Cloning vehicles for polypeptide expression in microbial hosts |
CA1341235C (en) * | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
FR2636643B1 (en) * | 1988-08-24 | 1990-12-28 | Sanofi Sa | PEPTIDE-SIGNAL, DNA SEQUENCES ENCODING SAME, EXPRESSION VECTORS CARRYING ONE OF SUCH SEQUENCES, AND METHOD FOR PERIPLASMIC PRODUCTION OF A POLYPEPTIDE |
US5223407A (en) * | 1988-08-31 | 1993-06-29 | Allelix Inc. | Excretion of heterologous proteins from e. coli |
EP0626448A3 (en) * | 1993-05-26 | 1998-01-14 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Process for preparing and purifying alpha-interferon |
US5470719A (en) | 1994-03-18 | 1995-11-28 | Meng; Shi-Yuan | Modified OmpA signal sequence for enhanced secretion of polypeptides |
US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
US5747662A (en) | 1995-03-01 | 1998-05-05 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
CA2403432A1 (en) * | 2000-03-22 | 2001-09-27 | Corixa Corporation | Immune mediators and related methods |
US20020082411A1 (en) * | 2001-01-23 | 2002-06-27 | Darrick Carter | Immune mediators and related methods |
-
2001
- 2001-06-05 JP JP2002501966A patent/JP2004510410A/en active Pending
- 2001-06-05 AU AU2001275267A patent/AU2001275267A1/en not_active Abandoned
- 2001-06-05 US US09/875,494 patent/US6875590B2/en not_active Expired - Fee Related
- 2001-06-05 DE DE60118370T patent/DE60118370T2/en not_active Expired - Lifetime
- 2001-06-05 WO PCT/US2001/018222 patent/WO2001094418A2/en active IP Right Grant
- 2001-06-05 ES ES01941959T patent/ES2263626T3/en not_active Expired - Lifetime
- 2001-06-05 AT AT01941959T patent/ATE321870T1/en not_active IP Right Cessation
- 2001-06-05 EP EP01941959A patent/EP1290197B1/en not_active Expired - Lifetime
- 2001-06-05 CA CA002412374A patent/CA2412374A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60118370D1 (en) | 2006-05-18 |
CA2412374A1 (en) | 2001-12-13 |
WO2001094418A3 (en) | 2002-09-26 |
JP2004510410A (en) | 2004-04-08 |
ATE321870T1 (en) | 2006-04-15 |
EP1290197B1 (en) | 2006-03-29 |
US6875590B2 (en) | 2005-04-05 |
WO2001094418A2 (en) | 2001-12-13 |
EP1290197A2 (en) | 2003-03-12 |
ES2263626T3 (en) | 2006-12-16 |
DE60118370T2 (en) | 2006-12-07 |
US20020072093A1 (en) | 2002-06-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2001275267A1 (en) | Leader peptides for enhancing secretion of recombinant protein from a host cell | |
NZ503850A (en) | April - a novel protein with growth effects | |
EP1092774A3 (en) | Borrelia burgdorferi antigen OspA, gene encoding it and uses thereof | |
AU2002360331A1 (en) | Egviii endoglucanase and nucleic acids encoding the same | |
MX9606492A (en) | Synthetic leader peptide sequences. | |
HK1065335A1 (en) | Fusion protein for the secretion of a protein of interest into the supernatant of the bacterial culture | |
NZ511991A (en) | Interleukin-17 related mammalian cytokines. Polynucleotides encoding them. uses | |
WO2002059315A3 (en) | Human nucleic acids and polypeptides and methods of use thereof | |
WO2003004636A3 (en) | Expression vectors encoding bacteriophage signal peptides | |
AU3479699A (en) | A polypeptide comprising the amino acid of an n-terminal choline binding proteina truncate, vaccine derived therefrom and uses thereof | |
WO2002090500A3 (en) | Novel human proteins, polynucleotides encoding them and methods of using the same | |
AU2001281464A1 (en) | Recombinant proteins containing repeating units | |
WO2002046408A3 (en) | Human proteins, polynucleotides encoding them and methods of using the same | |
WO2004089973A3 (en) | Peptides, polypeptides, and proteins of reduced immunogenicity and methods for their production | |
EP1181351A4 (en) | Method of purifying heterologous proteins | |
AU8748101A (en) | A novel polypeptide, a human protein stat2 and the polynucleotide encoding the polypeptide | |
AU1986501A (en) | A novel polypeptide-hexokinase protein 12 and polynucleotide encoding said polypeptide | |
AU2002210340A1 (en) | A novel polypeptide- human cbp20 protein 47.74 and the polynucleotide encoding said polypeptide | |
WO2002072770A3 (en) | Novel human proteins, polynucleotides encoding them and methods of using the same | |
AU4631501A (en) | A novel polypeptide, a human protein kinase tak1-27 and the polynucleotide encoding the polypeptide | |
AU5990100A (en) | ICBP90 polypeptide and its fragments and polynucleotides coding for said polypeptides and applications for diagnosing and treating cancer | |
AU6889901A (en) | A novel polypeptide-homo hs1 protein 16 and polynucleotide encoding said polypeptide | |
AU8953301A (en) | A novel polypeptide, a zinc-finger protein 34 and the polynucleotide encoding the polypeptide | |
AU4406501A (en) | A novel polypeptide-homo reverse-transcription -associated protein 9 and polynucleotide encoding said polypeptide | |
AU9364701A (en) | A novel polypeptide, a human latexin protein 53 and the polynucleotide encoding the polypeptide |